Yogesh Gupta, Ph.D.
Gupta Lab Expertise:
- Structural Biology
- Epigenetic Mechanisms
- Drug Discovery
Our studies seek to provide a complete and coherent picture of human mRNA modification complexes at the molecular and atomic level with a final goal to develop novel anticancer therapeutics targeting the RNA methylome and other nucleoprotein assemblies. We employ leading-edge structural biology methods such as fX-ray crystallography, NMR, SAXS, EM in combination with an array of other biophysical and chemical biology tools to elucidate structures and mechanisms of macromolecular complexes central to childhood malignancies.
Related Diseases: Pediatric cancers
Techniques: X-ray crystallography, NMR spectroscopy, small-angle X-ray scattering (SAXS) and other solution biophysics methods
Research & Grants
We are particularly interested in understanding the exact mechanisms by which different enzymes and accessory factors cross-talk, assemble, and install various covalent chemical modifications on both coding and noncoding RNAs. N6-methyladenosine (m6A) is the most prevalent form of internal post-transcriptional modifications in human mRNAs. The m6A associated complexes drive cellular transformation and sustained oncogenic translation in cancer. A complete structural elucidation of m6A sub-complexes would facilitate the designing of therapeutic strategies to target the dysregulated human RNA methylome in cancer selectively.