Randolph D Glickman, PhD

• Professional Background

  Education

  • 1981 - Postdoctoral Fellowship - Neuroscience (F32 Fellowship from the NEI) - Schepens Eye Research Institute
  • 1979 - Postdoctoral Fellowship - Neuroscience (T32 Fellowship from the NEI) - Harvard University
  • 1978 - PhD - Zoology - University of Toronto
  • 1971 - AB - Biological Sciences - Columbia College of Columbia University

  Appointments

  • 9/2006 - Research Professor - University of Texas at San Antonio, Physics & Astronomy, San Antonio
  • 9/2004 - Full Professor with tenure - University of Texas Health Science Center at San Antonio, Radiology, San Antonio
  • 9/2004 - Full Professor with tenure - University of Texas Health Science Center at San Antonio, Physiology, San Antonio
  • 9/2004 - Full Professor with tenure-Senderoff Professor of Vision - University of Texas Health Science Center at San Antonio, Ophthalmology, San Antonio
  • 9/1989 - Director of Retinal Physiology Laboratory (Department of Ophthalmology) - University of Texas Health Science Center at San Antonio, Ophthalmology, San Antonio

• Instruction & Training

  • 8/2014 - Present, Neuroanatomy, The University of Texas Health Science Center
  • 9/2006 - Present, Rotation Student Supervision, University of Texas Health Science Center at San Antonio
  • 9/2002 - Present, Fundamentals of Neuroscience II, The University of Texas Health Science Center
  • 1/1983 - Present, Grand Rounds

• Research & Grants

  Grants

  Federal

  Funding Agency NEI Title Dysfunction of retinal neurons and circuits early in diabetic retinopathy Status Active Period 5/2014 - 4/2019 Role Co-Investigator Grant Detail The project is investigating the role of dopaminergic amacrine cells in regulating the function and dysfunction of retinal circuits and blood vessels leading to diabetic retinopathy (DR). Pharmacological modulation of dopaminergic retinal neurons is investigated as an adjunct treatment of DR. The research is being conducted using the Akita diabetic mouse model.

  Private

  Funding Agency BioTime, Inc. Title Developing retinal restoration approaches in a large eye animal model of blast ocular injury, with emphasis on neuroprotection, biomaterials, and ocular drug delivery Status Active Period 8/2018 - 5/2019 Role Principal Investigator Grant Detail This contract will be directed at using the rabbit model previously developed to test the delivery techniques, assess the tolerance, and evaluate the veterinary procedures required to transplant stem cells and biomaterials into rabbit eyes and then maintain the animals after the transplantation procedures. This work will lay the groundwork for future studies directed at developing stem cell-derived therapies for blast-induced ocular trauma. Funding Agency TxBioMed (Subcontract from Owens Fdn grant) Title Pluripotent Stem Cell Derived Retina Progenitors for Treatment of Retina Degeneration Status Active Period 8/2017 - 3/2019 Role Co-Investigator Grant Detail Rats with genetic disposition to retinal degeneration will be treated with stem cell transplants. The ability of these transplants to restore or maintain visual function will be tested with ERG and retinal morphology assessed with histology. Funding Agency Mike Hogg Fund Title Early Detection and Spatial Co-Incidence of Localized Retinal Neuronal and Vascular Dysfunction in Diabetic Retinopathy Status Active Period 1/2018 - 12/2018 Role Co-Investigator Grant Detail Project goal is to develop an integrative analysis of several ophthalmic diagnostic tests to provide earlier and more sensitive detection of the onset of diabetic retinopathy.

  State

  Funding Agency Presidents` Translational Enterprise Fund (PTEF) Title EchoLase Imaging System Status Active Period 3/2018 - 2/2019 Role Principal Investigator Grant Detail Award is to support development of University-developed IP to the point at which it may be commercialized. We will develop the image reconstruction algorithm needed to use our PBDT detector for medical imaging.

• Publications

  Abstract

  Chan YY, Mora A, Hill, Jason H, Villanueva C, Issa, Nasser, Mein, Luke, Iltis, Joshua M, Wilde David, Renteria RC, Narayanan, Divya, Glickman RD. Early Detection and Spatial Co-incidence of Localized Retinal Neuronal and Vascular Dysfunction in Diabetic Retinopathy; 2019 May. (ARVO Abstracts). Glickman RD. Photoacoustic Imaging and Sensing: a New Way to See the Eye; 2019 Mar. (Association for Ocular Pharmacology and Therapeutics (AOPT) Annual Meeting abstracts). Glickman RD, Jones, K, Reilly, MA. Identification and Localization of Trauma-Related Biomarkers Using Matrix Assisted Laser Desorption/IOonication Imaging Mass Spectrometry Bellingham, WA; 2017 Feb. (Visualizing and Quantifying Drug Distribution in Tissue; Proc. SPIE 10046; 100460G; vol. 10046). Glickman RD. Nanotechnology-based strategies for drug delivery in the eye; 2016 Jun. (Annual Congress of International Drug Discovery Science and technology, Goyang City, South Korea). Wright LM, Catala A, Nash KL, Glickman RD. Release of Avastin From Laser Simulated Nanocarriers; 2016 May. (Annual meeting ARVO, Seattle WA). Jones K, Glickman RD, Asemota BI, Reilly MA. Torsinol Indirect Traumatic Optic Neuropathy (TITON): Identifying Biomarkers of Trauma using Maxtrix Assisted Laser Desorption/ Ionization (MALDI); 2016 May. (Annual Meeting ARVO, Seattle WA). Hernandez J, Reilly MA, Gray W, Lund B, Sponsel WE, Glickman RD. Ocular Trauma-Induced Changes in Aqueous and Plasma Biomarker Expression Levels; 2015 Jun. (Invest. Ophthalmol. Vis. Sci; vol. 56). Glickman RD, Gray W, Lund B, Sponsel WE, Sherwood, Reilly MA. Risk of Injury to Ocular Tissues from Primary Blast Overpressure Exposure; 2015 Jun. (Invest. Ophthalmol. Vis. Sci; vol. 56). Jones K, Hyek-Choi J, Sponsel WE, Gray W, Groth SL, Glickman RD, Reilly MA, Lund. Effects of in vivo Isolated Low-level Primary Blast Overpressure in Dutch Belted Rabbit: Corneal and Retinal Tomographic Responses; 2015 Jun. (Invest. Ophthalmol. Vis. Sci; vol. 56). Watson R, Gray W, Sponsel WE, Lund B, Glickman RD, Groth SL, Reilly MA. Simulations of Porcine Eye Exposure to Primary Blast Insult; 2015 Jun. (Invest. Ophthalmol. Vis. Sci; vol. 56). Watson R, Gray W, Glickman RD, Lund BJ, Sponsel WE, Reilly MA. Computational Modeling of Internal Eye Injury due to Primary Blast; 2014 Apr. (Invest Ophthalmol Vis Sci; vol. 55, no. 4453). Glickman RD. Characterization of Magnetic Nanoparticle Loaded Corneal Endothelial Cells; 2014 Apr. (Invest Ophthalmol Vis Sci; vol. 55, no. 1442). Glickman RD, Stidger D, Bach S, Kelley A, Gray W, Sponsel WE, Reilly MA. Identification of Trauma-Related Biomarkers Following Blast Injuries to the Eye; 2014 Apr. (Invest Ophthalmol Vis Sci; vol. 55, no. 4469). Asemota BI, Glickman RD, Sponsel WE, Reilly MA. Determination of Injury Thresholds for Torsional Indirect Traumatic Optic Neuropathy in a Rat Model; 2014 Apr. (Invest Ophthalmol Vis Sci; vol. 55, no. 6194). Sponsel WE, Reilly MA, Lund BJ, Gray W, Watson R, Groth S, Glickman RD, Thoe K. Anatomical Manifestations of Primary Blast Ocular Trauma Observed in an Ex Vivo Porcine Model; 2014 Apr. (Invest Ophthalmol Vis Sci; vol. 55, no. 4445).

  Book Chapter

  Glickman RD, Millenbaugh NJ, Kirui D, Maswadi S, Thomas RJ, Oian CA. Enhancement of Pathogen Detection and Therapy with Laser-Activated, Functionalized Gold Nanoparticles. In: Glickman RD, Millenbaugh NJ, Kirui D, Maswadi S, Thomas RJ, Oian CA. Volume VI: Nanobiomaterials in Antimicrobial Therap. 2015. Yasmin Z, Catala A, Maswadi S, Nash KL, Glickman RD. Sensing of Reactive Oxygen Species by Self-Aggregating Gold Nanoparticle Assemblies. In: Yasmin Z, Catala A, Maswadi S, Nash KL, Glickman RD. Volume I: Fabrication and SelfAssembly of Nanobiomaterials. 2015.

  Journal Article

  Rios, Jose David, Choi, Jae Hyek, McDaniel, Jennifer S., Becera, Sandra, Bice, Leticia, Johnson, Peter, Cleland, Jeffery M., Glickman RD, Reilly, Matthew A., Gray, Walt, Sponsel, William e., Lund, Brian J. Altered Expression of Aquaporin 1 and Aquaporin 5 in the Cornea after Primary Blast Exposure Journal of Molecular Vision 2019 Jan;. Lee, Yuan-Hao, Glickman RD. Radiation damaging effects on ocular tissues Annals of Ophthalmology and Visual Sciences 2018 Aug;1:1002-1005. Rossi, EL, Khatib, SA, Doerstling, SS, Bowers, LW, Pruski, M, Ford, NA, Glickman, RD, Niu, M, Yang, P, Cui, Z, DiGiovanni, J, Hursting, SD. Resveratrol inhibits obesity-associated adipose tissue dysfunction and tumor growth in a mouse model of postmenopausal claudin-low-breast cancer Molecular Carcinogenesis 2018 Mar;57(3):393-407. Roth, Caleb C, Glickman RD, Martens, Stacey L, Echchgadda, Ibtissam, Beier, Hope T, Barnes, Ronald A., Ibey, Bennet L. Adult human dermal fibroblasts exposed to nanosecond electrical pulses exhibit genetic biomarkers of mechanical stress Biochemistry and Biophysics Reports 2017 Mar;9:302-309. Jones K, Reilly, MA, Glickman RD. Identification and localization of trauma-related biomarkers using matrix assisted laser desorption/ionization imaging mass spectrometry Visualizing and Quantifying Drug Distribution in Tissue, Proc. SPIE 2017 Feb;10046:1-7. Jones K, Choi JH, Sponsel WE, Gray W, Groth SL, Glickman RD, Lund BJ, Reilly MA. Low-Level Primary Blast Causes Acute Ocular Trauma in Rabbits J Neurotrauma 2016 Jul;33(13):1194-1201. Roth CC, Glickman RD, Tolstykh GP, Estlack LE, Moen EK, Echchgadda I, Beier HT, Barnes RA, Ibey BL. Evaluation of the Genetic Response of U937 and Jurkat Cells to 10-Nanosecond Electrical Pulses (nsEP) PLoS One 2016 May;11(5):0154555-0154555. Maswadi S, Ibey, BL, Roth,CC, Tysboulski, DA, Beier, HT, Glickman RD, Oraevsky, AA. All-Optical Microscopy Based on Probe Beam Deflection Technique Photoacoustics 2016 Feb;. Roth CC, Barnes RA Jr, Ibey BL, BeierHT, Christopher Mimun L, Maswadi SM, Shadaram M, Glickman RD. Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse 9nsEP) Exposure SCi Rep 2015 Oct;5(15063). Watson R, Gray W, Sponsel WE, Lund BJ, Glickman RD, Groth SL, Reilly MA. Simulations of Porcine Eye Exposure to Primary Blast Insult Transl Vis Sci Technol 2015 Aug;4(4):8-8. Lee Y-H, Sun Y, Gerweck LE, Glickman RD. Regulation of DNA Damage Response by Estrogen Receptor Beta-Mediated Inhibition of Breast Cancer Associated Gene 2 Biomedicines 2015 Apr;3:182-200. Millenbaugh NJ, Baskin JB, DeSilva MN, Elliott WR, Glickman RD. Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles Int J Nanomedicine 2015 Mar;10:1953-1960. Yasmin Z, Khachatryan E, Lee Y-H, Maswadi S, Glickman RD, Nash KL. In vitro monitoring of oxidative processes with self-aggregating gold nanoparticles using all-optical photoacoustic spectroscopy Biosensors and Bioelectronics 2015 Feb;64:676-682. Lee Y-H, Sun Y, Glickman RD. Ursolic Acid-Regulation Energy Metabolism - Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage? Proteomes 2014 Sep;2:399-425. Lee YH, Wang E, Kumar N, Glickman RD. Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation Apoptosis 2014 May;19:816-828. Sherwood D, Sponsel WE, Lund BJ, Gray W, Watson R, Groth SL, Thoe K, Glickman RD, Reilly MA. Anatomical manifestations of primary blast ocular trauma observed in a postmortem porcine model Invest Ophthalmol Vis Sci 2014 Feb;55(2):1124-1132. Barnes RA, Jr., Maswadi S, Glickman RD, Shadaram M. Probe Beam Deflection Technique as Acoustic Emission Directionality Sensor with Photoacoustic Emission Source Applied Optics 2014 Jan;53(3):512-519. Feiz, Vahid, Nijm, Lisa, Glickman RD, Morse, Lawrence S, Telander, David G, Park Susanna S, Polage Christopher R, Christiansen, Steen M, Moshirfar, Majid. Vitreous and aqeous penetration of orally administered trimethoprim-sulfamethoxazole combination in humans Cornea 2013 Jan;31(10):1315-1320. Page L, Maswadi S, Glickman RD. Optoacoustic multispectral imaging of radiolucent foreign bodies in tissue Applied Spectroscopy 2013 Jan;67(1):22-28. Lee, Yuan-Hao, Kumar, Neeru C., Glickman RD. Modulation of Photochemical Damage in Normal and Malignant Cells by Naturally-Occurring Compounds Photochemistry and Photobiology 2012 Oct;88:1385-1395. Wang A, Liu M, Liu X, Dong LQ, Glickman RD, Slaga TJ, Zhou Z, Liu F. Up-regulation of adiponectin by resveratrol: The essential roles of the Akt/FOXO1 and AMPK signaling pathways and DsbA-L J Biol Chem 2011 Jan;286(1):60-66. De Angel RE, Smith SM, Glickman RD, Perkins SN, Hursting SD. Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer Nutr Cancer 2010 Nov;62(8):1074-1086. Davis LT, Kumar N, Nijm LM, Ulanski LJ, Tu EY, Fiscella RG, Peterson RJ, Glickman RD. An adaptable HPLC method for the analysis of frequently used antibiotics in ocular samples J Chromatogr B Analyt Technol Biomed Life Sci 2010 Sep;878(26):2421-2426. Akimov NP, Marshak DW, Frishman LJ, Glickman RD, Yusupov RG. Histamine reduces flash sensitivity of on ganglion cells in the primate retina Invest Ophthalmol Vis Sci 2010 Jul;51(7):3825-3834. Qiu J, Teichman JM, Wang T, Neev J, Glickman RD, Chan KF, Milner TE. Femtosecond laser lithotripsy: feasibility and ablation mechanism J Biomed Opt 2010 Mar;15(2):028001-028001. Glickman RD. Laser bioeffects associated with ultrafast lasers: role of multiphoton absorption Journal of laser applications 2008 May;20(2):89-97.

  Other

  Maswadi SM, Tsyboulski D, Roth CC, Glickman RD, Beier HT, Oraevsky AA, Ibey BL. "All-optical optoacoustic microscopy system based on probe beam deflection technique", in Photons Plus Ultrasound: Imaging and Sensing 2016 Proceedings of SPIE 2016 Jan;9708. Rozinek SC, Glickman RD, Thomas RJ, Brancaleon L. "Protein-protein binding before and after photo-modification of albumin", in Optical Interactions with Tissue and Cells XXVII Proceedings of SPIE 2016 Jan;9706. Roth CC, Barnes RA, Ibey BL, Glickman RD, Beier HT. ?Short infrared (IR) pulses can induce nanoporation?, in Clinical and Translational Neurophotonics: Neural Imaging and Sensing; and Optogenetics and Optical Manipulation Proceedings of SPIE 2016 Jan;9690. Roth CC, Ronald A Barnes RA, Ibey IL, Glickman RD. "Conductivity affects nanosecond electrical pulse induced pressure transient formation", in Optical Interactions with Tissue and Cells XXVII Proceedings of SPIE 2016 Jan;9706. Roth CC, Barnes RA, Ibey BL, Beier HT, Moen EK, Glickman RD. Cells Exposed to Nanosecond Electrical Pulses Exhibit Genetic Biomarkers of Mechanical Stress Proc. of SPIE 2015 Feb;9326. Roth C, Maswadi S, Ibey B, Beier H, Glickman RD. Characterization of acoustic shockwaves generated by exposure to nanosecond electrical pulses SPIE Proceedings 2014 Jun;8941. Khachatryan E, Maswadi S, Tsyboulski D, Barnes E, Sardar D, Oraevsky A, Nash K, Glickman RD. Optoacoustic microscopy using laser bearm deflection technique SPIE Proceedings 2014 Mar;8943. Roth C, Maswadi S, Glickman RD. Characterization of acoustic shockwaves generated by exposure to nonsecond electrical pulses SPIE Proceedings 2014 Mar;8941.