Anna Malkova, PhD

Currently seeking Ph.D. students

• Professional Background

  Education

  • 1993 - Ph.D - Molecular Genetics - St. Petersburg State University, St. Petersburg, Russia. Mentor: Dmitry Gordenin
  • 1987 - BS - Genetics - St. Petersburg State University St. Petersburg, Russia

  Training

  • 2003 - Post-Doctoral Fellow - Mechanisms of double-strand break repair - Brandeis University, Waltham, MA. Mentor: James Haber
  • 1996 - Post-Doctoral Fellow, - Mechanisms of double-strand break repair - Brandeis University, Waltham, MA. Mentor: James Haber

  Appointments

  • 2003 – 2009 - Assistant Professor of Biology - Indiana University Purdue University, Indianapolis
  • 2009 - 2013 - Associate Professor of Biology, - ndiana University Purdue University, Indianapolis
  • 2009 - 2013 - Adjunct Associate Professor - Department Medical and Molecular Genetics, Indiana University School of Medicine
  • 2014 - 2018 - Associate Professor of Biology, - University of Iowa
  • 2018 - 2022 - Professor of Biology, - University of Iowa
  • 2022 - 2024 - Roy J. Carver Professor of Biology - University of Iowa
  • 2024-Current - Adjunct Professor - University of Iowa

• Research & Grants

  Areas of Research Interest
  DNA repair, Homologous Recombination, Cancer Etiology, Break-Induced Replication (BIR), BRCA1/2; Telomere homeostasis, Microhomology-Mediated BIR (MMBIR) in cancer cells, genomic instability, mutagenesis, APOBEC; mutation clusters

  Malkova Lab

  Grants

  Current Status: Funded & ongoing

  SEPTEMBER 2022-
  MAY 2027 R01AG081263-01A1, NIA Genetic and environmental factors affecting alternative lengthening of telomeres.
  Role: PI (MPI: Comeron)
  Total Award amount: $1,864,784

  JUNE 2018 – MAY 2028
  R35GM127006, NIGMS
  Double strand break repair maelstrom: causes, mechanisms and genome destabilizing consequences.
  Role: PI
  Total Award amount: $3,742,750
  3R35GM127006-04S1 (Supplemental)
  Award amount: $98,998

  APRIL 2019 – MARCH 2024 R01CA232425, NCI
  The role of human RAD52 protein in genome stability
  Role: MPI (MPIs: Spies, Malkova, Pichierri)
  Total Award amount: $2,042,780

  Completed
  MAY 2022 – APRIL 2023
  UI Environmental Health Sciences Research Center
  Identifying conserved ncRNAs that trigger stress-induced epigenetic changes.
  Role: Co-I (PI: Prahlad)
  Total Award amount: $40,000

  JUNE 2022 – MAY 2023
  College of Public Health and the Carver College of Medicine (UI)
  Addressing Rural Environmental Health in a Changing Climate: Identifying Conserved Targets for Intervention to Address Climate Change-Mediated Health Effects.
  Role: Co-I (PI: Lehmler)
  Total Award amount: S500,000

  SEPTEMBER 2018- AUGUST 2020
  R21ES030307, NIEHS Genetic and environmental factors affecting alternative lengthening of telomeres
  Role: PI (MPI: Comeron)
  Total Award amount: $408,064

  APRIL 2018 – MARCH 2020
  R03ES029306, NIEHS
  Suppressors and drivers of long-tract repair DNA synthesis (LTRS)
  Role: PI
  Total Award amount: $152,500

  JULY 2008– APRIL 2019
  1R01GM084242, NIGMS
  Amplification of risk resulting from mis-routing of double-strand break repair
  Role: PI
  Total Award amount: $1,148,600
  3R01GM084242-08S1 (Supplemental)
  Award amount: $151,474
  3R01GM084242-07S1 (Supplemental)
  Award amount: $57,700

  AUGUST 2008– JUNE 2011
  1R03 ES016434; NIEHS
  Visualization of break-induced replication Role: PI (MPI: Lobachev)
  Total Award amount: $179,862

  MARCH 2006– FEBRUARY 2009
  R15GM074657; NIGMS
  Mechanisms of break-induced replication in yeast Role: PI
  Award amount: $227,250
  3R15GM074657-01A1S1 (Supplemental)
  Total Award amount: $34,000

  DECEMBER 2016-DECEMBER 2017
  UIowa Cancer Center Collaborative Pilot Grant
  The role of Srs2 helicase in regulation of homologous recombination
  Role: PI (MPI: Spies)
  Total Award amount: $100,000

  JUNE 2008-MAY 2009
  MAY 2004 -JULY 2004
  Purdue University Research Fund (PRF)
  Research Grants
  Role: PI
  Genetic consequences of failed break-induced replication. Award amount:: $16,375
  Mechanisms of DSB DNA repair by break-induced replication. Total Award amount: $7,000

  OCTOBER 2012-SEPTEMBER 2013
  NOVEMBER 2009-MAY 2010
  JULY 2007 – JUNE 2008
  JANUARY 2006–DECEMBER.2006

  Research Support Fund Grants (Indiana University)Role: PI
  Molecular mechanism of break-induced replication
  Funding Level: $35,000
  Development of Novel Biosensors for Mutagenic Exposures Funding Level: $14,000
  Analysis of molecular intermediates of break-induced replication Funding Level: $35,000
  Mechanism of break-induced replication in yeast
  Funding Level: $30,000

  JANUARY 2006-DECEMBER 2006
  American Cancer Society (Indiana University Institutional grant)
  Role: PI Mechanism of BIR and gross chromosomal rearrangements. Award amount: $20,000

• Publications

  ‪Anna Malkova‬ - ‪Google Scholar‬