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  • Yogesh Gupta
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Contact

210-562-9064

guptay@uthscsa.edu

Programs

  • M.D./Ph.D. in South Texas Medical Scientist Training Program
  • Ph.D. in Integrated Biomedical Sciences
  • Biochemical Mechanisms in Medicine
  • Cancer Biology
  • Molecular Immunology & Microbiology

Departments & Divisions

  • Department of Biochemistry & Structural Biology

Institutes & Centers

  • Greehey Children’s Cancer Research Institute

Research

Gupta Lab

Currently seeking Ph.D. students

Yogesh Gupta, Ph.D.

Assistant Professor

Gupta Lab Expertise:

  • Structural Biology
  • Epigenetic Mechanisms
  • Leukemia
  • Drug Discovery

Our studies seek to provide a complete and coherent picture of human mRNA modification complexes at the molecular and atomic level with a final goal to develop novel anticancer therapeutics targeting the RNA methylome and other nucleoprotein assemblies. We employ leading-edge structural biology methods such as fX-ray crystallography, NMR, SAXS, EM in combination with an array of other biophysical and chemical biology tools to elucidate structures and mechanisms of macromolecular complexes central to childhood malignancies.

Related Diseases: Pediatric cancers

Techniques:  X-ray crystallography, NMR spectroscopy, small-angle X-ray scattering (SAXS) and other solution biophysics methods

  • Research & Grants

    Lab Research

    We are particularly interested in understanding the exact mechanisms by which different enzymes and accessory factors cross-talk, assemble, and install various covalent chemical modifications on both coding and noncoding RNAs. N6-methyladenosine (m6A) is the most prevalent form of internal post-transcriptional modifications in human mRNAs. The m6A associated complexes drive cellular transformation and sustained oncogenic translation in cancer. A complete structural elucidation of m6A sub-complexes would facilitate the designing of therapeutic strategies to target the dysregulated human RNA methylome in cancer selectively.  

    Gupta Lab

    Grants

    • Dr. Gupta's Grants
  • Publications

    • Dr. Gupta's NCBI Bibliography

Related media

  • Gupta lab News & Events
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