Dongwen Lyu (Lv), Ph.D., M.S.

• Research & Grants

  My research addresses two broad topics. The first topic is to study the mechanism of cancers (particularly protein folding/dynamics, protein-protein interaction, membrane proteins, and intrinsically disordered proteins) and develop small molecules including covalent and non-covalent inhibitors, proteolysis targeting chimeras (PROTACs), molecular glue degraders (MGDs), and other types of degraders to treat cancers. The second topic is to study the cellular and molecular mechanisms of aging and age-related diseases (particularly alternative splicing, protein isoforms, and protein quality control) and discover new senolytic drugs that can selectively eliminate senescent cells to treat aging and age-related diseases.

  Research profile

  Grants

  Title: Development of Caspase Cleavage Targeting Chimeras (CACTACs) for Targeted Protein Cleavage (Funded, Ongoing, Percentile: 5.0  Score: 21, first submission, payline: 10%)

  PI: Dongwen Lyu (contact)

  Agency and Project Number: NCI R21 CA286307

  Duration: 12/01/2023 – 11/30/2025

  Amount: $ 311,122 Direct cost ($97,708 Indirect cost)

  Effort: 2.4 calendar months

   

  P01 CA275717-01A1 (Funded)

  PI: Sung, Patrick (Core Leader: Hromas, Robert)

  Role: co-investigator

  09/01/2024 – 08/31/2029

  Title: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis: Chromosome and Replication Analysis (CRA) Core

  Amount: $ 1,225,226

  Effort: 2.4 calendar months

   

  R01 GM128731 (Funded, Ongoing)

  PI: Shaun Olsen

  Role: co-investigator

  04/15/2019 – 02/28/2027

  Title: Structure and function of the essential cell cycle regulator cdc34

  Effort: 1.2 calendar months

   

  R01 CA260239 (Funded, Ongoing)

  PI(s): Weizhou Zhang, Daohong Zhou, Guangrong Zheng

  Role: co-investigator

  05/01/2021 – 04/30/2026

  Title: Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis

  Effort: 0.6 calendar months

   

  R01 CA241191 (Funded, Ongoing)

  PI(s): Guangrong Zheng, Daohong Zhou, Marina Y Konopleva

  Role: co-investigator

  04/01/2020 – 03/31/2025

  Title: Inhibition of BCL-xL by targeted degradation

  Effort: 1.2 calendar months

   

  R01 CA242003 (Funded, Ongoing)

  PI(s): Daohong Zhou, Jose G Trevino, Guangrong Zheng

  Role: co-investigator

  09/01/2019 – 08/31/2024

  Title: Use of BCL-xL proteolysis targeting chimeras to treat pancreatic cancer

  Effort: 2.4 calendar months

   

  American Cancer Society Pilot grant (Funded, Ongoing)

  PI(s): Sajid Khan

  Role: co-investigator

  06/01/2024 – 05/31/2025

  Title: Developing novel KRAS-targeting molecules for precision cancer therapy

  Effort: 0.48 calendar months

   

  R01 AG063801 (Funded, Completed)

  PI(s): Daohong Zhou, Jennifer H Elisseeff, Guangrong Zheng

  Role: co-investigator

  08/01/2019 – 03/31/2024

  Develop BCL-xL proteolysis targeting chimeras as safer and better senolytics

  Effort: 1.2 calendar months

• Service

  Institutional

  As the Associate Director of GCCRI-TDC, I developed a series of new technologies for target identification and validation. Additionally, I provide scientific guidance to ensure our services support basic science research and drug development both within our university and for external customers. These new technologies include genome-wide CRISPR knockout/activation screening, CRISPR/Cas9-based gene editing, Cas13 RNA editing, proximity labeling assay, HiBiT assay, HiBiTSA, and nanoBRET assay. Furthermore, I also actively contributed to the grant applications for the Chromosome Replication Analysis (CRA) core, CPRIT core grant, along with other NIH funding endeavors.

  https://gccri.uthscsa.edu/services/tdc/

  Service to the Profession

  Grant reviewer

  NIH Study Section: Mechanisms of Cancer Therapeutics A – MCTA, June 2024

   

  Editor

  Frontiers in Pharmacology (2022-present, Associate Editor)

  Frontiers in Oncology (2022-present, Associate Editor)

• Publications

  51. Xiao, Y., Yuan, Y., Liu, Y., Lin, Z., Zheng, G., Zhou, D., Lv, D.* (2024) Targeted protein degradation: current and emerging approaches to identify new E3 ligases. Journal of Medicinal Chemistry (*The corresponding author) https://doi.org/10.1021/acs.jmedchem.4c00723

  50. Lin, Z.*, Xie, Y., Gongora, J., Liu, X., Zahn, E., Palai, B.B., Ramirez, D., Zhao, C., Han, X., MacTaggart, B., Zhang, Y., Greenberg, M.J., Lv, D., Kashina, A., Garcia, B.A.* (2024) An unbiased proteomic platform for activity-based arginylation profiling. BioRxiv (*The corresponding author) https://doi.org/10.1101/2024.06.01.596974

  49. Sobh, A., Encinas, E., Patel, A., Surapaneni, G., Kaestner, C., Clerio, M., Vasan, K., Freeman, T., Lv, D., Riva, A., Barwick, B., Zhou, D., Boise, L., Mitsiades, C.S., Kim, B., Bennett, R.L., Chandel, N., Licht, J.D.* (2024) NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome. Blood 2023022859 (*The corresponding author) https://doi.org/10.1182/blood.2023022859

  48. Nayak, D.*, Lv, D.*, Yuan, Y., Zhang, P., Hu, W., Ruben, E.A., Lv, Z., Sung, P., Hromas, R., Zheng, G.**, Zhou, D.** and Olsen, S.K.** (2024) Structure-guided development of a more potent second-generation dual degrader of BCL-2 and BCL-xL. Nature Communications 15:2743 (*The co-first author; **The corresponding author) https://doi.org/10.1038/s41467-024-46922-4

  47. Wang, L.*, Xiao, Y.*, Luo, Y., Master, R.P., Mo, J., Kim, M.C., Liu, Y., Maharjan, C., Patel, U.M., De, U., Carelock, M.E., Tithi, T.I., Li, X., Shaffer, D., Guertin, K.R., Zhuang, H., Moser, E., Smalley, K.S., Lv, D., Zhou, D., Zheng, G.**, Zhang, W.** (2024) PROTAC-mediated NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy. Journal of Experimental Medicine 221(3):e20231519 (*The co-first author; **The corresponding author) https://doi.org/10.1084/jem.20231519

  46. Lin, Z.*, Garcia, B.* Lv, D.* (2023) Bifunctional Peptide Nanofibrils for Targeted Protein Degradation. Angew. Chem. Int. Ed. (*The corresponding author) https://doi.org/10.1002/anie.202316581

  45. Lin, Z.*, Gongora, J., Liu, X., Xie, Y., Lv, D., Garcia, B.* (2023) Automation and artificial intelligence to enable high-throughput chemical proteomics. Journal of Proteome Research 22 (12), 3676–3682. (*The corresponding author) https://doi.org/10.1021/acs.jproteome.3c00467

  44. Xiao, Y.*, Hale, S.*, Awasthee, N., Meng, C., Zhang, X., Liu, Yi., Ding, H., Huo, Z., Lv, D., Zhang, W., He, M., Zheng, G.**, Liao, D.** (2023) Discovery of a highly potent and selective HDAC3 and HDAC8 dual PROTAC degrader. Cell Chemical Biology 30 (11), 1421–1435. (*The co-first author; **The corresponding author) https://doi.org/10.1016/j.chembiol.2023.07.010

  43. Pei, J.*, Xiao, Y.*, Liu, X.*, Hu, W., Sobh A., Yuan, Y., Zhou S., Hua, N., Yang Y., Mackintosh, S.G., Zhang, X., Basso K.B., Kamat M., Yang, Q., Licht, J.D., Zheng, G.**, Zhou, D.**, Lv, D.** (2023) Piperlongumine conjugates induce targeted protein degradation. Cell Chemical Biology 30 (2), 203–213. (*The co-first author; **The corresponding author) https://doi.org/10.1016/j.chembiol.2023.01.004

  42. Lv, D.*, Pal, P.*, Liu, X., Jia, Y., Thummuri, D., Zhang, P., Hu, W., Pei, J., Zhang, Q., Zhou, S., Khan, S., Zhang, X., Hua, N., Yang, Q., Arango, S., Zhang, W., Nayak, D., Olsen, S.K., Weintraub, S.T., Hromas, R. Konopleva, M., Yuan, Y., Zheng, G., Zhou, D. (2021) A BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nature Communications 12, 6896. (*The co-first author) https://doi.org/10.1038/s41467-021-27210-x 

  41. Pal, P.*, Thummuri, D.*, Lv, D., Liu, X., Zhang, P., Hu, W., Pod, S., Hua, H, Khan, S., Yuan, Y., Zhang, X., Zhou, D., Zheng, G. (2021) Discovery of a Novel BCL-X L PROTAC Degrader with Enhanced BCL-2 Inhibition. Journal of Medicinal Chemistry 64(19), 14230–14246. (*The co-first author) https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00517

  40. He, Y., Koch, R., Budamagunta, V., Zhang, P., Zhang, X., Khan, S., Thummuri, D., Ortiz, Y.T., Zhang, X., Lv, D., Wiegand, J.S., Li, W., Palmer, A.C., Zheng, G., Weinstock, D.M., Zhou, D. (2020) DT2216, a BCL-XL proteolysis targeting chimera (PROTAC), is a potent anti T-cell lymphoma agent that does not induce significant thrombocytopenia. Journal of Hematology & Oncology 13, 95. https://doi.org/10.1186/s13045-020-00928-9

  39. He, Y., Khan, S., Huo, Z., Lv, D., Zhang, X., Liu, X., Yuan, Y., Hromas, R., Xu, M., Zheng, G., Zhou, D. (2020) Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. Journal of Hematology & Oncology 13, 103. https://doi.org/10.1186/s13045-020-00924-z

  38. Zhang, X., He, Y., Zhang, P., Budamagunta, V., Lv, D., Thummuri, D., Yang, Y., Pei, J., Yuan, Y., Zhou, D., Zheng, G. (2020) Discovery of IAP-based BCL-XL PROTACs as potent degraders across multiple cancer cell lines. European Journal of Medicinal Chemistry 199, 112397. https://doi.org/10.1016/j.ejmech.2020.112397

  37. He, Y., Zhang, X., Chang, J., Kim, H., Zhang, P., Wang, Y., Khan, S., Liu, X., Zhang, X., Lv, D., Song, L., Li, W., Thummuri, D., Yuan, Y., Wiegand, J.S., Ortiz, Y.T., Budamagunta, V., Elisseeff, J.H., Campisi, J., Almeida, M., Zheng, G., Zhou, D. (2020) Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. Nature Communications 11(1), 1996. https://doi.org/10.1038/s41467-020-15838-0

  36. Liu, X., Zhang, X., Lv, D., Yuan, Y., Zheng, G., Zhou, D. (2020) Assays and technologies for Developing Proteolysis Targeting Chimera Degraders. Future Medicinal Chemistry 12(12), 1155–1179. https://doi.org/10.4155/fmc-2020-0073

  35. He, Y., Li, W., Lv, D., Zhang, X., Zhang, X., Ortiz, Y.T., Budamagunta, V., Campisi, J., Zheng, G., Zhou, D. (2020) Inhibition of USP7 activity selectively eliminates senescent cells in a p53-dependent manner. Aging Cell e13117. https://doi.org/10.1111/acel.13117

  34. Zhang, K.*, Lv, D.-W.*, Li, R. (2020) Protein inhibitor of activated STAT1 (PIAS1) inhibits IRF8 activation of Epstein-Barr virus lytic gene expression. Virology 11, 75–87. (*The co-first author) https://doi.org/10.1016/j.virol.2019.11.011

  33. Khan, S.*, Zhang, X.*, Lv, D.*, Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J.S., Pei, J., Zhang, W., Sharma, A., McCurdy, C.R., Kuruvilla, V.M., Baran, N., Ferrando, A.A., Kim, Y., Rogojina, A., Houghton, P.J., Huang, G.,   Hromas, R.A., Konopleva, M.Y., Zheng G., Zhou, D. (2019) A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nature Medicine 25, 1938–1947. (*The co-first author) https://doi.org/10.1038/s41591-019-0668-z (cited by 453 times)

  32. Zhang, K., Lv, D.-W., Li, R. (2019) Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Cell Reports 28(2), 449–459. https://doi.org/10.1016/j.celrep.2019.04.020

  31. Cho, J., Xu, Z., Parthasarathy, U., Drashansky, T., Helm, E., Zuniga, A., Lorentsen, K., Mansouri, S., Cho, J., Edelmann, M., Duong, D., Gehring, T., Seeholzer, T., Krappmann, D., Uddin, M., Califano, D., Wang, R., Jin, L., Li, H., Lv, D., Zhou, D., Zhou, L., Avram, D.. (2019) Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nature Communications 10(1), 701. https://doi.org/10.1038/s41467-019-08605-3

  30. Zhang, X., Zhang, S., Liu, X., Wang, Y., Chang, J., Zhang, X., Mackintosh, S.G., Tackett, A.J., He, Y., Lv, D., Laberge, R.-M., Campisi, J., Wang, J., Zheng, G., Zhou, D. (2018) Oxidation resistance 1 is a novel senolytic target. Aging Cell e12780. https://doi.org/10.1111/acel.12780

  29.  Lv, D.-W., Zhang, K., Li, R. (2018) Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. PLOS Pathogens 14(1): e1006868. https://doi.org/10.1371/journal.ppat.1006868 

  28. Zhang, K., Lv, D.-W., Li, R. (2017) B cell receptor activation and chemical induction trigger caspase-mediated cleavage of PIAS1 to facilitate Epstein-Barr virus reactivation. Cell Reports 21, 3445–3457. https://doi.org/10.1016/j.celrep.2017.11.071

  27. Zhen S.-M., Deng X., Zhang M., Zhu, G.-R., Lv, D.-W., Wang Y., Zhu D., Yan, Y.-M. (2017) Comparative phosphoproteomic analysis under high-nitrogen fertilizer reveals central phosphoproteins promoting wheat grain starch and protein synthesis. Frontiers in Plant Science 8, 67. https://doi.org/10.3389/fpls.2017.00067

  26.  Lv, D.-W., Zhong, J., Zhang, K., Pandey, A., Li, R. (2017) Understanding Epstein-Barr virus life cycle with proteomics: A temporal analysis of ubiquitination during virus reactivation. OMICS 21, 27–37. https://doi.org/10.1089/omi.2016.0158

  25.  Lv, D.-W., Zhen S.-M., Zhu, G.-R., Bian, Y.-W., Chen, G.-X., Han, C.-X., Yu, Z.-T., Yan, Y.-M. (2016) Genome-wide identification and analysis of H2O2-responsive and novel miRNAs in Brachypodium distachyon by high throughput sequencing. Frontiers in Plant Science 7, 1567. https://doi.org/10.3389/fpls.2016.01567

  24.  Lv, D.-W., Zhu, G.-R., Zhu, D., Bian, Y.-W., Liang, X.-N., Cheng, Z.-W., Deng, X., Yan, Y.-M. (2016) Proteomic and phosphoproteomic analysis reveals the response and defense mechanism in leaves of diploid wheat T. monococcum under salt stress and recovery. Journal of Proteomics 143, 93–105. https://doi.org/10.1016/j.jprot.2016.04.013

  23. Li, R., Liao, G., Nirujogi, R.S., Pinto, S.M., Shaw, P.G., Huang, T.C., Wan, J., Qian, J., Gowda, H., Wu, X., Lv, D.-W., Zhang, K., Manda, S.S., Pandey, A., Hayward, S.D. (2015) Phosphoproteomic profiling reveals Epstein-Barr virus protein kinase integration of DNA damage response and mitotic signaling. PLOS Pathogens 11, e1005346. https://doi.org/10.1371/journal.ppat.1005346

  22.  Bian, Y.-W.*, Lv, D.-W.*, Cheng, Z.-W.*, Gu, A.-Q., Cao, H., Yan, Y.-M. (2015) Integrative proteome analysis of Brachypodium distachyon roots and leaves reveals a synergetic responsive network under H2O2 stress. Journal of Proteomics 128, 388–402. (*The co-first author) https://doi.org/10.1016/j.jprot.2015.08.020

  21.  Gu, A., Hao, P., Lv, D., Zhen, S., Bian, Y., Ma, C., Xu, Y. , Zhang, W., Yan, Y. (2015) Integrated proteome analysis of the wheat embryo and endosperm reveals central metabolic changes involved in water deficit response during the grain development. Journal of Agricultural and Food Chemistry 63, 8478–87. https://doi.org/10.1021/acs.jafc.5b00575

  20.  Hao, P.*, Zhu, J.*, Gu, A.*, Lv, D., Ge, P., Chen, G., Li, X., Yan, Y. (2014) An integrative proteome analysis of seedling organs in tolerant and sensitive wheat cultivars under drought stress and recovery. Proteomics 15, 1544–63. https://doi.org/10.1002/pmic.201400179

  19. Zhang, M., Chen, G.-X., Lv, D.-W., Li, X.-H., Yan, Y.-M. (2015) N-linked glycoproteome profiling of seedling leaf in Brachypodium distachyon L. Journal of Proteome Research 14, 1727-1738. https://doi.org/10.1021/pr501080r

  18.  Yu, Y.*, Guo, G.*, Lv, D.*, Hu, Y., Li, J., Li, X., Yan, Y. (2014) Transcriptome analysis during seed germination of elite Chinese bread wheat cultivar Jimai 20. BMC Plant Biology 14, 20. (*The co-first author) https://doi.org/10.1186/1471-2229-14-20

  17.  Lv, D.-W., Li, X., Zhang, M., Gu, A.-Q., Zhen, S.-M., Wang, C., Li, X.-H., Yan, Y.-M. (2014) Large-scale phosphoproteome analysis in seedling leaves of Brachypodium distachyon L. BMC Genomics 15, 375. https://doi.org/10.1186/1471-2164-15-375

  16.  Ma, C., Zhou, J., Chen, G., Bian, Y., Lv, D., Li, X., Wang, Z., Yan, Y. (2014) iTRAQ-based quantitative proteome and phosphoprotein characterization reveals the central metabolism changes involved in wheat grain development. BMC Genomics 15, 1029. https://doi.org/10.1186/1471-2164-15-1029

  15.  Zhang, M.*, Ma, C.-Y.*, Lv, D.-W.*, Zhen, S.-M., Li, X.-H., Yan, Y.-M. (2014) Comparative phosphoproteome analysis of the developing grains in bread wheat (Triticum aestivum L.) under well-watered and water-deficit conditions. Journal of Proteome Research 13, 4281–4297. (*The co-first author) https://doi.org/10.1021/pr500400t

  14.  Zhang, M.*, Lv, D.*, Ge, P.*, Bian, Y., Chen, G., Zhu, G., Li, X., Yan, Y. (2014) Phosphoproteome analysis reveals new drought response and defense mechanisms of seedling leaves in bread wheat (Triticum aestivum L.). Journal of Proteomics 109, 290–308. (*The co-first author) https://doi.org/10.1016/j.jprot.2014.07.010

  13.  Lv, D.-W., Ge, P., Zhang, M., Cheng, Z.-W., Li, X.-H., Yan, Y.-M. (2014) Integrative network analysis of the signaling cascades in seedling leaves of bread wheat by large-scale phosphoproteomic profiling. Journal of Proteome Research 13, 2381–2395. https://doi.org/10.1021/pr401184v

  12.  Chen, G.- X.*, Lv, D.-W.*, Li, W.-D.*, Subburaj, S., Yu, Z.-T., Wang, Y.-J., Li, X.-H., Wang, K., Ye, X.-G., Ma, W., Yan, Y.-M. (2014) The α-gliadin genes from Brachypodium distachyon L. provide evidence for a significant gap in the current genome assembly. Functional Integrative Genomics 14, 149–160. (*The co-first author) https://doi.org/10.1007/s10142-013-0353-0

  11.   Lv, D.-W., Subburaj, S., Cao, M., Yan, X., Li, X., Appels, R., Sun, D.-F., Ma, W., Yan, Y.-M. (2014) Proteome and phosphoproteome characterization reveals new response and defense mechanisms of Brachypodium distachyon leaves under salt stress. Molecular and Cellular Proteomics 13, 632–652. https://doi.org/10.1074/mcp.M113.030171

  10.  Subburaj, S., Chen, G., Han, C., Lv, D., Li, X., Zeller, F. J., Hsam, S. L., Yan, Y. (2014) Molecular characterisation and evolution of HMW glutenin subunit genes in Brachypodium distachyon L. Journal of Applied Genetics 55, 27–42. https://doi.org/10.1007/s13353-013-0187-4

  9.    Han, C., Yu, Z., Feng, S., Lv, D., Yan, X., Chen, G., Li, X., Ma, W., Yan, Y. (2013) Applications of capillary electrophoresis for rapidly separating and characterizing water-soluble proteins of wheat grains. Cereal Research Communications 41, 601–612. https://doi.org/10.1556/CRC.2013.0035

  8.    Ge, P., Hao, P., Cao, M., Guo, G., Lv, D., Subburaj, S., Li, X., Yan, X., Xiao, J., Ma, W., Yan, Y. (2013) iTRAQ-based quantitative proteomic analysis reveals new metabolic pathways of wheat seedling growth under hydrogen peroxide stress. Proteomics 13, 3046–3058. https://doi.org/10.1002/pmic.201300042

  7.    Li, J., Wang, S.-L., Cao, M., Lv, D.-W., Subburaj, S., Li, X.-H., Zeller, F., Hsam, S., Yan, Y.-M. (2013) Cloning, expression, and evolutionary analysis of α-gliadin genes from Triticum and Aegilops genomes. Journal of Applied Genetics 54, 157–67. https://doi.org/10.1007/s13353-013-0139-z

  6.    Yu, Z., Han, C., Wang, S., Lv, D., Chen, G., Li, X., Jiang, G.-L., Yan, Y. (2012) Fast separation and characterization of water-soluble proteins in wheat grains by reversed-phase ultra performance liquid chromatography (RP-UPLC). Journal of Cereal Science 57, 288–294.

  5.    Zhou, X., Wang, K., Lv, D., Wu, C., Li, J., Zhao, P., Lin, Z., Du, L., Yan, Y., Ye, X. (2013) Global Analysis of Differentially Expressed Genes and Proteins in the Wheat Callus Infected by Agrobacterium tumefaciens. PLOS One 8, e79390. https://doi.org/10.1016/j.jcs.2012.11.008

  4.    Wang, S.*, Wang, K.*, Chen, G.*, Lv, D.*, Han, X., Yu, Z., Li, X., Ye, X., Hsam, S. L., Ma, W., Appels, R., Yan, Y. (2012) Molecular characterization of LMW-GS genes in Brachypodium distachyon L. reveals highly conserved Glu-3 loci in Triticum and related species. BMC Plant Biology 12, 221. (*The co-first author) https://doi.org/10.1186/1471-2229-12-221

  3.    Jiang, S.S., Liang, X.N., Li, X., Wang, S.L., Lv, D.W., Ma, C.Y., Li, X.H., Ma, W.J., Yan, Y.M. (2012) Wheat drought-responsive grain proteome analysis by linear and nonlinear 2-DE and MALDI-TOF mass spectrometry. International Journal of Molecular Sciences 13, 16065–16083. https://doi.org/10.3390/ijms131216065

  2.    Guo, G.*, Lv, D.*, Yan, X.*, Subburaj, S., Ge, P., Li, X., Hu, Y., Yan, Y. (2012) Proteome characterization of developing grains in bread wheat cultivars (Triticum aestivum L.). BMC Plant Biology 12, 147. (*The co-first author) https://doi.org/10.1186/1471-2229-12-147

  1.    Guo, G., Ge, P., Ma, C., Li, X., Lv, D., Wang, S., Ma, W., Yan, Y. (2012) Comparative proteomic analysis of salt response proteins in seedling roots of two wheat varieties. Journal of Proteomics 75, 1867–1885. https://doi.org/10.1016/j.jprot.2011.12.032