Ying Li, Ph.D.

• Professional Background

  Education

  • 2012 - PhD - Epigentics - Jilin University

  Training

  • 2012 - Postdoctoral Associate - Hematology and Epigenetics - University of Florida College of Medicine

  Appointments

  • 2018 - Assistant Professor/Research - Penn State University College of Medicine

• Research & Grants

  My research interest is focused on epigenetic regulation function in malignant hematopoiesis and leukemia development. TET2, a ten eleven translocation methylcytosine dioxygenase, is one of the most commonly mutated/deleted genes in adult myeloid malignancies, which is also involved in RNA modification. Oncogenic/tumor suppressive RNAs is to take advantage of existing knowledge on myeloid malignancies with specific recurrent chromosomal aberrations. My current plan is to explore TET2 mediated specific modifications on the RNAs of interest and determine their impact on RNA functions such as stability and localization in myeloid malignancies.

  Grants

  R01HL174477 - Role: Co-Investigator: 07/01/24 - 06/30/28, Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation

• Publications

  • Alteration of CTCF associated chromatin organization inhibits TAL1-driven oncogenic transcription program and leukemogenesis
  • Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation
  • HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development
  • USF1 and hSET1A mediated epigenetic modification regulates lineage differentiation and HoxB4 transcription
  • Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis

  Zou Z*, Dou X*, Li Y*, Zhang Z, Wang J, Gao B, Xiao Y, Wang Y, Zhao L, Sun C, Liu Q, Yu X, Wang H, Hong J, Dai Q, Feng-Chun Yang F-C, Xu M¶, He C¶. RNA m5C oxidation by TET2 regulates chromatin state and leukemogenesis. Nature, 2024; 634:986-994.