Part of UT Health San Antonio

Part of UT Health San Antonio

You are here

Sandeep Burma, PhD

Departments & Divisions

Institutes & Centers

Currently seeking M.S. & Ph.D. students

Sandeep Burma, Ph.D.

Professor, Vice Chair (Research), Mays Family Foundation Distinguished Chair in Oncology

Research in the Burma Laboratory is focused on the responses of mammalian cells to DNA double-strand breaks (DSBs), collectively called the DNA damage response (DDR). We are involved in studying DDR events triggered by ionizing radiation and their carcinogenic and cancer therapeutic implications. We are particularly interested in 1) understanding DSB signaling and repair mechanisms with a focus on the regulation of DNA end resection by EXO1, 2) genetic basis of radio- and chemo-resistance of glioblastomas (GBM), with the translational objective of targeting DNA repair pathways for GBM therapy, and 3) genetic changes underlying gliomagenesis triggered by ionizing radiation, the only known risk factor for the development of GBM. A more mechanistic understanding of DDR events has emerged from our studies, providing important insights into how GBM is triggered, and leading to the development of better therapeutic approaches for GBM.  

  • Professional Background

    Education

    • 1995 - Ph.D. - Molecular Biology - National Institute of Immunology, India
    • 1990 - M.Sc. - Zoology (Specialization in Molecular Genetics and Cytogenetics) - Banaras Hindu University, India
    • 1988 - B.Sc - Botany, Zoology, Chemistry (Honors in Zoology) - Banaras Hindu University, India

    Training

    • 1999 - Postdoctoral Associate - DNA Repair - Life Sciences Division, Los Alamos National Laboratory
    • 1998 - Postdoctoral Associate - Transcription Regulation - Dept. of Biochemistry & Mol. Biology, Pennsylvania State University
    • 1996 - Postdoctoral Associate - Transcription Regulation - Dept. of Mol. Biophysics & Biochemistry, Yale University

  • Publications

      Original Research Articles:

      EGFR inhibition triggers an adaptive response driven by cooptation of antiviral signaling pathways in lung cancer. K. Gong, G. Guo, S. Panchani, M. Bender, D.E. Gerber, J.D. Minna, F. Fattah, B. Gao, M. Peyton, K. Kernstine, B. Mukherjee, S. Burma, C.M. Chiang, Z. Zhang, A.A. Sathe, C. Xing, K.H. Dao, D. Zhoa. E.A. Akbay, and A.A. Habib Nature Cancer (2020) In Press

      Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas. P.K. Todorova, E. Fletcher-Sananikone, B. Mukherjee, R. Kollipara, V. Vemireddy, X.J. Xie, P. Guida, M.D. Story, K.J. Hatanpaa, A.A. Habib, R. Kittler, R.M. Bachoo, R. Hromas, J. Floyd, and S. Burma Cancer Research 79:3749-3761 (2019)

      MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers. G. Srinivasan, E.A. Williamson, K. Kong, A.S. Jaiswal, G. Huang, H.S. Kim, O. Schärer, W. Zhao, S. Burma, P. Sung, and R. Hromas Proc Natl Acad Sci U S A. 116:17438-17443 (2019)

      Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma. G. Guo, K. Gong, V.T. Puliyapaddamba, N. Panchani, E. Pan, B. Mukherjee, Z. Damanwalla, S. Bharia, K.J. Hatanpaa, D. E. Gerber, B.E. Mickey, T.R. Patel, J.N. Sarkaria, D. Zhao, S. Burma, and A.A. Habib Neuro Oncology (2019) [Epub ahead of print]

      TNF drives an adaptive response that mediates resistance to EGFR inhibition in lung cancer. K. Gong, G. Guo, D.E. Gerber, B. Gao, M. Peyton, C. Huang, J.D. Minna, K.J. Hatanpaa, K. Kernstine, L. Cai, Y. Xie, H. Zhu, F.J. Fattah, S. Zhang, M. Takahashi, B. Mukherjee, S. Burma, J. Dowell, K. Dao, V.A. Papadimitrakopoulou, V. Olivas, T.G. Bivona, M. Ma, K. Politi, D. Zhao, and A. A. Habib Journal of Clinical Investigation 128:2500-2518 (2018)

      BRD4 promotes DNA repair and mediates the formation of TMPRSS2ERG gene rearrangements in prostate cancer. X. Li, G-H. Baek, S.G. Ramanand, A. Sharp, Y. Gao, W. Yuan, J. Welti, D.N. Rodrigues, D. Dolling, I. Figueiredo, S. Sumanasuriya, M. Crespo, A. Aslam, R. Li, Y. Yin, B. Mukherjee, M. Kanchwala, A.M. Hughes, W.S. Halse, C-M. Chiang, C Xing, G.V. Raj, S. Burma, J. de Bono, and R.S. Mani Cell Reports 22:796-808 (2018)

      A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma. G. Guo, K. Gong, S. Ali, N. Ali, S. Shallwani, K.J. Hatanpaa, E. Pan, B. Mickey, S. Burma, S. Kesari, Dawen Zhao, and A.A. Habib Nature Neuroscience 8:1074-1084 (2017)

      EGFR mutations compromise hypoxia-associated radiation resistance through impaired replication fork-associated DNA damage repair. M. Saki, H. Makino, P. Javvadi, N. Tomimatsu, L. Ding, J. Clark, E. Gavin, K. Takeda, J. Andrews, D. Saha, M.D. Story, S. Burma, and C. Nirodi Molecular Cancer Research 22:796-808 (2017)

      Androgen receptor variants mediate DNA repair following radiation in prostate cancer. Y. Yin, R. Li, K. Xu, S. Ding, J. Li, G.H. Baek, S. Ramanand, S. Ding, Z. Liu, Y. Gao, M. Kanchwala, X. Li, R. Hutchinson, X. Liu, S. Woldu, C. Xing, N. Desai, F. Feng, S. Burma, J. de Bono, S. Dehm, R. Mani, B. Chen, and G. Raj Cancer Research 77:4745-4753 (2017)

      DNA damage-induced Degradation of EXO1 Exonuclease Limits DNA End Resection to Ensure Accurate DNA Repair. N. Tomimatsu, B. Mukherjee, J.L. Harris, F.L. Boffo, M. Hardebeck, P.R. Potts, K.K. Khanna, and S. Burma Journal of Biological Chemistry 292:10779-10790 (2017)

      Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. M. Kalimutho, A. L. Bain, B. Mukherjee, P. Nag, D.M. Nanayakkara, S.K. Harten, J.L. Harris, G.N. Subramanian, D. Sinha, S. Shirasawa, S. Srihari, S. Burma, and K.K. Khanna Molecular Oncology 11:470-490 (2017)

      Endonuclease EEPD1 is a gatekeeper for repair of stressed replication forks. H.S. Kim, J.A. Nickoloff, Y. Wu, E.A. Williamson, G.S. Sidhu, B.L. Reinert, A.S. Jaiswal, G. Srinivasan, B. Patel, K. Kong, S. Burma, S.H. Lee, and R.A. Hromas Journal of Biological Chemistry 292:2795-2804 (2017)

      INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells. C. Morris, N. Tomimatsu, S. Burma, and P. Jalinot Cancer Research 76:6054-6065 (2016)

      Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma. C.R. Gil Del Alcazar, P.K. Todorova, A.A. Habib, B. Mukherjee, and S. Burma Molecular Cancer Research 14:928-940 (2016) Cover Image of Molecular Cancer Research October 2016 issue. Included in Molecular Cancer Research Must-Read 2016

      EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. Y. Wu, S.H. Lee, E.A. Williamson, B.L. Reinert, J.H. Cho, F. Xia, A.S. Jaiswal, G. Srinivasan, B. Patel, A. Brantley, D. Zhou, L. Shao, R. Pathak, M. Hauer-Jensen, S. Singh, K. Kong, X. Wu, H.S. Kim, T.S. Beissbarth, J. Gaedcke, S. Burma, J.A. Nickoloff, and R.A. Hromas PLoS Genetics 11:e1005675 (2015)

      DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification. C.V. Camacho, P.K. Todorova, M.C. Gillam, N. Tomimatsu, C.R. Gil del Alcazar, M. Ilcheva, B. Mukherjee, B. McEllin, V. Vemireddy, K. Hatanpaa, M.D. Story, A.A. Habib, V.V. Murty, R. Bachoo, and S. Burma  Oncogene 34:1064-72 (2015)

      Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone. G. Chakrabarti, M.A. Silvers, M. Ilcheva, Y. Liu, Z.R. Moore, X. Luo, J. Gao, G. Anderson, L. Liu, V. Sarode, D.E. Gerber, S. Burma, R.J. DeBerardinis, S.L. Gerson, and D.A. Boothman Science Reports 5:17066 (2015)

      Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. G. Chakrabarti, Z.R. Moore, X. Luo, M. Ilcheva, A. Ali, M. Padanad, Y. Zhou, Y. Xie, S. Burma, P.P. Scaglioni, L.C. Cantley, R.J. DeBerardinis, A.C. Kimmelman, C.A. Lyssiotis, and D.A Boothman Cancer Metabolism 3:12 (2015)

      Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. N. Tomimatsu, B. Mukherjee, M. Gillam, M. Ilcheva, M.C. Hardebeck, C.V. Camacho, J.L. Harris, M. Porteus, B. Llorente, K.K. Khanna, and S. Burma Nature Communications 5:3561-71 (2014)

      Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma. C. Gil Del Alcazar, M. Gillam, B. Mukherjee, N. Tomimatsu, X. Gao, J. Yan, X.J. Xie, R. Bachoo, L. Li, A.A. Habib, and S. Burma Clinical Cancer Research 20:1235-48 (2014)

      EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma. L. Li, V.T. Puliyappadamba, S. Chakraborty, A. Rehman, V. Vemireddy, D. Saha, R.F. Souza, K.J. Hatanpaa, P. Koduru, S. Burma, D.A. Boothman, and A.A.  Habib Oncogene 34:129-134 (2014)

      An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII. L. Li, S. Chakraborty, C.R. Yang, K.J. Hatanpaa, D.J. Cipher, V.T. Puliyappadamba, A. Rehman, A.J. Jiwani, B. Mickey, C. Madden, J. Raisanen, S. Burma, D. Saha, Z. Wang, S.C. Pingle, S. Kesari, D.A. Boothman, and A.A. Habib Oncogene 33:4253-64 (2014)

      Opposing effect of EGFRWT on EGFRvIII-mediated NF-kB activation with RIP1 as a cell death switch. V.T. Puliyappadamba, S. Chakraborty, S.S. Chauncey, L. Li, K.J. Hatanpaa, B. Mickey, S. Noorani, H.K. Shu, S. Burma, D.A. Boothman, and A.A. Habib Cell Reports 4:764-75 (2013)

      Cytoplasmic TRADD confers a worse prognosis in glioblastoma. S. Chakraborty, L. Li, H. Tang, Y. Xie, V.T. Puliyappadamba, J. Raisanen, S. Burma, D.A. Boothman, B. Cochran, J. Wu, and A.A.  Habib Neoplasia 15:888-97 (2013)

      The yeast Fun30 and human SMARCAD1 chromatin remodelers promote DNA end resection. T. Costelloe*, R. Louge*, N. Tomimatsu*, B. Mukherjee, B. Khadaroo, K. Dubois, W. Wiegant, E. Martini, A. Thierry, S. Burma, H. van Attikum, and B. Llorente Nature 489:581-584 (2012) *equal contribution

      INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. C. Morris, N. Tomimatsu, D.J. Richard, D. Cluet, S. Burma, K.K. Khanna, and P. Jalinot Cancer Research 72:2006-2016 (2012)

      Exo1 plays a major role in DNA end resection in humans and influences DNA repair and damage signaling decisions. N. Tomimatsu, B. Mukherjee, K. Deland, A. Kurimasa, E. Bolderson, K.K. Khanna, and S. Burma DNA Repair 11:441-448 (2012)

      The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKcs-mediated DNA damage responses. B. Mukherjee, N. Tomimatsu, K. Amancherla, C.V. Camacho, N. Pichamoorthy, and S. Burma Neoplasia 14:34-43 (2012)

      Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway. J. Kobayashi, H. Fujimoto, J. Sato, I. Hayashi, S. Burma, S. Matsuura, D.J. Chen, K. Komatsu PLoS One 7:e49245 (2012)

      AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. P. Raghavan, V. Tumati, L. Yu, N. Chan, N. Tomimatsu, S. Burma, R.G. Bristow, and D. Saha Int. J. Radiation Oncology Biol. Phys. 84:507-5014 (2012)

      Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells. Z. Kong, P. Raghavan, D. Xie, T. Boike, S. Burma, D.J. Chen, A. Chakraborty, J-T. Hsieh and D. Saha Int. J. Radiation Oncology Biol. Phys. 78:250-257 (2010)

      Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks. C. V. Camacho, B. Mukherjee, B. McEllin, L-H. Ding, B. Hu, A. Habib, X-J. Xie, C. Nirodi, D. Saha, M. Story, A. Balajee, R. M. Bachoo, D. A. Boothman, and S. Burma Carcinogenesis 31:1889-1896 (2010)

      WRN participates in translesion synthesis pathway through interaction with NBS1. J. Kobayashi, M. Okui, A. Asaithamby, S. Burma, B. Chen, K. Tanimoto, S. Matsuura, K. Komatsu, D.J. Chen Mech Ageing Dev. 131:436-444 (2010)

      Down-regulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Z. Kong, D. Xie, T. Boike, P. Raghavan, S. Burma, D.J. Chen, A.A. Habib, A. Chakraborty, J-T. Hsieh and D. Saha Cancer Research 70:2829-2839 (2010)

      PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or PARP inhibitors. B. McEllin, C.V. Camacho, B. Mukherjee, B. Hahm, N. Tomimatsu, R.M. Bachoo, and S. Burma Cancer Research 70:5457-5464 (2010)

      RIP-1 activates PI3K-Akt via a dual mechanism involving NF-kB-mediated inhibition of mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN. S. Park, D. Zhao, K.J. Hatanpaa, B.E. Mickey, D. Saha, D.A. Boothman, M.D. Story, E.T. Wong, S. Burma, M-M. Georgescu, V.M. Rangnekar, S.S. Chauncey, and A.A. Habib Cancer Research 69:4107-4111 (2009)

      EGFRvIII and DNA Double-Strand Break Repair:  A Molecular Mechanism for Radioresistance in Glioblastoma. B. Mukherjee, B. McEllin, C.V. Camacho, N. Tomimatsu, S. Sirasanagandala, S. Nannepaga, K.J. Hatanpaa, B. Mickey, C. Madden, E. Maher, D.A. Boothman, F. Furnari, W.K. Cavenee, R.M. Bachoo, and S. Burma Cancer Research 69:4252-4259 (2009)

      Histone H2AX participates in the DNA damage-induced ATM activation through interaction with Nbs1. J. Kobayashi, H. Tauchi, B. Chen, S. Burma, S. Tashiro, S. Matsuura, K. Tanimoto, D.J. Chen, K. Komatsu Biochem. Biphys. Res. Commun. 380:752-757 (2009)

      Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. N. Tomimatsu, B. Mukherjee, and S. Burma EMBO Reports 10:629-635 (2009)

      Phosphorylation of Exo1 modulates homolgous recombination repair of DNA double-strand breaks. E. Bolderson, N. Tomimatsu, D.J. Richards, D. Boucher, R. Kumar, T.K. Pandita, S. Burma, K.K. Khanna Nucleic Acids Res. 38:1821-1831 (2009)

      Modulation of the DNA-damage response to HZE particles by shielding. B. Mukherjee, C.V. Camcho, N. Tomimatsu, J. Miller, and S. Burma DNA Repair 7:1717-1730 (2008)

      Repair of HZE-partcle-induced DNA double-strand breaks in normal human fibroblasts. A. Asaithamby, N. Uematsu, A. Chatterjee, M.D. Story, S. Burma, and D.J. Chen Radiation Research 169:437-446 (2008)

      Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double-strand breaks.N. Tomimatsu, G.G. Tahimic, A. Otsuki, S. Burma, A. Fukuhara, K. Sato, G. Shiota, M. Oshimura, D.J. Chen, and A. Kurimasa Journal of Biological Chemistry 282:10138-10145 (‘07)

      Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability. J. Li, D.P. Sejas, S. Burma, D.J. Chen, and Q. Pang Carcinogenesis 28:1163-1170 (2007)

      DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. B. Mukherjee, C. Kessinger, J. Kobayashi, B.P. Chen, D.J. Chen, A. Chatterje, and S. Burma DNA Repair 5:575-590 (2006)

      Effect of Ku proteins on IRES-mediated translation. D. Silvera, N. Koloteva-Levine, S. Burma, and O. Elroy-Stein Biology of the Cell 98:353-361 (2006)

      Gene expression profiles of normal human fibroblasts after ionizing radiation: a comparative study with low and high doses. L.-H. Ding, M. Shingyoji, F. Chen, J.-J. Hwang, S. Burma, J.-F. Cheng, and D. J. Chen Radiation Research 164:17-26 (2005)

      Cell cycle dependence of DNA-PK phosphorylation in response to DNA double-strand breaks. B. Chen, D.W. Chan, J. Kobayashi, S. Burma, A. Asaithamby, K. Morotomi-Yano, E. Botvinick, J. Qin, and D.J. Chen Journal of Biological Chemistry 280:14709-14715 (2005)

      Amplification and overexpression of oncogene Mdm2 and orphan receptor gene Nrlh4 in immortal PRKDC knockout cells. R. Ai, A. Sandoval, D.J. Chen, S. Burma, and P. Labhart Molecular Biology Reports 31:91-96 (2004)

      Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis. M.S. Henrie, A. Kurimasa, S.Burma, J. Menissier-de Murcia, G. de Murcia, G.C. Li, and D.J. Chen DNA Repair 2:151-158 (2003)

      DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. R.A. Woo, M.T. Jack, Y. Xu, S. Burma, D.J. Chen, and P.W. Lee EMBO Journal 21:3000-3008 (2002)

      Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation. J. Little, H. Nagasawa, W.K. Dahlberg, M.Z. Zdzienicka, S. Burma , and D.J.Chen Radiation Research 158:319-326 (2002)

      ATM phosphorylates histone H2AX in response to DNA double-strand breaks. S. Burma, B.P. Chen, M. Murphy, A. Kurimasa, and D.J. Chen Journal of Biological Chemistry 276:42462-42467 (2001) “Of outstanding interest”-Current Opinions in Genetics & Development (2002), Citations > 1,100

      DNA-dependent protein kinase–independent activation of p53 in response to DNA damage.S. Burma, A. Kurimasa, G. Xie, Y. Taya, R. Araki, H.A. Crissman, M. Abe, H. Ouyang, G.C. Li, and D.J. Chen Journal of Biological Chemistry 274:17139-17143 (1999)

      Enhanced phosphorylation of p53 serine18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. R. Araki, R. Fukumura, A. Fujimori, Y. Taya, Y. Shiloh, A. Kurimasa, S. Burma, G.C. Li, D.J. Chen, K. Satoh, Y. Hoki, K. Tatsumi, and M. Abe Cancer Research 59:3543-3546 (1999)

      TFIIA regulates TBP and TFIID dimers. R.A. Coleman, A.K. Taggart, S. Burma, J.J. Chicca 2nd, and B.F. Pugh Molecular Cell 4:451-457 (1999)

      Dimer dissociation and thermosensitivity kinetics of the Saccharomyces cerevisiae and human TATA binding proteins. *A.J. Jackson-Fisher, *S. Burma, *M. Portnoy, L.A. Schneeweis, R.A. Coleman, M. Mitra, C. Chitikila, and B.F. Pugh Biochemistry 38:11340-11348 (1999) [*Equal contribution]

      Increase in p202 expression during skeletal muscle differentiation: Inhibition of MyoD protein expression and activity by p202. B. Datta, W. Min, S. Burma, and P. Lengyel Molecular and Cellular Biology 18:1074-1083 (1998)

      Bifunctionality of the AcMNPV homologous region sequence (hr1): enhancer and ori functions have different sequence requirements. S. Habib, S. Pandey, U. Chatterjee, S. Burma, R. Ahmed, A. Jain, and S.E. Hasnain  DNA and Cell Biology 15:737-747 (1996)

      Transcriptional regulation of cell line-dependent, baculovirus-mediated expression of foreign genes. B. Mukherjee, S. Burma, G.P. Talwar, and S.E. Hasnain  DNA and Cell Biology 14:7-14 (1995)

      The 30-kDa protein binding to the ‘initiator’ of the baculovirus polyhedrin promoter also binds specifically to the coding strand. B. Mukherjee, S. Burma, and S. E. Hasnain Journal of Biological Chemistry 270:4405-4411 (1995)

      An unusual 30-kDa protein binding to the polyhedrin gene promoter of the Autographa californica nuclear polyhedrosis virus. S. Burma, B. Mukherjee, A. Jain, S. Habib, and S.E. Hasnain Journal of Biological Chemistry 269:2750-2757 (1994)

       

      Reviews and Monographs:

      MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells. P.K. Todorova, B. Mukherjee, and S. Burma Annals of Translational Medicine 5:61-64 (2017)

      Mouse models of radiation-induced glioblastoma. B. Mukherjee, P.K. Todorova, and S. Burma Oncoscience 2:934-935 (2015)

      Concepts and challenges in cancer risk prediction for the space radiation environment. M.H. Barcellos-Hoff, E.A. Blakely, S. Burma, A.J. Fornace Jr, S. Gerson, L.Hlatky, D.G. Kirsch, IU. Luderer, J. Shay, Y. Wang, M.M. Weil Life Sci Space Res (Amst). 6:92-103 (2015)

      Immunofluorescence-based methods to monitor DNA end resection. B. Mukherjee, N. Tomimatsu, and S. Burma Methods in Molecular Biology 1292:67-75 (2015)

      DNA double-strand breaks make bedfellows of ATM and AKT. B. Mukherje and S. Burma Cell Cycle 10:3230 (2011)

      Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. K.J. Hatanpaa, S. Burma, D. Zhao, A.A. Habib Neoplasia 12:675-684 (2010)**

      Targeting Non-Homologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization. B. Mukherjee, H. Choy, C. Nirodi, and S. Burma Seminars in Radiation Oncology 20:250-257 (2010)

      Role of non-homologous end joining (NHEJ) in maintaining genomic stability in mammalian cells. S. Burma, B.P. Chen, and D.J. Chen DNA Repair 5:1042-1048 (2006)** Listed in “most downloaded/most cited DNA Repair articles”

      Role of DNA-PK in the cellular response to DNA double-strand breaks. S. Burma, and D.J.Chen DNA Repair 3:909-918 (2004)**

      Host factor with single-stranded DNA-binding activity involved in transcription from the baculovirus polyhedrin promoter. S.E. Hasnain, S. Habib, A. Jain, S. Burma, and B. Mukherjee Methods in Enzymology: RNA polymerase and associated factors (S. Adhya, volume editor), Academic Press, New York, 274:20-32 (1996)

      Baculovirus vector-mediated expression of heterologous genes in insect cells. P. Sridhar, C.A. Azim, S. Burma, S. Habib, A. Jain, B. Mukherjee, A. Ranjan, and S.E. Hasnain Journal of Biosciences 19: 603-614 (1994)

      The baculovirus expression vector system: Regulation of the polyhedrin gene promoter. S. Burma and S.E. Hasnain Proceedings of the India National Science Academy B60:365-374 (1994)

       

      Book Chapters:

      Role of non-homologous end joining in the repair of DNA double-strand breaks. S. Burma, B. Chen, D.J. Chen in DNA Repair Genetic Instability and Cancer (Q. Wei, L. Li, and D.J. Chen, eds), World Scientific Publishing Co., p157-175 (2007)

      Transcriptional regulation of the AcNPV polyhedrin gene promoter. S. Habib, S. Burma, U. Chatterjee, P. Das, A. Jain, B. Mukherjee, K. Natarajan, A.  Ranjan, and S.E. Hasnain in Current Developments in Animal Virology (E.K. Wagner and S. Jameel, eds.), Oxford and IBH Publishing Co., New Delhi, India and Science Publishers Inc., Lebanon, NH, USA, p205-210 (1996)

Related media