Yong Ge, PhD

Assistant Professor

My research is focused on investigating the microbe-host interactions and understanding the molecular mechanisms by which gut commensal bacteria sustain gut homeostasis against intestinal disorders. I am fascinated by the complexed interplay between gut microbes and their environment, in particular the intestinal epithelium and intestinal immunity. Specifically, how the signaling is initiated by the recognition of bacterial surface structures by innate sensing receptors, and how microbially derived metabolites such as vitamins (e.g., B12) are involved in modulating transcriptional, metabolic and epigenetic programming of host cells to resist intestinal pathogen infection.

Professional Background
Education
- 2014 - Microbiology - Doctor of Philosophy - Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Training
- 2008 - Bachelor - Biological Sciences - College of Life Sciences, Hubei University, Wuhan, China
Publications
1. Ge, Y., Zadeh, M., Yang, C., Candelario-Jalil, E., and Mohamadzadeh, M. (2022). Ischemic Stroke Impacts the Gut Microbiome, Ileal Epithelial and Immune Homeostasis. iScience 25, 105437. 10.1016/j.isci.2022.105437.
2. Ge, Y., Zadeh, M., and Mohamadzadeh, M. (2022). Vitamin B12 regulates the transcriptional, metabolic, and epigenetic programing in human ileal epithelial cells. Nutrients 14. https://doi.org/10.3390/nu14142825.
3. Ge, Y., Zadeh, M., and Mohamadzadeh, M. (2022). Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice. Journal of Experimental Medicine 219. 10.1084/jem.20220057.
4. Roth, W., Zadeh, K., Vekariya, R., Ge, Y., and Mohamadzadeh, M. (2021). Tryptophan Metabolism and Gut-Brain Homeostasis. Int J Mol Sci 22. 10.3390/ijms22062973.
5. Kumar, A., Priyamvada, S., Ge, Y., Jayawardena, D., Singhal, M., Anbazhagan, A.N., Chatterjee, I., Dayal, A., Patel, M., Zadeh, K., et al. (2021). A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity. Gastroenterology 160. 10.1053/j.gastro.2020.11.008.
6. Li, J., Ge, Y., Zadeh, M., Curtiss, R., 3rd, and Mohamadzadeh, M. (2020). Regulating vitamin B12 biosynthesis via the cbiMCbl riboswitch in Propionibacterium strain UF1. Proc Natl Acad Sci U S A 117, 602-609. 10.1073/pnas.1916576116.
7. Ge, Y., Gong, M., Zadeh, M., Li, J., Abbott, J.R., Li, W., Morel, L., Sonon, R., Supekar, N.T., Azadi, P., et al. (2020). Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation. Mucosal Immunol 13, 34-46. 10.1038/s41385-019-0210-0.
8. Choi, S.C., Brown, J., Gong, M., Ge, Y., Zadeh, M., Li, W., Croker, B.P., Michailidis, G., Garrett, T.J., Mohamadzadeh, M., and Morel, L. (2020). Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice. Sci Transl Med 12. 10.1126/scitranslmed.aax2220.
9. Morffy Smith, C.D., Gong, M., Andrew, A.K., Russ, B.N., Ge, Y., Zadeh, M., Cooper, C.A., Mohamadzadeh, M., and Moore, J.M. (2019). Composition of the gut microbiota transcends genetic determinants of malaria infection severity and influences pregnancy outcome. EBioMedicine 44, 639-655. 10.1016/j.ebiom.2019.05.052.
10. Ge, Y., Gong, M., Colliou, N., Zadeh, M., Li, J., Jones, D.P., Li, S., and Mohamadzadeh, M. (2019). Neonatal intestinal immune regulation by the commensal bacterium, P. UF1. Mucosal Immunology 12, 434-444. 10.1038/s41385-018-0125-1.
11. Bostick, J.W., Wang, Y., Shen, Z., Ge, Y., Brown, J., Chen, Z.E., Mohamadzadeh, M., Fox, J.G., and Zhou, L. (2019). Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species. Proc Natl Acad Sci U S A 116, 24760-24769. 10.1073/pnas.1908128116.
12. Tedesco, D., Thapa, M., Chin, C.Y., Ge, Y., Gong, M., Li, J., Gumber, S., Speck, P., Elrod, E.J., Burd, E.M., et al. (2018). Alterations in intestinal microbiota lead to production of interleukin 17 by intrahepatic gammadelta T-cell receptor-positive cells and pathogenesis of cholestatic liver disease. Gastroenterology 154, 2178-2193. 10.1053/j.gastro.2018.02.019.
13. Sahay, B., Colliou, N., Zadeh, M., Ge, Y., Gong, M., Owen, J.L., Valletti, M., Jobin, C., and Mohamadzadeh, M. (2018). Dual-route targeted vaccine protects efficiently against botulinum neurotoxin A complex. Vaccine 36, 155-164. 10.1016/j.vaccine.2017.11.008.
14. Hu, Y., Cai, Q., Tian, S., Ge, Y., Yuan, Z., and Hu, X. (2018). Regulator DegU is required for multicellular behavior in Lysinibacillus sphaericus. Research in Microbiology 169, 177-187. 10.1016/j.resmic.2017.12.006.
15. Fu, P., Ge, Y., Hu, Y., Yuan, Z., and Hu, X. (2018). A toxin-antitoxin system is essential for the stability of mosquitocidal plasmid pBsph of Lysinibacillus sphaericus. Microbiological Research 214, 114-122. 10.1016/j.micres.2018.06.013.
16. Colliou, N., Ge, Y., Gong, M., Zadeh, M., Li, J., Alonzo, F., 3rd, and Mohamadzadeh, M. (2018). Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection. Gut Microbes 9, 279-287. 10.1080/19490976.2017.1417731.
17. Fu, P., Xiang, X., Ge, Y., Yuan, Z., and Hu, X. (2017). Differential expression of duplicated binary toxin genes binA/binB in Lysinibacillus sphaericus C3-41. Letters in Applied Microbiology 65, 90-97. 10.1111/lam.12752.
18. Fu, P., Ge, Y., Wu, Y., Zhao, N., Yuan, Z., and Hu, X. (2017). The LspC3-41I restriction-modification system is the major determinant for genetic manipulations of Lysinibacillus sphaericus C3-41. BMC Microbiology 17, 116. 10.1186/s12866-017-1014-6.
19. Colliou, N., Ge, Y., Sahay, B., Gong, M., Zadeh, M., Owen, J.L., Neu, J., Farmerie, W.G., Alonzo, F., 3rd, Liu, K., et al. (2017). Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation. Journal of Clinical Investigation 127, 3970-3986. 10.1172/JCI95376.

Yong Ge, PhD

Education

Training