Benjamin T Enslow, M.D.

Journal Articles:

• Daw CC*, Ramachandran K*, Enslow BT*, Maity S, Bursic B, Novello MJ, Rubannelsonkumar CS**, Mashal AH**, Ravichandran J**, Bakewell TM, Wang W, Li K, Madaris TR, Shannon CE, Norton L, Kandala S, Caplan J, Srikantan S, Stathopulos PB, Reeves WB, Madesh M. Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism. Cell 2020 Oct 15;183(2):474-489.e17. doi: 10.1016/j.cell.2020.08.049. 

  • *Co-first authorship, **Undergraduate student researchers

• Nemani N, Dong Z, Daw CC, Madaris TR, Ramachandran K, Enslow BT, Rubannelsonkumar CS**, Shanmughapriya S, Mallireddigari V, Maity S, SinghMalla P, Natarajanseenivasan K, Hooper R, Shannon CE, Tourtellotte WG, Singh BB, Reeves WB, Sharma K, Norton L, Srikantan S, Soboloff J, Madesh M. Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity. Sci Signal. 2020 Apr 21;13(628):eaaz6206. doi: 10.1126/scisignal.aaz6206.

  • **Undergraduate student researchers

• Archer CR, Enslow BT, Carver CM, Stockand JD. Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC. J Biol Chem. 2020 Jun 5;295(23):7958-7969. doi: 10.1074/jbc.RA120.012606. 

• Enslow BT, Stockand JD, Berman JM. Liddle's syndrome mechanisms, diagnosis, and management. Integr Blood Press Control. 2019 Sep 3;12:13-22. doi: 10.2147/IBPC.S188869. 

• Huang Y, Li Z, Risinger AL, Enslow BT, Zeman CJ 4th, Gong J, Yang Y, Schanze KS. Fluorescence spectral shape analysis for nucleotide identification. Proc Natl Acad Sci 2019 Jul 30;116(31):15386-15391. doi: 10.1073/pnas.1820713116. 

• Archer CR, Enslow BT, Taylor AB, De la Rosa V, Bhattacharya A, Shapiro MS. A mutually induced conformational fit underlies Ca²⁺-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K⁺ channels. J Biol Chem. 2019 Apr 12;294(15):6094-6112. doi: 10.1074/jbc.RA118.006857. 

Abstracts:

• Paredes A, Noriega GS, Klepikova V, Ho A, Vanz C, Collins EC, Leadbetter EA, Enslow BT. Examining the relationship between B cell T-bet and CD36 expression. Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS), Pittsburg, Pennsylvania, November 2024.

• Cuidad E, Dudley EA, Leadbetter EA, Enslow BT. Obesity drives the expansion of Tfh and Tph cells in the spleen and liver, respectively. Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS), Pittsburg, Pennsylvania, November 2024.

• Noriega GS, Paredes A, Klepikova V, Ho A, Vanz C, Collins EC, Leadbetter EA, Enslow BT. Effects of adiponectin stimulation on B cell expression of T-bet and CD36. (AAI) Immunology2024, Chicago, Illinois, USA. May 2024.

• Paredes A, Noriega GS, Klepikova V, Ho A, Vanz C, Collins EC, Leadbetter EA, Enslow BT. Examining the relationship between B cell T-bet and CD36 expression. (AAI) Immunology2024, Chicago, Illinois, USA. May 2024.

• Enslow BT, Vanz C, Dudley EA, Hägglöf T, Leadbetter EA. PD-1^hi CD4+ T cells promote CD11c+ T-Bet+ B cell expansion in liver and spleen during obesity. (AAI) Immunology2023, Washington DC, USA, May 2023.

• Enslow BT, Vanz C, Dudley EA, Hägglöf T, Leadbetter EA. PD-1^hi CD4+ T cells promote CD11c+ T-Bet+ B cell expansion in liver and spleen during obesity. 10^th Annual San Antonio Postdoctoral Research Forum, San Antonio, TX, October 2022.

• Enslow BT, Dudley EA, Hägglöf T, Leadbetter EA. Diet-induced obesity promotes CD11c⁺, T-bet⁺ B cell expansion in liver and adipose tissue. IRACDA 2021 National Conference, Albuquerque, New Mexico, July 2022.

• Enslow BT, Dudley EA, Hägglöf T, Leadbetter EA. Diet-induced obesity promotes CD11c⁺, T-bet⁺ B cell expansion in liver and adipose tissue. (AAI) Immunology2022, Portland, Oregon, May 2022.

• Enslow BT, Dudley EA, Hägglöf T, Leadbetter EA. Distinct PD-1^hi CD4+ T cells promote CD11c+ T-Bet+ B cell expansion in liver and spleen during obesity.” 9^th Annual San Antonio Postdoctoral Research Forum. October 2021.

• Enslow BT, Vanz C, Schute T, Parthasarathy R, Dudley EA, Kumagai A, Keegan J, Koenigs A, Hägglöf T, Leadbetter EA. Diet-induced obesity promotes CD11c⁺, T-bet⁺ B cell expansion in liver and adipose tissue. San Antonio Postdoctoral Research Forum. (Virtual), December 2021.

• Enslow BT, Vanz C, Schute T, Parthasarathy R, Dudley EA, Kumagai A, Keegan J, Koenigs A, Hägglöf T, Leadbetter EA. Diet-induced obesity promotes CD11c⁺, T-bet⁺ B cell expansion in liver and adipose tissue. 6^th Annual Vaccine Development Center of San Antonio Conference. (Virtual), November 2021.

• Enslow BT, Vanz C, Schute T, Parthasarathy R, Dudley EA, Kumagai A, Keegan J, Koenigs A, Hägglöf T, Leadbetter EA. iNKT Cells Facilitate T-bet+ B Cell Expansion in Adipose Tissue, but Not In Liver or Omentum, During Obesity. IRACDA 2021 National Conference. (Virtual), June 2021.

• Enslow BT, Vanz C, Schute T, Parthasarathy R, Dudley EA, Kumagai A, Keegan J, Koenigs A, Hägglöf T, Leadbetter EA. Obesity is Associated with an Tbet⁺, CD11c⁺ B Cell-Dependent Expansion of Adipose, Hepatic, and Omentual iNKT Cells in Mice. American Associate of Immunologists (AAI) Virtual Immunology2021^Tm. (Virtual), May 2021. 

• Enslow BT, Vanz C, Schute T, Parthasarathy R, Dudley EA, Kumagai A, Keegan J, Koenigs A, Hägglöf T, Leadbetter EA. Obesity Results in an Increase in Intrahepatic CD11c⁺ Tbet⁺ B Cells. San Antonio Postdoctoral Research Forum. (Virtual), December 2020. 

• Enslow BT, Madaris TR, Ravichandran J, Jacob R, Srikantan S, Stathopulos P, Muniswamy M. Identification of Critical MCUR1 Domains in the Mitochondrial Calcium Uniporter Complex that Regulates Cellular Metabolism. Experimental Biology (EB). San Diego, California, April 2020. (Accepted, Canceled due to COVID19 Travel Restrictions.)

• Enslow BT, Daw CC, Madaris TR, Ramachandran K, Norton L, Srikantan S, Soboloff, J, Madesh, M. Mitochondrial Pyruvate and Fatty Acid Flux Modulate MICU1-Dependent Control of MCU. Association for Clinical and Translational Science (ACTS). Washington DC, April 2020. (Accepted; Canceled due to COVID19 Travel Restrictions.)

• Enslow BT, Madaris T, Ravichandran J, Jacob R, Stathopulos P, Srikantan S, Muniswamy M. Identification of Critical MCUR1 domains in the Mitochondrial Calcium Uniporter Complex that Regulates Cellular Metabolism. San Antonio Postdoctoral Research Forum. Sep. 2019. 

• Archer CR, Enslow BT, Green RR, Stockand JD. ENaC is Regulated by PIP2 Through Weak Electrostatic Interactions on Multiple Binding Sites. San Antonio Postdoctoral Research Forum. Sep 2018.

• Archer CR, Bhattacharya A, Enslow BT, Taylor, AB Ivanov, DN, Shapiro MS. A Possible Structural Mechanism of Phosphorylation in Mediating Crosstalk Between Calmodulin and PIP2 on KCNQ4 K+ Ion Channels. Gordon Research Seminar and Conference, Calcium Signaling; Jun 16-23, 2017 and FASEB SRC, Ion Channels, July 9-16, 2017.

• Archer CR, Bhattacharya A, Enslow BT, Taylor, AB Ivanov, DN, Shapiro MS. Novel Insights from Structural Analysis of Interactions of KCNQ K+ Channels with Calmodulin. Biophysical Journal. Vol. 112, issue 3, Supplement 1, p109a–110a, 3 Feb 2017.

• Wandrey N, Ortiz D, Enslow BT, Yang A, Lenhan B, Garcia D, Butler S, Chen T, Henzi D, Winkler P. Salud al Pasito: Small Steps Towards Better Health. Endocrine Practice. AACE Annual Scientific and Clinical Congress. Vol. 22, Supplement 2, p.171, May 2016.

• Archer CR, Enslow BT, Shapiro MS. Biochemical Analysis of the Regulation of Kv7 Channels by PIP₂ and Calmodulin. Biophysical Society 60^th Annual Meeting; Feb 27 – Mar 2, 2016; Los Angeles, CA.  Biophysical Journal, Feb 2016. Vol. 110, issue 3, p.102a.

• Archer CR, Enslow BT, Reed PA, Shapiro MS. Biochemical Analysis of the Regulation of Kv7 Channels by PIP₂ and Calmodulin. Journal of General Physiologists, 146: p3a, Feb 2016.