Jean X. Jiang, Ph.D.
Professor and Zachry Distinguished University Chair
Currently seeking M.S. & Ph.D. students
Cells connect and communicate via an information superhighway named gap junctions. Gap junctions are clusters of transmembrane channels that connect the cytoplasm of adjacent cells. These channels are formed by a family of proteins called connexins. Gap junction channels permit small metabolites, ions, and second messengers to pass from cell to cell. Cells like lens fibers within the interior of the vertebrate eye lens neither have blood supply nor organelles. Thus, lens survival and homeostasis are uniquely dependent upon intercellular communication via gap junctions with the cells localized at the lens surface. For cells like bone osteocytes, signals generated by mechanical loading can be transmitted extensively through gap junction channels. Therefore, gap junctions provide the critical means for cell survival and for physiological regulation of cellular functions. In addition to forming gap junctions, connexins are recently shown to form hemichannels, un-apposed halves of gap junction channels. Hemichannels mediate the passage of biological molecules, especially for cells under stress conditions. Our current research interests are:
1). To determine the gap junction or hemichannel-dependent and independent mechanisms of connexins in cell growth, differentiation and lens development.
2). To investigate the functional significance of gap junctions, hemichannels and integrins in signaling transmission, skeletal tissue remodeling and cancer metastasis of breast cancer and osteosarcoma.
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Professional Background
Education
- 1995 - Postdoctoral Fellowship - Cell Biology - Harvard Medical School,
- 1991 - PhD - Biochemistry - State University of New York at Stony Brook
- 1986 - BS - Biochemistry - Nanjing University
Training
- 2012 - Leadership (LEAD) Academy - University of Texas System
Highlights
National Research Service Award, NIH, San Antonio’s 40 under 40 Rising Star, University of Texas LEAD (Leadership) Fellow, CTRC Discovery of the Year Award, Ashbel Smith Professorship, Master Research Award for Distinguished Researcher, Presidential Distinguished Senior Research Scholar Award, Women in Medicine Month Honoree, Zachry Distinguished University Chair, Fellow, American Society of Bone and Mineral Resear, Fellow, American Association for Advancement of Science (AAAS)
Appointments
- 1/2016-present - Associate Director, Joint Biomedical Engineering Program - UTHSCSA and UTSA
- 1/2015-1/2016 - Interim Associate Director, Joint Biomedical Engineering Program - UTHSCSA and UTSA
- 1/2015-present - COGS Chair, Joint Biomedical Engineering Program - UTHSCSA/UTSA
- 2016-present - Member, Department Executive Committee (DEC), Dept of Biochemistry and Structural Biology, - UTHSCSA
- 2016-2010 - Co-leader, Membrane Biology and Cell Signaling Graduate Track - UTHSCSA
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Instruction & Training
1998- Present - Pre-Doctoral Student Supervision - UTHSCSA1998-Present - Membership on Supervising Committee - UTSA/UTHSCSA1997 - Present - Post-Doctoral Student Supervision - UTSA2000-present - Didactic lectures for Graduate Students - UTSA/UTHSCSA2003-present - Didactic lectures for Medical Students - UTHSCSA1998 - Present - Ph.D. Dissertations Directed - UTHSCSA1995 - Teaching for Medical Students - Harvard Medical School
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Research & Grants
Our current research interests are:
1). To determine the gap junction or hemichannel-dependent and independent mechanisms of connexins in cell growth, differentiation and lens development.
2). To investigate the functional significance of gap junctions, hemichannels and integrins in signaling transmission, skeletal tissue remodeling and cancer metastasis of breast cancer and osteosarcoma.
GrantsRO1 (AR076190) Jiang (MPI) and Wang (Contact PI) 07/01/2019-06/30/2024
NIH/NIAMS
“Proteoglycans and age-related deterioration of bone toughness”
The major objective of this study is to elucidate the underlying mechanism of proteoglycans in toughening of bone and its contribution to the age-related bone fragility.
RO1 (AR072020) Jiang (PI) 08/01/2018-07/31/2023
NIH/NIAMS
“Connexin channels in transducing mechanical signals in bone”
The major objective of this grant is to determine the specific mechanistic role of Cx43 hemichannels in mediating the anabolic effect of mechanical loading on the skeletal tissues.
RO1 (EY012085) Jiang (PI) 03/01/2018-2/28/2023.
NIH/NEI
“Intracellular Communication in the Eye lens”
The major objective of this grant is to understand the roles of connexin hemichannels in mediating transport of glucose and antioxidiant in maintaining lens transparency and homeostasis, and cell protective function against oxidative stress.
Role: PI
BC161273 Jiang (Lead PI) and An (Partner PI) 09/30/2017-09/29/2021
DoD
“Development of hemichannel-targeting antibody therapies for breast cancer bone metastasis”
The major objective of this grant is to develop a therapeutic antibody that targets connexin hemichannel and can be used to treat breast cancer bone metastasis.
Research funding Jiang (PI)
AlaMab Therapeutics 12/01/2017-11/30/2020
“Development of therapeutics for disease Indications”
The major objective of this grant funding is to develop antibody therapeutics and determine efficacies in several disease indications.
Role: PI
RO1 (CA196214) Jiang (Contact PI) and Sun (MPI) 02/01/2016-01/31/2021
NIH/NCI
“Connexin hemichannels in suppression of breast cancer bone metastasis”
The major objective of this grant is to explore the mechanistic roles of activated Cx43 hemichannels in osteocytes in inhibition of breast cancer cell migration and bone metastasis and the involvement of purinergic signaling in cancer cells.
Role: Contact PI.
Research Grant (AQ-1507) Jiang (PI) 06/01/2019-05/31/2022
Welch Foundation
“Modulating hemichannel activities using targeting antibodies”
The objective of this project is to use structural biology, antibody and microscopic approaches to understand the gating mechanism of connexin hemichannels.
Research grant Jiang (PI) 07/01/2019-01/31/2020
President’s Translational and Entrepreneurial Research Fund/UTHSCSA
“Novel small molecule, chemical compounds in the treatment of cancer metastasis”
The objective of this project is to test the efficacy of novel chemical compounds on suppression of cancer bone metastasis.
Role: PI
Zachry Distinguished University Chair Endowment Jiang (PI) 03/20/2019-
UTHSCSA
University endowment for the holder of Zachry Distinguished University Chair in Cancer Research
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Service
Institutional
Search Committee for Chair and faculty of Dept BSB and othe Dept; Chair and member, PTEC; Reviewer, UTHSA internal grants; Chair and Member, Dept and Institutional PTEC; Chair and Member, Dept and Univ. XYZ compensation committee, Chair, Graduate Faculty Assembly; Chair, Biosafety Committee and Library Committee
National
Chair, Eduction Coimmittee and Member, Executive Committee of ICMRS; Mentor, ARVO Leadership Development Program; Mentor, ASBMR-National Research Network Mentoring Program; Faculty Advisor, BMEGS-SA; Mentor, Global Mentoring Program, ARVO; Member, Scientific Program Development Committee, IGJC;
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Publications
Jiang, J.X., and London, E. (1990). Involvement of denaturation-like changes in Pseudomonas exotoxin A hydrophobicity and membrane penetration determined by characterization of pH and thermal transitions. J. Biol. Chem. 265, 8636-8641.
Jiang, J.X., Abrams, F., and London, E. (1991). Folding changes in membrane-inserted diphtheria toxin that may play important roles in its translocation. Biochemistry 30, 3857-3864.
Jiang, J.X., Chung, L.A., and London, E. (1991). Self-translocation of diphtheria toxin across model membranes. J. Biol. Chem. 266, 24003-24010.
London, E., Ulbrandt, N.D., Tortorella, D., Jiang, J.X., and Abrams, F.S. (1993). Insight into membrane protein folding and translocation from the behavior of bacterial toxins: models for membrane translocation. Society of General Physiologists Series. 48, 45-61.
Jiang, J.X., Paul, D.L., and Goodenough, D.A. (1993). Posttranslational phosphorylation of lens fiber connexin 46: a slow occurrence. Invest. Opthalmol. & Visual Sci. 34, 3558-3565.
Jiang, J.X., White, T.W., Goodenough, D.A., and Paul, D.L. (1994). Molecular cloning and functional characterization of chick lens fiber connexin 45.6. Mole. Biol. Cell 5, 363-373.
Jiang, J.X., White, T.W., Paul, D.L., and Goodenough, D.A. (1994). Molecular and functional characterization of lens fiber connexins. Progress in cell research. ed. Y. Kanno et al, Elsevier Science Press. 4, 377-381
Jiang, J.X., White, T.W., and Goodenough, D.A. (1995). Changes in connexin expression and distribution during chick lens development. Dev. Biol. 168, 649-661.
Jiang, J.X., and Goodenough, D.A. (1996). Heteromeric connexon formation in lens gap junctions. Proc. Natl. Acad. Sci. USA . 93, 1287-1291.
Jiang, J.X. and Goodenough, D.A. (1998). Retroviral expression of connexins in embryonic chick lens. Invest. Opthalmol. Visual Sci. 39, 537-543.
Jiang, J.X. and Goodenough, D.A. (1998). Phosphorylation of lens-fiber connexins in lens organ cultures. Eur. J. Biochem. 255, 37-44. PMID: 9692898
Jiang, J.X. and Goodenough, D.A. (1998). Expression of retroviruses containing connexins in chick embryonic lens in situ. Gap Junctions. ed. R. Werner, IOS Press. 96-101. 10.
He, D., Jiang, J.X., Taffet, S. M. and Burt, J.M. (1999). Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells. Proc. Natl. Acad. Sci. USA. 96, 6495-6500.
Yin, X., Jedrzejewski, P., and Jiang, J.X. (2000). Phosphorylation of lens fiber connexin 45.6 on Ser363 by casein kinase II and its functional significance. J. Biol. Chem. 275, 6850-6856. PMID: 10702244
Gu, S., Roderick, H.L., Camacho, P., and Jiang, J.X. (2000). Identification and characterization of an amino acid transporter expressed differentially in liver. Proc. Natl. Acad. Sci. 97, 3230-3235. PMID: 10716701
Jiang, J.X. (2000). Use of retrovirus to express connexins. Methods in Molecular Biology, Gap Junction Protocols, ed. R. Bruzzone and C. Giaume, Humana Press Inc. pp 159-174. PMID: 11218647
Cheng, B., Zhao, S., Luo, J., Sprague, E., Bonewald, L.F. and Jiang, J.X. (2001). Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells. J. Bone Miner. Res. 16, 249-259. PMID: 11204425
Gu, S., Roderick, H.L., Camacho, P., and Jiang, J.X. (2001). Identification and characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport. J. Biol. Chem. 276, 24137-24144. PMID: 11325958
Gu, S., Adan-Rice, D., Leach, R.J. and Jiang, J.X. (2001). A novel human amino acid transporter, PAAT1: cDNA cloning, chromosomal mapping, genomic structure, expression and functional characterization. Genomics 74, 262-272. PMID: 11414754
Cheng, B., Kato, Y., Zhao, S., Luo, J., Sprague, E., Bonewald, L.F., and Jiang, J.X. (2001). Prostaglandin E2 is essential for gap junction-mediated intercellular communication between osteocytes in response to mechanical strain. Endocrinology 142, 3464-3473. PMID: 11459792
Yin, X., Gu, S., and Jiang, J.X. (2001). The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation. J. Biol. Chem. 276, 34567-34572. PMID: 11448971
Jiang, J.X., and Cheng, B. (2001). Mechanical stimulation of gap junctions in bone osteocytes is mediated by prostaglandin E2. Cell Communica. Adhesion 8, 283-288. PMID: 12064603
Yin, X., Gu, S., and Jiang, J.X. (2001). Regulation of lens connexin 45.6 by apoptotic protease, caspase-3. Cell Communica. Adhesion 8, 355-359. PMID: 12064621
Choi, D., Oh, H.J., Chang, U.J., Koo, S.K., Jiang, J. X., Hwang, S.Y., Lee, J.D., Yeoh, G.C., Shin, H.S., Lee, J-S., and Oh, B. (2002). In vivo differentiation of mouse embryonic stem cells into hepatocytes. Cell Transplant 11, 359-368.
Jiang, J.X. Yin, X., Gu, S., Yu, X.S., Siller-Jackson, A., Priyadarshini, P., and Villegas, C. (2002). Function and regulation of gap junctions and connexins in the vertebrate eye lens. Recent Research Developments in Biological Chemistry, ed. S.G. Pandalai, Research Signpost Press Inc. 307-318.
Gu, S., Yu, X. S., Yin, X., and Jiang, J.X. (2003). Stimulation of lens cell differentiation by a gap junction protein Cx45.6. Invest. Opthamol. Vis. Sci. 44, 2103-2111. PMID: 12714649
Gu, S., Langlais, P., Liu, F., and Jiang, J.X. (2003). mNAT3, an N-system amino acid transporter expressed in hepatocytes and regulated by an insulin-activated and PI3 kinase-dependent signaling. Biochem. J. 371, 721-731. PMID: 12537539
Jiang, J.X., and Cherian, P.P. (2003). Hemichannels formed by Cx43 play an important role in the release of prostaglandin E2 by osteocytes in response to mechanical strain. Cell Communica. Adhesion 10, 259-264. PMID: 14681026
Cherian, P.P., Cheng, B., Gu, S., Sprague, E., Bonewald, L.F., and Jiang, J.X. (2003). Effects of mechanical strain on the function of gap junctions in osteocytes is mediated through the prostaglandin EP2 receptor. J. Biol. Chem. 278, 43146-56. PMID: 12939279
Gu, S., and Jiang, J.X. (2003). A novel gene family-solute carrier family (Slc38a) representing system N and A-related amino acid transporters-A review. J. Lanzhou Univ. 39, 28-34.
Yu, X.S., and Jiang, J.X. (2004). Interaction of major intrinsic protein (aquaporin-0) with fiber connexins in lens development. J. Cell Sci. 117, 871-880. PMID: 14762116
Yu, X.S., Yin, X., Lafer, E.M. and Jiang, J.X. (2005). Developmental regulation of the direct interaction between the intracellular loop of connexin 45.6 and the C-terminus of major intrinsic protein (aquaporin-0). J. Biol. Chem. 280, 22081-22090. PMID: 15802270
Cherian, P.P., Siller-Jackson, A, J., Gu, S., Wang, X., Bonewald, L.F., Sprague, E. and Jiang, J.X. (2005). Hemichannels formed by connexin 43 provide a novel pathway for the release of prostaglandin E2 by osteocytes in response to mechanical strain. Mol. Biol. Cell 16, 3100-3106. (*Highlighted as a hottest paper, Science STKE 291, tw242, 2005). PMCID: 1165395
Gu, S., Villegas, C., and Jiang, J.X. (2005). Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes. J. Biol. Chem. 280, 26055-26062. PMID: 15899884Jiang, J.X. and Gu, S. (2005). Gap junction-independent actions of connexins. Biochem. Biophys. Acta. 1711, 208-214. PMCID: PMC1831832
Cherian, P.P., Siller-Jackson, A, J., Gu, S., Wang, X., Bonewald, L.F., Sprague, E. and Jiang, J.X. (2005). Mechanical strain opens connexin hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Sci. Signal. 16, 3100.
Gluhak-Heinrich, J., Gu, S., Pavlin, D., and Jiang, J.X. (2006). Mechanical loading stimulates expression of connexin 43 in alveolar bone cells in the tooth movement. Cell Communica. Adhsion. 13, 115-125 PMID: 16613785
Jiang, J.X., Siller-Jackson, A.J., and Burra, S. (2007). Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front. Biosci. 12, 1450-1462 PMCID: PMC1797155
Moret C., Dave, M.H., Schulz, N., Jiang, J.X., Verrey, F., Wagner, C.A. (2007). Regulation of renal amino acid transporters during metabolic acidosis. Am. J. Physiol. Renal Physiol. 292, F555-566
Banks E.A., Yu, X.S, Qian, S. and Jiang, J.X. (2007). Promotion of lens epithelial-fiber differentiation by C-terminus of connexin 45.6, a role independent of gap junction communication J Cell Sci. 12, 3602-3612. (*highlighted “in this issue”). PMID: 17895360
Cherian, P.P., Xia, X., and Jiang, J.X. (2008) Role of gap junction, hemichannels, and connexin 43 in mineralizing MLO-A5 cells in response to intermittent and continuous application of parathyroid hormone. Cell Communica. Adhsion. 15, 43-54. PMID: 18649177
Yin, X., Liu, J. and Jiang, J.X. (2008) Lens fiber connexin turnover and caspase-3-mediated cleavage are regulated alternately by phosphorylation. Cell Communica. Adhsion. 15, 1-11. PMCID: 2719281
Kihara, A.H., Paschon, V., Akamine, P.S., Saito, K.C., Leonelli, M., Jiang, J.X., Hamassaki, D.E. and Britto, L.R.G. (2008) Connexin expression during histogenesis of the chick retina. Dev. Neurobiol. 68, 1287-302.
Siller-Jackson, A.J., Burra, S., Gu, S., Bonewald, L.F., Sprague, E., and Jiang, J.X. (2008) Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading J. Biol. Chem. 283, 26374-26382. (*highlighted in “Not to be missed”, BoneKEy, a knowledge environment for the bone field). PMCID: PMC2546557
Banks, E.A., Toloue, M.M., Shi, Q., Zhou, Z.J., Liu, J., Nicholson, B.J. and Jiang, J.X. (2009) Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner. J. Cell Sci. 122: 378-388. PMID: 19126675
Biswas, S.K., Jiang, J.X. and Lo, W-K. (2009). Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens. Mole. Vis. 15:1492-1508. PMID: 19657477
Burra, S., and Jiang, J.X. (2009). Connexin 43 hemichannel opening associated with prostaglandin E2 release is adaptively regulated by mechanical stimulation. Communi. & Integra. Biol. 2(3). PMID: 19641742. PMCID:2717532
Rath, A.L., Bonewald, L.F., Ling, L., Jiang, J.X., Van Dyke,, M.E., and Nicolella, D.P. (2009) Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J. Biomech. 43, 1560-1564. PMCID: PMC2866825
Xia, X., Batra, N., Shi, Q., Bonewald, L.F., Sprague, E., and Jiang, J.X. (2010) Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by GSK-3-β-catenin signaling. Mol. Cell. Biol. 30, 206-219. PMCID: PMC2798309
Jiang, J.X. (2010). Gap junctions/hemichannel-depedent and independent roles of connexins in cataractogenesis and lens development. Cur. Mole. Med. 10, 851-63. PMID: 21091421
Shi, Q., Banks, E.A., Yu, X.S., Gu, S., Lauer, J., Fields, G.B., and Jiang, J.X. (2010) An amino acid residue V362 plays a critical role in maintaining the structure of Connexin 50 C-terminus and in lens epithelial-fiber differentiation. J. Biol. Chem. 285, 18415-18422. PMCID:2881767
Kitase, Y., Barragan, L., Jiang, J.X., Johnson, M.L., Bonewald, B.F. (2010). Mechanical induction of PGE2 in osteocytes blocks glucocorticoid induced apoptosis through both the β-catenin and PKA pathways. J. Bone Miner. Res. 25, 2381-92. PMCID: 3179278
Xia, X., Kar, R., Gluhak-Heinrich, J., Yao, W., Lane, N. Bonewald, L.F., Biswas, S.K., Lo, W-K., and Jiang, J.X. (2010). Glucocorticoid induced autophagy in osteocytes. J. Bone Miner. Res. 25, 2479-2488. PMCID:3179284
Burra, S., Nicolella. D.P., Francis, W.L., Freitas, C.J., Mueschke, N.J., Poole, C., and Jiang, J.X. (2010) Dendritic process of osteocytes is a mechanotransducer that induces the opening of hemichannels. Proc. Natl. Acad. Sci. 107, 13648-13653. PMCID: PMC2922284
Biswas, S.K., Lee, J.E., Brako, L., Jiang, J.X. and Lo, W-K (2010) p junctions are selectively associated with interlocking ball-and-sockets but not protrusions in the lens. Mole. Vis. 16:2328-2341. PMID: 21139982
Liu, J., Xu, J., Gu, S., Nicholson, B.J., and Jiang, J.X. (2010) Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50. J. Cell Sci. 124, 198-206. PMCID: PMC3010190
Burra, S., Nicolella. D.P., and Jiang, JX. (2010) Dark horse in osteocyte biology: Glycocalyx around the dendrites is critical for osteocyte mechanosensing. Communi. & Integra. Biol. 4, 48-50. PMCID: PMC3073269
Bao, B., Jiang, J.X., Yanase, T., Nishi, Y., Morgan, J.R. (2011) Connexon-mediated cell adhesion drives microtissue self-assembly. FASEB J. 25, 255-264. PMCID: PMC3005422
Orellana, J.A., Shoji, K.F., Abudara, V., Ezan, P., Amigou, E., Jiang, J.X., Sáez, J.C. and Giaume, C. (2011). Amyloid β-induced neuronal death involves glial and neuronal hemichannels. J. Neurosci. 31, 4962-4977
Fang, X., Huang, T., Zhu, Y., Jiang, J.X., Wang, P., Kitamura, M., and Yao. J. (2011) Gap junction hemichannel exaggerates cadmium-induced oxidative stress and cell injury. Antioxid. Redox Signal. 14:2427-2439. PMCID: PMC3096519
Orellana, J.A., Froger, N., Ezan, P., Jiang, J.X., Bennett, M.V.L., Naus, C.C., Giaume, C. and Sáez, J.C. (2011) ATP and glutamate released via astroglial connexin43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J. Neuro. Chem. 118:826-840.
Liu, J., Ek Vitroin, J.F., Weintraub, S.T., Gu, S., Shi, Q., Burt, J.M., Burt, J.M., and Jiang, J.X. (2011). Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel function. J. Biol. Chem. 286:16914-28. PMCID: PMC3089535
Burra, S. and Jiang, J.X. (2011). Regulation of cellular function by connexin hemichannels. Int. J. Biochem. Mol. Biol. 2:119-128. PMCID:3180094
Jia, J., Yao, W., Min Guan, Dai, W., Quarles, D., Kar, R., Bonewald, L., Jiang, J.X., and Lane, N.E. (2011) Glucocorticoid dose determines osteocyte cell fate FESEB J. 25, 3366-3376. PMCID:3177583
Shi, Q., Padmanabhan Iyer, R., Villegas, C.J., Gu, S., and Jiang, J.X. (2011) Membrane topological structure of SNAT4 neutral amino acid transporter. J. Biol. Chem. 286, 38086-38094. PMCID:3207422
Orellana, J.A., Sáez, P.J., Elizondo, R., Cortés-Campos, C., Shoji, K.F., Contreras-Duarte, S., Figueroa, V., Velarde, V., Jiang, J.X., Nualart, F., Sáez, J.C., and García, M.A. (2012). Glucose increases intracellular Ca2+ in tanycytes via ATP released through connexin 43 hemichannels. Glia 60, 53-68.
Batra, N., Kar, R., and Jiang, J.X. (2012). Gap junctions and hemichannels in signal transmission, function and development of bone. Biochem. Biophys. Acta. 1818:1909-1918. PMCID3440861
Batra, N., Burra, S., Siller-Jackson, A.J., Gu, S., Xia, X., Weber, G., DeSimone, D., Bonewald, L.F., Lafer, E.M., Sprague, E., Schwartz, M.A., and #Jiang, J.X. (2012) Mechanical stress activates integrin α5β1 induces opening of connexin 43 hemichannels. Proc. Nat. Acad. Sci. 109:3359-64. PMCID:3295295 (highlighted in “Editor’s Choice”, Science, 335, 1021 (2012)
Rosario, F. J., Schumacher M. A., Jiang J.X., Kanai, Y., Powell, Theresa L, and Jansson, T. (2012) Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth. J. Physiol. 590:1495-509.
Kar, R., Batra, N., Riquelme, M. A. and Jiang, J.X. (2012) Biological role of connexin intercellular channels and hemichannels. Acta. Biochem. Biophys. 524:2-15
Wang, K., Gu, S., Yin, X., Weintraub, S.T., Hua, Z. and Jiang, J.X. (2012) Developmental truncations of connexin 50 by caspases adaptively regulate gap junctions/hemichannels and protect cells against UV radiation. J. Biol. Chem. 287, 15786-15797. PMCID: 3346145
Klionsky, D.J., Abdalla, F.C.,….Jiang, J.X., etc (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8, 1-100.
Batra, N. and Jiang, J.X. (2012). “INTEGRINating” the connexin hemichannel function in bone osteocytes through the action of integrin α5. Communi. & Integra. Biol. 5, 1-3.
Padmanabhan Iyer, R., Gu, S., Nicholson, B.J., and Jiang, J.X. (2012) Residue cysteine 232 is important for substrate transport of neutral amino acid transporter, SNAT4. Int. J. Biochem. Mol. Biol. 3, 374-383.
Loiselle, A.E., Jiang, J.X., Donahue, H.J. (2013). Gap junction and hemichannel functions in osteocytes. Bone 54, 205-212.
Padmanabhan, R., Gu, S. Xu, J., Nicholson, B.J. and Jiang, J.X. (2013) Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter. PloS One e56792.
Yao, W. Dai, W., Jiang, J.X. and Lane, N.E. (2013). Glucocorticoids and osteocyte autophagy. Bone 54, 279-284.
Kar, R., Riquelme, M.A., Werner, S., and Jiang, J.X. (2013) Connexin 43 channels protect osteocytes against oxidative stress-induced cell death. J. Bone Miner. Res. 28, 1611-1621. PMCID3688648
Riquelme, M.A., Kar, R., Gu, S., Jiang, J.X. (2013) Antibodies targeting extracellular domain of connexins for studies of hemichannels. Neuropharmacology 75, 525-532.
Pei, C., Xu, Y., Jiang J.X., Cu, L-J., Li, L., and Qin, L. (2013). Application of sustained delivery microsphere of cyclosporine A for preventing posterior capsular opacification in rabbits. Inter. J. Opthalmol. 6, 1-7.
Sáez, P.J., Shoji, K.F., Retamal, R., Harcha, P.A., Ramirez, G., Jiang, J.X., Von Bernhardi, R.; and Saez, J.C. (2013) ATP is required and advances the cytokine-induced gap junction formation in microglia in vitro. Mediators of Inflammation 2013, 216402.
Sáez, P.J., Orellana, J.A., Vega-Riveros, N., Figueroa, V.A., Hernández, D.E., Castro, J.F., Klein, A.D., Jiang, J.X., Zanlungo, S. and Sáez, J.C. (2013) Disruption in connexin-based communication is associated with intracellular Ca2+ signal alterations in astrocytes from Niemann-Pick type C mice PLOS ONE. 8, e71361.
Ren, Q., Riquelme, M.A., Xu, J., Yang, X., Nicholson, B.J., Gu, S., and Jiang, J.X. (2013) Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death. PLOS ONE 8, e74732.
Riquelme, M.A. and Jiang, J.X. (2013) Elevated intracellular Ca2+ signals by oxidative stress activate connexin 43 hemichannels in osteocytes. Bone Research 4, 355-361.
Batra, N., Riquelme, M.A., Burra, S., and Jiang, J.X. (2014) 14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels. J. Cell Sci. 127, 137-146. PMCID3874784
Zhou, J.X. and Jiang, J.X. (2014) Gap junction and hemichannel independent actions of connexins on cell and tissue functions – an update. FEBs Letters 588, 1186-1192.
Lo, W-K., Biswas, S., Brako, L., Shiels, A., Gu, S., and Jiang, J.X. (2014) AQP0 targets interlocking domains to control integrity and transparency of eye lens. Invest. Opthalmol. Vis. Sci. 55, 12021-1212.
Batra, N., Riquelme, M.A., Burra, S., and Jiang, J.X. (2014) Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation. J. Biol. Chem. 289, 10582-10591. PMCID4036178
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Xu, H., Gu, S., Riquelme, M.A., Burra, S., Callaway, D.A, Cheng, H., Guda, T., Schmitz, J., Fajardo, R., Werner, S.L., Zhao, H., Shang, P., Johnson, M.L., Bonewald, L.F., and Jiang, J.X. Connexin 43 channels are essential for normal bone structure and osteocyte viability. (2015) J. Bone Miner. Res. 30, 436-448. PMCID:PMC431576
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Callaway, D.A., Riquelme, M.A., Sharma, R., Lopez-Cruzan, M., Herman, B.A. and Jiang, J.X. (2015) Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Bone 76, 40-48.
Jiang, J.X., Riquelme, M.A., and Zhou, J.Z. ATP, a double-edged sword in cancer. (2015) Oncoscience 2, 673-674.
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Padmanabhan Iyer, R., Gu, S., and Jiang, J.X. (2016) N-Glycosylation Influences Transport, but not Cellular Trafficking, of a Neuronal Amino Acid Transporter SNAT1. Biochem. J. 473, 4227-4242
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Hu, Z., Riquelme, M.A., Wang, B., Brenner, R., Gu, S., and Jiang, J.X. (2018) Cataract-causing connexin 46 mutation alters its interaction with calmodulin and gating of hemichannels. J. Biol. Chem. 293, 2573-2585.
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Kar, R., Riquelme, M.A., Hua R., Jiang, J.X. (2018) Glucocorticoid-induced autophagy protects osteocytes against oxidative stress through activation of MAPK/ERK signaling. J. Bone Mineral Res. Plus 3, e10077.
Werner, S.L., Sharma, R., Woodruff, K., Horn, D., Harris, S.E., Gorin, Y., Lee, D-Y., Hua, R., Gu, S., Fajardo, R.J., Habib, S.A. and Jiang, J,X. (2018) CSF-1 in osteocytes inhibits Nox4-mediated oxidative stress and promotes normal bone homeostasis. J. Bone Mineral Res. Plus 4, e10080
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Chen, C-X., Luo, K-J, Yang, J-P., Huang, Y-C., Cardenas, E.R., Nicholson, B.J., and Jiang, J.X. (2020) Connexins and cAMP in cross-talk in cancer metastasis. Cancers 13, 58
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Liu, X., Riquelme, M.A., Tian, Y., Acosta, F.M., Gu, S. and Jiang, J.X. (2021) ATP inhibits breast cancer migration and bone metastasis through down-regulation of CXCR4 and purinergic receptor P2Y11. Cancers 13, 4293.
Han, Y., Gomez, J., Hua, R., Xiao, P., Gao, W., Jiang, J.X., and Wang, X. (2021) Removal of glycosaminoglycans affects the in situ mechanical behavior of extrafibrillar matrix in bone. Mechan. Behav. Biomed. Mater. 123, 104766.
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Acosta, F.M., Stojkova, K., Zhang, J., Huitron, E.I.G., Jiang, J.X., Rathbone, C.R., and Brey, E.M. (2022) Engineering functional vascularized beige adipose tissue from microvascular fragments isolated from healthy and diabetic adipose tissue. J. Tissue Engineer. 13, 1-17.
Zhao, D., Riquelme, M.A., Guda, T., Tu, C., Xu, H., Gu, S., and Jiang, J.X. (2022) Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading. eLife 11, e74365.
Emoto, T., Lu, J., Sivasubramaniyam, T., Khan, A.B., Abow, A.A., Schroer, S.A., Maan, H., Hyduk, S., Althagafi, M., McKee, T., Fu, F., Shabro, S., Ulndreaj, A., Chiu, F., Paneda, E., Pacheco, S., Wang, T., Li, A., Jiang, J.X., Libby, P., Husain, M., Wang, B., Rubin, B.B., Cybulsky, M., and Robbins, C.S. (2022) CSF-1 producing sinusoidal endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche. Immunity 55, 862-870
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