UT San Antonio
UT Health San Antonio

Nathan P. Wiederhold, Pharm.D

Professor

Fungus Testing Laboratory

Special Chemistry Section Director

Dr. Wiederhold serves as the Director of the Fungus Testing Laboratory, an academic reference mycology laboratory for clinical dianostic testing, including antifungal susceptibility testing, fungal species identification, and antifungal therapeutic drug monitoring. His research focuses on the preclinical evaluation of investigational therapeutic modalities and diagnostic technologies for the diagnosis and treatment of fungal infections.  This includes assessment for activity against a wide range of fungal pathogens, including multi-drug resistant clinical isolates.  This work is supported through NIH/NIAID contracts and grants from industry, and they collaborate closely with other researchers in the Departments of Microbiology and Immunology, Medicine/Infectious Diseases, and Pathology in these studies. The Fungus Testing Laboratory also evaluates for changes in antifungal resistance patterns over time and in the discovery of novel mechanisms of antifungal resistance.  Several new species of fungi have also been discovered by the laboratory in collaboration with other international mycology laboratories, both through morphologic/phenotypic assessment and phylogenetic analysis. Dr. Wiederhold serves on the editorial boards for Antimicrobial Agents and Chemotherapy, the Journal of Clinical Microbiology, and ASM Case Reports. He is also the currently the Chair of the Clinical and Laboratory Standards Institute (CLSI) Antifungal Susceptibility Subcommittee.

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