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Dr. Muralimanoharan

Contact

210-562-4164

muralimanoha@uthscsa.edu

Departments & Divisions

Sribalasubashini Muralimanoharan, Ph.D.

Assistant Professor - Research

Currently seeking M.S. students

My Scientific career has been devoted to study the molecular mechanism in developmental biology and regulation of key genes in perinatal biology and female reproduction.                                                                                                                                                               Previously I have been investigating the role of miRNA in placental development and function. We were the first group to report the miRNA mediated regulation of mitochondrial function in the placenta, we have found several transcription factors that play a key role in pathogenies of placental dysfunction during pregnancy related complications such as preeclampsia, gestational diabetes and maternal obesity.  Currently I am involved in understanding the role of MED12 mutation mediated replication stress and genomic instbility in the uterine fibroids . 

  • Professional Background

    Education

    • 2007 - PhD - Biochemistry

    Highlights

    Received Best oral presentation Award at the National Conference on Natural products as health protectors - Feb 26th -28th 2006. Travel award from Sea horse Biosciences to attend the 59th SGI meeting, March 2012 at San Diego, California.NIH travel award to attend the IFPA meeting to be held during Sep 18-21st, 2012, Hiroshima Japan. Travel award from Sea horse Biosciences to attend the 61st SGI meeting, March 2014 at Florence, Italy.

    Appointments

    • 12.1.2017 - Instructor, Department of Biochemistry - UT Southwestern, Dallas, Texas

  • Service

    Institutional

    Serving as primary member for IRB-2 and secondary member for IRB-1

  • Publications

      1. Sribalasubashini Muralimanoharan, Alina Maloyan, James Mele, Chunming Guo, Louise G. Myatt, and Leslie Myatt. miR-210 modulates mitochondrial respiration in placenta with preeclampsia. Placenta 2012: 33(10):816-23.
      2. Maloyan A, Mele J, Muralimanoharan B, Myatt L. Measurement of mitochondrial respiration in trophoblast culture. Placenta 2012 May; 33(5):456-8.
      3. Sribalasubashini Muralimanoharan, Alina Maloyan, and Leslie Myatt. Experimental evidence for sexual dimorphism in placental function with preeclampsia. Placenta. 2013 Dec;34(12):1183-9.
      4. Alina Maloyan, Sribalasubashini Muralimanoharan, Laura A. Cox,  Mark Nijland, Peter W. Nathanielsz, Steve Huffman,  and  Leslie Myatt. Identification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity. Physiol Genomics. 2013 Oct 1;45(19):889-900.
      5. Mele James*, Sribalasubashini Muralimanoharan*, Alina Maloyan and Leslie Myatt. Mitochondrial dysfunction in placenta with increasing maternal adiposity. 2014. *Contributed equally (In press, American Journal of Physiology Endocrinology and Metabolism).
      6. Myatt L, Muralimanoharan S, and Maloyan A. Effect of preeclampsia on placental function: influence of sexual dimorphism, microRNAs and mitochondria. In: Zhang L and Ducsay CA, Eds. Advances in Fetal and Neonatal Physiology.  Advances in Experimental Medicine and Biology Volume 814, 2014, pp 133-146.
      7. Sribalasubashini Muralimanoharan, Alina Maloyan, Chunming Guo, and Leslie Myatt. Sexual dimorphism in miR-210 expression and regulation placenta with maternal adiposity. Int J Obes (Lond). 2015 Aug;39(8):1274-81.
      8. Sribalasubashini Muralimanoharan, Xiaoli Gao, Susan Weintraub, Leslie Myatt and Alina Maloyan. Sexual dimorphism in activation of placental autophagy in response to maternal obesity. Autophagy. 2016 May 3;12(5):752-69.
      9. Sribalasubashini Muralimanoharan, Alina Maloyan, Chunming Guo, and Leslie Myatt. Mitochondrial Function and glucose metabolism in the Placenta with Gestational Diabetes Mellitus: Role of miR-143.  Clin Sci (Lond). 2016 Jun 1;130(11):931-41.
      10. Muralimanoharan S, Li C, Nakayasu ES, Casey CP, Metz TO, Nathanielsz PW, Maloyan A Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol. 2017 108:181-193
      11. Zhang M, Muralimanoharan S, Wortman A and Mendelson CR. Primate-Specific miR-515 Family Members Inhibit Key Genes in Human Trophoblast Differentiation and are Upregulated in Preeclampsia. PNAS, October, 2016. 
      12. Muralimanoharan S, Kwak YT and Mendelson CR. Redox sensitive transcription factor NRF2 enhances trophoblast differentiation via induction of miRNA 1246 and aromatase. Endocrinology. 2018 May 1;159(5):2022-2033. 
      13. Kwak YT, Muralimanoharan S, Gogate AA, Mendelson CR. Human Trophoblast Differentiation Is Associated With Profound Gene Regulatory and Epigenetic Changes. Endocrinology. 2019 Sep 1;160(9):2189-2203. 
      14. R.Rukkumani, M.Sribalasubashini and V.P.Menon. Comparative effects of curcumin and photo-irradiated curcumin on alcohol and       polyunsaturated fatty acid induced hyperlipidemia. Pharmacol.Res. (2002) 46: 49-4.
      15. Sribalasubashini.M, R.Rukkumani and V.P.Menon.  Protective effects of ferulic acid on Hyperlipidemic diabetic rats. Acta. Diabetol (2003) 40: 118-22. 
      16. R.Rukkumani, M.Sribalasubashini and V.P.Menon Protective effects of curcumin and photoirradiated curcumin on circulatory lipids andlipid peroxidation products in alcohol and polyunsaturated fatty acid induced toxicity. Phytother.Res. (2003) 17.925-29.M.Sribalasubashini, R.Rukkumani and V.P.Menon.  Ferulic acid alleviates lipid peroxidation in diabetic rats, Phytother.Res . (2004). 18: 310-314.
      17. Thirunavukarasu Mahesh, Muralimanoharan Sribalasubashini and Venugopal Padmanabhan menon. Photo – Irradiated curcumin supplementation in streptozotocin-induced Diabetic Rats: Effect on lipid peroxidation. Therepie (2004) 59: 639-644. 
      18. T.Mahesh, M.Sribalasubashini and Venugopal P. Menon. Effect of photo- irradiated   curcumin treatment against oxidative stress in streptozotocin induced diabetic rats. J Med Food (2005) 8(2): 251-255. 
      19. Sribalasubashini.M, Karthigayan. S, SomasundaramS.T, Balasubramanina. T, Viswanathan. P, Venugopal P Menon. In vivo and In vitro Characterization of the Biochemical and Pathological Changes Induced By Lionfish (Pterios Volitans) venom in Mice. Tox.Mech.Met. 2006 16 (1): 1-7. 
      20. Sribalasubashini. M, Karthigayan. S, SomasundaramS.T, Balasubramanina. T, Viswanathan. P, Raveendran. P, Venugopal P  Menon.Fish venom (Pterios volitans) peptide reduces tumour burden and ameliorates oxidative stress in Ehrlich’s ascites carcinoma  xenografted mice. Bioorg Med Chem Lett. 2006 16: 6219-6225. 
      21. Sribalasubashini.M, Karthigayan. S, SomasundaramS.T, Balasubramanina. T, Venugopal P Menon. FV peptide induces apoptosis in HEp 2 and HeLa cells: an insight into the mechanism of induction. J Carcinogenesis. 2006 5 (27):1-9. 
      22. Karthigayan. S, Sribalasubashini. M, Sengottuvelan. M, Balasubramanina.  T, Somasundaram. S.T, Anticancer Principles from salivary gland extract of Octopus ageina. IJCR. 2006 2 (3): 242-252. 
      23. Karthigayan. S, Sribalasubashini. M, Sengottuvelan. M, Balasubramanina.  T, Somasundaram. S.T. PGEfrom O.segina induces apoptosis in Ehrlich’s ascites carcinoma of mice. Toxicol Mech Meth. 2007, 17 (8): 451-458. 
      24. Muralimanoharan SB, Kunnumakkara AB, Shylesh B, Kulkarni KH, Haiyan X, Ming H, Aggarwal BB, Rita G, Kumar AP. Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate. 2009: 1;69(5):494-504.
      25. Cara Horny, Muralimanoharan Sribalsubashini, Krishna Komanduri, Manonmani Ganapathy, I-Tien yeh, Rita Ghosh and Addanki P Kumar. 2-methoxyestradiol prevents LNCaP tumor development in nude mice: Potential role of G2/M regulatory proteins. Journal of Cell Death. 2009: (2)1-8.