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Goutam Ghosh Choudury, PhD

Contact

210-567-4830

choudhuryg@uthscsa.edu

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Departments & Divisions

Research

Research profile

Currently seeking Ph.D. students

Goutam Ghosh-Choudhury, PhD

Professor

Department of Medicine/Nephrology. Senior Research Career Scientist

South Texas Veterans Health Care System

Our research interests include the signal transduction pathways activated by growth factors, cytokines and hyperglycemic condition. We are interested in mechanisms that support the development of diabetic kidney disease and renal cell carcinomas. Nearly 50% of the patients with diabetes develop nephropathy. Importantly, diabetic patients with kidney disease have 87% higher risk of cardiovascular mortality when compared with those without kidney disease. The early pathologic changes in diabetic nephropathy involve renal, especially glomerular and tubular hypertrophy and expression of matrix proteins such as collagen, fibronectin and laminin. My laboratory has been studying the signal transduction mechanisms that lead to the progression of diabetic nephropathy. To test our concepts, we use renal cells (glomerular mesangial cells and proximal tubular epithelial cells) in culture and mouse and rat models of type 1 and type 2 diabetes. TGF (transforming growth factor-) mediates many pathologic effects of hyperglycemia. Therefore, we study the signaling mechanisms of this cytokine in mesangial and proximal tubular epithelial cells. We discovered that the tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome 10) is downregulated in the kidneys of diabetic rodents. We established that the suppressed PTEN contributes to the pathologies of diabetic nephropathy. To identify the mechanisms that may regulate the suppression of PTEN under hyperglycemic condition, we studied several microRNAs. In last few years, we showed that miR-21, miR-26a and miR-214 control the expression of PTEN in renal cells in response to high glucose/TGF and in the kidneys of diabetic mice. These studies opened the door to the novel application of anti-microRNA therapy for diabetic nephropathy. We previously showed that mTOR plays an important role in the pathologies of diabetic nephropathy. For the pathologic effects in the disease, mTOR is activated in sustained manner. More recently, we have focused on a novel protein, called deptor, which is a component of mTOR complexes 1 and 2. In fact deptor is an endogenous inhibitor of mTOR activity. For the first time, we showed that the renal expression of deptor was significantly reduced in humans with diabetes and in diabetic rodents and that this reduction contributed to the increased mTOR activity. In cultured mesangial and proximal tubular epithelial cells incubated with high glucose or TGF, the expression of deptor was significantly reduced, which resulted in sustained activation of both mTORC1 and mTORC2. Thus, it is important to study the mechanism of deptor downregulation by hyperglycemia. We are currently investigating the epigenetic, post-transcriptional (microRNAs) and post-translational mechanisms of deptor downregulation in diabetic nephropathy. We have just published our first set of studies demonstrating the involvement of miR-181a in suppressi

  • Professional Background

    Education

    • 1986 - PhD - Biochemistry - University of Calcutta
    • 1978 - MS - Biochemistry - University of Calcutta
    • 1976 - BS - Chemistry (Honors), Physics, Mathematics - University of Calcutta
    • Postdoctoral Fellowship - Signal Transduction by Tyrosine Kinases - Department of Cell Systems and Anatomy, UT Health San Antonio
    • Postdoctoral Fellowship - Molecular Virology (Adenoviruses) - McMaster University, Dept of Biology and Pathology

    Appointments

    • 10/2016 - Senior Research Career Scientist - Audie L. Murphy Memorial Veterans Hospital/South Texas Veterans Health Care System , San Antonio, TX
    • 9/2007 - Professor with Tenure - University of Texas Health Science Center at San Antonio, Medicine, San Antonio
    • 5/1995 - Research Health Scientist - Audie L. Murphy Memorial Veterans Hospital/South Texas Veteran`s Health Care SystemSan Antonio

  • Instruction & Training

    • 6/2017 - Present, Membership on Supervising Committee, UT Health San Antonio Dental School
    • 6/2017 - Present, Membership on Supervising Committee, UT Health San Antonio Dental School
    • 11/2016 - Present, Post-Doctoral Student Supervision, UT Health San Antonio
    • 1/2010 - Present, Post-Doctoral Student Supervision, University of Texas Health Science Center at San Antonio
    • 8/2006 - Present, Post-Doctoral Student Supervision, University of Texas Health Science Center at San Antonio

  • Research & Grants

    Research profile

    Grants

    Federal

    Funding Agency Veterans Administration - Career Scientist Award Title VA-Research Career Scientist Award Status Active Period 10/2016 - 9/2021 Role Principal Investigator Grant Detail This is a VA salary grant, which supports Dr. Ghosh Choudhury's full VA 7/8th Salary. Funding Agency Veterans Administration - Merit Review Title Mechanism of Renal Cell Injury Status Active Period 7/2016 - 6/2020 Role Principal Investigator Grant Detail This proposal investigates the epigenetic, proteasomal and microRNA regulation of deptor down regulation for mTORC1 and mTORC2 activation during the progression of diabetic nephropathy. Funding Agency National Institute of Health R01 Title Mechanism of Renal Cell Injury in Diabetes Status Active Period 6/2010 - 5/2017 Role Principal Investigator Grant Detail This proposal investigates the transcriptional and microRNA mechanisms for expression of PTEN in diabetes.

    This grant has been active since 1996.

     

  • Service

    Department

    Mentoring: Hak Joo Lee, Ph.D. 2010-Present Postdoctoral Fellow, Nephrology, U UT Health SA THSCSA
    Mentoring: Falguni Das, Ph. D. 2005-Present Postdoctoral Fellow, Nephrology, UT Health SA
    Mentoring: Soumya Maity, Ph. D. 2016-Present Postdoctoral Fellow, Nephrology, UT Health SA

    School

    Fall 2020 TSCI 5080 Integration of Molecular Biology, 5 Students with Patient Oriented Research (Practicum)
    Fall 2019 TSCI 5080 Integration of Molecular Biology, 3 Students with Patient Oriented Research (Practicum)

    Institutional

    10/2016 – Present: Member, VA Institutional Animal Care and Use Committee
    2018 - Present: Post-Tenure Review Committee, Department of Medicine

    National

    02/2017 – 06/2021, Member, VA BLRD Merit Review Nephrology Study Section

  • Publications

      Abstract

      Das F., Ghosh-Choudhury N., Kasinath B. S. and Ghosh Choudhury G. Activation of PI 3 kinase (PI 3 K) by PDGF receptor beta (PDGFRb) regulates Akt-dependent Hif1a to express Glut1 for mesangial cell (MC) hypertrophy in response to high glucose (HG); 2017 Jan. (J AM Soc Nephrol). Lee H. J., Feliers D., Barnes J. L., Oh B. S., Ghosh Choudhury G., Galvan V, Strong R., Nelson J. F., Salmon A., Kevil C. G. and Kasinath B. S. Hydrogen sulfide ameliorates aging associated kidney changes in mice; 2017 Jan. (J AM Soc Nephrol; vol. 28). Das F., Ghosh-Choudhury N., Kasinath B. S. and Ghosh Choudhury G. TGFbeta (TGFb)-stimulated PI 3 kinase (PI 3 K)/Akt downregulates deptor to increase podocyte hypertrophy and matrix protein expression; 2017 Jan. (J AM Soc Nephrol; vol. 28). Maity S., Das F., Ghosh-Choudhury N., Kasinath B. S. and Ghosh Choudhury G. MicroRNA-181a (miR-181a) drives deptor downregulation by TGFbeta (TGFb) to induce mesangial cell (MC) hypertrophy and fibronectin expression; 2017 Jan. (J AM Soc Nephrol; vol. 28). Das F., Ghosh-Choudhury N., Kasinath B. S.,Ghosh-Choudhury G. mTORC2/PKCb II node contributes to TGFb-incuded Twist 1 expression and proximal tubular epithelial cell (PTEC)injury; 2016 Jan. (J AM Soc Nephrol Abs FR PO211). Das, F., Ghosh-Choudhury N.
      Kasinath, B., Ghosh-Choudhury G.
      . Suppressed MicroRNA-214 (miR-214) dictates IGF-1 receptor (IGF-1R) expression to stimulate mTORC1 signaling for proflieration of renal cancer cells; 2016 Jan. (J AM Soc Nephrol Abs FR PO216). Lee, H
      Feliers, D
      Barnes,J., Ghosh-Choudhury G.,
      Wang, R.
      Kasinath, B.

      . Gender-dependent Hypertension - induced kidney injury in cystathionine g lyase knocked out mice. Amelioration by Sodium Hydro sulfide; 2016 Jan. (J AM Soc Nephrol Abs FR PO364).

      Das F., Ghosh-Choudhury N., Venkatesan B., Kasinath B. S. and Ghosh-Choudhury G. Activation of PDGF receptor beta (PDGFRb) by high glucose (HG) forces mTORC1 signaling to induce proximal tubular epithelial cell (PTEC) hypertrophy and matrix protein expression; 2016 Jan. (J AM Soc Nephrol Abs FR-PO210). Lee, H.
      Sataranatarjan, K.
      Mariappan, M. M.
      Feliers, D., BARNES J. L., Ghosh-Choudhury G., Kevil C. G., Kasinath B. S.

      . Hydrogen sulfide deficiency in the kidney and brain in aging mice; 2015 Jan. (J AM Soc Nephrol Abs FR PO473).

      Das F., Ghosh-Choudhury N., Abboud H. E., Kasinath B. S. and Ghosh-Choudhury G. Hydrophobic motif site phosphorylation of Protein Kinase C beta II by mTORC2 regulates high glucose (HG)-induced mesangial cell hyperatrophy; 2015 Jan. (J AM Soc Nephrol Abs TH-PO297). Ghosh-Choudhury G
      Bera, A.
      Das, F.
      Kasinath, B
      Addound, H. Rictor-PDCD4 interaction controlled by microRNA-21 contributes to renal cancer cell proliferation; 2014 Jan. (J AM Soc Nephrol ABS FR PO670). Lee H. J., Lee D. Y., Mariappan M. M., Feliers D., Ghosh Choudhury G., Abboud H. E., Gorin Y. and Kasinath B. S. Hydrogen sulfide (H2S) inhibits high glucose-induced NOX4 expression by activating nitric oxide (NO)AMPK axis in proximal tubular epithelial (MCT) cells; 2014 Jan. (J AM Soc Nephrol). Satanatarajan K, Bokov AF, Feliers D, Lee HJ, Mariappan MM, Ghosh-Choudhury G, Barnes JL, Richardson AG, Kasinath BS. Rapamycin fails to ameliorate established renal injury and augments mortality in diabetic mice; 2013 Jan. (J Am Soc Nephrol). Das F, Bera A, Ghosh-Choudhury N, Kasinath BS, Abboud HE, Ghosh-Choudhury G. PDGF launches mesangial cell proliferation via a positive feedback loop involving EKK5 and Akt downstream of PI kinase; 2013 Jan. (J Am Soc Nephrol). Bera A, Das F, Mariappan MM, Ghosh-Choudhury N, Kasinath BS, Ghosh-Choudhury G. microRNA-214 regulates mesangial cell (MC) hypertrophy and matrix expansion through PTEN; 2013 Jan. (J Am Soc Nephrol). Lee HJ, Feliers D, Mariappan MM, Sataranatarajan K, Gorin Y, Ghosh-Choudhury G, Kasinath BS. Tadalafil integrates nitric oxide-hydrogen sulfide-AMPK pathways to inhibit high glucose-induced matrix protein synthesis in podocytes; 2013 Jan. (J Am Soc Nephrol). Bera A, Dey N, Das F, Kasinath BS, Abboud HE, Ghosh-Choudhury N, Ghosh-Choudhury G. microRNA-21-dependent positive feedback loop involving NFkappaB (NFkB) regulates renal cancer cell proliferation; 2012 Dec. (J Am Soc Nephrol; vol. 23). Das F, Ghosh-Choudhury N, Dey N, Abboud HE, Kasinath BS, Ghosh-Choudhury G. A signal relay from transforming growth factor beta (TGFb)-stimulated Smad 3 to mTOR involves deptor suppression to force mesangial cell hypertrophy; 2012 Nov. (J Am Soc Nephrol; vol. 23). Dey N., Das F., Ghosh-Choudhury N., Kasinath B. S., Abboud H. E. and Ghosh Choudhury G. Reciprocal expression of microRNA-241 (miR-214) and insulin-like growth factor-1 receptor (IGF-1R) dictates renal cell carcinoma cell proliferation via Akt/TORC1 circuit; 2011 Jan. (J AM Soc Nephrol). Das F., Dey N., Ghosh-Choudhury N., Kasinath B. S., Abboud H. E. and Ghosh Choudhury G. Hyperactive TORC1 and TORC2 launch Hif1a-dependent expression of PTEN to regulate phosphorylation of Akt in tuberous sclerosis complex (TSC); 2011 Jan. (J AM Soc Nephrol). Eid A. A., Ford B. M., Barnes J. L., Gorin Y., Ghosh Choudhury G. and Abboud H. E. mTOR regulates Nox4-mediated podocyte loss in diabetic renal injury; 2011 Jan. (J AM Soc Nephrol). Das F., Ghosh-Choudhury N., Mandal C. C., Dey N., Kasinath B. S. and Ghosh Choudhury G. A feedback loop in high glucose-induced inactivation of FoxO1 regulates Akt activation, mesangial cell hypertrophy and fibronectin expression via downregulation of catalase; 2010 Jan. (J AM Soc Nephrol). Mandal C. C., Ghosh-Choudhury N., Yoneda T., Ghosh Choudhury G. and Ghosh-Choudhury N. Simvastatin prevents breast cancer skeletal metastasis by increasing p53 levels to increase PTEN and inhibit CD44 expression; 2010 Jan. (Cancer Res). Dey N., Ghosh-Choudhury N., Das F., Mariappan M. M., Madal C., Kasinath B. S. and Ghosh Choudhury G. Micro-RNA-21 (miR-21) targets PTEN to regulate mesangial cell hypertrophy and fibronectin expression by high glucose; 2010 Jan. (J AM Soc Nephrol). Lee H. J., Feliers D., Mariappan M. M., Sataranatarajan K., Ghosh Choudhury G. and Kasinath B. S. Hydrogen sulfide activates AMPK and inhibits high glucose induction of protein and matrix laminin synthesis in glomerular endothelial cells; 2010 Jan. (J AM Soc Nephrol). Mandal C. C., Ghosh-Choudhury N., Yoneda T., Ghosh Choudhury G. and Ghosh-Choudhury N. Unveiling dual function of p53 in preventing breast cancer bone metastasis by simvastatin targeting CD44 and PTEN; 2010 Jan. (J Bone and Mineral Res; vol. 25). Mariappan M. M., D'Silva K., Lee M. J., Sataranatarajan K.,Ghosh Choudhury G. and Kasinath B. S. High glucose-stimulated UBF-1 activation increases ribosome biogenesis for enhanced protein synthesis in glomerular epithelial cells; 2010 Jan. (J AM Soc Nephrol). Mariappan M. M., Sataranatarajan K., Ghosh Choudhury G. and Kasinath B. S. Amelioration of diabetes-induced renal injury by sodium nitroprusside is associated with glycogen synthase kinase 3 beta activation; 2010 Jan. (J AM Soc Nephrol). Mandal C. C., Ganapathy S., Ghosh Choudhury g. and Ghosh-Choudhury N. BMP-2-stimulated Nox4-PI 3 kinase-Akt signaling axis induces osteoblast (OB) differentiation; 2009 Jan. (J Bone and Mineral Res). Dey N., Ghosh-Choudhury N., Das F., Kasinath B. S. and Ghosh Choudhury G. Phosphorylated PRAS40 is an intermediate in high glucose-induced hypertrophy of mesangial cells (MC) and diabetic glomeruli; 2009 Jan. (J AM Soc Nephrol). Das F., Ghosh-Choudhury N., Dey N., Kasinath B. S. and Ghosh Choudhury G. S6 kinase/p90Rsk axis regulates eEF2 dephosphorylation to induce TGF-beta-stimulated mesangial cell (MC) hypertrophy; 2009 Jan. (J AM Soc Nephrol). New D. D., Block K., Gorin Y, Ghosh Choudhury G. and Abboud H. E. IGF-1 increases expression of fibronectin by activation of Nox4-dependent PI 3 kinase/Akt signaling; 2009 Jan. (J AM Soc Nephrol). Mandal C. C., Ghosh Choudhury G., Yoneda T. and Ghosh-Choudhury N. Omega-3 fatty acids (OFAs) intercept miR-21 and miR-214 targeting PTEN to prevent breast cancer bone metastasis; 2009 Jan. (J Bone and Mineral Res). Wagner B, Rincono, JM, Gorin Y, Arar MY, Kazalauskas, A, Ghosh-Choudhury G, Abboud HE. PDGF receptor beta modulates metanephric mesenchyme chemotaxis induced by PDGF AA; 2008 Nov. (Journal of the American Society of Nephrology; vol. 19). Dey N., Ghosh-Choudhury N., Li X., Das F., Venkatesan B., Kasinath B. S. and Ghosh Choudhury G. Proline-rich Akt substrate 40 (PRAS40) regulates high glucose-induced protein synthesis in mesangial cells (MC); 2008 Jan. (J AM Soc Nephrol). Das F., Ghosh-Choudhury N., Venkatesan B., Kasinath B. S. and Ghosh Choudhury G. Mnk-1-mediated phosphorylation of eIF4E is required for TGFbeta-induced mesangial cell (MC) hypertrophy; 2008 Jan. (J AM Soc Nephrol). Mandal C. C., Ghosh Choudhury G. and Ghosh-Choudhury N. BMP-2 stimulates a feedback activation loop for expression of NFATc1 in osteoblasts; 2008 Jan. (J Bone and Mineral Res). Ghosh Choudhury G., Venkatesan B., Das F., Habib S. L., Ghosh-Choudhury N., Kasinath B. S. and Abboud H. E. Mechanism for reduced malignancy of TSC2 null tumors; 2008 Jan. (J AM Soc Nephrol). Mariappan M. M., Sataranatarajan K., Lee M. J., Ghosh Choudhury G. and Kasinath B. S. High glucose-induced protein synthesis in rat glomerular endothelial cells (GEC) involves ribosomal biogenesis; 2008 Jan. (J AM Soc Nephrol). Sataranatarajan K., Feliers D., Mariappan M. M., Lee M. J., Jemenenez F., Chen Y, Ghosh Choudhury G., Ahuja S. and Kasinath B. S. Toll-like receptor 4 knockout (TLR4ko) mice are resistant to diabetic kidney injury; 2008 Jan. (J AM Soc Nephrol). Venkatesan B., Das F., Ghosh-Choudhury N., Kasinath B. S., Abboud H. E. and Ghosh Choudhury G. Resveratrol targets PTP1B to inhibit PDGF-induced mesangial cell (MC) proliferation; 2008 Jan. (J AM Soc Nephrol). Mandal C. C., Ghosh Choudhury G., Ganapathy S., harris S. E. and Ghosh-Choudhury N. BMP-2-stimulated signaling niche in osteoblasts comprising of Smad and PI 3 kinase/Akt regulates NFATc1 expression and its nuclear translocation; 2008 Jan. (J Bone and Mineral Res). Das F., Venkatesan B., Ghosh-Choudhury N., Mahimainathan L., Abboud H. E. and Ghosh Choudhury G. Mechanism of TGFbeta inhibition of PDGF-induced DNA synthesis in mesangial cells; 2007 Jan. (J Am Soc Nephrol). Das F., Ghosh-Chouhdury N., Venkatesan B., Mahimainathan L. and Ghosh Choudhury G. Role of linker region phosphorylation of Smad 3 in PAI-1 expression in mesangial cells (MC); 2007 Jan. (J AM Soc Nephrol). Mahimainathan L., Ghosh-Choudhury N., Abboud H. E. and Ghosh Choudhury G. Tumor suppressor PTEN is the latest taget of hypoxia inducible factor1-alpha (Hif1a); 2007 Jan. (J AM Soc Nephrol). Venkatesan B., Ghosh-Choudhury N., Mahimainathan L., Kasinath B. S. and Ghosh Choudhury G. SIRT1 (Silence information regulator1) regulates p53-dependent PTEN expression in high glucose-stimulated mesangial cells; 2007 Jan. (J Am Soc Nephrol). Sataranatarajan K., Mariappan M. M., Lee Ml J., Feliers D., Ghosh Choudhury G. and Kasinath B. S. Regulation of elongation phase of mRNA translation in diabetic nephropathy-amelioration by rapamycin; 2007 Jan. (J Am Soc Nephrol). Lee M. J., Sataranatarajan K., Mariappan M. M., Feliers D., Ghosh Choudhury G. and Kasinath B. S. Resveratrol ameliorates renal hypertrophy in diabetic mice; 2007 Jan. (J Am Soc Nephrol). Mariappan M. M., Sataranatarajan K.,Ghosh Choudhury G. and Kasinath B. S. Role of GSK3beta inactivation in high glucose- and high insulin-induced extracellular matrix protein synthesis in proximal tubular epithelial (MCT) cells; 2007 Jan. (J Am Soc Nephrol). Das F., Ghosh-Choudhury N., Li X., Mahimainathan L. and Ghosh Choudhury G. Transcriptional co-activator CBP regulates TGFbeta-induced PAI-1 expression by acetylation of Smad 3 in mesangial cells (MC); 2007 Jan. (J Am Soc Nephrol). Das F., Venkatesan B., Kasinath B. S. and Ghosh Choudhury G. Raptor-rictor antagonism regulates TGFbeta-induced protein synthesis in mesangial cells; 2007 Jan. (J Am Soc Nephrol). Ghosh-Choudhury G. Osteoblastic master regulator osterix mediates feedback regulation of BMP-2 auto-expression via PI 3 kinase/Akt signaling; 2007 Jan. (J Bone and Mineral Res). Mandal C. C., Drissi H., Ghosh Choudhury G. and Ghosh-Chouhdury N. BMP-2 inducible osterix increases CSF-1 and RANKL/OPG ratio to induce osteoclast maturation; 2007 Jan. (J Bone and Mineral Res). Mariappan M. M., Feliers D., Ghosh Choudhury G. and Kasinath B. S. Stimulation of laminb1 (lamb1) mRNA translation by high glucose (HG), high insulin (HI) and their combination (HG + HI) in proximal tubular epithelial (MCT) cells; 2006 Jan. (J Am Soc Nephrol). Sataranatarajan K., Mariappan M. M., Feliers D., Lee M. J., Ghosh Choudhury G., Barnes J. L. and Kasinath B. S. Amelioration of type 2 diabetes-associated kidney diseases by mammalian target of rapamycin (mTOR) inhibition; 2006 Jan. (J Am Soc Nephrol). Lee M. J., Feliers D., Mariappan M. M., Sataranatarajan K., Mahimainathan L., Musi N., Weinberg J., Ghosh Choudhury G. and Kasinath B. S. A role for AMP-activated protein kinase (AMPK) in diabetes-induced renal hypertrophy; 2006 Jan. (J Am Soc Nephrol). Ghosh-Choudhury G, Ghosh-Choudhury N, Mahimainathan L, Das, F. Transforming growth factor-beta (TGF β) ?stimulated PI 3 kinase/Akt signaling targets Smad3 transactivation for PAI-1 gene expression in mesangial cell (MC); 2006 Jan. (J Am Soc Nephrol). Venkatesan B., Mahimainathan L. and Ghosh Choudhury G. Signal relay from phospholipase C (PLC) and Src to phosphatidylinositol (PI) 3 kinase/Akt stimulates transforming growth factor-beta-induced fibronectin expression in mesangial cell (MC); 2006 Jan. (J Am Soc Nephrol). Mahimainathan L., Ghosh-Choudhury N., Habib S. L., Abboud H. E. and Ghosh Choudhury G. Antagonistic relationship between tuberin and PTEN is mediated by hypoxia-inducible factor1a (Hif1a); 2006 Jan. (J Am Soc Nephrol). Ghosh-Choudhury G. Sprouty-2 (Spy-2) intercepts MAPK-dependent transcription and mTOR mediated mRNA translation to inhibit PDGF-induced mitogenesis in mesangial cell; 2006 Jan. (J Am Soc Nephrol). Ghosh Choudhury G., Ghosh-Choudhury N., Mahimainathan L. and Das F. Transfroming growth factor-beta-stimualted PI 3 kinase/Akt signaling targets Smad 3 transactivation for PAI-1 gene expression mesangial cells; 2006 Jan. (J Am Soc Nephrol). Das F., Mahimainathan L., Kasinath B. S., Ghosh-Choudhury N. and Ghosh Choudhury G. Mechanism of transforming growth factor-beta (TGFb)-induced protein synthesis in mesangial cell hypertrophy; 2006 Jan. (J Am Soc Nephrol). Mahimainathan L, Das F, Ghosh-Choudhury N, Gorin Y, Kasinath BS, Abboud HE, Ghosh-Choudhury G. A Cross talk between two small GTPases Rac1 and Rheb regulates IGF-1-induced protein synthesis in mesangial cell (MC). [SA-PO788]; 2006 Jan. (J Am Soc Nephrol). Mahimainathan L, Ghosh-Choudhury N, Gorin Y, Mummidi S, Kasinath BS, Abboud HE, Ghosh-Choudhury G. Rheb trafficks IGF-1 signals in renal cells: Role of reactive oxygen species (ROS). (Abstract SA- PO177); 2005 Jan. (J Am Soc Nephrol; vol. 16). Ghosh-Choudhury G, Dai Q, Vankatesan B, Mahimainathan L. PI 3 kinase/Akt signaling cooperates with Smad 3 to regulate TGFβ-induced plasminogen activator inhibitor-1 (PAI-1) expression in mesangial cells (MC); 2005 Jan. (J Am Soc Nephrol; vol. 16). Nataranatarajan K, Mariappan MM, Ghosh-Choudhury G, Kasinath BS. Dual regulation of elongation phase of laminin mRNA translation by high glucose (HG) and high insulin (HI) in proximal tubular epithelial (MCT) cells; 2005 Jan. (J Am Soc Nephrol; vol. 16). Feliers D, Gorin Y, Ghosh-Choudhury G, Abboud HE, Kasinath BS. Angiotensin II-induced rapid phase increase in VEGF mRNA translation in renal tubular epithelial cells is dependent on reactive oxygen species production; 2005 Jan. (Diabetes; vol. 54, no. Sup 1). Feliers D, Lee MY, Ghosh-Choudhury G, Bomsztyk K, Kasinath BS. Role of heterogeneous nuclear ribonucleoprotein K (hnRNPK) in diabetic renal disease; 2005 Jan. (J Am Soc Nephrol; vol. 16). Marrippan MM, Ghosh-Choudhury G, Kasinath BS. Rapid stimulation of laminin beta1 synthesis by high glucose, high insulin and their combination is regulated by mRNA translation in proximal tubular epithelial cells; 2005 Jan. (J Am Soc Nephrol). Venkatesan B, Mahimainathan L, Dai Q, Ghosh-Choudhury G. Hydrogen peroxide (H2O2)-induced oxidative stress-mediated inactivation of FoxO1 regulates catalase expression in mesangial cells (MC); 2005 Jan. (J Am Soc Nephrol; vol. 16). Mahimainathan L, Ghosh-Choudhury G. High glucose-induced mesangial hypertrophy is mediated by PTEN, a target of TGFβ; 2005 Jan. (J Am Soc Nephrol; vol. 16). Gorin Y, Block K, Ricono J, Kim N-H, Bhandari B, Ghosh-Choudhury G, Abboud HE. Arachidonic acid-dependent activation of a Nox4/p22phox-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin synthesis via activation of Akt/PKB; 2005 Jan. (J Am Soc Nephrol; vol. 16). Venkatesan B., Mahimainathan L., Gorin Yl., Abboud H. E. and Ghosh Choudhury G. Activation of signaling complex containing PKC-epsilon (PKCe) and Akt kinase by phosphatidylinositol 3 kinase (PI 3 kinase) regualtes interferon-g (IFNg)-induced monocyte chemotactin protein-1 (MCP-1); 2005 Jan. (J Am Soc Nephrol). Feliers D, Gorin Y, Ghosh-Choudhury G, Abboud HE, Kasinath BS. Angiotensin II (Ang II)-Induced Rapid phase increase in VEGF mRNA translation in renal proximal tubular epithelial cells is dependent on reactive oxygen species (ROS); 2004 Oct. (J Am Soc Nephrol; vol. 15). Venkatesan B, Mahimainathan L, Gorin Y, Bhandari B, Valente AJ, Abboud HE, Ghosh-Choudhury G. Two signals emanating from phosphatidylinositol 3 kinase (PI 3-K) regulate interferon-gamma (IFN-gamma)-induced monocyte chemotactic protein-1 (MCP-1) expression in mesangial cells (MC); 2004 Oct. (J Am Soc Nephrol; vol. 15). Mahimainathan L, Ghosh-Choudhury G. Tumor suppressor PTEN regulates TGF beta and high glucose-induced mesangial hypertrophy: Involvement of Akt Kinase via PI 3 Kinase signaling; 2004 Jan. (Journal of Invest Medicine; vol. 52, no. S1). Mariappan M, Ghosh-Choudhury G, Kasinath BS. Novel role for PLC in regulation of VEGF-induced Erk activation in proximal tubular epithelial cells and its role in protein synthesis; 2004 Jan. (J Investig Med; vol. 52, no. Sup 1). Gorin Y., Ricono J. M., Wagner B., Kim N. H., Bhandari B., Ghosh Choudhury G. and Abboud H. E. Nox4 mediates angiotensin II-induced mesangial cell hypertrophy via activation of Akt/PKB; 2004 Jan. (J Invest Med). Chen X, Ghosh-Choudhury G, Madaio M, Kasinath BS. A role for VEGF in high glucose induction of VCAM-1 in glomerular endothelial (G-endo) cells; 2004 Jan. (J Am Soc Nephrol; vol. 15). Mahimainathan L, Danda R, Ghosh-Choudhury G. p27Kip1 cyclin kinase inhibitor regulates epidermal growth factor (EGF)-induced DNA synthesis via phosphatidylinositol 3 kinase (PI 3 K)- and PDK-1-dependent MAPK activity in mesangial cells (MC); 2004 Jan. (J Am Soc Nephrol; vol. 15). Mahimainathan L, Danda R. and Ghosh Choudhury G. p27kip-1 cyclin kinase regulates epidermal growth factor-induced DNA synthesis via phosphatidylinositol 3 kinase and PDK-1-dependent MAPK activity mesangial cells; 2004 Jan. (J Am Soc Nephrol). Chen X, Akis N, Ghosh-Choudhury G, Madaio M, Kasinath BS. Dual signaling pathways regulate vascular endothelial growth factor (VEGF) induction of eNOS in glomerular endothelial (G Endo) cells; 2004 Jan. (J Investig Med; vol. 52, no. Sup 1). Ye P., Habib S. L., Ricono J. M., Kim N. H., Ghosh Choudhury G., Barnes J. L., Abboud H. E and Arar M. Y. Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation; 2004 Jan. (Kidney Int). Mahimainathan L. and Ghosh Choudhury G. TGFbeta and high glucose downregulate the tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome 10) to regulate mesangial cell hypertrophy; 2003 Jan. (J AM Soc Nephrol). Chen X., Feliers D., Akis A., Ghosh Choudhury G., Madaio M. S. and Kasinath B. S. Vascular endothelial growth factor (VEGF) regulation of eNOS in glomerular endothelial (G Endo) cells; 2003 Jan. (J AM Soc Nephrol). Mahimainathan L, Ghosh-Choudhury G. Direct inactivation of PDGF receptor by tumor suppressor PTEN by adenovirus mediated gene transfer in mesangial cells; 2003 Jan. (Journal of Invest Medicine; vol. 51, no. S1). Simon M., Gorin Y., Bhandari B., Ghosh Choudhury G. and Abboud H. E. Tumor necrosis factor alpha modulates the apoptotic effect of anti-Thy-1 antibody; 2003 Jan. (TXSAN 2003). Ghosh-Choudhury N, Chandrasekar B, Abboud SL, Ghosh-Choudhury G. BMP-2 controls cardiomyocyte contractility by activating phosphatidylinositol 3 kinase signaling pathway; 2003 Jan. (J Bone Miner Res; vol. 18, no. supp2). Gorin Y., Ricono J. M., Kim N. H., simon M., Bhandari B., Ghosh Choudhury G. and Aboud H. E. Nox4 mediates angiotensin II-induced mesangial cell hypertrophy via activation of Akt/PKB; 2003 Jan. (TXSAN 2003). Wagner B., Ricono J. M., Gorin Y., Ghosh Choudhury G. Abboud H. E. PDGFRbeta-mediated PLC-gamma activation inhibits Akt (PKB) and Erk1/2 phosphorylation in metanephric mesenchymal cell; 2003 Jan. (National Kidney Foundation Clinical Meeting). Feliers D., Senthil D., Ghosh Choudhury G., Madaio M. S. and Kasinath B. S. Vascular endothelial growth factor (VEGF) regulation expression in proximal tubular epithelial cells (MCT) by angiotensin II; 2003 Jan. (J AM Soc Nephrol). Senthil D, Ghosh-Choudhury G, Kasinath BS. Stimulation of protein synthesis in mouse proximal tubular epithelial cells by VEGF: Potential relevance to diabetic nephropathy; 2003 Jan. (Diabetes; vol. 52, no. Sup 1). Senthil, D, Ghosh-Choudhury G, Kasinath BS. VEGF-regulation of protein synthesis in renal proximal tubular epithelial (PTE) cells. Importance of initial steps in protein translation; 2002 Jan. (Diabetes; vol. 51, no. Sup 2). Duraisamy S., Ghosh Choudhury G. and Kasinath B. S. Type 2 VEGF receptor recruits IRS-1 in the signaling pathway; 2002 Jan. (Keystone Symposia Protein Phosphorylation and Mechanisms of Cellular Regulation). Duraisamy S, Ghosh-Choudhury G, Kasinath BS. Type 2 VEGF receptor (Flk-1/KDR), recruits IRS-1 in its signaling pathway; 2002 Jan. (Diabetes; vol. 51, no. Sup 2). Bhandari B, Senthil, D, Faulkner, JL, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Regulation of protein tyrosine phosphatases PTP) in Type 2 diabetes; 2002 Jan. (Diabetes; vol. 51, no. Sup 2). Senthil, D, Ghosh-Choudhury G, Kasinath BS. Angiotensin II (Ang II) regulates expression of vascular endothelial growth factor (VEGF) and Type 2 VEGF receptor in proximal tubular epithelial (PTE) cells; 2002 Jan. (Diabetes; vol. 51, no. Sup 2). Ghosh Choudhury G. PI 3 kianse/Akt signaling cascade regulates TGFb-induced fibronectin expression in glomerular mesangial cells (MC); 2002 Jan. (Keystone Symposia Protein Phosphorylation and Mechanisms of Cellular Regulation). Ghosh-Choudhury N, Abboud SL, Ghosh-Choudhury G. BMP-2-induced phosphatidylinositol 3 kinase (PI 3-K) regulates GATA-4 and MEF-2 transcription factors during cardiomyocyte differentiation; 2002 Jan. (J Bone Miner Res; vol. 17). Ghosh-Choudhury N., Abboud S. L. and Ghosh Choudhury G. Recruitment of transcriptional coactivator CREB binding protein (CBP) during BMP-2-induced stimulation of clolony stimulating factor-1 (CSF-1) gene transcription: A role of BMP-2 in osteoclastogenesis; 2002 Jan. (4th International Conference on BMPs). Senthil D., Faulkner J. L., Ghosh Choudhury G., Abboud H. E. and Kasinath B. S. Angiotensin II inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E biding protein 4EBP-1 in renal epithelial cells; 2001 Jan. (Keystone Symposia, Signaling Systems: Chemistry, Bilogy and Pathology). Riley DJ, Fred-Miranda I, Abboud HE, Ghosh-Choudhury G. Bone morphogenetic protein 2 attenuates mesangioproliferative glomerulonephritis in rats; 2001 Jan. (J Am Soc Nephrol; vol. 12). Senthil D., Faulker J. L., Ghosh Choudhury G., Abboud H. E. and Kasinath B. S. Angiotensin II (AII) inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4EBP-1) in renal epithelial (PTE) cells; 2001 Jan. (Diabetes; vol. 50). Faulkner JL, Gadre S, Senthil D, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Activation of renal cortical PI 3 kinase, Akt (PKB) and Erk-1/2 type MAPK but not of p38 MAPK, is associated with renal hypertrophy in mice with type 1 diabetes; 2001 Jan. (Diabetes; vol. 50, no. Sup 2). Ghosh-Choudhury N, Abboud SL, Ghosh-Choudhury G. Phosphatidylinositol 3 kinase (PI 3-K) and Akt serine/threonine kinase regulate BMP-2 induced osteoblast differentiation and Smad-dependent transcription of BMP-2 gene; 2001 Jan. (J Bone Miner Res; vol. 16). Senthil D., Faulkner J. L., Abboud H. E., Ghosh Choudhury G. and Kasinath B. S. IGF-1 stimulates eukaryotic initiation factor 4E (eIF4E) binding protein 4EBP-1 phosphorylation in PTE cells; 2001 Jan. (Keystone Symposia, Signaling Systems: Chemistry, Bilogy and Pathology). Ghosh Choudhury G. c-Src dependent phosphatidylinositol 3 kinase (PI 3 K) and Erk1/2 (MAPK) regulate PDGF-induced DNA synthesis in glomerular mesangial cells; 2001 Jan. (Keystone Symposia, Signaling Systems: Chemistry, Bilogy and Pathology). Senthil D, Faulkner JL, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Vascular endothelial growth factor (VEGF) recruits insulin receptor substrate (IRS-1) in its signaling pathway; 2001 Jan. (J Am Soc Nephrol Abstract A3063; vol. 12). Ghosh-Choudhury G. PDGF-stimulated phosphatidylinositol 3 kinase (PI 3-K) target Akt regulates forkhead transcription factor and p27Kip1 cyclin kinase inhibitor gene transcription in mesangial cells (MC): Potential role in regulation of PDGF-induced DNA synthesis. (Abstrac; 2001 Jan. (J Am Soc Nephrol; vol. 12). Senthil D, Bhandari B, Feliers D, Faulkner JL, Ghosh-Choudhury G, Abboud HE, Kasinath BS. PI 3 kinase and mTOR are required for insulin induced phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4EBP1) in proximal tubular epithelial (PTE) cells; 2000 Jan. (Diabetes; vol. 49, no. Sup 1). Senthil D., Faulkner J. L., Ghosh Choudhury G., Abboud H. E. and Kasinath B. S. Angiotensin II inhibits insulin-dependent phosphorylation of eukariotic initiation factor 4E (eIF4E) binding protein (4EBP-1) in mouse proximal tubular epithelial cells: Cross talk between angiotensin II receptor and insulin receptor signal transduction; 2000 Jan. (J AM Soc Nephrol; vol. 11). Ghosh-Choudhury G. Akt serine threonine kinase regulates PDGF-induced DNA synthesis and MAPK ?dependent c-fos gene transcritpion in mesangial cells: Use of adenovirus mediated gene transfer; 2000 Jan. (J Am Soc Nephrol; vol. 11). Faulkner JL, Feliers D, Senthil D, Ghosh-Choudhury G, Abboud HE, Kasinath BS. Renal cortical Akt (PKB) kinase activation in db/db mice with type 2 diabetes; 2000 Jan. (Diabetes; vol. 49, no. Sup 1). Ghosh-Choudhury N., Abboud S. L. and Ghosh Choudhury G. Mechanism for inhibitor role of BMP-2 on growth of estrogen-responsive and non-responsive human breast cancer cells; 2000 Jan. (International Symposium on BMPs). Feliers D, Faulkner JL, Senthil D, Lee AV, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Regulation of PI 3 kinase, Akt and MAP kinase pathways in the kidney and liver of db/db mice with type 2 diabetes; 2000 Jan. (Diabetes; vol. 49, no. Sup 1). Faulkner JL, Senthil D, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Increase in renal cortical Akt (PKB) and Erk-1 type MAP kinase activities is associated with renal hypertrophy in type I diabetes; 2000 Jan. (J Am Soc Nephrol; vol. 11). Ricono JM, Zhang BX, Ghosh-Choudhury G, Soriano P, Abboud HE. Differential effect of PDGF AA and BB on migration of metanephric mesenchymal cells (MMC): Role of calcium; 2000 Jan. (J Am Soc Nephrol; vol. 11). Senthil D, Faulkner JL, Abboud HE, Ghosh-Choudhury G, Kasinath BS. IGF-I-stimulated eukaryotic initiation factor 4E (eIF4E) binding protein 4EBP-1 phosphorylation: Cross talk between PI 3 kinase and Erk-1 type MAP kinase pathways in mouse proximal tubular epithelial (PTE) cells; 2000 Jan. (J Am Soc Nephrol; vol. 11). Faulkner JL, Senthil D, Feliers D, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Activation of renal cortical Akt (PKB) in db/db mice with type II diabetes may be mediated by insulin; 2000 Jan. (J Am Soc Nephrol; vol. 11). Ghosh-Choudhury N, Ghosh-Choudhury G, Woodruff KA, Bsoul S, Nishimura R, Qi W, Celeste A, Abboud SL. Identification of a smad-binding element (SBE) in BMP-2 responsive CSF-1 gene promoter: a mechanism of BMP-2-mediated transregulation of osteoclastogenesis during bone remodeling; 2000 Jan. (J Bone Miner Res; vol. 15). Gorin Y, Kim N-H, Bsoul S, Feliers D, Zhang J-H, Ghosh-Choudhury G, Abboud HE. Induction of hypertrophy by angiotensin II in glomerular mesangial cells via an arachidonic acid and redox dependent pathway involving extracellular signal regulated protein kinase; 2000 Jan. (J Am Soc Nephrol; vol. 11). Ghosh-Choudhury G, Calhoun C. c-Src tyrosine kinase regulates PDGF-induced mitogenic signaling in mesangial cells (MC) via regulation of Akt serine threonine kinase; 2000 Jan. (J Am Soc Nephrol; vol. 11). Gorin Y, Feliers D, Eakes AT, Ghosh-Choudhury G, Abboud HE. Angiotensin II-induced activation of Akt/protein kinase B serine/threonine kinase in mesangial cells: Involvement of phosphoinositide 3-kinase-independent and redox-dependent mechanisms; 1999 Sep. (J Am Soc Nephrol; vol. 10). Ghosh Choudhury G. Jin D. C., Kim Y. S., Celeste A., Ghosh-Choudhury N. and Abboud H. E. Bone morphogenetic protein 2 (BMP-2) inhibits EGF-induced DNA synthesis in mesangial cells (MC) via blocking MAPK-dependent Elk-1 transactivation and by increasing p21 cyclin kinase inhibitor transcription respectively; 1999 Jan. (J AM Soc Nephrol; vol. 10). Ghosh-Choudhury N, Ghosh-Choudhury G, Besoul S, Woodruff KA, Abboud SL. Regulation of CSF-1 gene transcription by BMP-2 during osteoblast differentiation: Mapping of BMP-2 responsive element; 1999 Jan. (J Bone Miner Res; vol. 14). Ghosh-Choudhury G, Gilroy J. Synergistic action of interferon-gamma (IFNgamma) on PDGF-induced DNA synthesis is mediated via c-fos gene transcription in mesangial cells; 1999 Jan. (J Am Soc Nephrol; vol. 10). Gilroy JM, Zheng B, Ghosh-Choudhury G, Arar MY, Abboud HE. Signaling of PDGF isoforms in PDGF beta receptor deficient metanephric mesenchymal cells (MMC): PDGF alpha mediates migration but not DNA synthesis; 1999 Jan. (J Am Soc Nephrol; vol. 10). Ghosh-Choudhury G, Jin D-C, Kim Y-S, Celeste A, Ghosh-Choudhury N, Abboud HE. Bone morphogenetic protein 2 (BMP-2) inhibits EGF-induced DNA synthesis in mesangial cells (MC) via blocking MAPK-dependent Elk-1 transactivation and by increasing p21 cyclin kinase inhibitor transcription respectively; 1999 Jan. (J Am Soc Nephrol; vol. 10). Ghosh-Choudhury G, Kyomoto H, Abboud HE. Activation of PDGF receptor beta (PDGFR) induces PI 3 kinase and MAPK in Thy-1-induced mesangioproliferative glomerulonephritis in rats; 1999 Jan. (J Am Soc Nephrol; vol. 10). Arar MY, Gonzalez M, Gilroy J, Bunegin M, Ghosh-Choudhury G, Barnes JL, Elshihabi I, Abboud HE. Effect of fibronectin on tubulogenesis; 1999 Jan. (J Am Soc Nephrol; vol. 10). Ghosh-Choudhury G. MAPK regulates EGF-induced DNA synthesis via Elk-1-dependent transcription in mesangial cells (MC); 1999 Jan. (J Am Soc Nephrol; vol. 10). Gorin Y., Feliers D., Eakes A. T., Ghosh Choudhury G. and Abboud H. E. Oxidative stress in glomerular mesangial cells: Activation of Erk kinase by angiotensin II in cells via a redox-dependent pathway; 1999 Jan. (Keystone Symposia Specificity in Signal Transduction). Kasinath B. S., Feliers D., Stewart J. L., Abboud H. E. and Ghosh Choudhury G. Activation of PI 3 kinase and MAP kinase pathways in the kidney of mice with type 2 diabetes; 1999 Jan. (Keystone Symposia Specificity in Signal Transduction). Abboud SL, Woodruff K, Ghosh-Choudhury G. Putative cis-acting elements in the 5? flanking region of the CSF-1 promoter involved in cell-specific gene expression of CSF-1; 1998 Jan. (J Bone Miner Res; vol. 23). Ghosh Choudhury G., Grandaliano G., Gilroy J. and Abboud H. E. Protein kinase C regulates PDGF-induced STAT1a activation in glomerular mesangial cells; 1998 Jan. (Keystone Symposia Specificity in Signal Transduction). Feliers D, Grandaliano G, Wenzel U, Valente AJ, Ghosh-Choudhury G, Abboud HE. PDGF stimulates MCP-1 transcription in rat mesangial cells; 1998 Jan. (FASEB J). Eakes AT, Abboud HE, Ghosh-Choudhury G. Stimulation of Akt kinase by interferon gamma and PDGF in cultured mesangial cells; 1998 Jan. (Mol Biol Cell; vol. 9). Ghosh-Choudhury N, Ghosh-Choudhury G, Celeste A., Ghosh P, Stapleton M., Kreisberg J. Bone morphogenetic protein 2 blocks estrogen-induced human breast cancer cell growth by intercepting mitogen activated protein kinase (MAPK)-dependent nuclear signals; 1998 Jan. (Bone; vol. 22). Gilroy JM, Arar MY, Nishihara F, Jin DC, Ghosh-Choudhury G, Abboud HE. Differential mitogenic signaling of platelet-derived growth factor (PDGF) isoforms in metanephric mesenchymal cells (MMC): Activation of phosphatidylinositol 3 kinase (PI 3K) and mitogen activated protein kinase (MAPK); 1998 Jan. (Mol Biol Cell; vol. 9). Ghosh Choudhury G. Kim Y. S., Simon M., Ghosh-Choudhury N., Wozney J., Harris H. E. and Abboud H. E. Antagonism of PDGF receptor -induced mitogenesis by bone morphogenetic protein 2 in glomerular mesangial cells: Interception of mitogen-activated protein kinase dependent c-fos gene expression; 1998 Jan. (Internatioal Society of Nephrology Forefronts in Nephrology Symposium, Wyoming). Ghosh-Choudhury N, Celeste A, Harris SE, Ghosh-Choudhury G. Bone morphogenetic protein 2 (BMP-2)-induced osteoblast cell proliferation is mediated by mitogen-activated protein kinase (MAPK)-dependent c-fos gene transcription; 1998 Jan. (Bone; vol. 22). Ghosh-Choudhury G, Abboud HE. PDGF-induced serine phosphorylation of STAT1alpha regulates its transcriptional activity in mesangial cells (MC); 1998 Jan. (Am Soc Nephrol; vol. 9). Abboud SL, Woodruff K, Ghosh-Choudhury G. Potential cis-acting elements in the 5? flanking region of the IGFBP5 promoter required for basal promoter activity in stromal cells and osteoblasts; 1998 Jan. (J Bone Miner Res; vol. 23). Duch JM, Lee A, Stewart JL, Ghosh-Choudhury G, Kasinath BS. Activation of signaling pathways in the renal cortex of type II diabetic mice; 1998 Jan. (J Am Soc Nephrol; vol. 9). Bardgette J, Abboud HE, Yee J, Woodruff K, Abboud SL, Ghosh-Choudhury G. Retroviral mediated gene transfer of angiotensin II (AII) receptor type I into glomerular mesangial cells (MC): Studies on cell hypertrophy; 1997 Jan. (J Am Soc Nephrol; vol. 8). Ghosh Choudhury G., Kim Y. S., Bardgette J., Ghosh-Choudhury N., Wozney J., Harris S. E. and Abboud H. E. Bone morphogenetic protein 2 (BMP-2) inhibits PDGF-induced c-fos gene transcription in a PI 3 kinase and MAPK dependent manner leading to inhibition of mitogenesis in mesangial cells (MC); 1997 Jan. (J AM Soc Nephrol; vol. 8). Ghosh Choudhury G., Kim Y. S., Simon M., Wozney J., Harris S. E. and Abboud H. E. Bone morphogenetic protein 2 (BMP-2) inhibits human glomerular mesangial cell (MC) growth: Negative regulation by protein kinase C alpha; 1997 Jan. (2nd International Conference on BMPs, Sacramento, CA). Bardette J, Abboud HE, Wenzel UO, Ghosh-Choudhury G. Protein tyrosine phosphatases regulateSTAT1 in cultured mesangial cells; 1996 Jan. (J Am Soc Nephrol; vol. 7). Ghosh-Choudhury G, Marra F, Abboud HE. Interferon-gamma-stimulated STAT1alpha regulates receptor tyrosine kinase mediated DNA synthesis in glomerular mesangial cells; 1996 Jan. (Mol Biol Cell; vol. 7). Ghosh-Choudhury G. Phosphatidylinositol 3 kinase regulates glomerular mesangial cell chemotaxis and proliferation: Involvement of mitogen activated protein kinase dependent and independent pathways; 1996 Jan. (FASEB J; vol. 10). Simon M, Uttomo MA, Ghosh-Choudhury G, Abboud HE. Effects of Shiga-like toxin (SLT-1) on human mesangial cells; 1996 Jan. (J Am Soc Nephrol; vol. 7). Ghosh-Choudhury G, Abboud H. Direct activation of STAT1 by platelet-derived growth factor receptor (PDGFR) in mesangial cells (MC); 1996 Jan. (J Am Soc Nephrol; vol. 7). Arar MY, Elshihabi I, Ghosh-Choudhury G, Gentilini A, Abboud HE. Effect of platelet-derived growth factor b-chain on glomerulogenesis; 1996 Jan. (J Am Soc Nephrol; vol. 7). Park J, Yee J, Ghosh-Choudhury G, Kiyomoto H, Lianos E, Abboud HE. Differential expression of plasminogen activator inhibitor 1 (PAI-1), urokinase type plasminogen activator (uPA) and matrix metalloproteinase 2 (MMP-2) in mesangioproliferative glomerulonephritis (MesGN) in rats; 1996 Jan. (J Am Soc Nephrol; vol. 7). Ghosh-Choudhury G, Gentilini A, Karamitsos C, Abboud HE. Phosphatidylinositol 3 kinase (PI3 K) and protein kinase alpha (PKC-alpha) regulate human mesangial cell (MC) migration in response to platelet-derived growth factor (PDGF); 1996 Jan. (J Am Soc Nephrol; vol. 7). Ghosh-Choudhury G, Marra F, Abboud HE. Association of the SH2-SH3-domain-containing adaptor protein Nck with focal adhesion kinase in thrombin-stimulated mesangial cells; 1995 Jan. (J Am Soc Nephrol; vol. 6). Ghosh-Choudhury G, Marra F, Abboud HE. Association of the SH2-SH3 domain containing adaptor protein Nck with a tyrosine phosphorylated protein p125 in thrombin-stimulated mesangial cell; 1995 Jan. (Proceedings of the American Association of Cancer Research; vol. 36). Kiyomoto H, Park IS, Ghosh-Choudhury G, Abboud HE. Stimulation of mitogen activated protein kinase (MAPK) and suppression of protein tyrosine phosphatase (PTPase) in experimental proliferative glomerulonephritis; 1995 Jan. (J Am Soc Nephrol; vol. 6). Ghosh-Choudhury G, Marra F, Abboud HE. Platelet-derived growth factor (PDGF) stimulates tyrosine phosphorylation of Janus kinase 1 (JAK 1) protein tyrosine kinase in human mesangial cells (MC); 1995 Jan. (J Am Soc Nephrol; vol. 6). Wenzel UO, Bhandari B, Ghosh-Choudhury G, Valente AJ, Abboud HE. A reporter mesangial cell line transfected with a monocyte chemoattractant protein 1 (MCP-1) promoter. Transcriptional activation by thrombin; 1995 Jan. (J Am Soc Nephrol; vol. 6). Kiyomoto H, Ghosh-Choudhury G, Fouqueray B, Abboud HE. Activation of glomerular phosphotyrosine phosphatase in streptozotocine-induced diabetes (STZD) in the rat; 1994 Jan. (J Am Soc Nephrol; vol. 5). Ghosh-Choudhury G, Abboud H. Vanadate activates phosphatidylinositol 3 kinase (PI 3 kinase) via enhanced tyrosine phosphorylation of platelet-derived growth factor receptor beta (PDGFRbeta) in human mesangial cells (HMC); 1994 Jan. (J Am Soc Nephrol; vol. 5). Kasinath BS, Grellier P, Terhune WC, Maldonado R, Ghosh-Choudhury G, Abboud SL. High glucose medium reduces glomerular basement membrane (GBM) heparan sulphate proteoglycan (HSPG) core protein gene expression in glomerular epithelial cells; 1994 Jan. (J Am Soc Nephrol; vol. 5). Kiyomoto H, Abboud HE, Fouqueray B, Ghosh-Choudhury G. Phorbol myristate acetate (PMA)-induced inhibition of the cytoplasmic tyrosine phosphatase PTP1B enhances tyrosine phosphorylation in human mesangial cells (HMC); 1994 Jan. (J Am Soc Nephrol; vol. 5). Kasinath BS, Grellier P, Terhune WC, Ghosh-Choudhury G, Maldonado R, Abboud SL. Regulation of basement membrane (BM) heparansulphate proteoglycan (HSPG) core protein gene expression by high glucose medium in glomerular epithelial cells (GEC); 1994 Jan. (Clin Res; vol. 43). Kiyomoto H, Biswas P, Ghosh-Choudhury G, Abboud HE. Activation of renal protein kinase C isoforms in streptozotocin-induced diabetes (STZD); 1993 Jan. (J Am Soc Nephrol; vol. 4). Wenzel U, Grandaliano G, Fouqueray B, Ghosh-Choudhury G, Abboud HE. Vanadate induces mitogenesis and platelet-derived growth factor B-chain gene expression in human mesangial cells; 1993 Jan. (J Am Soc Nephrol; vol. 4). Ghosh-Choudhury G, Biswas P, Grandaliano G, Abboud HE. Thrombin-mediated Mitogenic signaling involves protein kinase C alpha (PKC-alpha) in human glomerular mesangial cells; 1993 Jan. (FASEB J; vol. 7). Biswas P, Ghosh-Choudhury G, Grandaliano G, Abboud HE. Thrombin stimulates DNA synthesis and PDGF B chain mRNA expression via different signaling pathways in human mesangial cells; 1993 Jan. (J Am Soc Nephrol; vol. 4). Fougueray B, Ghosh-Choudhury G, Grandaliano G, Biswas P, Wenzel U, Abboud HE. Involvement of protein tyrosine phosphatases in human mesangial cell early signaling; 1993 Jan. (J Am Soc Nephrol; vol. 4). Ghosh-Choudhury G, Grandaliano G, Abboud HE. Differential activation of PDGF-receptor subunits by homo- and heterodimeric forms of PDGF; 1993 Jan. (J Am Soc Nephrol; vol. 4). Grandaliano G.,Ghosh Choudhury G., Biswas P. and Abboud H. E. Mitogenic signaling of thrombin in mesangial cells: Role of tyrosine phosphorylation; 1993 Jan. (J AM Soc Nephrol; vol. 4). Biswas P, Ghosh-Choudhury G, Grandaliano G, Abboud HE. Platelet-derived growth factor (PDGF)-induced mitogenesis involves activation of protein kinase C-alpha (PKC-alpha) in human glomerular mesangial cells (HMC); 1992 Jan. (J Am Soc Nephrol; vol. 3). Ghosh-Choudhury G, Biswas P, Abboud HE. Activation of phosphatidylinositol 3 kinase in human mesangial cells in response to platelet-derived growth factor; 1992 Jan. (J Am Soc Nephrol; vol. 3). Sakaguchi A. Y., Sylvia V. L., Martinez L., Lalley P. A., Shows T. B., Han E. S., Smith E. A. and Ghosh Choudhury G. Assignment of tyrosine specific T-cell phosphatase to conserved syntenic groups on human chromosome 18 and mouse chromosome 18; 1991 Jan. (11th International Workshop on Human Gene Mapping). Sylvia V. L., Ghosh Choudhury G., Fernandes G., Lee B. K. and Sakaguchi A. Y. Colony stimulating factor-1 receptor-mediated signal transduction in macrophages declines with age; 1990 Jan. (43rd Annual Symposium on Fundamental Cancer Research). Ghosh Choudhury G., Sylvia V. L., Harvey S. and Sakaguchi A. Y. Dysregulation of serum-induced signal transduction in aging fibroblast; 1990 Jan. (43rd Annual Symposium on Fundamental Cancer Research). GhoshChoudhury G., Wang L. M., Sylvia V. L., Martinez L. and Sakaguchi A. Y. Human colony stimulating factor-1 receptor activates two potential signal transducing molecules; 1990 Jan. (Texas Genetics Society 17th Annual Meeting, Austin). Ghosh Choudhury G., Wang L. M., Martinez L., Han E. S. and Sakaguchi A. Y. Human colony stimulating factor-1 receptor associates with a phosphatidylinositol kinase: A mutational analysis; 1989 Jan. (Human Genetics; vol. 45).

      Journal Article

      Shi Q., Viswanadhapalli S., Friedrichs W. E., Velagapudi C., Szyndralewiez C., Bansal S. , Bhat M.,*Ghosh Choudhury G and Abboud H. E. (*corresponding author). Nox4 is a target for tuberin deficiency syndrome Scientific Reports 2018 Feb;8. Das F., Ghosh-Choudhury N., Kasinath B. S., Ghosh-Choudhury G. Tyrosines-740/751 of PDGFRbeta contribute to the activation of Akt/Hif1a/TGFb nexus to drive high glucose-induced glomerular mesangial cell hypertrophy Cellular Signalling 2018 Jan;42:44-53. Maity S., Bera A., Ghosh-Choudhury N., Das F., Kasinath B. S., Ghosh-Choudhury G. microRNA-181a downregulates deptor for TGFbeta-induced glomerular mesangial cell hypertrophy and matrix protein expression Experimental Cell Research 2018 Jan;364:5-15. Lee HJ, Lee DY, Mariappan MM, Feliers D, Ghosh-Choudhury G, Abboud HE, Gorin Y, Kasinath BS. Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells J Biol Chem 2017 Apr;292(14):5665-5675. Bera A., Das F., Ghosh-Choudhury N., Mariappan M. M., Kasinath B. S., Ghosh-Choudhury G. Reciprocal expression of miR-214 and PTEN by high glucose regulates glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion (Dr. Bera received a Rising Star Award by the New Brunswick Health Research Foundation, Canada American Journal of Physiology Cell Physiology 2017 Jan;313:C430-C447. Das F., Ghosh-Choudhury N., Venkatesan B., Kasinath B. S., Ghosh-Choudhury G. PDGF receptor-beta uses Akt/mTORC1 node to promote high glucose-induced renal proximal tubular epithelial cell collagen I (alpha2) expression American Journal of Physiology Renal Physiology 2017 Jan;313:F291-F307. Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, Mariappan MM, Tabatabai-Mir H, Diaz V, Prasad S, Javors MA, Choudhury GG, Hubbard GB, Barnes JL, Richardson A, Kasinath BS. Rapamycin increases mortality in db/db mice, a mouse model of type-2 diabetes J Gerontol A Biol Sci Med Sci 2016 Jan;71:850-857. Das F., Dey N., Bera A.,Ghosh-Choudhury N., Kasinath B. S., Ghosh-Choudhury G. MicroRNA-214 reduces insulin-like growth factor-1 (IGF-1) receptor expression and downstream mTORC1 signaling in renal carcinoma cells Journal of Biological Chemistry 2016 Jan;291:14662-14676. Mandal CC, Das F, Ganapathy S, Harris SE, Ghosh-Choudhury G, Ghosh-Choudhury N. Bone Morphogenetic Protein-2 (BMP-2) Activates NFATc1 Transcription Factor via an Autoregulatory Loop Involving Smad/Akt/Ca2 Signaling J Biol Chem 2016 Jan;291:1148-1161. Das F, Ghosh-Choudhury N, Mariappan MM, Kasinath BS, Ghosh-Choudhury G. Hydrophobic Motif Site-phosphorylated Protein Kinase CβII between mTORC2 and Akt Regulates High Glucose-induced Mesangial Cell Hypertrophy Am J Physiol Cell Physiol 2016 Jan;310(7):C583-C596. Lee HJ, Feliers D, Mariappan MM, Sataranatarajan K, Ghosh-Choudhury G, Gorin Y, Kasinath BS. Tadalafil integrates nitric oxide-hydrogen sulfide signaling to inhibit high glucose-induced matrix protein synthesis in podocytes J Biol Chem 2015 Jan;290:12014-12026. Dey N., Bera A., Das F., Ghosh-Choudhury N., Kasinath B. S. and Ghosh Choudhury G. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression Cell Signal 2015 Jan;27:1276-1285. Bera A, Das F, Ghosh-Choudhury N, Li X, Pal S, Gorin Y, Kasinath BS, Abboud HE, Ghosh-Choudhury G. A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF Am J Physiol Cell Physiol 2014 Jun;306(11):C1089-C1100. Mariappan MM, Prasad, S, D`Silva, K, Cedillo, E, Sataranatarajan, K, Ghosh-Choudhury G, Kasinath BS. Activation of glycogen synthase kinase 3beta ameliorates diabetes-induced kidney injury J Biol Chem 2014 Jan;289:35363-35375. Ricono JM*, Wagner B* (Corresponding Author), Gorin Y, Arar MY, Kazlauskas A, Ghosh-Choudhury G, Abboud HE. *Equally contributing authors. PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA Am J Physiol Renal Physiol 2009 Feb;296(2):406-417. Wagner B*, Ricono JM*, Gorin Y, Block K, Arar MY, Riley DJ, Choudhury GG, Abboud HE. *Equally contributing authors. Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells J Am Soc Nephrol 2007 Nov;18(11):2903-2911. Kim NH, Rincon-Choles H, Bhandari B, Ghosh-Choudhury G, Abboud HE, Gorin Y (Corresponding Author). Redox dependence of glomerular epithelial cell hypertrophy in response to glucose Am J Physiol Renal Physiol 2006 Jul;290(1):F741-F751. Mariappan MM, Senthil D, Natarajan KS, Ghosh-Choudhury G, Kasinath BS. Phospholipase Cgamma-Erk Axis in vascular endothelial growth factor-induced eukaryotic initiation factor 4E phosphorylation and protein synthesis in renal epithelial cells J Biol Chem 2005 Aug;280(31):28402-28411. Gorin Y, Ricono JM, Wagner B, Kim N-H, Bhandari B, Ghosh-Choudhury G, Abboud HE. Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells Biochem J 2004 Jul;381:231-239. Ye P., Habib S. L., Ricono J. M., Kim N. H., Ghosh Choudhury G., Barnes J. L., Abboud H. E. and Arar M. Y. Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation Kidney Int 2004 Jan;:1356-1364.

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      Lee H. J., Feliers D., Barnes J L., Oh S., Ghosh Choudhury G., Diaz V., Galvan V., Strong R., Nelson J, Salmon A., Kevil C. G. and Kasinath B. S. Hydrogen sulfide ameliorates aging-associated changes in the kidney GeroScience 2018 Jan;.