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Dr. Shanmugasundaram

Contact

shanmugasund@uthscsa.edu

Departments & Divisions

Karthigayan Shanmugasundaram, Ph.D.

Assistant Professor - Research

Currently seeking M.S. students

  • Professional Background

    Education

    • 2008 - PhD - Biotechnology

    Appointments

    • 09/2018 - Assistant Professor - UTHSCSA

  • Research & Grants

    My Scientific career has been devoted to study the molecular mechanism, regulation of key genes in cancer biology and drug development for the same for the past 16 years, of which I am working on Kidney cancer for more than 9 years. My major focus is on both metabolome and transcriptome in order to comprehensively characterize the metabolism of Kidney cancer. Currently working on reserach projects to understand role of NOX4 in promoting proliferation, pseudohypoxia through increased fumarate levels and fatty acid oxidation defects in RCC. 

    Renal cancer; Uterine FIbroids; Oxidative stress; Metabolic singaling and targeted therapy-PROTACs

     

     

  • Publications

      1. Sudarshan S, Shanmugasundaram K, Naylor SL, Lin S, Livi CB, O'Neill CF, Parekh DJ, Yeh IT, Sun LZ, Block K. Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion. PLoS One. 2011;6(6):e21037.
      2. Fitzgerald JP, Nayak B, Shanmugasundaram K, Friedrichs W, Sudarshan S, Eid AA, Denapoli T, Parekh DJ, Gorin Y, Block K. Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production. PLoS One. 2012;7(1):e30712.
      3. Shanmugasundaram K, Block K, Livi CB, Sudarshan S "PI3K regulation of the p27/SKP-2 axis through mTORC2". Oncogene 2012 Jun 25.
      4. Karthigayan Shanmugasundaram, Bijaya Nayak, Eun-Hee Shim, Carolina B. Livi, Karen Block, Sunil Sudarshan. The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncannonical Activation of NF-κB Signaling. J Biol Chem. 2014 Jul.
      5. Nayak BK*, Shanmugasundaram K*, Friedrichs WE, Cavaglierii RC, Patel M, Barnes J, Block K. HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice. Diabetes. 2016 May;65(5):1387-97. (* equal contribution).
      6. Shanmugasundaram K, Block K.  Renal Carcinogenesis, Tumor Heterogeneity, and ROS: The Devil wears Prada.  Antioxid Redox Signal. 2016  Jun 10.
      7. Shanmugasundaram K, Nayak BK, Friedrichs WE, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance.         Nat Commun. 2017 Oct 19;8(1):997.
      8. Dharam Kaushik  Keith A Ashcraft, Hanzhang Wang , Karthigayan Shanmugasundaram, Pankil K Shah , Gabriela Gonzalez , Alia Nazarullah , Cooper B Tye , Michael A Liss , Deepak K Pruthi , Ahmed M Mansour , Wasim Chowdhury , Dean Bacich, Hao Zhang , Amanda L Watson 2, Karen Block 6, Denise O'Keefe 2, Ronald Rodriguez.  Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma. Transl Res Sep 2020 223:1-14
      9. Karthigayan. S, Sri Balasubashini. M, Sengottuvelan. M, Balasubramanian. T, Somasundaram. S.T, Anticancer Principles from salivary gland extract of Octopus ageina. IJCR. 2006. 2 (3); 242-252
      10. Sri Balasubashini. M, Karthigayan. S, SomasundaramS.T, Balasubramanian. T, Viswanathan. P, Venugopal P Menon. In vivo and In vitro Characterization of the Biochemical and Pathological Changes Induced by Lionfish (Pterios Volitans) venom in Mice. Tox.Mech.Met. 2006 16 (1): 1-7.
      11. Sri Balasubashini. M, Karthigayan. S, SomasundaramS.T, Balasubramanian. T, Viswanathan. P, Raveendran. P, Venugopal P Menon. Fish venom (Pterios volitans) peptide reduces tumour burden and ameliorates oxidative stress in Ehrlich’s ascites carcinoma xenografted mice. Bioorg Med Chem Lett. 2006 16: 6219-6225.
      12. Sri Balasubashini. M, Karthigayan. S, SomasundaramS.T, Balasubramanian. T, Venugopal P Menon. FV peptide induces apoptosis in HEp 2 and HeLa cells: an insight into the mechanism of induction. J Carcinogenesis. 2006 5 (27):1-9.
      13. Karthigayan. S, Sri Balasubashini. M, Balasubramanian. T, Somasundaram. S.T. PGE from O.segina induces apoptosis in Ehrlich’s ascites carcinoma of mice. Toxicol Mech  Meth. Volume 17, Issue 8, 2007, Pages 451 – 458.
      14. Karthikeyan, R., S. Karthigayan, M. Sri Balasubashini, S. Vijayalakshmi and T.Balasubramanian, 2007. Histopathological changes induced by mice after intramuscular injection of venom from spin-bellied sea snake, Lepemis curtus (Shaw, 1802). Journal of Pharmacology and Toxicology. 2(4): 307-318. 
      15. Karthikeyan, R., S. Karthigayan, M. Sri Balasubashini,   S. Vijayalakshmi, S.T. Somasundaram and T. Balasubramanian, Antitumor effect of snake venom (Hydrophis spiralis) on Erhlich Ascites Carcinoma bearing mice, International Journal of Cancer Research. 2007. 3 (4); 187-190.
      16. Karthikeyan, R., S. Karthigayan, M. Sri Balasubashini,   S. Vijayalakshmi, S.T. Somasundaram and T. Balasubramanian.  Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. International Journal of Cancer Research. 2007. 3 (4); 167-173, 2007.
      17. Karthikeyan R, Karthigayan S, Sri Balasubashini M, Somasundaram ST, Balasubramanian T. Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom. Toxicon. 2008 Jan;51(1):157-61.   
      18. Aravindan N, Aravindan S, Shanmugasundaram K, Shaw AD. Periods of systemic partial hypoxia induces apoptosis and inflammation in rat skeletal muscle. Mol Cell Biochem. 2007 Aug; 302(1-2): 51-8. 
      19. Aravindan N, Shanmugasundaram K, Natarajan M. Hyperthermia induced NFkappaB mediated apoptosis in normal human monocytes. Mol Cell Biochem. 2009Jul;327(1-2):29-37.
      20. Tantiwong, Puntip*, Shanmugasundaram K*, Sriwijitkamol A, Cersosimo E, DeFronzo RA, Mohan S, Musi N. NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions. Am J Physiol Endocrinol Metab. 2010 299(5):E794-801. (* equal contribution).

      21. Liang H, Tantiwong P, Sriwijitkamol A, Shanmugasundaram K, Mohan S, Espinoza S, Defronzo RA, Dubé JJ, Musi N. Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects. J Physiol. 2013 Jun 1;591.