Shamimunisa Begum Mustafa, Ph.D.
Associate Professor
My research interests lie in the area of regulation of lung epithelial ion transport via sodium channels; we are interested in the regulation of sodium channels by synthetic glucocorticoids, cAMP, and proinflammatory mediators. Another main area of interest is the effects of synthetic analogs of dexamethasone in the premature lung. The use of postnatal dex to alleviate respiratory disease in premature babies is limited because of the long-term growth retardation of the developing lung and associated neurological defects in children that were exposed to postnatal dex as preterm babies. The synthetic analogs are currently being assessed in non-human primate lung tissue, mainly I am looking at the efficacy of these agents in elevating markers of lung maturation, e.g. surfactant-associated proteins and sodium channels. In early preterm lung tissue, I am also investigating the effect of these analogs on angiogenic growth factors which are known to promote lung development, in particular, alveolarization. I am also pursuing the area of lung development in caveolin-1 deficient newborn mice, as these mice, as adults are highly susceptible to respiratory infection and do present with lung disease similar to the human lung diseases of COPD and pulmonary fibrosis. More recently, I have focused my efforts on investigating the therapeutic effects of stem cells in animal models of BPD. This project is in collaboration with my division chief, Dr. Steve Seidner, and two international investigators, Drs. Bernard Thebaud and Marius Mobius. I am also investigating the effects of postnatal adaptation and short-term mechanical ventilation on endogenous lung mesenchymal stromal cells using the preterm rabbit model.
Sub-Field of Study: Regulation of Surfactant proteins and angiogenic growth factors. Mesenchymal stromal cell biology
Specific Field of Study: Basic science research
Associated Diseases: Bronchopulmonary Dysplasia, Chronic lung disease prevalent in premature babies
Techniques Used: Physiological, molecular biology
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Professional Background
Education
- 1992 - PhD - Biological Chemistry - University College London
- 1988 - BS - Medicinal Chemistry (With Honors, Upper Second) - University College London
- Postdoctoral Fellowship - Biochemistry - The University of Texas Health Science Center
Appointments
- 9/2009 - Associate Professor - University of Texas Health Science Center, Pediatrics, San Antonio
- 1/2009 - Director, Neonatal Research - University of Texas Health Science Center, Pediatrics, San Antonio
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Instruction & Training
- 7/1999 - Present, Individual Instruction, UTHSCSA
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Research & Grants
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Publications
Abstract
A Moreira, C Winter, J Joy, L Winter, M Jones, M Noronha, M Porter, K Quim, A Corral, Y Alayli, T Seno, SB Mustafa, P Hornsby, and S Ahuja. Intranasal delivery of mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia; 2019 May. (Ped Research).
Mustafa SB McDaniel D, Jooby J, Winter C, Noronha M, Quim K, Mustafa SB, Moreira A. Feasibility and Therapeutic Potential of Mesenchymal Stem Cell-Conditioned Media Administered Intranasally in a Rat Model of Bronchopulmonary Dysplasia; 2019 May. (Ped Research).
Mustafa SB A Moreira, C Winter, L Winter, M Jones, K Quim, M Noronha, M Porter, A Corral, Y Alayli, J Joy, T Seno, P Hornsby, J Hsieh and SB Mustafa. Intranasal delivery of mesenchymal stem cells restores lung development in experimental bronchopulmonary dysplasia; 2019 Feb. (Journal of Investigative Medicine).
Mustafa SB J Joy, D McDaniel, C Winter, SB Mustafa and A Moreira. The effect of umbilical cord-derived mesenchymal stem cells in an in-vitro model of bronchopulmonary dysplasia; 2019 Feb. (Journal of Investigative Medicine).
Dawn McDaniel, Caitlyn Winter, Yasmeen Alayli, Sam Kahlenberg, LuZhe Sun, Shamim B. Mustafa, and Alvaro Moreira. Effects of Umbilical Cord-derived Mesenchymal Stem Cells in an in vitro Experimental Model of Bronchopulmonary Dysplasia; 2018 May. (Peds Res).
Rolando Macias, Alvaro Moreira, Sartaj Siddiqui, Desiree Wilson, Teresa Johnson-Pais, Jonathan A. L. Gelfond, Steven R. Seidner, and Shamim B. Mustafa. Gene expression profiles of endogenous lung mesenchymal stromal cells following postnatal adaptation and mechanical ventilation; 2018 May. (Peds Res).
Saloni Agarwal, Caitlyn Winter, Maxwell Jones, Shamim B. Mustafa, Peter Hornsby, Alvaro Moreira. Comparison of Preterm and Term Wharton?s Jelly Mesenchymal Stem Cell Properties in Differing Oxygen Tensions; 2018 May. (Peds Res).
Saloni Agarwal, Caitlyn Winter, Alexis Corral, Shamim B. Mustafa, Peter Hornsby, Alvaro Moreira. Comparison of preterm versus term umbilical cord-derived mesenchymal stem cells in differing oxygen tension; 2018 Feb. (Journal of Investigative Medicine).
Dawn McDaniel, Caitlyn Winter, Yasmeen Alayli, Sam Kahlenberg, LuZhe Sun, Shamim B. Mustafa, and Alvaro Moreira. Effects of Umbilical Cord-derived Mesenchymal Stem Cells in an in vitro Experimental Model of Bronchopulmonary Dysplasia; 2018 Feb. (Journal of Investigative Medicine).
Rolando Macias, Alvaro Moreira, Sartaj Siddiqui, Desiree Wilson, Teresa Johnson-Pais, Jonathan A. L. Gelfond, Steven R. Seidner, and Shamim B. Mustafa. The Effect of Postnatal Adaptation and Mechanical Ventilation on the Gene Expression Profile of Endogenous Lung Mesenchymal Stromal Cells; 2018 Feb. (Journal of Investigative Medicine).
Seidner SR, Mobius M, Mustafa SB, McCurnin DC, Blanco CL, Freund D, Rudiger M, Thebaud B. Decreased Pressor Use and Fluid Requirements Following Intravenous Administration of Human Umbilical Cord Derived Mesenchymal Stem Cells to Preterm Baboons of Borderline Viability; 2017 May. (Peds Res).
Nienke Wagenaar, MD1; Frank van Bel, MD PhD1; Manon J.N.L. Benders, MD PhD1; Cynthia L. Blanco, MD2; Donald C. McCurmin, MD2; Shamim B. Mustafa, PhD2; Floris Groenendaal, MD PhD1; Linda S. de Vries, MD PhD1; Cobi J. Heijnen, PhD3; Cora H. Nijboer, PhD4. Intranasally applied mesenchymal stem cells migrate to injured brain regions of newborn non-human primates; 2017 May. (Peds Res).
Caitlyn Winter, Saloni Agarwal, Lauryn Winter, Shamimunisa Mustafa, Peter Hornsby, Alvaro Moreira. Comparing the Properties of Human Umbilical Cord-Derived Mesenchymal Stem Cells from Full Term versus Preterm Infants; 2017 May. (Peds Res).
Acevedo, S. J, Alana, N. B.,Carr, N. J., Mustafa, S. B., Blanco, C. L., & King, J. M. Regulation of EGF and Prostaglandin Expression During Neonatal Gastrointestinal Injury in a Non-Human Primate Explant Model; 2017 May. (Peds Res).
C.G. Pe?a, Ph.D., T. Evans, Ph.D., S. Mustafa, Ph.D., L. Moreno, L. McManus, Ph.D. Mentorship Training for Postdoctoral Researchers: Results from a Four Week Intervention Program; 2017 Apr. (FASEB).
Caitlyn Winter, Saloni Agarwal, Lauryn Winter, Shamimunisa Mustafa, Peter Hornsby, Alvaro Moreira. Comparing the Properties of Human Umbilical Cord-Derived Mesenchymal Stem Cells from Full Term versus Preterm Infants; 2017 Feb. (Journal of Investigative Medicine; vol. 65, no. 2).
SR Seidner,M Mobius, SB Mustafa, DC McCurnin, CL Blanco, M Rudiger, B Thebaud. Intravenous Administration of Human Umbilical Cord Derived Mesenchymal Stem Cells Decreases Pressor Use and Fluid Requirements in Preterm Baboons of Borderline Viability; 2017 Feb. (Journal of Investigative Medicine; vol. 65).
Sartaj K. Siddiqui, Shamim Mustafa, Margarita Vasquez, Sherry L. Werner, Steve Seidner. Mechanical Ventilation Alters the Differentiation Potential and Ultrastructure of Endogenous Lung Mesenchymal Stromal Cells; 2016 Jan. (Peds Res).
Steven J. Acevedo, Nicholas B. Alana, Nicholas R. Carr, Shamim B. Mustafa, Cynthia L. Blanco, Johnathan M. King. Modulation of Inflammatory Responses on Term and Preterm Neonatal Gastrointestinal Non-Human Primate Explants; 2016 Jan. (Peds Res).
Journal Article
Balgi-Agarwal S, Winter C, Corral A, Mustafa SB, Hornsby P, and Moreira A. Comparison pf preterm and Term Wharton?s Jelly-derived Mesenchymal Stem Cell Properties in differing Oxygen Tensions Cell Tissues Organs 2018 Apr;.
Moreira A, Alayli Y, Balgi S, Winter C, Kahlenberg S, Mustafa SB, Hornsby P. Upcycling umbilical cords: bridging regenerative medicine with neonatology The Journal of Maternal-Fetal 2017 Nov;.
Lanka GK; Yu JJ; Gong S; Gupta R; Mustafa SB; Murthy AK; Zhong G; Chambers JP; Guentzel MN; Arulanandam BP. IgA modulates respiratory dysfunction as a sequela to pulmonary chlamydial infection as neonates Pathogens and Disease 2016 Jan;74(3).
Mustafa SB, Isaac, Seidner SR, Dixon PS, Henson BM, and DiGeronimo RJ. Experimental Lung Research. 40(8):380-91, 2014. Mechanical stretch induces lung alpha-epithelial Na+ channel expression Experimental Lung Research 2014 Nov;40(8):380-391.
Mustafa SB, J. Isaac, SR. Seidner, PS. Dixon, BM. Henson, and RJ. DiGeronimo. Mechanical stretch Induces Lung alpha-Epithelial Na Channel Expression Experimental Lung Research 2014 Jun;.