Departments & Divisions
Institutes & Centers
Nobuo Horikoshi, Ph.D.
Assistant Professor
Dr. Horikoshi studies the mechanistic connection between aging, cellular and/or mitochondrial metabolism, and carcinogenesis, focusing on the sirtuin gene family. He studies whether the energy generating fatty acid β-oxidation can function as a tumor suppressor pathway; yet the potential pathways for prevention and/or treatment of cancer remains unrealized. He will test whether ACSS1, the most critical enzyme that directs fatty acid β-oxidation, is disrupted in aggressive breast cancer leading a loss of normal energy production and a breast cancer tumor permissive phenotype.
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Professional Background
Education
- 1989 - Ph.D. - Pharmaceutical Science - University of Tokyo, Japan
- 1986 - M.S. - Pharmaceutical Science - University of Tokyo, Japan
- 1984 - B.S. - Pharmaceutical Science - University of Tokyo, Japan
Appointments
- 1997-2000 - Assistant Professor of Medicine - Harvard Medical School
- 2000-2009 - Assistant Professor of Radiation Oncology - Washington University School of Medicine
- 2009-2014 - Assistant Professor of Radiation Oncology - University of Texas Southwestern
- 2014-2017 - Assistant Professor of Radiation Oncology - Weill Cornell Medical College
- 2017-2020 - Research Assistant Professor of Radiation Oncology - Northwestern University Medical School