Departments & Divisions
Sumathy Mohan, Ph.D.
Professor/Research
Areas of Research Interest: Atherosclerotic lesions typically occur in areas of low shear flow regions. The mechanisms involved in developing these lesions are poorly understood. My long-term goal is first to identify molecular targets. Once this is accomplished it will then be possible to develop strategies for novel interventional procedures and agents to control the development of the disease. I have been studying endothelial cell biology in health and disease, in particular, its responses and gene expression under conditions that influence the process. I have several years of experience in vitro studies in which human vascular endothelial cells are maintained under flow shear stress, which simulate a tissue microenvironment mimicking the in vivo conditions. I have a long-standing interest in examining the alterations in the nuclear factor kappa B regulation under conditions of shear stress which promotes the endothelial cells to be “activated” thus favoring the atherogenic process. I have also extended my expertise in the area of diabetes-research to explore similar possible mechanisms that contribute to accelerated-atherosclerosis in diabetic arteries. These studies reported from my laboratory have demonstrated the profound involvement of endothelial nitric oxide synthase under hyperglycemic conditions. My current studies are focused on determining how the balance of activities of Inhibitor kappa B kinase and endothelial nitric oxide synthase reflect oxidative stress responses of endothelial cells that are induced by high glucose.
Associated Diseases: Atherosclerosis, Diabetes
Techniques Used: Endothelial cell culture, DNA Transfection, Western Blotting, Nitric oxide Measurement & Shear stress process.
Research area/Field of study: Vascular Biology
Sub-field of Study: Endothelial Cell Biology
Specific Field of Study: Diabetes and Atherosclerosis
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Professional Background
Education
- 1995 - PhD - Biochemical Genetics - P.G. Inst. of Basic Medical Sciences, University of Madras
- 1995 - Postdoctoral Training - Biochemical Genetics - University of Madras
- 1981 - MS - Biochemistry - P.G. Inst. of Basic Medical Sciences, University of Madras
- 1979 - BS - Biochemistry - Avinashilingam Home Science College, University of Madras
- Postdoctoral Training - Biochemical Genetics - Bureau of Police Research and Development
- Postdoctoral Training - Applied Mechanics in Biomedical Res. Application - Indian Institute of Technology
- Postdoctoral Fellowship - Microbiology - University of Texas Health Science Center at San Antonio
Appointments
- 9/2016 - Professor/Research and . - University of Texas Health Science Center, Pathology
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Instruction & Training
- 10/2018 - Present, Membership on Supervising Committee, UT Health Science Center
- 9/2017 - Present, Post-Doctoral Student Supervision, UT Health Science Center
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Research & Grants
Grants
Federal
Funding Agency NIH Title Dysfunction of retinal neurons and circuits early in diabetic retinopathy. Status Complete Period 5/2014 - 4/2019 Role Co-Investigator Grant Detail To determine VEAFaction in Retinal endothelial cells under the influence of high glucose Funding Agency VA MERIT Title Diabetic Complications and Risk of Kidney Cancer Status Complete Period 6/2014 - 5/2018 Role Co-Investigator Grant Detail Screening of type-2 diabetic db/db mice among Tsc2++/TSC 2+/- mice. Funding Agency NIH Title Influence of High Glucose on Endothelial Function Status Complete Period 7/2012 - 6/2017 Role Principal Investigator Grant Detail The major goal is to understand the mechanism of endothelial dysfunction in Type-1 diabeties.
State
Funding Agency San Antonio Area Foundation Title Diabetes, Aging and Endothelial Dysfunction Status Active Period 4/2019 - 9/2020 Role Principal Investigator Grant Detail
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Publications
Journal Article
Al-Obaidi N1, Mohan S2, Liang S1, Zhao Z1, Nayak BK1, Li B3, Sriramarao P4, Habib SL1,5. Galectin-1 is a new fibrosis protein in type 1 and type 2 diabetes FASEB 2019 Jan;10(1096). Sumathy Mohan1, Natarajan Mohan1 Robert L. Reddick1 Krishnan Manickam1, Kathy Woodruff1, Diane Horn1, Samy Habib2, Rene de Crom 3, and Sherry L. Werner. Overexpression of endothelial nitric oxide synthase on a Ins2Akita-type-1 diabetic background exacerbates kidney injury J of Diabetes & its complications 2019 Jan;:23-32. Sureshkumar MA, Delma CR, Liang S, Zhao Z, Nayak BK, Li B, Sriramarao P, Habib SL, Natarajan M. Heterozygous Tsc2 (Tsc2 /-) mouse model to study induced renal cancer in response to ionizing radiation in low doses Carcinogenesis 2018 Dec;. Natarajan, M, Aravindan N, Sprague EA and Mohan S. Hemodynamic Flow-induced Mechanotransduction Signaling Influences Radiation Response of Vascular Endothelium (In Press) Radiat Res 2016 Jul;. *Chandra SB, *Mohan S, Ford BM, Huang L, Janardhanan P, Deo KS, Cong L, Muir ER, Duong TQ. Targeted overexpression of endothelial nitric oxide synthase in endothelial cells improves cerebrovascular reactivity in Ins2Akita-type-1 diabetic mice Journal of Cerebral Blood Flow and Metabolism *Both authors contributed equally 2016 Jun;36(6):1135-1142. Krishnan M, Janardhanan P, Roman L, Reddick RL, Natarajan M, van Haperen R, Habib SL, de Crom R, Mohan S. Enhancing eNOS activity with simultaneous inhibition of IKKB restores vascular function in Ins2Akita /- type-1 diabetic mice Lab Invest 2015 Oct;95(10):1092-104. Natarajan M, Konopinski R, Krishnan M, Roman L, Bera A, Hongying Z, Habib S, Mohan S. Inhibitor kappa B kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells Am J Physiol Cell Physiol 2015 Apr;308(8):C673-83. Adam K, Hung-1 C, Mohan S, Sitai L, Yidong C, Habib SL. Microarray profile of human kidney from diabetes, renal cell carcinoma and renal cell carcinoma with diabetes Genes & Cancer 2015 Jan;6(1-2). Habib SL, Mohan S, Liang S, Li B, Yadav M. Novel mechanism of transcriptional regulation of cell matrix protein through CREB Cell Cycle 2015 Jan;14(16):2598-608. Ghosh S, Lertwattanarak R, Gardu?o J, Galeana JJ, Li J, Zamarripa F, Lancaster JL, Mohan S, Hussey S, Musi N. Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging J. Gerontol A Biol Sci Med Sci 2014 May;70(2):232-46. Yeh CK, Harris SE, Mohan S, Horn D, Fajardo R, Chun YHP, Jorgensen J, MacDougall M, Werner SA. Hyperglycemia and Xerostomia are key determinants of tooth decay in Type 1 diabetic mice Lab Invest 2012 Jun;92(6):868-882. Wittrant Y, Gorin Y, Mohan S, Wagner B, Abboud-Werner SL. Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts Endocrinology 2009 Nov;150(11):4977-4988.