Contact
For administrative calls, please contact:
- Danielle Hardaway
- Hardaway@uthscsa.edu
- 210-567-7477
Programs
Departments & Divisions
Institutes & Centers
Research
Anne–Marie Langevin, MD
Professor
Greehey Distinguished Chair in Pediatric Oncology
Publications
SARCOMA
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P, Gorlick R, Windhager R, Helmke K, Eriksson M, Hoogerbrugge PM, Schomberg P, Tunn PU, Kühne T, Jürgens H, van den Berg H, Böhling T, Picton S, Renard M, Reichardt P, Gerss J, Butterfass-Bahloul T, Morris C, Hogendoorn PC, Seddon B, Calaminus G, Michelagnoli M, Dhooge C, Sydes MR, Bernstein M; EURAMOS-1 investigators.J Clin Oncol. 2015 Jul 10;33(20):2279-87. doi: 10.1200/JCO.2014.60.0734. Epub 2015 Jun 1.PMID: 26033801 Free PMC article. Clinical Trial.
Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward. Lagmay JP, Krailo MD, Dang H, Kim A, Hawkins DS, Beaty O 3rd, Widemann BC, Zwerdling T, Bomgaars L, Langevin AM, Grier HE, Weigel B, Blaney SM, Gorlick R, Janeway KA.J Clin Oncol. 2016 Sep 1;34(25):3031-8. doi: 10.1200/JCO.2015.65.5381. Epub 2016 Jul 11.PMID: 27400942 Free PMC article. Clinical Trial.
Zoledronic acid therapy for recurrent giant cell tumor of the C2 vertebra in an adolescent. Bartanusz V, Ziu M, Jimenez DF, Crownover RL, Langevin AM.Spine J. 2015 Aug 1;15(8):1886-7. doi: 10.1016/j.spinee.2015.03.030. Epub 2015 Mar 25.PMID: 25817726 No abstract available.
In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma. Sanchez-Diaz PC, Hsiao TH, Zou Y, Sugalski AJ, Heim-Hall J, Chen Y, Langevin AM, Hung JY.Oncoscience. 2014 Sep 23;1(9):599-608. doi: 10.18632/oncoscience.85. eCollection 2014.PMID: 25594070 Free PMC article.
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. Sugalski AJ, Jiwani A, Ketchum NS, Cornell J, Williams R, Heim-Hall J, Hung JY, Langevin AM.J Pediatr Hematol Oncol. 2014 Aug;36(6):e353-8. doi: 10.1097/MPH.0000000000000104.PMID: 24487915 Free PMC article.
Highly aggressive thoracic desmoid tumors in adolescent siblings with fatal outcomes in an FAP kindred: a need for increased vigilance and intervention in at-risk AYAs. Gad MM, Langevin AM, Sugalski AJ, Tomlinson GE.Fam Cancer. 2020 Apr 13. doi: 10.1007/s10689-020-00177-2. Online ahead of print.PMID: 3228104612.
SUPPORTIVE CARE
Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial. Dupuis LL, Kelly KM, Krischer JP, Langevin AM, Tamura RN, Xu P, Chen L, Kolb EA, Ullrich NJ, Sahler OJZ, Hendershot E, Stratton A, Sung L, McLean TW.Cancer. 2018 Mar 15;124(6):1188-1196. doi: 10.1002/cncr.31198. Epub 2017 Dec 19.PMID: 29266260 Free PMC article. Clinical Trial.
Risk factors for chemotherapy-induced nausea in pediatric patients receiving highly emetogenic chemotherapy. Dupuis LL, Tamura RN, Kelly KM, Krischer JP, Langevin AM, Chen L, Kolb EA, Ullrich NJ, Sahler OJZ, Hendershot E, Stratton A, Sung L, McLean TW.Pediatr Blood Cancer. 2019 Apr;66(4):e27584. doi: 10.1002/pbc.27584. Epub 2018 Dec 18.PMID: 30561134 Clinical Trial.
Chemotherapy-Induced Nausea and Vomiting Prophylaxis: Practice Within the Children's Oncology Group. Patel P, Robinson PD, Orsey A, Freedman JL, Langevin AM, Woods D, Sung L, Dupuis LL.Pediatr Blood Cancer. 2016 May;63(5):887-92. doi: 10.1002/pbc.25915. Epub 2016 Jan 27.PMID: 26864262 Free PMC article. Clinical Trial.
CANCER CARE DISPARITIES
Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program. Roth ME, O'Mara AM, Seibel NL, Dickens DS, Langevin AM, Pollock BH, Freyer DR.J Oncol Pract. 2016 Apr;12(4):e388-95. doi: 10.1200/JOP.2015.009084. Epub 2016 Mar 29.PMID: 27026648 Free PMC article.
Hemophagocytic lymphohistiocytosis in Texas: observations on ethnicity and race. Niece JA, Rogers ZR, Ahmad N, Langevin AM, McClain KL.Pediatr Blood Cancer. 2010 Mar;54(3):424-8. doi: 10.1002/pbc.22359.PMID: 1995365111.
Understanding the Barriers to Pediatric Oncologist Engagement and Accrual to Clinical Trials in National Cancer Institute-Designated Community Oncology Research Programs. Dickens DS, Roth ME, Pollock BH, Langevin AM.JCO Oncol Pract. 2020 May 12:JOP1900707. doi: 10.1200/JOP.19.00707. Online ahead of print.PMID: 32396490
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Professional Background
Education
- 1989 - Clinical Fellowship - Drug Development - University of North Carolina/Burroughs Wellcome
- 1988 - Clinical Fellowship - Pediatrics Hematology/Oncology - Hospital for Sick Children
- 1984 - Residency - Adult Hematology - University of Montreal
- 1982 - Residency - Internal Medicine - University of Montreal
- 1980 - MD - Medicine - University of Montreal
- 1975 - Health Science - College Marie-Victorin
Appointments
- 12/2014 - Greehey Distinguished Chair in Pediatric Oncology - University of Texas Health Science Center, Pediatrics
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Instruction & Training
- 2/2017 - Present, Post Graduate Rotation Supervision, UTHSCSA
- 9/2011 - Present, Pediatric Hematology Oncology Board Didactics, CHRISTUS Santa Rosa Hospital
- 1/2009 - Present, Post Graduate Rotation Supervision, UTHSCSA/CSRCH/UHS
- 2/2008 - Present, Hematology-Oncology Journal Club, UTHSCSA
- 4/2005 - Present, Adult Sarcoma Tumor Board, UTHSCSA
- 7/2003 - Present, Pediatric Tumor Board, UTHSCSA/CSRCH
- 6/1999 - Present, Hematology/Oncology #1, The University of Texas Health Science Center
- 3/1992 - Present, Rotation Student Supervision, UTHSCSA
- 3/1992 - Present, Post Graduate Rotation Supervision, UTHSCSA
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Research & Grants
Clinical Trials, Pediatric Cancer, Phase I, Sarcoma
Population Science and Prevention Program
Grants
Federal
Funding Agency NCI Title South Texas Pediatric NCORP Status Active Period 8/2014 - 7/2019 Role Principal Investigator Grant Detail The goals of this infrastructure grant are to: 1) Provide the infrastructure necessary to maintain an active NCI-sponsored clinical trial program at the institutional level as well as at three other pediatric oncology program covering central and South Texas; 2) Increase enrollment of minority and underserved populations (i.e. Hispanics and Adolescents and Young Adults) on clinical trials; and 3)Develop an infrastructure system that will support cancer care delivery research.
Private
Funding Agency Genentech/MSK Title POETIC (GO29665) Status Active Period 4/2016 - Present Role Principal Investigator Grant Detail Funding Agency Genentech/MSK Title POETIC (GO29664) Status Active Period 10/2015 - Present Role Principal Investigator Grant Detail Funding Agency AMGEN Title POETIC (POE14-01) Status Active Period 4/2016 - Present Role Principal Investigator Grant Detail Funding Agency PUMA Title POETIC (POE16-01) Status Active Period 7/2017 - Present Role Principal Investigator Grant Detail
Funding Agency St. Baldrick's Foundation Title Project Every AYA - Everyone Deserves a Chance Status Active Period 1/2017 - 12/2017 Role Principal Investigator Grant Detail
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Publications
Abstract
Lipsitt AE,
Diaz VR,
Hung J,
Weitman S,
Langevin AM. Complete Remission in a Young Adult with Recurrent Extranodal NK/T-cell Lymphoma Treated on the iMATRIX Early-Phase Open-Label Atezolizumab Trial (GO29664); 2018 Jul. (POETIC Summer Meeting - 2018). Lopez MP,
Diaz VR,
Langevin AM. Localized Translation and Real-Time interpretation of Informed Consent Forms in Pediatric Oncology Clinical Trial Participation; 2018 Feb. (Advancing the Science of Cancer in Latinos - Inaugural Meeting San Antonio 2018). Higgerson K,
Langevin AM,
Rajani R,
Heim-Hall J,
Hung J,
Sugalski AJ. Characterization of Localized Osteosarcoma of the Extremity in Children, Adolescents, and Young Adults from South Texas: Increasing Insight into Hispanic Populations; 2018 Feb. (Advancing the Science of Cancer in Latinos - Inaugural Meeting San Antonio 2018). Cruz A, Bensal H, Tomlinson M, Bansal S, Langevin AM, Weitman SD. Hydroxychloroquine in Combination with Vorinostat to Improve Response in Pediatric Solid Tumor Cell Lines; 2017 Mar. (POETIC Winter Meeting - 2017). Trippett T, Rossato G, Langevin AM, Michon J, Frappas D, Locatelli F, Kowgler M, Tagen M, Kwan A, Das Thakur M, Georger B. A Phase I/II study of atezolizumab in pediatric and young adult patients with refractory/relapsed solid tumors (iMATRIX-Atezolizumab); 2017 Jan. (49th Annual SIOP Meeting 2017). Hung JY; Heim-Hall J; Chen Y; Langevin AM. MicroRNA signatures in osteosarcoma associated with clinical outcome; 2013 Sep. (Pediatric Blood and Cancer - SIOP 45th Congress).Journal Article
Langevin AR. Risk factors for chemotherapy-induced nausea in pediatric patients receiving highly emetogenic chemotherapy Pediatric Blood and Cancer 2018 Dec;. Dupuis LL
Kelly KM
Krischer JP
Langevin AM
Tamura RN
Xu P
Chen L
Kolb EA
Ullrich NJ
Sahler OJZ
Hendershot E
Stratton A
Sung L
McLean TW. Acupresure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: a single-blinded randomized controlled trial Cancer 2018 Mar;124(6):1188-1196. Joanne P. Lagmay, Mark Krailo, Ha Dang, AeRang Kim, Douglas Hawkins, Mason Bond, Orren Beaty, Brigette Widemann, Ted Zwerdling, Lisa Bomgaars, Anne-Marie Langevin, Holcombe Grier, Brenda Weigel, Richard Gorlick, Katherine Janeway. Outcome of recurrent osteosarcoma patients enrolled in seven phase II trials through CCG, POG, and COG: Learning from the past to move forward Journal of Clinical Oncology 2016 Sep;34(25). Patel Priya
Robinson, Paula D
Orsey, Andrea
Freedman, Jason L
Langevin AR
Woods Debbie
Sung Lillian
Dupuis Lee. Chemotherapy-Induced Nausea and Vomiting Prophylaxis: Practice Within the Children?s Oncology Group Pediatric Blood and Cancer 2016 May;:1-6. Roth, Michael
O`Mara, Ann
Seibel, Nita
Dickens, David
Langevin AR
Pollock, Brad
Freyer, David. Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program Journal of Oncology Practice 2016 Apr;. Bartanusz V, Ziu M, Jimenez DF, Crownover RL, Langevin AM. Zoledronic acid therapy for recurrent giant cell tumor of the C2 vertebra in an adolescent Spine J 2015 Mar;15(8):1886-1887. Patricia C. Sanchez-Diaz, Tzu-Hung Hsiao1, Yi Zou1, Aaron J. Sugalski, Josefine Heim-Hall, Yidong Chen, Anne-Marie Langevin, Jaclyn Y. Hung1. In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma Oncoscience 2014 Sep;. -
Clinical
Board Certifications
- American Board of Pediatrics/Hematology-Oncology