Gaczynska, Maria Eleonora | Faculty Directory

Professional Background

Education

1997 - Postdoctoral Fellowship - Cancer Biology - Massachusetts Institute of Technology, Center for Cancer Research
1995 - Postdoctoral Fellowship - Cell Biology - Harvard Medical School
1991 - Postdoctoral Fellowship - Immunology and Microbiology - University of Arizona College of Medicine
1990 - BS - Physics - Nicolaus Copernicus University, Poland
1990 - Postdoctoral Training - Senior Researcher, Department of Biophysics - University of Lodz, Poland
1989 - PhD - Biophysics - University of Lodz, Poland
1985 - MS - Molecular Biology - University of Lodz, Poland

Appointments

9/2005 - Associate Professor - University of Texas Health Science Center at San Antonio, Molecular Medicine, San Antonio

Instruction & Training

Present - MMED 5020 Research Practicum, Course Director - University of Texas Health Science Center at San Antonio

Present - CSAT 6069 Cancer Biology Core 2: “Ubiquitin-Proteasome System and Cancer” (4 hrs) - University of Texas Health Science Center at San Antonio

Present - INTD 5007, Module INTD 6009 Advanced Cell and Molecular Biology, Advanced Molecular Biology Module, “Protein synthesis, posttranslational modifications and proteolysis” module (8 hrs) in the core IMGP course - University of Texas Health Science Center at San Antonio

Present - MMED 5015 Modern Methods/Cell Molecular Biology, “Molecular Imaging”’ (2 hrs) - University of Texas Health Science Center at San Antonio

Present - IBMS 5000 Fundamentals of Biomedical Sciences: “Atomic Force Microscopy: from Molecules to Cells” (1hr) - University of Texas Health Science Center at San Antonio

Present - MMED 6016 Advanced Molecular, Cellular and Synthetic Biology “Protein synthesis, processing, targeting and degradation” and “Synthetic Biology” (10 hrs total; the latter 2-hours lecture shared with Dr. Osmulski) - University of Texas Health Science Center at San Antonio

Publications

Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s disease-like symptoms through increased turnover of β-

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunctio

Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing.

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

New Peptide-Based Pharmacophore Activates 20S Proteasome

Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer

Pipecolic esters as minimized templates for proteasome inhibition

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer

Small Molecule Modulation of Proteasome Assembly

Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway

Maria E Gaczynska, PhD

Education

Appointments