Faculty Directory
Assistant Professor - Research
My research interest is focused on epigenetic regulation function in malignant hematopoiesis and leukemia development. TET2, a ten eleven translocation methylcytosine dioxygenase, is one of the most commonly mutated/deleted genes in adult myeloid malignancies, which is also involved in RNA modification. Oncogenic/tumor suppressive RNAs is to take advantage of existing knowledge on myeloid malignancies with specific recurrent chromosomal aberrations. My current plan is to explore TET2 mediated specific modifications on the RNAs of interest and determine their impact on RNA functions such as stability and localization in myeloid malignancies.
1. R01HL174477 - Role: Co-Investigator: 07/01/24 - 06/30/28
Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation
2. CPRIT: RP250055 Multi-PIs: XU (contact) and Li (MPI) 04/01/25 - 03/31/28
TET2 mutations promote myeloid malignancies by dysregulating m5C oxidation of chromatin-associated RNAs
Zou Z*, Dou X*, Li Y*, Zhang Z, Wang J, Gao B, Xiao Y, Wang Y, Zhao L, Sun C, Liu Q, Yu X, Wang H, Hong J, Dai Q, Feng-Chun Yang F-C, Xu M¶, He C¶. RNA m5C oxidation by TET2 regulates chromatin state and leukemogenesis. Nature, 2024; 634:986-994.