Bess Frost, Ph.D.

1. Frost B, Ollesch J, Wille H, Diamond MI. Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem 2009 Feb;284(6):3546-3551.

2. Frost B, Jacks RL, Diamond MI. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 2009 May;284(19):12845-12852.

3. Frost B, Diamond MI. The expanding realm of prion phenomena in neurodegenerative disease. Prion 2009 Apr;3(2):74-77.

4. Frost B, Diamond MI. Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci 2010 Mar;11(3):155- 159.

5. Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nat Neuroscience 2014 Feb;17(3):357-366.  

   **Featured as a “News and Views” in Nature Neuroscience:Soukup S, Verstreken, P. PIWIL1 protein power targets tau therapy. Nature Neuroscience. 2014 Feb;17(334-335).

6. Merlo P, Frost B, Peng S, Yang YJ, Park PJ, Feany M. p53 prevents neurodegeneration by regulating synaptic genes. Proc Natl Acad Sci USA 2014 Dec;111(50):18055-18060.

7. Frost B, Gotz J, Feany M. Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology 2015 Jan;25(1):46-53.

8. Frost B, Bardai FH, Feany MB. Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Current Biology 2016 Jan;26(1):129-136.

9. Frost B. Alzheimer’s disease: An acquired neurodegenerative laminopathy. Nucleus 2016 May;7(3):275-283.  

10. Sun W, Yan C, Frost B, Wang X, Hou C, Zeng M, Gao H, Kang Y, Liu J. Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Scientific Reports 2016 Aug;6:342-346.

11. Sun W, Frost B, Liu J. Oleuropein, unexpected benefits! Oncotarget 2017 Mar;14(8):17409-17409.

12. Orr ME, Sullivan AC, Frost B. A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.  Trends in Pharmacological Sciences 2017 Jul;38(7):637-648.

13. Sun W, Samimi H, Gamez M, Zare H, Frost B. Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nature Neuroscience 2018 Jul;21(8):1038-1048. 

   **Featured as a “Research Highlight” in Nature Reviews Neurology:  C Ridler. Does tau pathology activate jumping genes? Nature Reviews Neurology. 2018 Jul;14(559).

14. Cornelison GL, Levy SA, Jenson T, Frost B. Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila. Aging Cell 2019 Feb;18(1):e12847.

15. Ochoa Thomas E, Zuniga G, Sun W, Frost B. Awakening the dark side: Retrotransposon activation in neurodegenerative disorders. Current Opinions in Neurobiology 2020 Feb;61:65-72.

16. Mahoney R, Ochoa Thomas E, Ramirez P, Miller HE, Beckmann A, Zuniga G, Dobrowolski R, Frost B. Pathogenic tau causes a toxic depletion of nuclear calcium mediated by BK channels. Cell Reports 2020.  32(2): 107900 PMCID: PMC 7428851.