Yuji Ikeno, M.D., Ph.D.

Currently seeking Ph.D. students

• Professional Background

  Education

  • 1993 - PhD - Medicine/Pathology - Nagasaki University School of Medicine
  • 1987 - MD - Medicine - Nagasaki University School of Medicine

  Appointments

  • 9/2016 - Professor - , Barshop Institute
  • 9/2013 - Associate Professor with tenure - UTHSCSA, Department of Pathology, San Antonio
  • 1/2011 - Research Health Scientist - GRECC, South Texas Veterans Health Care System, Audie L. Murphy Division
  • 9/2007 - Project Pathologist - National Institutes of Health, NIA Interventions Testing Program, San Antonio
  • 9/2004 - Pathologist - Contractor - National Institutes of Health, NIA - Primate Aging Study, Lab of Experimental Gerontology, Bethesda
  • 6/2000 - Research Health Scientist - South Texas Veterans Health Care System, Audie L. Murphy Division, Research Services, San Antonio
  • 7/1997 - Director - Nathan Shock Pathology Core - UTHSCSA, Department of Barshop InstituteSan Antonio

• Instruction & Training

  • 5/2010 - Present, Membership on Supervising Committee, The University of Texas Health Science Center at San Antonio
  • 1/2010 - Present, Membership on Supervising Committee, Drexel University

• Research & Grants

  Over the past 31 years, I have been directly responsible for the pathological analyses of all animals studied in multiple Program Projects and the San Antonio Nathan Shock Aging Center.

  Research profile

  Grants

  Federal

  Funding Agency NIH/NIA Title NIH/NIA Targeting Cellular Senescence to Extend Healthspan Status Active Period 6/2019 - 1/2024 Role Principal Investigator Grant Detail The aims are to: 1) To conduct comprehensive pathological analyses of genetically- and/or pharmacologically-manipulated mice/rats and their control animals in the aging colonies; 2) To conduct cellular senescence characterization, histopathological, immunohistochemical, and morphometric analyses of tissues obtained from genetically- and/or pharmacologically-manipulated mice/rats and their control animals in the aging colonies at a specific age point; and 3) To develop a comprehensive database of histopathological findings and a tissue and digital image archive, and to provide histology services as a resource for the analysis of samples by special request and for new morphological research. (PI: J. Kirkland and S. Khosla) Funding Agency NIH/NIA Title NIH/NIA Effect of Aging on Preadipocyte Differentiation Status Active Period 4/2016 - 3/2021 Role Co-Investigator Grant Detail The aims are to: 1) delineate mechanisms and effects of targeting senescent cells in vitro, 2) test effectiveness of senolytic agents in clearing senescent cells in vivo, and 3) determine the impact of senolytic agents on healthspan phenotypes. (PI: J. Kirkland) Funding Agency NIH/NIA Title Nathan Shock Aging Center Status Active Period 7/2015 - 6/2020 Role Principal Investigator Grant Detail   Funding Agency   Title Mechanisms by which CU/ZNSOD overexpression improves metabolic health in rats Status Active Period 9/2018 - 8/2019 Role Principal Investigator Grant Detail The goal of this project is to pursue our seminal findings by assessing the specific mechanisms that improve age-related changes in metabolic health under increased adiposity in rats with enhanced levels of a major antioxidant enzyme. We will investigate whether increasing an antioxidant enzyme in skeletal muscle and/or adipose tissue attenuates age-related changes in metabolic health by reducing senescent cell accumulation and enhancing insulin signaling. Funding Agency NIA Title Center for Testing Potential Anti-Aging Interventions Status Complete Period 8/2014 - 4/2019 Role Co-Investigator Grant Detail The goal of this project is to test pharmacological interventions for their anti-aging effects in a genetically heterogeneous stock of mice at 3 separate sites. This project is beginning its 3rd 5-year cycle of funding and has discovered several drugs that have life-extending properties as well as delay physiological aspects of aging. Funding Agency NIH Title The Mouse Phenotyping and Pathological Assessment Core (Cellular Senescence and Aging) Status Active Period 5/2012 - 4/2017 Role Co-Principal Investigator Grant Detail Core B - PI: Dr. Yuji Ikeno
  Project 1 - PI: Dr. Kirkland and Dr. Ikeno - CoPI

• Publications

  Tandukar, G., Flores, L.C., Allen, C., Bai, Y., and Ikeno, Y.  Technical development of Senescence-Associated β-Galactosidase staining in frozen kidney tissue of Sprague Dawley rat. Aging Pathobiol. Ther. 6: 117-124. DOI: 10.31491/APT.2024.09.150. 2024.

  Wang, B., Wang, L., Gasek, N.S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Torrance, B.L., Zhou, Y., Flores, L.C., Allen, C., Andrade, A.M., Guo, C., Cohn, R.L., Jellison, E.R., Kuchel, G.A., Li, S., Pirtskhalava, T., Tchkonia, T., Haynes, L., Kirkland, J.L., Ikeno, Y., and Xu, M. Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function. Cell Metabolism. 36: 1795-1805. DOI:10.1016/j.cmet.2024.07006. 2024.

  Clark A, Villarreal MR, Rivas P, Huang S-B, Jayamohan S, Hussain SS, Ybarra M, Osmulski P, Gaczynska ME, Yang X, Exhilan CXP, Natarajan M, Pierce BL, Lai Z, Wang L-J, Michalek JE, Higginson DS, Ikeno Y, Chen Y, Ghosh R, and Kumar AP. Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer. Cancer Lett. 2024: 597: 217063. doi: 10.1016/j.canlet.2024.217063.

  Wen Y, Zhang X, Cacciani N, Hedstrom Y, Ikeno Y, Bergquist J, and Larsson L. Proteomics panel of BAL fluid associated with the ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2024; 71(1): 12-15. doi: 10.1165/rcmb.2023-0431LE. PMID: 38949323.

  Ikeno Y. Ethylnitrosourea-induced gliomas: a song in the attic? Aging Pathobiol Ther. 2023;5(2):48-51. Epub 20230628. doi: 10.31491/apt.2023.06.111. PubMed PMID: 38487310; PMCID: PMC10939132.

  Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023;133(8). Epub 20230417. doi: 10.1172/jci162519. PubMed PMID: 36809340; PMCID: PMC10104901.

  Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nature Communications. 2022;13(1):4827. doi: 10.1038/s41467-022-32552-1.

  Liang T, Dunn J, Zou X, Nayak B, Ikeno Y, Fan L, Bai Y. Characterizing the Electron Transport Chain: Functional Approach Using Extracellular Flux Analyzer on Mouse Tissue Samples. Methods Mol Biol. 2022;2497:117-28. doi: 10.1007/978-1-0716-2309-1_8. PubMed PMID: 35771439.

  Liang T, Deng J, Nayak B, Zou X, Ikeno Y, Bai Y. Characterizing the Electron Transport Chain: Structural Approach. Methods Mol Biol. 2022;2497:107-15. doi: 10.1007/978-1-0716-2309-1_7. PubMed PMID: 35771438.

  Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S. Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity. Aging Cell. 2022;21(5):e13602. Epub 20220401. doi: 10.1111/acel.13602. PubMed PMID: 35363946; PMCID: PMC9124310.

  Ikeno Y. Thioredoxin - a magic bullet or a double-edged sword for mammalian aging? Aging Pathobiol Ther. 2021;3(2):17-9. Epub 20210629. doi: 10.31491/apt.2021.06.056. PubMed PMID: 35368730; PMCID: PMC8974492.

  Lee, H. J., Donati, A., Feliers, D., Sun, Y., Ding, Y., Madesh, M., Salmon, A. B., Ikeno, Y., Ross, C., O'Connor, C. L., Ju, W., Bitzer, M., Chen, Y., Choudhury, G. G., Singh, B. B., Sharma, K., & Kasinath, B. S. (2021). Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging cell, 20(7), [e13407]. https://doi.org/10.1111/acel.13407

  Duran-Ortiz, S., List, E. O., Ikeno, Y., Young, J., Basu, R., Bell, S., McHugh, T., Funk, K., Mathes, S., Qian, Y., Kulkarni, P., Yakar, S., Berryman, D. E., & Kopchick, J. J. (2021). Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan. Aging cell, 20(12), [e13506]. https://doi.org/10.1111/acel.13506

  Cantwell, A. M., Singh, H., Platt, M., Yu, Y., Lin, Y. H., Ikeno, Y., Hubbard, G., Xiang, Y., Gonzalez-Juarbe, N., & Dube, P. H. (2021). Kinetic multi-omic analysis of responses to SARS-CoV-2 infection in a model of severe COVID-19. Journal of virology, 95(20), [e01010-21]. https://doi.org/10.1128/JVI.01010-21

  Salmon, A. B., Nelson, J. F., Gelfond, J. A. L., Javors, M., Ginsburg, B., Lopez-Cruzan, M., Galvan, V., Fernandez, E., Musi, N., Ikeno, Y., Hubbard, G., Lechleiter, J., Hornsby, P. J., & Strong, R. (2021). San Antonio Nathan Shock Center: your one-stop shop for aging research. GeroScience, 43(5), 2105-2118. https://doi.org/10.1007/s11357-021-00417-y

  Poudel, S. B., Dixit, M., Yildirim, G., Cordoba-Chacon, J., Gahete, M. D., Yuji, I., Kirsch, T., Kineman, R. D., & Yakar, S. (2021). Sexual dimorphic impact of adult-onset somatopause on life span and age-induced osteoarthritis. Aging cell, 20(8), [e13427]. https://doi.org/10.1111/acel.13427

  Jiang, Z., Bahr, T., Zhou, C., Jin, T., Chen, H., Song, S., Ikeno, Y., Tian, H., & Bai, Y. (2020). Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker. Mitochondrion, 55, 145-153. https://doi.org/10.1016/j.mito.2020.09.007

  Souza LdCM, Chen M, Ikeno Y, Salvadori DMF, Bai Y. The implications of mitochondria in doxorubicin treatment of cancer in the context of traditional and modern medicine. Traditional Medicine and Modern Medicine. 2020;03(04):239-54. doi: 10.1142/s2575900020300076.

  Roman MG, Flores LC, Cunningham GM, Cheng C, Dube S, Allen C, Van Remmen H, Bai Y, Hubbard GB, Saunders TL, Ikeno Y. Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice. Aging Pathobiol Ther. 2020;2(1):20-31. Epub 20200327. doi: 10.31491/apt.2020.03.009. PubMed PMID: 35356005; PMCID: PMC8963792.

  Roman MG, Flores LC, Cunningham GM, Cheng C, Allen C, Hubbard GB, Bai Y, Saunders TL, Ikeno Y. Thioredoxin and aging: What have we learned from the survival studies? Aging Pathobiol Ther. 2020;2(3):126-33. doi: 10.31491/apt.2020.09.028. PubMed PMID: 35493763; PMCID: PMC9049237.

  Olstad KJ, Imai DM, Keesler RI, Reader R, Morrison JH, Roberts JA, Capitanio JP, Didier ES, Kuroda MJ, Simmons H, Salimi S, Mattison JA, Ikeno Y, Ladiges W. Development of a Geropathology Grading Platform for nonhuman primates. Aging Pathobiol Ther. 2020;2(1):16-9. doi: 10.31491/apt.2020.03.008. PubMed PMID: 33283205; PMCID: PMC7717498.

  Ikeno Y, Flores LC. Oxidative stress and aging; stayin' alive? Aging Pathobiol Ther. 2020;2:20-31. doi: DOI: 10.31491/APT.2020.06.015.

  Colon G, Saccon T, Schneider A, Cavalcante MB, Huffman DM, Berryman D, List E, Ikeno Y, Musi N, Bartke A, Kopchick J, Kirkland JL, Tchkonia T, Masternak MM. The enigmatic role of growth hormone in age-related diseases, cognition, and longevity. Geroscience. 2019;41(6):759-74. Epub 20190904. doi: 10.1007/s11357-019-00096-w. PubMed PMID: 31485887; PMCID: PMC6925094.

  Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y. H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J., & Dixit, V. D. (2019). Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metabolism, 30(6), 1024-1039.e6. https://doi.org/10.1016/j.cmet.2019.10.006

  Mitchell, S. J., Bernier, M., Mattison, J. A., Aon, M. A., Kaiser, T. A., Anson, R. M., Ikeno, Y., Anderson, R. M., Ingram, D. K., & de Cabo, R. (2019). Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories. Cell Metabolism, 29(1), 221-228.e3. https://doi.org/10.1016/j.cmet.2018.08.011

  Habermehl, T. L., Parkinson, K. C., Hubbard, G. B., Ikeno, Y., Engelmeyer, J. I., Schumacher, B., & Mason, J. B. (2019). Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice. GeroScience, 41(1), 25-38. https://doi.org/10.1007/s11357-018-0049-4

  Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., ... Jurk, D. (2019). Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metabolism, 29(5), 1061-1077.e8. https://doi.org/10.1016/j.cmet.2018.12.008

  Mao, K., Quipildor, G. F., Tabrizian, T., Novaj, A., Guan, F., Walters, R. O., Delahaye, F., Hubbard, G. B., Ikeno, Y., Ejima, K., Li, P., Allison, D. B., Salimi-Moosavi, H., Beltran, P. J., Cohen, P., Barzilai, N., & Huffman, D. M. (2018). Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nature communications, 9(1), [2394]. https://doi.org/10.1038/s41467-018-04805-5

  Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J., Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L. (2018). Senolytics improve physical function and increase lifespan in old age. Nature Medicine, 24(8), 1246-1256. https://doi.org/10.1038/s41591-018-0092-9

  Cunningham, G. M., Flores, L. C., Roman, M. G., Cheng, C., Dube, S., Allen, C., Valentine, J. M., Hubbard, G. B., Bai, Y., Saunders, T. L., & Ikeno, Y. (2018). Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice. GeroScience, 40(5-6), 453-468. https://doi.org/10.1007/s11357-018-0039-6

  Zhang, Y., Unnikrishnan, A., Deepa, S. S., Liu, Y., Li, Y., Ikeno, Y., Sosnowska, D., Van Remmen, H., & Richardson, A. (2017). A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence. Redox Biology, 11, 30-37. https://doi.org/10.1016/j.redox.2016.10.014

  Ashpole, N. M., Logan, S., Yabluchanskiy, A., Mitschelen, M. C., Yan, H., Farley, J. A., Hodges, E. L., Ungvari, Z., Csiszar, A., Chen, S., Georgescu, C., Hubbard, G. B., Ikeno, Y., & Sonntag, W. E. (2017). IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. GeroScience, 39(2), 129-145. https://doi.org/10.1007/s11357-017-9971-0

  Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C., Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & De Cabo, R. (2016). Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism, 23(6), 1093-1112. https://doi.org/10.1016/j.cmet.2016.05.027

  Ashpole, N. M., Herron, J. C., Mitschelen, M. C., Farley, J. A., Logan, S., Yan, H., Ungvari, Z., Hodges, E. L., Csiszar, A., Ikeno, Y., Humphrey, M. B., & Sonntag, W. E. (2016). IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. Journal of Bone and Mineral Research, 31(2), 443-454. https://doi.org/10.1002/jbmr.2689

  Zhang, Y., Liu, Y., Walsh, M., Bokov, A., Ikeno, Y., Jang, Y. C., Perez, V. I., Van Remmen, H., & Richardson, A. (2016). Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice. Mechanisms of Ageing and Development, 154, 1-8. https://doi.org/10.1016/j.mad.2016.01.005

  Sataranatarajan, K., Ikeno, Y., Bokov, A., Feliers, D., Yalamanchili, H., Lee, H. J., Mariappan, M. M., Tabatabai-Mir, H., Diaz, V., Prasad, S., Javors, M. A., Choudhury, G. G., Hubbard, G. B., Barnes, J. L., Richardson, A., & Kasinath, B. S. (2016). Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 71(7), 850-857. https://doi.org/10.1093/gerona/glv170

  Richardson, A., Austad, S. N., Ikeno, Y., Unnikrishnan, A., & Mccarter, R. J. (2016). Significant life extension by ten percent dietary restriction. Annals of the New York Academy of Sciences, 1363(1), 11-17. https://doi.org/10.1111/nyas.12982

  Treuting, P. M., Snyder, J. M., Ikeno, Y., Schofield, P. N., Ward, J. M., & Sundberg, J. P. (2016). The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. Veterinary pathology, 53(2), 244-249. https://doi.org/10.1177/0300985815620629

  Salmon, A. B., Lerner, C., Ikeno, Y., Perrine, S. M. M., McCarter, R., & Sell, C. (2015). Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I. American Journal of Physiology - Endocrinology and Metabolism, 308(7), E545-E553. https://doi.org/10.1152/ajpendo.00558.2014

  Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M. G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P. S., Ikeno, Y., Kennedy, B. K., Cohen, P., Morgan, T. E., Dorff, T. B. & Longo, V. D. (2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism, 22(1), 86-99. https://doi.org/10.1016/j.cmet.2015.05.012

  Laberge, R. M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P. Y., Benz, C. C., Kapahi, P., ... Campisi, J. (2015). MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nature Cell Biology, 17(8), 1049-1061. https://doi.org/10.1038/ncb3195

  Ikeno, Y. (2015). New insights and current concepts of the oxidative stress theory of aging. Archives of Biochemistry and Biophysics, 576, 1. [6956]. https://doi.org/10.1016/j.abb.2015.03.019

  Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., Li, X., Serre, T., Qi, W., Van Remmen, H., Miller, R. A., Bath, K. G., De Cabo, R., Xu, H., Neretti, N., & Sedivy, J. M. (2015). Reduced expression of MYC increases longevity and enhances healthspan. Cell, 160(3), 477-488. https://doi.org/10.1016/j.cell.2014.12.016

  List, E. O., Berryman, D. E., Ikeno, Y., Hubbard, G. B., Funk, K., Comisford, R., Young, J. A., Stout, M. B., Tchkonia, T., Masternak, M. M., Bartke, A., Kirkland, J. L., Miller, R. A., & Kopchick, J. J. (2015). Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/-mice. Aging, 7(7), 500-512. https://doi.org/10.18632/aging.100766

  Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., ... Kirkland, J. L. (2015). The achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging cell, 14(4), 644-658. https://doi.org/10.1111/acel.12344