Project #: N/A 01/01/20 - 12/31/20
Funding Agency: MD Anderson Neurodegeneration Consortium
Title: Transposable element activation as a therapeutic target in human Alzheimer’s disease and associated tauopathies
Role: Principal Investigator
Total Costs: $250,000.00
Grant Detail: The scope of this work is to investigate elevated DNA copy number of transposable elements in human Alzheimer’s disease and related tauopathies, and to determine their contribution to neuroinflammation and/or somatic DNA mutation
Project #: 1 R01 AG062475-01A1 09/01/19 - 05/31/24
Funding Agency: NIA/NINDS
Title: Regulation of neuronal clearance pathways via nuclear calcium signaling in Alzheimer’s disease
Role: Co-Investigator, PI: Radek Dobrowolski
Total Direct Costs to Frost: $631,360.00
Grant Detail: The goal of the proposed project is to determine the mechanism whereby Presenilin 1 and tau regulate nuclear calcium and the extent to which deficits in nuclear calcium contribute to neurodegeneration.
Project #: 1 RF1 NS112391-01 (R01 equivalent) 07/01/19 - 06/30/24
Funding Agency: NIA/NINDS
Title: Investigating the role of transposable element dysregulation as a driver of neurotoxicity in tauopathy
Role: Principal Investigator
Total Direct Costs: $1,250,000.00
Grant Detail: The goal of the proposed project is to understand how transposable element activation induces neurotoxicity, to extend our studies to mouse models of tauopathy, and to determine the extent of transposable element activation and mobilization in human tauopathy.
Project #: 1 R01 AG058778-01 03/01/19 - 11/30/23
Funding Agency: NIH/NINDS
Title: Regulation of ER-stress Activated UPR kinase PERK in Neurodegenerative Diseases
Role: Co-Investigator, PI: James Lechleiter
Total Direct Costs to Frost: $325,050
Grant Detail: The major goal of this grant is to understand how cytosolic and luminal regulation of PERK activity contribute to neurodegeneration in tauopathies
Project #: 1 R01 AG057896 02/15/19 - 11/30/23
Funding Agency: NIA/NINDS
Title: Mechanisms of tau- and aging-induced neurological dysfunction: Focus on the nucleus
Role: Principal Investigator
Total Direct Costs: $1,329,223.00
Grant Detail: The goal of the proposed project is to identify repercussions of nuclear disruption in tauopathy and aging with a focus on RNA export.
Project #: N/A 09/01/19 - 08/31/20
Funding Agency: UTHSCSA Pepper Center
Title: Evaluating the extent of transposable element activation in brain and fluid from patients with Alzheimer’s disease
Role: Principal Investigator
Total Costs: $25,000.00
Grant Detail: This project utilizes single-nucleus retrotransposon capture sequencing from control and human Alzheimer’s disease brain tissue at mid- and late-stage disease to determine if transposable elements actively mobilize in the context of human Alzheimer’s disease.
Project #: N/A 08/01/19 - 07/31/20
Funding Agency: Rainwater Foundation/Tau Consortium
Title: Development of a Drosophila model of prion-like tau propagation for future genetic modifier and drug screening
Role: Principal Investigator
Total Costs: $200,000.00
Grant Detail: The goal of this project is to create in vivo reporters of tau aggregation and prion-like tau spread in neurons of the adult Drosophila brain.
Project #: N/A 06/01/19 - 05/31/20
Funding Agency: William and Ella Owens Medical Research Foundation
Title: Dysregulation of Transposable Element Sequences as a Novel Disease Mechanism in Alzheimer’s Disease and Related Tauopathies
Role: Principal Investigator
Total Costs: $100,000.00
Grant Detail: The goal of this project was to determine if transposable elements actively mobilize in human tauopathy.
Project #: N/A 05/01/19 - 04/31/20
Funding Agency: MD Anderson Neurodegeneration Consortium
Title: Reverse transcriptase inhibitors for Alzheimer’s disease
Role: Principal Investigator
Total Costs: $100,000.00
Grant Detail: The scope of this work was to investigate transposable element activation and reverse transcriptase activity in human Alzheimer’s disease and related tauopathies, and to validate candidate proteins as potential therapeutic targets.
Project #: N/A 01/01/19 - 12/31/19
Funding Agency: Center for Biomedical Neurosciences Pilot Grant
Title: Testing 3TC as a novel therapeutic for transposable element activation and consequent neurodegeneration in a mouse model of tauopathy
Role: Principal Investigator
Total Costs: $50,000.00
Grant Detail: The goals of this project were to determine if orally administered 3TC penetrates the mouse brain and suppresses tau-induced neurotoxicity.
Project #: N/A 08/01/18 - 07/31/19
Funding Agency: Rainwater Foundation/Tau Consortium
Title: Investigating transposable element activation as a causal mediator of neuronal death in tauopathy
Role: Principal Investigator
Total Costs: $200,000.00
Grant Detail: The goal of this project was to investigate transposable element activation as a driver of neuroinflammation in neurodegenerative tauopathies, and to determine if transposable element activation occurs in mouse models of tauopathy.
Project #: N/A 04/01/17 - 03/31/18
Funding Agency: William and Ella Owens Medical Research Foundation
Title: Dysregulation of Transposable Element Sequences as a Novel Disease Mechanism in Alzheimer’s Disease and Related Tauopathies
Role: Principal Investigator
Total Costs: $100,000.00
Grant Detail: The goal of this project was to investigate transposable elements and piwi-interacting RNAs in a Drosophila model of tauopathy, and to determine if genetic manipulation of transposable elements modifies tau-induced neurotoxicity.
Project #: N/A 07/01/16 - 06/30/19
Funding Agency: American Federation for Aging Research
Title: Investigating a Toxic Role of Nucleoplasmic Reticulum Expansion in Alzheimer’s Disease and Related Tauopathies
Role: Principal Investigator
Total Costs: $100,000.00
Grant Detail: The goal of this project was to determine if nuclear envelope invaginations affect mRNA export and nuclear calcium signaling in tauopathies and aging, and to determine if these processes contribute to tau neurotoxicity.
Project #: N/A 07/01/16 - 12/31/17
Funding Agency: Nathan Shock Pilot Grant & Briscoe Women’s Health Scholar Fund
Title: Investigating Loss of Terminal Differentiation of Neurons in Tauopathy
Role: Principal Investigator
Total Costs: $50,000.00
Grant Detail: The goal of this project was to determine if pathological tau causes neurons to lose their terminally differentiated status, and if genetically forcing neurons to remain terminally differentiated rescues tau neurotoxicity.
Project #: N/A 06/01/16 - 05/31/17
Funding Agency: San Antonio Life Sciences Institute: Cluster in Research Excellence
Title: Utilizing Imaging Mass Spectrometry and Electron Microscopy to Investigate Nucleoplasmic Reticulum Expansion in Alzheimer’s Disease
Role: multi-PI (Bess Frost, George Perry and Stephan Bach)
Total Costs: $100,000.00
Grant Detail: The goal of this project was to characterize the nucleoplasmic reticulum in postmortem human Alzheimer’s disease brains using imaging mass spectrometry and focused ion beam electron microscopy.
Project #: Rising STARs Program 11/01/15 - 10/31/17
Funding Agency: University of Texas System
Title: N/A
Role: Principal Investigator
Total Costs: $250,000.00
Grant Detail: The purpose of the Science and Technology Acquisition and Retention Program is to encourage faculty members to perform their research at UT institutions. This award was used to purchase state-of-the art laboratory equipment.
Project #: N/A 08/01/14 - 11/30/15
Funding Agency: HNDC & ADRC 2014 Neurodegenerative Disease Pilot Study Grants Program
Title: Investigating Lamin Dysfunction as a Novel Mechanism of Tau Neurotoxicity
Role: Principal Investigator
Total Costs: $40,000.00
Grant Detail: The goal of this project was to utilize super-resolution microscopy to visualize the interaction between lamin and heterochromatin in tauopathy.
Project #: 1 K99/R00 NS 088429 08/01/14 - 11/30/19
Funding Agency: NIH/NINDS
Title: Mechanisms and Consequences of Heterochromatin Loss in Tauopathies
Role: Principal Investigator
Total Costs: $932,754.00
Grant Detail: The goal of this project was to probe lamin dysfunction as the cause of heterochromatin relaxation in tauopathies, and to investigate the expression of small and long noncoding RNAs that are abnormally expressed as a consequence of heterochromatin relaxation in tauopathies.
Project #: 1 F32 AG 039193 09/01/10 - 08/30/13
Funding Agency: NIH/NIA
Title: Tau-mediated chromatin regulation and neurodegeneration
Role: Principal Investigator
Total Costs: $145,000.00
Grant Detail: The goal of this project was to determine if there are heterochromatic changes in tau transgenic Drosophila.
Project #: 5T32AG000278 09/01/06 - 08/01/07
Funding Agency: NIH/NIA
Title: NIH Training Grant for Aging and Neurodegenerative Diseases
Status: Complete
Role: Trainee
Total Costs: $28,000.00
Grant Detail: This grant was awarded to the Hillblom Center for the Biology of Aging, directed by Dr. Cynthia Kenyon. The goal of my project was to determine if the microtubule-associated protein tau has prion-like characteristics.
Project #: N/A 09/01/04 - 08/30/05
Funding Agency: University of California San Francisco
Title: Graduate Dean’s Health Science Fellowship
Status: Complete
Grant Detail: This fellowship is awarded to first year graduate students on the basis of scholarship, promise of outstanding achievement, and professional contribution.
Project #: N/A 09/01/02 - 08/30/03
Funding Agency: University of Texas Austin
Title: University Cooperative Undergraduate Research Fellowship
Role: PI
Total Costs: $1,000.00
Grant Detail: The goal of this project was to identify transcriptional changes in the mouse brain in response to chronic ethanol treatment.
