UT Health San Antonio

Babatunde O. Oyajobi, M.D., Ph.D., M.B.A.

Professor

Department of Cell Systems and Anatomy

Director, Office of Postdoctoral Affairs

Dr. Oyajobi's lab conducts studies aimed at understanding the pathogenesis of cancer-induced bone diseases and specifically, the multiple myeloma-associated bone disease. We are particularly interested in the translation of novel insights into the biology of multiple myeloma-induced bone disease into therapies for patients and employ a variety of complementary in vitro and in vivo approaches. To evaluate efficacy of novel therapeutic agents, we utilize primarily the Radl 5T model of myeloma which replicates many of the features seen in the human disease. In this model, when murine 5TGM1 myeloma cells genetically engineered to express either green fluorescent protein or luciferase are injected intravenously in naïve syngeneic C57BL/kaLwRijHsd mice, they home to the skeleton where they form tumors in the medullary cavities.