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Ken Hargreaves
Trigeminal Ganglion

Contact

210-567-3381

hargreaves@uthscsa.edu

Departments & Divisions

Research

Research profile

Kenneth M. Hargreaves, D.D.S., Ph.D.

Professor and Chair

Currently seeking M.S. & Ph.D. students

Dr. Hargreaves received his B.A. in neurobiology from the University of California at Berkeley in 1977, his D.D.S. from Georgetown University in Washington, D.C., in 1983, and his Ph.D. in Physiology from the Uniformed Services University of the Health Sciences in Bethesda, Maryland, in 1986.

From 1986 to 1990, he was a Staff Fellow and Senior Staff Fellow at the Neurobiology and Anesthesiology Branch of the National Institute of Dental Research (now NIDCR) at the NIH. He completed his residency in Endodontics at the University of Minnesota in 1993 and is a Diplomate of the American Board of Endodontics. Dr. Hargreaves is currently professor and chair of the Department of Endodontics, and professor in the Department of Pharmacology, Department of Physiology, and Department of Surgery at UT Health San Antonio. He also maintains a private practice limited to endodontics.

  • Professional Background

    Education

    • 1993 - Postdoctoral Training - Endodontics - University of Minnesota, School of Dentistry
    • 1990 - Postdoctoral Fellowship - Sr Staff Fellow-Neurobiol & Anesthes Branch - National Institute of Dental Research, NIH
    • 1988 - Postdoctoral Fellowship - Postdoc Fellow-Neurobiol & Anesthes Branch - National Institute of Dental Research, NIH
    • 1986 - PhD - Physiology - Uniformed Services University of the Health Sciences
    • 1985 - Postdoctoral Fellowship - NRSA Postdoc Fellow-Neurobiol & Anesthes Branch - National Institute of Dental Research, NIH
    • 1983 - DDS - Dentistry - Georgetown University
    • 1977 - BA - Neurobiology - University of California at Berkeley

    Highlights

    Diplomate, American Board of Endodontics

    President’s Award, American Association of Endodontists (2020)

    ADA Research Gold Medal Award (2018)

    President’s Distinguished Senior Scholar Award (2013; Highest University Faculty Honor)

    AAE Louis I. Grossman Award for Research (2007)

    IADR Distinguished Scientist Awards (1999 & 2000), AADR Senior Scholar Award in Neuroscience (2017)

    NIH MERIT Award (1999)

     

     

     

    Appointments

    • 12/2015 - COSTAR Director - University of Texas Health Science Center at San AntonioSan Antonio
    • 3/2007 - Professor - University of Texas Health Science Center at San Antonio, Surgery, San Antonio
    • 3/2007 - Professor - University of Texas Health Science Center at San Antonio, Physiology, San Antonio
    • 9/2005 - President`s Council Chair in Dental Research Endowment - University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio
    • 1/2003 - Editor-in-Chief - Journal of Endodontics, official journal of the American Association of Endodontists
    • 7/1997 - Professor - University of Texas Health Science Center at San Antonio, Pharmacology, San Antonio
    • 7/1997 - Professor and Chair and Department Chair - University of Texas Health Science Center at San Antonio, Dental School, Endodontics, San Antonio
    • 5/1990 - Associate Professor - University of Minnesota School of Dentistry

  • Instruction & Training

    • 1/2015 - Present, Ph.D. Dissertations Directed, University of Texas Health Science Center at San Antonio
    • 1/2014 - Present, Masters' Thesis Directed, University of Texas Health Science Center at San Antonio
    • 1/2014 - Present, Ph.D. Dissertations Directed, University of Texas Health Science Center at San Antonio
    • 9/2011 - Present, Ph.D. Dissertations Directed, PhD Program in Pharmacology, UTHSCSA
    • 4/2011 - Present, Pharmacology, The University of Texas Health Science Center
    • 1/2010 - Present, Membership on Supervising Committee, Physiology, UTHSCSA
    • 8/2008 - Present, Fundamentals of Neuroscience II, The University of Texas Health Science Center
    • 1/2008 - Present, Graduate (Adv Education in Endodontics)
    • 7/1999 - Present, Endodontics Clinic, The University of Texas Health Science Center
    • 1/1999 - Present, Clinical Endodontics I, The University of Texas Health Science Center
    • 1/1999 - Present, Clinical Endodontics
    • 1/1999 - Present, Core Course Oral Biology (Dental Biomedical Core II)
    • 1/1999 - Present, Clinical Endo II, The University of Texas Health Science Center
    • 1/1999 - Present, Clinical Endodontics II, The University of Texas Health Science Center
    • 1/1999 - Present, Clinical Endo II, The University of Texas Health Science Center
    • 1/1999 - Present, ENDO5011 Clinical Endodontics I
    • 7/1998 - Present, Endodontics Seminar, The University of Texas Health Science Center
    • 7/1998 - Present, Neuropsychopharmacology
    • 1/1998 - Present, Endodontics Clinic, The University of Texas Health Science Center
    • 1/1998 - Present, Clinical Endodontics
    • 1/1998 - Present, Graduate Endodontics
    • 1/1998 - Present, Sophomore Endodontics
    • 1/1998 - Present, Periodontal Topics
    • 1/1998 - Present, Clinical Seminar I, The University of Texas Health Science Center
    • 1/1998 - Present, Endodontics Lecture, The University of Texas Health Science Center
    • 9/1997 - Present, Endodontics Lecture, The University of Texas Health Science Center
    • 1/1997 - Present, Junior Endodontics

  • Research & Grants

    Pain mechanisms and development of novel analgesics

    Experimental and Developmental Therapeutics Program

    Pain & Inflammation, Analgesics, Hyperalgesia, Clinical Therapeutics

    Primary research interests are in the areas of pain and inflammation. Ken's ongoing basic research includes studies on mechanisms of inflammatory pain and pharmacological regulation of peripheral nociceptors, whilst current clinical trials are evaluating peripheral pain mechanisms in endodontic patients, as well as the clinical outcomes of non-surgical endodontic procedures.

    Research profile

    Grants

    Federal

    Source: NIH R01 NS110948

    Title: Mechanisms for Omega-6 Modulation of Primary Afferent Nociceptors

    Period:  2019-2024

    Reqiuested Total Costs: Current Year/Total Direct:  $250,000 / $1,250,000

    Role:     Principal Investigator

     

    Source: NIH R01 DE26139

    Title: Regulation of TRPV1 activities by a sexually dimorphic mechanism

    Period:  2016-21

    Reqiuested Direct Costs: Current Year/Total Direct:  $250,000 / $1,250,000

    Role:     Principal Investigator

     

    Source: Dept of Defense Contract #W81XWH-15-1-0129

    Title: Developing novel analgesics for treating burn pain

    Period:  2015-19

    Direct Costs: Current Year/Total Direct:  $321,887 / $965,662

    Role:     Principal Investigator 

     

    Source: American Association of Endodontists Foundation

    Title: Regeneration of pulp-dentin development in teeth with necrotic pulps

    Period:  2013-21

    Direct Costs: Current Year/Total Direct:  $283,333/$1,700,000

    Role:     Principal Investigator 

     

    Source: NIH, NCATS UL1TR001120 (UTHSCSA CTSA Application)

    Title:  Institute for Integration of Medicine & Science: A Partnership to Improve Health

    Period:  2018-2023

    Direct Costs: Current Year/Total Direct:  $4,324,613/$21,623,065

    Role:     Co-Principal Investigator  (Co-PIs: Robert Clark, Don Dougherty, Ken Hargreaves and Paula Shireman)

     

    Source: NIDCR T32 DE14318

    Title:  CO*STAR Training Grant

    Period:  2018-2023 

    Direct Costs: Current Year/Total Direct:  $171,791/$858,955

    Role:  CO*STAR Program Director and Director of DDS/PhD track

    Private

    Funding Agency USAA Foundation Title New Method to Treat Burn Pain in Our Wounded Warriors Status Active Period 6/2010 - 1/2029 Role Principal Investigator Grant Detail   Funding Agency Barker Foundation Title Pain Management Status Active Period 1/2013 - 1/2018 Role Principal Investigator Grant Detail  

     

    Funding Agency American Association for Endodontists Foundation Title Regeneration of pulp-dentin development in teeth with necrotic pulps and immature roots Status Active Period 1/2013 - 1/2019 Role Principal Investigator Grant Detail PI of UTHSCSA Study Site: Dr. Anibal Diogenes. Study Chair: Dr. Ken Hargreaves.
    This is a multi-center randomized controlled clinical trial evaluating regenerative endodontic therapies to MTA apexification. Although there is no scientific or technical overlap with the proposed application, it documents a strong commitment and foundation in the area of regenerative endodontics.

  • Publications

  • Clinical

    Endodontist

    Board Certifications

    • 1999 - American Board of Endodontics

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