Mostafa S Shehabeldin, DDS, MS, PhD

Assistant Professor/Clinical

Dr. Mostafa Shehabeldin is an experienced clinician with over 10 years of clinical experience in general dentistry, dentoalveolar surgery, periodontics, and implant dentistry. He earned his dental degree from Cairo University (Egypt) with distinction and honors in 2010, then went on to pursue clinical practice in hospital, academic and private settings. Between 2014 and 2021, Dr. Shehabeldin pursued a master's and a PhD degree in Oral and Craniofacial sciences at the University of Pittsburgh. In 2024, Dr. Shehabeldin completed an advanced specialty training in Periodontics and Dental Implant Surgery and a second master's degree from the University of Michigan. During his graduate studies, Dr. Shehabeldin conducted high quality basic, clinical and translational research focusing on bone regeneration and periodontal disease immunotherapeutics. Dr. Shehabeldin is a published author with several original research and review articles published in well-respected dental and biomedical journals such as the Proceedings of the National Academy of Sciences, the Journal of Immunology and the Journal of Periodontology. Dr. Shehabeldin is currently an assistant professor in the Department of Periodontics where he is involved in teaching, clinical research and maintains an active faculty practice.

Professional Background
Education
- 2024 - Certificate - MS Periodontics - University of Michigan
- 2021 - PhD - Doctor of Philosophy - University of Pittsburgh
- 2016 - Masters - Master of Science - University of Pittburgh
- 2010 - BDS - Bachelor of Dental Surgery - Cairo University
Publications

Articles in Scientific Journals

1. Zhuang Z, Yoshizawa-Smith S, Glowacki A, Maltos K, Pacheco C, Shehabeldin M, Mulkeen M, Myers N, Chong R, Verdelis K, Garlet GP, Little S, Sfeir C. 2019. Induction of m2 macrophages prevents bone loss in murine periodontitis models. J Dent Res. 98(2):200-208.

2. Patel SK, Greene AC, Desai SM, Rothstein S, Basha IT, MacPherson JS, Wang Y, Zou Y, Shehabeldin M, Sfeir CS, Little SR, Rohan LC. 2021. Biorelevant and screening dissolution methods for minocycline hydrochloride microspheres intended for periodontal administration. International Journal of Pharmaceutics. 596:120261.

3. Zaky SH, Shehabeldin M, Ray H, Sfeir C. 2021. The role of inflammation modulation in dental pulp regeneration. Eur Cell Mater. 41:184-193.

4. Pacheco CMF, Maltos KLM, Shehabeldin MS, Thomas LL, Zhuang Z, Yoshizawa S, Verdelis K, Gaffen SL, Garlet GP, Little SR, Sfeir C. 2021. Local sustained delivery of anti-il-17a antibodies limits inflammatory bone loss in murine experimental periodontitis. J Immunol. 206(10):2386-2392 (co-first authorship)

5. Lorentz KL, Gupta P, Shehabeldin MS, Cunnane EM, Ramaswamy AK, Verdelis K, Fedorchak MV, Little SR, Weinbaum JS, Sfeir CS, Mandal BB, Vorp DA. 2021. Ccl2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae. Acta Biomaterialia.

6. Greene AC, Shehabeldin M, Gao J, Balmert SC, Ratay M, Sfeir C, Little SR. 2022. Local induction of regulatory t cells prevents inflammatory bone loss in ligature-induced experimental periodontitis in mice. Scientific Reports. 12(1):5032.

7. Shehabeldin M, Saleh MHA, Shih-Chang Tseng E, Sirinirund B, Zalucha J, Chan HL, Wang HL. Intrasocket reactive tissue: The state of current knowledge. Int J Oral Implantol (Berl). 2023 May 9;16(2):95-103. PMID: 37158179.

8. Ultrasound-based Jawbone Surface Quality Evaluation after Alveolar Ridge Preservation Amanda B. Rodriguez, DDS, MS, Oliver D. Kripfgans, PhD, Kenneth M. Kozloff, PhD, Ankita Samal, BDS, Mostafa Shehabeldin, BDS, MS, PhD, Hsun-Liang Chan, DDS, MS. Journal of Periodontology (Conditionally accepted).

9. Therapeutic Delivery of CCL2 Modulates Immune Response and Restores Host-microbe Homeostasis. M. Shehabeldin, J. Gao, Y. Ki, R. Chong, T. Tabib, L. Li, M. Smardz, S. L. Gaffen, P, I. Diaz, R. Lafyatis, S. Little, C. Sfeir. Proccedings of the National Academy of Science (Under review).

Chapters in Books

1. Shehabeldin M, Intini G, Sfeir C, Van Dyke TE. 2020. Inflammation and bone destruction: Pathogenesis and therapeutic intervention. In: Zaidi M, editor. Encyclopedia of bone biology. Oxford: Academic Press. p. 122-135.

Abstracts

• Prevention of Inflammatory Bone Loss Via Induction of M2 Macrophages. Z Zhuang, S. Yoshizawa, M. Shehabeldin*, C. Sfeir (AADR/CADR Annual Meeting, March 2018).

• Induction of M2 Macrophages Prevents Periodontal Breakdown and Accelerates Repair. M. Shehabeldin*, J Gao, R. Chong, C. Sfeir (IADR/AADR/CADR Annual Meeting, June 2019)

• Local Induction of Endogenous Regulatory T Cells for the Treatment of Periodontal Disease. Greene A.*, Shehabeldin M., Ratay M., Sfeir C., Little S. R. (2018 AIChE Annual Meeting)

Mostafa S Shehabeldin, DDS, MS, PhD

Education