Contact
For administrative calls, please contact:
- Debbie Espinoza
- espinozad@uthscsa.edu
- 210-567-8115
Programs
Departments & Divisions
Institutes & Centers
Qiang Shen, Ph.D.
Assistant Professor/Research
Research Imaging Institute
I have over 15 years of experiences in developing and applying magnetic resonance imaging (MRI) to study anatomy, physiology and function of the central nervous system in normal and diseased states in animal models. In the past 2 years, I have applied my skills to study traumatic brain injury and Parkinson's disease. My specific interest are:
1) stroke imaging, imaging biomarkers for early detection, longitudinal monitoring, and prediction of tissue fate of ischemic
stroke;
2) novel MRI/MRS methodologies to dynamically measure blood flow,tissue oxygen tension, blood volume;
3) high-resolution functional MRI techniques for mapping layer-specific and columnar organization.
As a principal investigator, my stroke research work has been supported by Scientist Development Grant and Beginning-Grant-in-Aid of American Heart Association.
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Professional Background
Education
- 1997 - PhD - Biomedical Engineering - Xi'an Jiaotong University
- 1995 - MS - Biomedical Engineering - Xi'an Jiaotong University
- 1992 - BS - Biomedical Engineering - Xi'an Jiaotong University
- Postdoctoral Training - Biomedical Engineering - Xi'an Jiaotong University
- Postdoctoral Fellowship - Magnetic Resonance Imaging - University of Massachusetts Medical School
Appointments
- 11/2008 - Research Assistant Professor - UT Health San Antonio, Radiology, San Antonio
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Instruction & Training
- 1/2009 - Present, Post-Doctoral Student Supervision, UTHSCSA
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Research & Grants
Grants
Federal
Funding Agency
NIH/NIA
Title
Complex Intergrated Multi-Componet Projects in Aging Research (U19)
Status
Active
Period 7/2018 - 6/2023
Role
Co-Investigator
Grant Detail
Funding Agency
NIH/OD
Title
Supports the infrastructure of the Southwest National Primate Research Center
Status
Active
Period 5/2016 - 4/2021
Role
Co-Investigator
Grant Detail
NIH/OD P51, Southwest National Primate Research Center
Funding
Agency Department of Defense
Title
Effects of Short Pulse Radio Frequency Exposure on Brain Tissue
Status
Active
Period 6/2019 - 5/2020
Role
Principal Investigator
Grant Detail
Funding Agency
Veterans Health Administration
Title
Analysis of Olfactory Dysfunction for Early Diagnosis of Parkinson`s Disease
Status
Active
Period
4/2016 - 3/2020
Role
Co-Investigator
Grant Detail
This project will define the basis for olfactory dysfunction in early Parkinson?s disease in a genetic murine model employing expertise in olfaction, neurodegeneration, oxidative stress, neurobehavioral testing, and advanced imaging technologies.
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Publications
Book Chapter
Shen Q, Duong TQ. Dynamic Contrast Enhanced MRI for the Analysis of Blood-Brain Barrier Leakage in Traumatic Brain Injury. In: Amit K. Srivastava and Charles S. Cox, Jr. Pre-Clinical and Clinical Methods in Brain Trauma Research. 233 Spring Street, New York, NY 10013, USA: Springer Science+Business Media, LLC, part of Springer Nature; 2018. p. 271-282.
Journal Article
Biju KC, Shen Q, Hernandez ET, Mader MJ, Clark RA. Reduced cerebral blood flow in an α-synuclein transgenic mouse model of Parkinson`s disease Journal of Cerebral Blood Flow and Metabolism 2019 Dec;.
Musi M, Valentine, JM, Sickora, KR, Baeuerle, E, Thompson, CS, Shen Q, Orr ME. Tau protein aggregation is associated with cellular senescence in the brain Aging Cell 2018 Dec;17(6).
YV Tiwari, J Lu, Q Shen, B Cerqueira, TQ Duong. Magnetic resonance imaging of blood-brain barrier permeability in ischemic stroke using diffusion-weighted arterial spin labeling in rats Journal of Cerebral Blood Flow & Metabolism 2017 Jan;.
W Li, L Watts, J Long, W Zhou, Q Shen, Z Jiang, Y Li, TQ Duong. Spatiotemporal changes in blood-brain barrier permeability, cerebral blood flow, T 2 and diffusion following mild traumatic brain injury Brain Research 2016 Sep;1646:53-61.
Li W, Long JA, Watts L, Shen Q, Liu Y, Jiang Z, Duong TQ. Spatiotemporal changes in diffusion, T2 and susceptibility of white matter following mild traumatic brain injury NMR Biomed 2016 Jul;29(7):896-903.
Tiwari YV, Jiang Z, Sun Y, Du F, Rodriguez P, Shen Q, Duong TQ. Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke Brain Research 2016 Mar;1635:121-129.
Sun Y, Shen Q, Watts LT, Muir ER, Huang S, Yang GY, Suarez JI, Duong TQ. Multimodal MRI characterization in the acute phase of experimental subarachnoid hemorrhage Neuroscience 2016 Mar;316:53-62.
Shen Q, Huang S, Duong TQ. Time-to-Peak of T2*-Weighted Signal Change of Oxygen Challenge Improves the Identification of Penumbra in Ischemic Stroke Journal of Cerebral Blood Flow and Metabolism 2016 Feb;36(2):283-291.
Watts TL, Long JA, Boggs RC, Manga H, Huang S, Shen Q, Duong TQ. Delayed Methylene Blue Improves Lesion Volume, Multi-Parametric Quantitative Magnetic Resonance Imaging Measurements, and Behavioral Outcome after Traumatic Brain Injury Journal of Neurotrauma 2016 Jan;33(2):194-202.
Long JA, Watts LT, Li W, Shen Q, Muir E, Huang S, Boggs R, Suri A, Duong TQ. The effects of perturbed cerebral blood flow and cerebrovascular reactivity on structural MRI and behavioral readouts in mild traumatic brain injury Journal of Cerebral Blood Flow and Metabolism 2015 Nov;35(11):1852-1861.
Watts LT, Shen Q, Deng, S, Chemello, J, Duong TQ. Manganese-enhanced MRI in a controlled cortical impact model of mild traumatic brain injury Journal of Neurotrauma 2015 Jul;32:1001-1010.
Watts LT, Long JA, Manga H, Huang S, Shen Q, Duong TQ. Normobaric oxygen worsens outcome following mild Traumatic Brain Injury Journal of Cerebral Blood Flow and Metabolism 2015 Jul;35(7):1137-1144.
Zhao Jiang, Lora Talley Watts, Shiliang Huang, Qiang Shen, Pavel Rodriguez, Chunhua Chen, Changman Zhou and Timothy Q. Duong. Methylene Blue?s Effects on Autophagy and Apoptosis in Normal Tissue, Ischemic Penumbra and Ischemic Core defined by MRI PLoS One 2015 Jun;10(6).
Yunxia Li, Qiang Shen, Shiliang Huang, Wei Li, Justin Long, Timothy Q. Duong. Cerebral angiography, blood flow and vascular reactivity in progressive hypertension Neuroimaging 2015 May;111:329-337.
Long JA, Watts LT, Chemello J, Huang S, Shen Q, Duong TQ. Multiparametric and longitudinal MRI characterization of mild Traumatic Brain Injury in rats Journal of Neurotrauma 2015 Apr;32(8):598-607.
Shen Q, Huang S, Duong TQ. Ultra-High Spatial Resolution Basal and Evoked Cerebral Blood Flow MRI of the Rat Brain Brain Research 2015 Mar;1599:126-136.
Li W, Long JA, Watts LT, Zhao J, Shen Q, Li, Y, Duong TQ. A quantitative MRI method for imaging blood brain barrier leakage in experimental traumatic brain injury PLoS One 2014 Dec;9(12).
Pavel Rodriguez, Zhao Jiang, Shiliang Huang, Qiang Shen, Timothy Q. Duong. Methylene blue treatment delays progression of perfusion?diffusion mismatch to infarct in permanent ischemic stroke Brain Research 2014 Nov;1588:144-149.
Talley Watts L, Long JA, Chemello J, Van Koughnet S, Fernandez A, Huang S, Shen Q, Duong TQ. Methylene blue is neuroprotective against mild traumatic brain injury Journal of Neurotrauma 2014 Jun;31(11):1063-1071.
Review Article
Shen Q and Duong TQ. Magnetic resonance imaging of cerebral blood flow in animal stroke models Brain Circulation 2016 Jan;2(1):20-27.