Luisa M. Rodriguez, MD, MS

• Professional Background

  Education

  • 2010 - Master of Science - Clinical Investigation - Baylor College of Medicine, Houston TX
  • 1998 - Doctor of Medicine - Medicine - University of Puerto Rico School of Medicine, San Juan, Puerto Rico
  • 1994 - Associates Degree - University o Puerto Rico, Ponce, Puerto Rico

  Training

  • 2004 - Fellowship - Pediatric Endocrinology and Metabolism - Texas Children's Hospital, Baylor College of Medicine, Houston TX
  • 2001 - Internship and Residency - Pediatrics - University of Puerto Rico, University Pediatric Hospital, San Juan, Puerto Rico

  Highlights

  1. National Hispanic Fund Scholarship, 1995
  2. Medical Advancement Program II member, University of Virginia, Charlottesville, Virginia, 1994.
  3. Summa Cum Laude, University of Puerto Rico, Ponce, Puerto Rico, 1994.
  4. Dean Award, University of Puerto Rico, Ponce, Puerto Rico, 1994.
  5. Dean Honor List, University of Puerto Rico, Ponce, Puerto Rico, 1991-1994.

  Appointments

  • 6/2021 - Present - Associate Professor, Department of Pediatrics - UT Health San Antonio, San Antonio TX
  • 2014 - 2020 - Associate Professor, Department of Pediatrics - Baylor College of Medicine, Houston TX
  • 2004 - 2014 - Assistant Professor, Department of Pediatrics - Baylor College of Medicine, Houston TX

• Research & Grants

  Research interests:

  Pediatric clinical research that involves new treatment options for children with Type 2 diabetes and appetite suppression in obesity.

  Grants

  2012-2014                   National Institutes of Health National Institutes of Health RO3 DK096067.    Effort 10%, (L.M. Rodriguez PI), Title: Glucose lowering effect of metformin and sitagliptin in adolescents with Type 1 diabetes. This grant provides $50,000 per year to fund my research project. The goal of this project is to study the glucose lowering effect oral hypoglycemic agents in type 1 diabetes children when used in combination with insulin.

  2008-2013                   National Institutes of Health Clinical Mentored Award 1 K23 DK075931 Effort- 75%, (L.M. Rodriguez PI), Title: The Role of Amylin and GLP-1 mimetics in Pediatric Type 2 Diabetes. This Grant provides salary support plus $25,000 to fund my research project. The major goal of this project is to study the effect of pramlintide and exenatide in regulating postprandial glucose homeostasis.

  2011-2013                   Daiichi Sankyo Pharmaceuticals Industry Initiated Multicenter trial.  Effort 1% (S.V. McKay PI; L.M. Rodriguez Co-PI) Title Colesevelam oral suspension as monotherapy or add-on to metformin therapy in pediatric subjects with Type 2 Diabetes Mellitus. The goal of this study is to demonstrate the effects of Colesevelam as monotherapy or add-on to metformin on mean change of HbA1c from baseline to 6 months. This is a randomized double blind multicenter industry initiated trial.

  2005-2013       Eli Lily &Co Investigator Initiated Grant, Effort 1%. (L.M. Rodriguez –PI, Co-PI from 2005-2011), Concomitant use thyroid hormone, GnRHa and growth hormone to improve final height of adolescents with prolonged hypothyroidism. The goal of this study is to evaluate the concomitant effect of GH and GnRHa in addition to thyroxine on the final height of adolescents with prolonged hypothyroidism. Total direct cost $125,000 or $25,000 per year. 

  2004- 2013                  Genentech Clinical Research Award, ISS#304-CO3, Grant Effort 5% (L.M. Rodriguez PI) Title:  Effects of Growth Hormone therapy on glucose and protein metabolism in children with Growth Hormone Deficiency. The major goal of this project was to better understand the pathophysiology of hypoglycemia in GHD and how rhGH treatment impacts glucose homeostasis

  2008-2012       TERCICA Pharmaceuticals Industry Initiated Multicenter trial. (L.M. Rodriguez –PI, from 2005-2011 PI P. Yazdani, Co-PI L.M. Rodriguez) (Title: Recombinant human growth hormone and recombinant insulin like growth factor -1 combination therapy in children with short stature associated with IGF-1 deficiency. This is a three year randomized open label, parallel group, active treatment controlled dose selection trial of combination therapy involving rGH and rIGF-1 in children with IGF-1 deficiency.

  2004-2010      National Institutes of Health, Juvenile Diabetes Research Foundation, and Benaroya Research Institute , UO1DK062418, Grant Effort 5% (Carla Greenbaum PI, L.M.  Rodriguez Co-PI ,) Title: Type 1 diabetes Genetic Consortium, North American Network, The major goals of this project was to identify genes related to Type 1 diabetes.

  2004- 2006      National Institutes of Health Mentored Diabetes Investigator Award, 1 K12 DK63691,  Grant Effort- 75%  (M.W. Haymond PI,  L.M. Rodriguez Recipient of award) Title: The Role of Amylin in Pediatric Type 2 Diabetes. This Grant provided salary support plus $30,000 to fund my research project. The goal of this project was to study the physiology of amylin in regulating postprandial glucose homeostasis.

   

   

   

   

• Service

  Department

  2010- 2020      Director Research Conference, Pediatric Endocrinology Section, Department of Pediatrics, Baylor College of Medicine.

  School

  1993- 1994      Laboratory Technician, Ponce School of Medicine, Ponce, Puerto Rico

  1998-2001       Examiner Standardized Pediatric Patient, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico      

  2001-2002       Internal Ethics Committee Review Board Member, Baylor College of Medicine

  2010- Present  Journal Reviewer-Diabetes Technology and Therapeutics.

   

  2011- 2020      Fellow’s Day Abstract Review and Award Selection Committee, Department of Pediatrics, Baylor College of Medicine.

  2013               Baylor College of Medicine, Department of Pediatrics, Pilot Award, Selection Committee Member

  2013    Baylor College of Medicine, Texas Children’s Hospital Clinical Research Center, Scientific Review Committee Member

  Service to the Profession

   

   

   

  National

  2009-2010       Organizing  committee, Pediatric Society of Pediatric Endocrinology of Texas, Oklahoma, Louisiana and Arkansas (PESTOLA)

  2002-2010       Medical director and member of the organizing committee for Camp Lotta Bright Hope, a camp for children with diabetes, sponsored by the American Diabetes Association, Houston TX.

• Publications

  • Effects Of Mixing Glargine And Short Acting Insulin Analogs On Glucose Control
  • The Role Of Amylin And Glucagon In The Dampening Of Glycemic Excursions In Children With Type 1 Diabetes
  • Serum 1,5-Anhydroglucitol (Glycomark) Levels in Children with and without Type-1 Diabetes
  • The Role of Prandial Pramlintide in the Treatment of Adolescents With Type 1 Diabetes
  • Gastric emptying and postprandial glucose excursions in adolescents with type 1 diabetes
  • A randomized, controlled trial comparing twice-a-day insulin glargine mixed with rapid-acting insulin analogs
  • Types of pediatric diabetes mellitus defined by anti-islet autoimmunity and random C-peptide at diagnosis

  Heptulla RA, Rodriguez LM, Mason KJ, Haymond MW. Twenty-four hour Simultaneous Subcutaneous Basal-Bolus Administration of Insulin and Amylin in Adolescents with Type 1 Diabetes Decreases Post-Prandial Hyperglycemia. . J Clin Endocrinol Metab. 2009 Feb 3.

  van der Heijden GJ, Wang ZJ, Chu ZD, Sauer PJ, Haymond MW, Rodriguez LM, Sunehag AL. A 12-Week Aerobic Exercise Program Reduces Hepatic Fat Accumulation and Insulin Resistance in Obese, Hispanic Adolescents. Obesity. 2009 Aug 20.

  Shannon French, Luisa Rodriguez, Alan Schlesinger, Laurence McCullough, Jennifer Dietrich, John Hicks and Lefkothea Karaviti , FSH Injections and Ultrasonography Determine Presence of Ovarian Components in the Evaluation of Ovotesticular Disorders of Sex Development, International Journal of Pediatric Endocrinology, 2010.

  Rodriguez LM,  Mason KJ, Knight R, Heptulla RA Continuous glucose monitoring in subjects after simultaneous pancreas-kidney and kidney alone transplantation. Diabetes Technology & Therapeutics. Diabetes Technol Ther. 2010 May;12(5):347-51.

  Raman VS, Mason KJ, Rodriguez LM, Hassan K, Yu X, Bomgaars L, Heptulla RA. The role of adjunctive exenatide therapy in pediatric type 1 diabetes. Diabetes Care. 2010 Jun;33(6):1294-6.

  Mohammad MA, Sunehag AL, Rodriguez LM, Haymond MW. Galactose promotes fat mobilization in obese lactating and nonlactating women. Am J Clin Nutr. 2011 Feb;93(2):374-81.

  Redondo MJ, Rodriguez LM, Escalante M, O'Brian Smith E, Balasubramanyam A, Haymond MW.Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes. Pediatr Diabetes. 2012 Nov;13(7):564-71

  Abstracts/Poster Presentations:

  Circulating Biomarkers of Adiposity and Inflammation in Obese and Lean Children with New Onset Type 1 Diabetes (T1D). Maria J. Redondo; Luisa M. Rodriguez; Morey W. Haymond, Christiane S. Hampe, E.O’Brian Smith, Ashok Balasubramanyam, Sridevi Devaraj,  Baylor College of Medicine, Houston, Texas, USA, University of Washington, Seattle, Washington, USA. The 73st Scientific Sessions American Diabetes Association, Chicago IL, 2013.

  A Study to Assess the Glucose Lowering Effects of Metformin and Sitagliptin in Adolescents with Type 1 Diabetes.  Bonnie Goldsmith, MD, Maria Redondo, MD, Morey Haymond, MD, Sridevi Devaraj, PhD, Luisa Rodriguez, MD; Annual BCM Department of Pediatrics Fellow’s Research Symposium. Houston, TX, April 2013 

  Insulin Resistance and Abnormal Glucagon in Prepubertal Obese Children. Katherine N. Velez, MD; Maria J. Redondo MD; Susan Sampson MD, Luisa M.  Rodriguez, MD; Annual BCM Department of Pediatrics Fellow’s Research Symposium. Houston, TX, April 2013

  The effect of obesity and hyperglycemia on ghrelin suppression. Katherine N. Velez, MD; Maria J. Redondo MD; Luisa M.  Rodriguez, MD; Annual BCM Department of Pediatrics Fellow’s Research Symposium. Houston, TX, April 2012

  Postprandial hyperglucagonemia and augmented GLP-1 in Children with Type 2 Diabetes. Rodriguez, Luisa M., Haymond, Morey W.1; Holst, Jens J.; Burrin, Douglas; Sunehag, Agneta; Heptulla, Rubina A.  The 71st Scientific Sessions American Diabetes Association, San Diego, 2011.

  Abnormal Postprandial Metabolism in Children with Type 2 Diabetes. Rodriguez, Luisa M., Haymond, Morey W.1; Holst, Jens J.; Burrin, Douglas; Sunehag, Agneta; Heptulla, Rubina A.  69th Scientific Sessions American Diabetes Association, June 5-9, 2009 New Orleans, LA, USA

  Galactose promotes fat mobilization in lactating and non-lactating women. Mohammad A M, Sunehag AL, Rodriguez LM, Haymond MW. FASEB J. 23:546.12, 2009 (Abstract).

  Neonatal Diabetes Mellitus in Twins Due to KCNJ11 Mutation and Favorable Response to Glyburide Therapy. VS Raman, SC Sreenath Nagamani, JJ Bell, C Buggs, K Hwu, L Rodriguez, GS Jeha .The Endocrine Society 84th Annual Meeting, San Francisco, CA. June 15, 2008

   

• Clinical

  2022 - Medical Director, Pediatric Endocrinology 

  Board Certifications

  • 2022 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2021 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2020 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2019 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2018 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2017 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2016 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2015 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2014 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2013 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2012 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2011 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2010 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2009 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2008 - Diplomat, American Board of Pediatrics
  • 2008 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2007 - Diplomat, American Board of Pediatrics
  • 2007 - Diplomat, American Board of Pediatrics, Pediatric Endocrinology
  • 2006 - Diplomat, American Board of Pediatrics
  • 2005 - Diplomat, American Board of Pediatrics
  • 2004 - Diplomat, American Board of Pediatrics
  • 2003 - Diplomat, American Board of Pediatrics
  • 2002 - Diplomat, American Board of Pediatrics
  • 2001 - Diplomat, American Board of Pediatrics