Amy S. Garrett, Ph.D.
Neuroimaging Core for Department of Psychiatry/ Assistant Professor
Department of Radiology and Psychiatry
My research goal is to understand the neural changes that accompany psychotherapy for children with symptoms of anxiety and mood dysregulation. My recently completed K01 award used magnetic resonance imaging (MRI) to investigate changes in brain function following Trauma Focused Cognitive Therapy for adolescents with symptoms of post traumatic stress. I also collaborate with researchers at Stanford University and UCLA to study the neural changes following Family Focused Therapy for children with mood dysregulation who are at familial risk for bipolar disorder.
- PhD - Neuroscience - Wake Forest University, Bowman Gray School of medicine
- Postdoctoral Training - Magnetic Resonance Imaging of Emotion - University of California Davis
- Postdoctoral Fellowship - Neuroimaging in Child Psychiatry - Stanford University
- BS - Aerospace Engineering - University of Illinois
- 12/2017 - cross appointment Department of Radiology - University of Texas Health Science Center San AntonioSan Antonio
- 10/2016 - Director, Neuroimaging Core for Department of Psychiatry - University of Texas Health Science Center San Antonio, Psychiatry
- 6/2016 - Assistant Professor Department of Psychiatry - University of Texas Health Science Center at San Antonio, Psychiatry, San Antonio
Research & Grants
National Institute of Mental Health
Cognitive Treatment of PTSD in Youth
4/2013 - 5/2016
Mentors: W. Stewart Agras, M.D., Victor Carrion, M.D., Judith Cohen, M.D., Kiki Chang, M.D., Greg Siegle, Ph.D.
National Institute of Mental Health
Early Intervention for Youth at Risk for Bipolar Disorder
1/2012 - 1/2016
Goal: Longitudinal study that examines clinical outcome and brain function before and after Family Focused Therapy for Youth with mood dysregulation at high familial risk for bipolar disorder
Miklowitz DJ, Schneck CD, Walshaw PD, Garrett AS, Singh, MK, Sugar, C., Chang, K. D. Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family-focused treatment Early Intervention in Psychiatry 2017 Jul;:1-9.
Chang K, Garrett A, Kelley R, Howe M, Sanders EM, Acquaye T, Bararpour L, Li S, Singh M, Jo B, Hallmayer J, Reiss A. Anomalous prefrontal-limbic activation and connectivity in youth at high-risk for bipolar disorder J Affect Disorders 2017 Jun;222:7-13.
Kim E, Garrett A, Boucher S, Park MH, Howe M, Sanders E, Kelley RG, Reiss AL, Chang KD, Singh MK. Inhibited Temperament and hippocampal volume in offspring of parents with bipolar disorder Journal of Child and Adolescent Psychopharmacology 2016 Oct;.
Park MH, Garrett AS, Boucher S, Howe M, Sanders E, Kim E, Singh M, Chang K. Amygdalar volumetric correlates of social anxiety in offspring of parents with bipolar disorder Psychiatry Research 2015 Nov;234(2):252-258.
Garrett A, Gupta S, Reiss AL, Waring J, Sudheimer K, Anker L, Sosa N, Hallmayer JF, O`Hara R, Garrett AS. Impact of 5-HTTLPR on hippocampal subregional activation in older adults Transl Psychiatry 2015 Sep;5:639-639.
Singh MK, Garrett AS, Chang KD. Using neuroimaging to evaluate and guide pharmacological and psychotherapeutic treatments for mood disorders in children CNS Spectr 2015 Aug;20(4):359-368.
Sudheimer K, Keller J, Gomez R, Tennakoon L, Reiss A, Garrett A, Kenna H, O`Hara R, Schatzberg AF, Garrett AS. Decreased hypothalamic functional connectivity with subgenual cortex in psychotic major depression Neuropsychopharmacology 2015 Mar;40(4):849-860.
Garrett AS, Miklowitz D, Howe M, Singh M, Acquaye T, Hawkey CG, Glover GH, Reiss AL, Chang KD. Changes in brain activation following psychotherapy for youth with mood dysregulation at familial risk for bipolar disorder Progress in Neuro-Psychopharmacology and Biological Psychiatry 2015 Jan;56(2):215-220.
Bruno JL, Garrett AS, Quintin EM, Mazaika PK, Reiss AL. Aberrant face and gaze habituation in fragile x syndrome Am J Psychiatry 2014 Oct;171(10):1099-1106.
Garrett AS, Lock J, Datta N, Beenhaker J, Kesler SR, Reiss AL. Predicting clinical outcome using brain activation associated with set-shifting and central coherence skills in anorexia nervosa Journal of Psychiatry Research 2014 Jan;57:26-33.
Kelley R, Chang KD, Garrett AS, Alegria D, Thompson P, Howe M, Reiss AL. Deformations of amygdala morphology in familial pediatric bipolar disorder Bipolar Disorders 2013 Jan;15(7):795-805.
Kelley RG, Garrett AS, Cohen J, Gomez R, Keller J, Reiss AL, Schatzberg AF. Altered brain function underlying verbal memory encoding and retrieval in psychotic major depression Psychiatry Research: Neuroimaging 2012 Nov;.
Singh MK, Chang KD, Chen MC, Kelley RG, Garrett AS, Mitsunaga MM, Bararpour L, Howe ME, Reiss AL, Gotlib IH. Volumetric Reductions in the Subgenual Anterior Cingulate Cortex in Adolescents with Bipolar I Disorder Bipolar Disorders 2012 Jan;14(6):585-596.
Garrett AS, Carrion V, Kletter H, Karchemskiy A, Weems CF, Reiss A. Brain activation to facial expressions in youth with PTSD symptoms Depression & Anxiety 2012 Jan;29(5):449-459.
Chang K, Delbello M, Chu WJ, Garrett AS, Kelley R, Mills N, Howe M, Bryan H, Adler C, Eliassen J, Spielman D, Strakowski SM. Neurometabolite Effects of Response to Quetiapine and Placebo in Adolescents with Bipolar Depression Journal of Child and Adolescent Psychopharmacology 2012 Jan;22(4):261-268.
Garrett AS, Reiss A, Howe M, Kelley R, Singh MK, Adleman N, Karchemskiy A, Chang K. Abnormal amygdala and prefrontal cortex activation to facial expressions in pediatric bipolar disorder Journal of the American Academy of Child and Adolescent Psychiatry 2012 Jan;51(8):821-831.
Karchemskiy A, Garrett A, Howe M, Adleman N, Simeonova DI, Alegria D, Reiss A, Chang K, Garrett AS. Amygdalar, hippocampal, and thalamic volumes in youth at high risk for development of bipolar disorder Psychiatry Res 2011 Dec;194(3):319-325.
Mitsunaga MM, Garrett A, Howe M, Karchemskiy A, Reiss A, Chang K, Garrett AS. Increased subgenual cingulate cortex volume in pediatric bipolar disorder associated with mood stabilizer exposure J Child Adolesc Psychopharmacol 2011 Apr;21(2):149-155.
Lock J, Garrett A, Beenhakker J, Reiss AL, Garrett AS. Aberrant brain activation during a response inhibition task in adolescent eating disorder subtypes Am J Psychiatry 2011 Jan;168(1):55-64.
Liu IY, Howe M, Garrett AS, Karchemskiy A, Kelley R, Alegria D, Reiss A, Chang K. Striatal volumes in pediatric bipolar patients with and without comorbid ADHD Psychiatry Research: Neuroimaging 2011 Jan;194(1):14-20.
Mitsunaga M, Garrett AS, Howe M, Karchemskiy A, Reiss A, Chang K. Increased subgenual cortex volume in pediatric bipolar disorder associated with mood stabilizer exposure Journal of Child and Adol Psychopharmacology 2011 Jan;21(2):149-155.
Singh M, Chang K, Mazaika P, Garrett AS, Adleman N, Kelley R, Howe M, Reiss A. Neural Correlates of Response Inhibition in Pediatric Bipolar Disorder Journal of Child and Adolescent Psychopharmacology 2010 Jan;20(1):15-24.
Carrion VG, Haas BW, Garrett AS, Song S, Reiss AL. Reduced hippocampal activity in youth with posttraumatic stress symptoms: An fMRI Study Journal of Pediatric Psychology 2009 Jun;35(5):559-569.
Arnow BA, Millheiser L, Garrett A, Lake Polan M, Glover GH, Hill KR, Lightbody A, Watson C, Banner L, Smart T, Buchanan T, Desmond JE, Garrett AS. Women with hypoactive sexual desire disorder compared to normal females: a functional magnetic resonance imaging study Neuroscience 2009 Jan;158(2):484-502.
Garrett A, Penniman L, Epstein JN, Casey BJ, Hinshaw SP, Glover G, Tonev S, Vitolo A, Davidson M, Spicer J, Greenhill LL, Reiss AL, Garrett AS. Neuroanatomical abnormalities in adolescents with attention-deficit/hyperactivity disorder J Am Acad Child Adolesc Psychiatry 2008 Nov;47(11):1321-1328.
Keller J, Shen L, Gomez RG, Garrett AS, Solvason B, Reiss A, Schatzberg AF. Hippocampal and amygdala volumes in psychotic and nonpsychotic unipolar depression American Journal of Psychiatry 2008 Jan;165(7):872-880.
Garrett A, Chang K, Garrett AS. The role of the amygdala in bipolar disorder development Dev Psychopathol 2008 Jan;20(4):1285-1296.
Chang KD, Wagner C, Garrett AS, Howe M, Reiss A. A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar activation changes in adolescents with bipolar depression treated with lamotrigine Bipolar Disorders 2008 Jan;10:426-431.
Epstein JN, Casey BJ, Tonev ST, Davison M, Reiss A, Garrett AS, Hinshaw SP, Greenhill LL, Glover G, Vitolo A, Kotler LA, Jarrett MA, Spicer J. Assessment and prevention of head motion during imaging of patients with Attention Deficit Hyperactivity Disorder Psychiatry Research: Neuroimaging 2007 Jan;155(1):75-82.
Epstein JN, Casey BJ, Toney ST, Davidson M, Reiss AL, Garrett AS, Hinshaw SP, Greenhill LL, Glover G, Shafritz KM, Vitolo A, Kotler LA, Jarrett MA, Spicer J, Buhle J, Liston C. ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD Journal of Child Psychology and Psychiatry 2007 Jan;48(9):899-913.
Casey BJ, Epstein JN, Buhle J, Liston C, Davidson MC, Tonev ST, Spicer J, Niogi S, Millner AL, Reiss A, Garrett AS, Hinshaw SP, Greenhill LL, Shafritz KM, Vitolo A, Kotler LA, Jarrett MA, Glover G. Frontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHD American Journal of Psychiatry 2007 Jan;164(11):1729-1736.
Garrett AS, Maddock RJ. Separating subjective emotion from the perception of emotion-inducing stimuli: an fMRI study Neuroimage 2006 Oct;33(1):263-274.
Chang K, Adelman N, Wagner C, Barnea-Goraly N, Garrett AS. Will neuroimaging ever be used to diagnose pediatric bipolar disorder? Development and Psychopathology 2006 Jan;18(4):1133-1146.
Chang K, Karchemskiy A, Barnea-Goraly N, Garrett A, Simeonova DI, Reiss A, Garrett AS. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder J Am Acad Child Adolesc Psychiatry 2005 Jun;44(6):565-573.
Mobbs D, Garrett AS, Menon V, Rose FE, Bellugi U, Reiss AL. Anomalous brain activation during face and gaze processing in Williams syndrome Neurology 2004 Jun;62(11):2070-2076.
Garrett AS, Menon V, MacKenzie K, Reiss AL. Here`s looking at you, kid: neural systems underlying face and gaze processing in fragile X syndrome Arch Gen Psychiatry 2004 Mar;61(3):281-288.
Kesler SR, Garrett AS, Bender B, Yankowitz J, Zeng SM, Reiss AL. Amygdala and hippocampal volumes in Turner syndrome: A high-resolution MRI study of X-monosomy Neuropsychologia 2004 Jan;42:1971-1978.
Maddock RJ, Buonocore MH, Kile SJ, Garrett AS. Brain regions showing increased activation by threat-related words in panic disorder Neuroreport 2003 Mar;14(3):325-328.
Maddock RJ, Garrett AS, Buonocore MH. Posterior cingulate cortex activation by emotional words: FMRI evidence from a valence decision task Human Brain Mapping 2003 Jan;18(1):30-41.
Garrett AS, Maddock RJ. Time course of the subjective emotional response to aversive pictures: relevance to fMRI studies Psychiatry Res 2001 Nov;108(1):39-48.
Maddock RJ, Garrett AS, Buonocore MH. Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval Neuroscience 2001 Jan;104(3):667-676.
Garrett AS, Flowers DL, Absher JR, Fahey FH, Gage HD, Keyes JW, Porrino LJ, Wood FB. Cortical activity related to accuracy of letter recognition Neuroimage 2000 Feb;11(2):111-123.