Programs
Departments & Divisions
Research
Currently seeking Ph.D. students
Elizabeth Leadbetter, Ph.D.
Associate Professor
Department of Microbiology, Immunology & Molecular Genetics
Research
Dr. Leadbetter's laboratory has two long term research goals, to thoroughly investigate the mechanisms and nature of cooperation between iNK T and B cells during responses to model and bacterial lipid antigens and to extend these finding to inform the development of a new family of lipid-based vaccine candidates. Relevant Diseases
These studies currently include studies of model lipid, protein, and polysaccharide antigens in murine models of infection, metabolic disease, and autoimmunity; including clinically relevant vaccine studies harnessing iNKT and B cell cooperation for protection.
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Research & Grants
Dr. Leadbetter's laboratory has two long term research goals, to thoroughly investigate the mechanisims and nature of cooperation between iNK T and B cells during responses to model and bacterial lipid antigens and to texnted these findings to inform the development of a new family of lipid based vaccine candidates.
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Publications
Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G,Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan;16(1):85-95. doi:10.1038/ni.3047. Epub 2014 Dec 1.