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Part of UT Health San Antonio

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Dr Diogenes, DDS, PhD

Contact

210-450-3606

diogenes@uthscsa.edu

Departments & Divisions

Institutes & Centers

Research Areas

Regenerative Medicine

Anibal Diogenes, D.D.S., Ph.D.

Professor & Vice-Chair

Dr. Anibal Diogenes received his D.D.S. from the Federal University of Pernambuco in Brazil, his M.S. in Molecular Biology from the University of Nebraska, and his Ph.D. in Pharmacology and Certificate in Endodontics from the University of Texas Health Science Center at San Antonio. Dr. Diogenes is a Professor and Chair of the Department of Endodontics and Director of the American Board of Endodontics. He conducts translational research to better understand how to resolve inflammation, bone loss, and pain resulting from root canal infections. Dr. Diogenes specializes in microscopic endodontics, including initial treatments, retreatments, endodontic microsurgeries, and regenerative therapies.

  • Professional Background

    Education

    • 2009 - Certificate - Endodontics - University of Texas Health Science Center San Antonio
    • 2009 - Residency - Endodontics - University of Texas Health Science Center at San Antonio
    • 2009 - Postdoctoral Fellowship - Pharmacology - University of Texas Health Science Center, Dept of Endodontics
    • 2006 - PhD - Pharmacology - University Texas Health Science Center San Antonio
    • 2002 - MS - Molecular Biology - University of Nebraska
    • 1998 - DDS - Dentistry - Federal Univ. of Pernambuco

    Highlights

    Minnie Stevens Piper Professor Award ; Osetek Award (American Association of Endodontists); Ut School of Dentistry Distinguished Research Award; International of Dental Research Distinguished Research Award

    Appointments

    • 9/2019 - Professor and Vice Chair - UT Health San Antonio, Endodontics, San Antonio
    • 11/2015 - Adjunct Professor - Uniformed Services University of the Health Sciences, Endodontics, San Antonio
    • 9/2015 - Associate Professor with Tenure - University of Texas Health Science Center at San Antonio, Endodontics, San Antonio
    • 2/2015 - Associate Professor Cross Appointment - University of Texas Health Science Center at San Antonio, Cellular & Structural Biology, San Antonio
    • 1/2015 - Associate Professor Post-Doctoral Director - University of Texas Health Science Center at San AntonioSan Antonio
    • 1/2009 - Private Practice Limited to Endodontics - University of Texas Health Science Center at San AntonioSan Antonio
    • 1/2009 - Associate Editor - Journal of Endodontics

  • Instruction & Training

    • - Present
    • 1/2015 - Present, Ph.D. Dissertations Directed, UTHSCSA
    • 7/2014 - Present, Clinical Endodontics I, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Endodontics III, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations III, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations III, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Sem II, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations II, The University of Texas Health Science Center
    • 7/2014 - Present, Supervised Teaching, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Endo II, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations II, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations II, The University of Texas Health Science Center
    • 7/2014 - Present, Lit Review II, The University of Texas Health Science Center
    • 7/2014 - Present, Literature Review II, The University of Texas Health Science Center
    • 7/2014 - Present, Literature Review I, The University of Texas Health Science Center
    • 7/2014 - Present, Literature Review I, The University of Texas Health Science Center
    • 7/2014 - Present, Literature Review I, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Endodontics II, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Endo II, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations I, The University of Texas Health Science Center
    • 7/2014 - Present, Supervised Teaching, The University of Texas Health Science Center
    • 7/2014 - Present, ENDO Surgical Anatomy, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Seminar I, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations I, The University of Texas Health Science Center
    • 7/2014 - Present, Case Presentations I, The University of Texas Health Science Center
    • 7/2014 - Present, Clinical Seminar I, The University of Texas Health Science Center
    • 4/2014 - Present, ENDO5011 Clinical Endodontics I
    • 1/2014 - Present, Post-Doctoral Student Supervision
    • 1/2009 - Present, Current Literature Review, The University of Texas Health Science Center
    • 1/2009 - Present, Current Literature Review, The University of Texas Health Science Center
    • 1/2009 - Present, ENDO6077 Current Literature Review
    • 1/2009 - Present, HHD5004 Histology
    • 1/2009 - Present, Pharmacology, The University of Texas Health Science Center
    • 1/2009 - Present, PHAR5041 Pharmacology

  • Research & Grants

    Microscopic Endodontics, Endodontic microsurgery, root canal retreatments and regenerative endodontics

    Grants

    Private

    Funding Agency AAEF Title Regeneration of pulp-dentin development in immature permanent teeth with necrosis Status Active Period 1/2010 - Present Role Co-Investigator Grant Detail This is a a 5-year grant to conduct a multi-center clinical trial comparing a regenerative endodontic treatment to MTA Apexification procedures .

     

    Funding Agency NIDCR Title Trigeminal Afferent Regulation of Apical Periodontitis Status Active Period 7/2018 - Present Role Principal Investigator Grant Detail Grant Detail: This is a a 5-year grant to evaluate how different trigeminal afferent subtypes modulate the development and maintenance of apical periodontitis

  • Publications

      Abstract

      Ruparel N. Bacterial Byproducts/Biofilm Affect Differentiation of Stem Cells of Apical Papilla; 2016 Jan. (AADR Abstract 0750).

      Journal Article

      De Berdt P, Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A, et al. Author Correction: Stem cells from human apical papilla decrease neuroinflammation and stimulate oligodendrocyte progenitor differentiation via activinA secretion Cell Mol Life Sci 2018 Jan;. Miller AA, Takimoto K, Wealleans J, Diogenes A. Effect of 3 Bioceramic Materials on Stem Cells of the Apical Papilla Proliferation and Differentiation Using a Dentin Disk Model J Endod 2018 2018 Jan;44(4):599-603. De Berdt P, Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A. Stem cells from human apical papilla decrease neuroinflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion Cell Mol Life Sci. 2018 2018 Jan;. Estrela C, Couto GS, Bueno MR, Bueno KG, Estrela LRA, Porto OCL, Diogenes A. Apical foramen position in relation to proximal root surfaces of human permanent teeth determined by using a new cone-beam computed tomographic software Journal of Endodontics 2018 Jan;. Arruda MEF, Neves MAS, Diogenes A, Mdala I, Guilherma BPS, Siqueira JR Jr., Rocas IN. Infection control in teeth with apical periodontitis using a triple antibiotic solution or calcium hydroxide with chlorhexidine: A randomized clinical trial Journal of Endodontics 2018 Jan;44(10):1474-1479. Vishwanat L, Duong R, Takimoto K, Phillips L, Espitia CO, Diogenes A, Ruparel SB, Kolodrubetz D, Ruparel NB. Effect of Bacterial Biofilm on the Osteogenic Differentiation of Stem Cells of Apical Papilla Journal of Endodontics 2017 Jun;43(6):916-922. Song JS, Takimoto K, Jeon M, Vadakekalam J, Ruparel NB,Diogenes A. Decellularized Human Dental Pulp as a Scaffold for Regenerative Endodontics Journal of Dental Research 2017 Jan;96(6):640-646. Chrepa V, Austah O,Diogenes A. Evaluation of a Commercially Available Hyaluronic Acid Hydrogel (Restylane) as Injectable Scaffold for Dental Pulp Regeneration: An In Vitro Evaluation Journal of Endodontics 2017 Jan;43(2):257-262. Diogenes A, Hargreaves KM. Microbial Modulation of Stem Cells and Future Directions in Regenerative Endodontics Journal of Endodontics 2017 Jan;43(9S):S95-S101. Viswanath A, Vanacker J, Germain L, Leprince JG, Diogenes A, Shakesheff KM, et al. Extracellular matrix-derived hydrogels for dental stem cell delivery Journal of Biomed Mater Res A 2017 Jan;105(1):319-328. Palma PJ, Ramos JC, Martins JB, Diogenes A, Figueiredo MH, Ferreira P, et al. Histologic Evaluation of Regenerative Endodontic Procedures with the Use of Chitosan Scaffolds in Immature Dog Teeth with Apical Periodontitis Journal of Endodontics 2017 Jan;43(8):1279-1287. Eskander, M.A., Takimoto, K., Diogenes A. Evaluation of mesenchymal stem cell modulation of trigeminal neuronal responses to cold Neuroscience 2017 Jan;360:61-67. Chrepa V, Pitcher B, Henry MA, Diogenes A. Survival of the Apical Papilla and Its Resident Stem Cells in a Case of Advanced Pulpal Necrosis and Apical Periodontitis Journal of Endodontics 2017 Jan;43(4):561-567. Fayazi S, Takimoto K,Diogenes A. Comparative Evaluation of Chemotactic Factor Effect on Migration and Differentiation of Stem Cells of the Apical Papilla Journal of Endodontics 2017 Jan;43(8):1288-1293. Estefan BS, El Batouty KM, Nagy MM,Diogenes A. Influence of Age and Apical Diameter on the Success of Endodontic Regeneration Procedures Journal of endodontics 2016 Jan;42(11):1620-1625. Yuan C, Wang P, Zhu S, Zou T, Wang S, Xu J, Heng BC, Diogenes A, Zhang C. EphrinB2 Stabilizes Vascular like Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla Journal of Endodontics 2016 Jan;42(9):1362-1370. Austah O, Ruparel NB, Henry MA, Fajardo R, Schmitz JE, Diogenes A. Capsaicin-sensitive Innervation Modulates the Development of Apical Periodontitis Journal of Endodontics 2016 Jan;42(10):1496-1502. Diogenes A, Ruparel N, Shiloah Y, Hargreaves KM. Regenerative endodontics: A way forward J Am Dent Assc 2016 Jan;147(5):372-380. Smith AJ, Duncan HF, Diogenes A, Simon S, Cooper PR. Exploiting the Bioactive Properties of the Dentin-Pulp Complex in Regenerative Endodontics Journal of Endodontics 2016 Jan;42(1):47-56. Kishen A, Peters OA, Zehnder M, Diogenes A, Nair MK. Advances in endodontics: Potential applications in clinical practice J Conserv Dent 2016 Jan;19(3):199-206. Shrestha S, Diogenes A, Kishen A. Temporal-controlled Dexamethasone Releasing Chitosan Nanoparticle System Enhances Odontogenic Differentiation of Stem Cells from Apical Papilla Journal of Endodontics 2015 Jan;41(8):1253-1258. Germain L, De Berdt P, Vanacker J, Leprince J, Diogenes A, Jacobs D, et al. Fibrin hydrogels to deliver dental stem cells of the apical papilla for regenerative medicine Regen Med 2015 Jan;10(2):153-167. Middleton G, Diogenes A. Preemptive Nonsteroidal Anti-inflammatory Drugs Increases the Success Rate of Inferior Alveolar Nerve Blocks in Mandibular Posterior Teeth with Symptomatic Irreversible Pulpitis Texas Dental 2015 Jan;132(6):358-358. De Berdt P, Vanacker J, Ucakar B, Elens L, Diogenes A, Leprince JG, et al. Dental Apical Papilla as Therapy for Spinal Cord Injury J Dent Res 2015 Jan;94(11):1575-1581. Chrepa V, Henry MA, Daniel BJ, Diogenes A. Delivery of apical mesenchymal stem cells into root canals of mature teeth Journal of Dental Research 2015 Jan;94(12):1653-1659.

      Review Article

      Diogenes A, Ruparel NB. Regenerative Endodontic Procedures: Clinical Outcomes Dental Clinic North America 2017 Jan;61(1):111-125.

  • Clinical

    Board Certifications

    • Board Certified Endodontist