Part of UT Health San Antonio

Part of UT Health San Antonio

You are here

AG_pic_UTHSCSA

Contact

210-450-7831

galaleldeen@uthscsa.edu

Departments & Divisions

Ahmad Galaleldeen, Ph.D.

Professor and Program Director

BS in Medical Sciences Program

  • Professional Background

    Education

    • 2012 - Postdoctoral Training - Biochemistry and Structural Biology - UTHSCSA
    • 2009 - PhD - Biochemistry and Structural Biology - UTHSCSA
    • 2001 - MS - Biochemistry - Texas A&M University-Kingsville
    • 1992 - BS - Biochemistry - University of Alexandria, Egypt

    Appointments

    • 2024 - Professor/Director of the BS in Medical Sciences Program - UTHSCSA
    • 2023 - Professor of Biological Sciences (Tenured) - St. Mary's University
    • 2016 - Associate Professor of Biological Sciences (Tenured) - St. Mary's University
    • 2012 - Assistant Professor of Biological Sciences - St. Mary's University

  • Publications

      Sea K. W., Taylor A. B., Thomas T. T., Liba A., Bergman I. B., Holloway S. P., Cao X., Gralla E., Valentine J. S., Hart P. J., and Galaleldeen A. (2021) pH switch controls zinc binding in tomato copper-zinc superoxide dismutase. Biochemistry. 60(20):1597-1608. doi: 10.1021/acs.biochem.1c00133. Epub 2021 May 7. PubMed PMID: 33961402; PubMed Central PMCID: PMC8754426.

      Ayers J. I., Xu G., Dillon K., Lu Q., Chen Z., Beckman J., Moreno-Romero A. K., Zamora D. L., Galaleldeen A. and Borchelt D. R. (2021) Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding; a study of the influence of primary amino acid sequence. Acta Neuropathologica Comms. 9(1):92. doi: 10.1186/s40478-021-01191-w. PubMed PMID: 34016165; PubMed Central PMCID: PMC8139116.

      Crown A., McAlary L., Fagerli E., Brown H., Yerbury J. J., Galaleldeen A., Cashman N. R., Borchelt D. R., Ayers J. I. (2020) Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection, PLoS One 15(1):e0227655. doi: 10.1371/journal.pone.0227655. eCollection 2020. PubMed PMID: 31999698; PubMed Central PMCID: PMC6991973.

      Kim K., Subrhamunium, S., Galaleldeen, A., Nakazawa, A., Umetsu, M., Teizer, W. and Bhattacharyya S. (2019) Nanoparticle Assisted Remodeling of Proteotoxic SOD1 Mutants Alters the Biointerface of the Functional Interaction of Microtubules and Kinesin Motors, ACS Appl. Bio Mater. 2(10):4121.

      Ayers, J. I., Riffe, C. J.,  Sorrentino, Z. A., Diamond, J., Fagerli, E., Brooks, M., Galaleldeen, A., Hart, P. J., and Giasson B. I. (2018) Localized induction of wild-type and mutant alpha-synuclein aggregation reveals propagation along neuroanatomical tracts, Journal of Virology 92(18). doi: 10.1128/JVI.00586-18. Print 2018 Sep 15. PubMed PMID: 29976670; PubMed Central PMCID: PMC6146706.

      Ayers, J. I., Diamond, J., Sari, A., Fromholt, S., Galaleldeen, A., Ostrow, L. W., Glass, J. D., Hart, P. J., and Borchelt, D. R. (2016) Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS, Acta Neuropathologica, 132(6):827-840. doi: 10.1007/s00401-016-1623-4. Epub 2016 Oct 4. PubMed PMID: 27704280; PubMed Central PMCID: PMC5107152.

      Peterson, R. L., Galaleldeen, A., Villarreal, J., Taylor, A. B., Cabelli, D. E., Hart, P. J., and Culotta, V. C. (2016) The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases, Journal of Biological Chemistry, 291(40):20911-20923. doi: 10.1074/jbc.M116.748251. Epub 2016 Aug 17. PubMed PMID: 27535222; PubMed Central PMCID: PMC5076504.

      Becker, A., Kannan, T. R., Taylor, A. B., Pakhomova, O. N., Zhang, Y., Somarajan, S. R., Galaleldeen, A., Holloway, S. P., Baseman, J. B., and Hart, P. J. (2015) Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae, Proc Natl Acad Sci USA, 112(16):5165-70. doi: 10.1073/pnas.1420308112. Epub 2015 Apr 6. PubMed PMID: 25848012; PubMed Central PMCID: PMC4413325.

      Gleason*, J. E., Galaleldeen*, A., Peterson, R. L., Taylor, A. B., Holloway, S. P., Waninger-Saroni, J., Cormack, B. P., Cabelli, D. E., Hart, P. J., and Culotta, V. C. (2014) Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense, Proc Natl Acad Sci USA, 111(16):5866-71. doi: 10.1073/pnas.1400137111. Epub 2014 Apr 7. PubMed PMID: 24711423; PubMed Central PMCID: PMC4000858.

       * contributed equally

      Ivanova, M. I., Sievers, S. A., Guenther, E. L., Johnson, L. M., Winkler, D. D., Galaleldeen, A. Sawaya, M. R. Hart, P. J., and Eisenberg, D. (2014) Aggregation-triggering segments of SOD1 fibrillation support a common pathway for familial and sporadic ALS, Proc Natl Acad Sci USA, 111(1):197-201. doi: 10.1073/pnas.1320786110. Epub 2013 Dec 16. PubMed PMID: 24344300; PubMed Central PMCID: PMC3890817.

      Galaleldeen, A., Taylor, A. B., Chen, D., Schuermann, J. P., Holloway, S. P., Hou, S., Gong, S., Zhong, G. and Hart, P. J. (2013) Structure of the Chlamydia trachomatis Antigen Pgp3,  J. Biol. Chem. 288(30):22068-79. doi: 10.1074/jbc.M113.475012. Epub 2013 May 23. PubMed PMID: 23703617; PubMed Central PMCID: PMC3724661.

      Lin, A. P., Demeler, B., Minard, K. I., Anderson S. L., Schirf, V., Galaleldeen, A., and McAlister-Henn, L. (2011) Construction and Analyses of Tetrameric Forms of Yeast NAD(+) Specific Isocitrate Dehydrogenase, Biochemistry, 50(2):230-9. doi: 10.1021/bi101401h. Epub 2010 Dec 21. PubMed PMID: 21133413; PubMed Central PMCID: PMC3137751.

      Chen, D., Lei, L., Lu, C., Galaleldeen, A., Hart, P. J., and Zhong, G. (2010) Characterization of Pgp3, a Chlamydia trachomatis Plasmid-encoded Immunodominant Antigen, J. Bacteriol. 192(22):6017-24. doi: 10.1128/JB.00847-10. Epub 2010 Sep 17. PubMed PMID: 20851898; PubMed Central PMCID: PMC2976438.

      Galaleldeen, A., Strange, R., Whitson, L. J., Antonyuk, S., Taylor, A. B., Hasnain, S. S., and Hart, P. J. (2009) Structural and Biophysical Properties of Metal-Free Pathogenic SOD1 Mutants A4V and G93A, Arch. Biochem. Biophys. 492(1-2):40-7. doi: 10.1016/j.abb.2009.09.020. Epub 2009 Oct 1. PubMed PMID: 19800308; PubMed Central PMCID: PMC2787720.

      Galaleldeen, A., and Hart, P. J. (2007) Human Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis In: Uversky VN, Fink AL, editors. Protein Misfolding, Aggregation, and Conformational Diseases 1 ed. Boston, MA: Springer; 2007. Chapter 16; p.327-344. 538p.