Peng Zhang, Ph.D

• Professional Background

  Education

  • 2012 - PhD - Genetics - University of Chinese Academy of Sciences

  Training

  • 2017 - Postdoctoral Associate - Hematology and Epigenetics - University of Miami Miller School of Medicine
  • 2015 - Postdoctoral Research Fellow - Stem Cell - Indiana University School of Medicine

• Research & Grants

  My work currently focuses on the studies of cellular and molecular mechanisms of epigenetic regulators (e.g. ASXL1 and ASXL2) in normal hematopoiesis and malignant diseases. My long-term research goal is to provide the comprehensive understanding of the epigenetic regulators in hematopoietic stem cells and how alterations contribute to hematologic malignancies. 

• Publications

  • 1. The role of ASXL1/2 and their associated proteins in malignant hematopoiesis
  • 2. Chromatin regulator Asxl1 loss and Nf1 halpoinsufficiency cooperate to accelerate myeloid malignancy
  • 3. Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem cell fates
  • 4. Loss of Asxl2 leads to myeloid malignancies in mice
  • 5. Loss of Asxl1 alters self-renewal and cell fate of bone marrow stromal cell, leading to Bohring-Opitz-like syndrome in mice