Yun Shi, MD

Publications on PubMed

Peer-Reviewed Articles

1. Shi Y, Pizzini J, Wang H, Das F, Azees PA, Choudhury GG, Barnes J, Zang M, Weintraub S, Yeh CK, Katz MS, Kamat A. Beta2-adrendergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states. Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E90-E104. PMID: 34029162
2. Shi Y, Shu ZJ, Wang H, Barnes JL, Yeh CK, Ghosh PM, Katz MS, Kamat A. Altered expression of hepatic β-adrenergic receptors in aging rats: implications for age-related metabolic dysfunction in liver. Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R574-R583. PMID: 29212811
3. Shi Y, Shu ZJ, Xue X, Yeh CK, Katz MS, Kamat A. β2-adrenergic receptor ablation modulates hepatic lipid accumulation and glucose tolerance in aging mice. Exp Gerontol. 2016 Jun 1;78:32-8 PMID: 26952573
4. Evans TM, Bhattacharya A, Chauduri A, Qi W, Shi Y, Van Remmen H. Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX), Neurosci Lett. 2016 Jun 15;624:1-7. PMID: 27138280
5. Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H. A lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength. PLOS ONE 2014 Jun 27;9(6):e100834. PMCID: PMC4074103
6. Pulliam DA, Deepa SS, Liu Y, Hill S, Lin A, Bhattacharya A, Shi Y, Sloane LB, Viscomi C, Zeviani M, Van Remmen H. Complex IV deficient surf1(-/-) mice initiate mitochondrial stress responses, Biochem. J. 2014 Sep 1;462(2):359-71. PMCID: PMC4145821
7. Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki1A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, McArdle A, Brooks SV. Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD knockout mice, FASEB J 2014 Apr;28(4):1666-81. PMCID: PMC3963022
8. Shi Y, Pulliam DA, Liu Y, Hamilton RT, Jernigan AL, Bhattacharya A, Sloane LB, Qi W, Chauduri A, Buffenstein R, Ungvari U, Austad SN, Van Remmen H. Reduced mitochondrial ROS generation and distinct age-related changes in oxidative damage in skeletal muscle of long-lived Peromyscus leucopus compared to Mus musculus, Am J Physiol Regul Integr Comp Physiol 2013 Mar;304(5):R343-55. PMID: 23325454
9. Konigsberg M, Perez VI, Rios C, Liu Y, Lee S, Shi Y, Van Remmen H. Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells, Redox Biol 2013 Sep 27;1(1):475-82. PMCID: PMC3814963
10. Zhang Y, Davis CS, Sakellariou GK, Shi Y, Kayani AC, Bhattacharya A, Richardson A, Jackson MJ, McArdle A, Brooks SV, Van Remmen H. CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice, FASEB J 2013 Sep;27(9):3536-48. PMCID: PMC3752542
11. Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chauduri A, Van Remmen H. Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1-/- mice: a plausible link between oxidative stress and demyelination, PLOS ONE 2013 Jun 4;8(6): e65725. PMCID: PMC3672154
12. Deepa SS, Walsh ME, Hamilton RT, Pulliam DA, Shi Y, Hill SA, Li Y, Van Remmen H. Rapamycin modulates markers of mitochondrial biogenesis and fatty acid oxidation in the adipose tissue of db/db mice, J Biochem Pharmacol Res 2013 Jun;1(2):114-123. PMCID: PMC3760510
13. Deepa SS, Pulliam D, Hill S, Shi Y, Walsh ME, Salmon A, Sloane L, Zhang N, Zeviani M, Viscomi C, Musi N, Van Remmen H. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity, FASEB J. 2013 Apr;27(4):1371-80. PMID: 23241310
14. Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle mass during aging, Aging Cell 2011 Jun;10(3):493-505. PMCID: PMC3094473
15. Bhattacharya A, Lustgarten MS, Shi Y, Liu Y, Jang YC, Pulliam DA, Jernigan A, Van Remmen H. Increased mitochondrial matrix directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria, Free Radic Biol Med. 2011 Mar 1; 50(5): 592-601 PMCID: PMC4017321
16. Zhang Y, Zhang, H, Shi Y, Lustgarten MS, Li Y, Qi W, Zhang B, Van Remmen H. Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts, Free Radic Biol Med. 2010 Nov 1;49(8): 1255-62. PMCID: PMC3418666

Books/Book Chapters:

1. Vallera B, Shi, Y. "Bipolar disorder". The essential evidence plus, Wiley 2025 [electronic publication]
2. Shi Y, Alvarado M. “Ulcerative colitis”. The 5-Minute Clinical Consult 2022, Domino, Frank J; Baldor, Robert A; Golding, Jeremy; Stephens, Mark B. (Ed.) Wolters Kluwer 2022
3. Shi Y, Buffenstein R, Van Remmen H. "Mitochondria, Oxidative Damage, and Longevity: What Can Comparative Biology Teach Us?" Comparative Biology of Aging, Wolf, Norman S. (Ed.) Springer 2010