Nicolas Musi, M.D.
San Antonio Claude D. Pepper Older Americans Independence Center and Barshop Institute for Longevity and Aging Studies
I am a physician-scientist and received clinical training in Internal Medicine at the University of Miami-Jackson Memorial Medical Center. I then completed a clinical and research fellowship in Endocrinology and Metabolism at the Joslin Diabetes Center of Harvard Medical School in 2001, after which I joined the Harvard faculty. I was recruited to the University of Texas Health Science Center (UTHSCSA) in 2003 and currently I am a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center.
I am an active educator and research mentor, and supervise clinical and research fellows, residents and graduate students. In this role, I function as Director of a T32 Training Grant on the Biology of Aging.
- 2001 - Postdoctoral Fellowship - Endocrinology and Metabolism - Joslin Diabetes Center-Beth Israel Deaconnes Med Ct and Harvard Medical Sch
- 1998 - Residency - Internal Medicine - University of Miami-Jackson Memorial Medical Center
- 1996 - Internship - Internal Medicine - University of Miami-Jackson Memorial Medical Center
- 1995 - MD - NA (Magna Cum Laude) - Universidad Anahuac
- 6/2015 - Director, San Antonio Claude D. Pepper Older Americans Independence Center - UTHSCSASan Antonio
- 9/2013 - Director, Barshop Institute for Longevity and Aging Studies - UTHSCSASan Antonio
- 9/2012 - Professor of Medicine - UTHSCSA
- 1/2011 - Sam and Ann Barshop Endowed Chair in Translational/Clinical Research in Geriatrics - UTHSCSA
- 7/2010 - Director, Center for Healthy Aging - UTHSCSASan Antonio
- 7/2010 - Director, Geriatric Research, Education and Clinical Center - South Texas Veterans Health Care SystemSan Antonio
Instruction & Training
- 6/2017 - Present, Pre-Doctoral Student Supervision, UTHSCSA
- 6/2016 - Present, Pre-Doctoral Student Supervision, UTHSCSA
- 12/2015 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 8/2015 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 4/2014 - Present, Pre-Doctoral Student Supervision, UTHSCSA
- 3/2011 - Present, Biology of Aging, The University of Texas Health Science Center
- 6/2009 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 6/2008 - Present, Pre-Doctoral Student Supervision, UTHSCSA
- 4/2008 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 2/2008 - Present, Pre-Doctoral Student Supervision, UTHSCSA
- 1/2006 - Present, Clinical Endocrinology, The University of Texas Health Science Center
Research & Grants
Funding Agency National Institutes of Health Title University of Texas Adult Clinical Center, NIH Molecular Transducers of Physical Activity Consortium (MoTrPAC) Status Active Period 12/2016 - 11/2022 Role Principal Investigator Grant Detail The purpose of the MoTrPAC is to catalyze the identification and mapping of molecular and cellular transducers underlying the physiological effects of physical activity. Funding Agency NIH/NIA Title San Antonio Nathan Shock Center of Excellence in the Biology of Aging Status Active Period 7/2015 - 6/2020 Role Co-Principal Investigator Grant Detail The purpose of the Nathan Shock Center is to support aging research at the Health Science Center by providing core services that are of exceptional interest to researchers in the biology of aging.
Role: Core Director, Healthspan Core Funding Agency NIH Title San Antonio Claude D. Pepper Older Americans Independence Center Medicine Status Active Period 6/2015 - 4/2020 Role Principal Investigator Grant Detail The central premise underlying the proposed San Antonio Claude D. Pepper Older Americans Independence Center (OAIC) is that we are at a point in the history of aging research when there are scientifically valid anti-aging therapies to test in humans. We propose an Intervention Program that will move forward discoveries obtained in rodents to the pre-clinical arena using a non-human primate model, the common marmoset, and from the pre-clinical arena to humans through randomized clinical studies. Our Center will provide investigators with state-of-the-art scientific infrastructure and services that are required in developing innovative interventions which target the aging process and aging-related diseases. Initially, a major focus will be on pharmacologic interventions, however, regenerative and gene transfer interventions also will be tested as they become available. The Specific Objectives of the OAIC are: 1. To provide support, through Resource Core (RC)-1, to pre-clinical studies in non-human primates to investigate the mechanism of action, efficacy, and tolerability of aging interventions. This Core also will provide functional assessment (healthspan) services and will determine the effect of interventions on lifespan. 2. RC-2 will provide human clinical research and pharmacology services to studies of interventions aimed at preventing physiological decline and aging-related diseases. Services provided by this core include subject recruitment, compliance, and procedures to assess physical performance, cognition, glucose metabolism, vascular function, atherosclerosis, exercise tolerance, gait, balance, imaging, and specimen (blood, muscle, fat) processing. This core also performs pharmacokinetic human studies. 3. To provide, through the Biostatistics Core (RC3), expertise in data entry systems, data quality control, data security, and state of the art quantitative and qualitative analytic and medical informatics strategies. 4. To provide assistance to faculty for Funding Agency NIDDK Title Role of TLR4 on insulin resistance in human subjects Status Active Period 9/2014 - 9/2018 Role Principal Investigator Grant Detail The purpose of this study is to determine the role of toll-like receptor 4 (TLR4) on insulin resistance and type 2 diabetes in human subjects.
Kunhua Qin, Ning Zhang, Zhao Zhang, Michael Nipper, Zhenxin Zhu, Jake Leighton, Kexin Xu, Nicolas Musi, Pei Wang. SIRT6 medicated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice; 2018 Jan. (Diabetes; vol. 61, no. 4). Ghosh S1, Lertwattanarak R2, Gardu?o Jde J2, Galeana JJ2, Li J3, Zamarripa F3, Lancaster JL3, Mohan S4, Hussey S1, Musi N5. Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging: PubMed; 2015 Feb. (J Gerontol A Bio Sci Med Sci; vol. 70, no. 2). Halter JB1, Musi N2, McFarland Horne F3, Crandall JP4, Goldberg A5, Harkless L6, Hazzard WR7, Huang ES8, Kirkman MS9, Plutzky J10, Schmader KE11, Zieman S12, High KP13.
. Diabetes and cardiovascular disease in older adults: current status and future directions PubMed: PubMed; 2014 Aug. (Diabetes; vol. 63, no. 8). Cersosimo E, Xu X, Upala S, Triplitt C, Musi N. Acute insulin resistance stimulates and insulin sensitization attenuates vascular smooth muscle cell migration and proliferation: PubMed; 2014 Aug. (Physiol Rep; vol. 2, no. 8).
Musi, M.D. N. Models and Studies of Aging: Report from the U13 Conference Series Jags 2018 Apr;. Musi, M.D. N. Older Subjects with β-cell Dysfunction have an Accentuated Incretin Release The Journal of Clinical Endocrinology 2018 Apr;. Ning Zhang,1,* Joseph M. Valentine,1,* You Zhou,1
Mengyao E. Li,1,2 Yiqiang Zhang,1 Arunabh Bhattacharya,1
Michael E. Walsh,1 Katherine E. Fischer,1,?
Steven N. Austad,1,? Pawel Osmulski,1 Maria Gaczynska,1
Steven E. Shoelson,2 Holly Van Remmen,1,? Hung I. Chen,3,4
Yidong Chen,3,4 Hanyu Liang1 and Nicolas Musi1,5. Sustained NFkB Inhibition Improves Insulin Sensitivity but is Detrimental to Muscle Health Aging Cell 2017 Aug;16(4):847-858. Thakur S, Garg N, Zhang N, Hussey SE, Musi N, Adamo ML. . IGF-1 receptor haploinsufficiency leads to age-dependent development of metabolic syndrome Biochem Biophys Res Commun 2017 May;486(4):937-944. McGill-Vargas L1, Gastaldelli A2,3, Liang H2, Anzueto Guerra D1, Johnson-Pais T4, Seidner S1, McCurnin D1, Muscogiuri G2, DeFronzo R2,5, Musi N2,5,6,7, Blanco C1,8. Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons Endocrinology 2017 May;158(5):1140-1151. Gastaldelli A, Gaggini M, Daniele G, Cersosimo E, Tripathy D, Triplitt C, Fox P, Musi, N, DeFronzo R, Iozzo P. Exenatide improves both hepatic and adipose tissue insulin resistance: A dynamic positron emission tomography study Hepatology 2016 Dec;64(6):2028-2037. Espinoza SE, Wang CP, Tripathy D, Clement SC, Schwenke DC, Banerji MA, Bray GA, Buchanan TA, Henry RR, Kitabchi AE, MAdaliar S, Stentz FB, Reaven PD, DeFronzo RA, Musi N. Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance Age (Dordr) 2016 Dec;38(5):485-493. Cusi K, Orsak B, Bril F, Lomonaco R, Hecht J, Ortiz-Lopez C, Tio F, Hardies J, Darland C, Musi N, Webb A, Portillo-Sanchez P. Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized, Controlled Trial Annals of Internal Medicine 2016 Jun;:1-20. Tripathy D, Schwenke DC, Banerji MA, Bray GA, Buchanan TA, Clement SC, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD, DeFronzo RA. Diabetes incidence and glucose tolerance after termination of pioglitazone therapy: Results from ACT NOW J Clin Endocrinol Metab 2016 May;101(5):2056-2062. Daniele G1, Iozzo P2, Molina-Carrion M1, Lancaster J1, Ciociaro D2, Cersosimo E1, Tripathy D1, Triplitt C1, Fox P1, Musi N1, DeFronzo R1, Gastaldelli A3. Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System Diabetes 2015 Oct;64(10):3406-3412. Zhang N, Liang H, Farese RV, Li J, Musi N, Hussey SE. Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats PLoS One 2015 Jul;10(7):1-14. Blanco CL, Mcgill-Vargas LL, Gastaldelli A, Seidner SR, McCurinin DC, Leland MM, Anzueto DG, Johnson MC, Liang H, DeFronzo RA, Musi N. Peripheral Insulin Resistance and Impaired Insulin Signaling Contribute To Abnormal Glucose Metabolism in Preterm Baboons Endocrinology 2015 Mar;156(3):813-823. Coletta DK, Fernandez M, Cersosimo E, Gastaldelli A, Musi N, DeFronzo RA. The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo Diabet Med 2015 Jan;32(5):657-664. Tripathy D, Cobb JE, Gall W, Adam KP, George T, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Reaven PD, Musi N, Ferrannini E, DeFronzo RA. A Novel Insulin Resistance Index to Monitor Changes in Insulin Sensitivity and Glucose Tolerance: the ACT NOW Study J Clin Endocrinol Metab 2015 Jan;:1855-1862. DeFronzo RA, Tripathy D, Abdul-Ghani M, Musi N, Gastaldelli A. The disposition index does not reflect β-cell function in IGT subjects treated with pioglitazone J Clin Endocrinol Metab 2014 Oct;99(10):3774-3781. Tripathy D, Clement SC, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Gastaldelli A, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD, DeFronzo RA
. Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW Diabetes Care 2014 Jun;37(6):1706-1711.
Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ
. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor Cell Rep 2014 May;7(4):1227-1238.
Ghosh S, Lertwattanarak R, Gardu?o JD, Galeana JJ, Li J, Zamarripa F, Lancaster JL, Mohan S, Hussey S, Musi N. Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging J Gerontol A Biol Sci Med Sci 2014 May;epub. Hussey SE, Lum H, Alvarez A, Cipriani Y, Gardu?o-Garcia J, Anaya L, Dube J, Musi N. A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle Diabetologia 2014 Apr;57(3):582-91. Blanco CL, Moreira AG, McGill-Vargas LL, Anzueto DG, Nathanielsz P, Musi N. Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle J Endocrinol 2014 Apr;221(2):253-260. Muscogiuri G1, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function Diabetes 2013 Dec;62(12):4201-4207. Musi, M.D. N. Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk Diabetes Care 2013 Nov;36(11):3607-3612. Defronzo RA1, Tripathy D, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Gastaldelli A, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD; ACT NOW Study. Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates Diabetes 2013 Nov;62(11):3920-3926. Deepa SS, Pulliam D, Hill S, Shi Y, Walsh ME, Salmon A, Sloane L, Zhang N, Zeviani M, Viscomi C, Musi N, Van Remmen H. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity FASEB J 2013 Apr;27(4):1371-1380. Styskal J, Nwagwu FA, Watkins YN, Liang H, Richardson A, Musi N, Salmon AB. Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function Free Radic Biol Med 2013 Mar;56:123-132. Joya-Galeana J, Fernandez M, Cervera A, Reyna S, Ghosh S, Triplitt C, Musi N, Defronzo RA, Cersosimo E. Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects Diabetes Metab Res Rev 2011 May;27(4):373-382. Deepa SS, Zhou, L, Ryu, J, Wang, C, Mao, X, Li, C, Zhang, N, Musi N, Zhang, BB, Liu F, Dong LQ. APPL1 Mediates Adiponectin-induced LKB1 Cytosolic Localization through the PP2A-PKCz Signalling Pathway Mol. Endocrinol 2011 Jan;25(10):1773-1785. BOGDAN BALAS, HUIYUN LIANG, ARLAN RICHARDSON, RALPH A. DEFRONZO, WALTER WARD, NICOLAS MUSI. Whole-Body Overexpression of PGC-1[alpha] Has Opposite Effects on Hepatic and Muscle Insulin Sensitivity AM J Physiol Endocrinol Metab 2009 Apr;296(4):E945-E954.
Halter JB, Musi N, McFarland M, Crandall JP, Goldberg A, Harkless L, Hazzard WR, Huang E, Kirkman MS, K Schmader, Zieman S, High K. Diabetes Mellitus and Cardiovascular Disease in Older Adults Diabetes 2014 Jan;epub.
- American Board of Internal Medicine/Endocrinology