UT Health San Antonio

Jihoon Lee, Ph.D.

Assistant Professor

Currently seeking M.S. & Ph.D. students

Dr. Lee's research aims to elucidate how epigenetic and epitranscriptomic modifications regulate the flow of genetic information from DNA to protein, with a particular focus on the roles of RNA adenosine and cytosine methylation (m⁶A/m⁵C) in human diseases such as cancer. We are especially interested in uncovering novel therapeutic opportunities through this work. To achieve these goals, we employ a highly multidisciplinary approach that integrates biochemistry, structural biology, proteomics, genomics, epigenomics, and systems biology. 

Our comprehensive studies seek to define the context-specific networks linking epigenetic and epitranscriptomic regulation of the epigenome and transcriptome, and to understand how disruptions in these networks contribute to disease development and progression.