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Research
Sandeep Burma, Ph.D.
Professor, Vice Chair (Research), Mays Family Foundation Distinguished Chair in Oncology
Currently seeking M.S. & Ph.D. students
Research in the Burma Laboratory is focused on the responses of mammalian cells to DNA double-strand breaks (DSBs), collectively called the DNA damage response (DDR). We are involved in studying DDR events triggered by ionizing radiation and their carcinogenic and cancer therapeutic implications. We are particularly interested in 1) understanding DSB signaling and repair mechanisms with a focus on the regulation of DNA end resection by EXO1, 2) genetic basis of radio- and chemo-resistance of glioblastomas (GBM), with the translational objective of targeting DNA repair pathways for GBM therapy, and 3) genetic changes underlying gliomagenesis triggered by ionizing radiation, the only known risk factor for the development of GBM. A more mechanistic understanding of DDR events has emerged from our studies, providing important insights into how GBM is triggered, and leading to the development of better therapeutic approaches for GBM.
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Professional Background
Education
- 1995 - Ph.D. - Molecular Biology - National Institute of Immunology, India
- 1990 - M.Sc. - Zoology (Specialization in Molecular Genetics and Cytogenetics) - Banaras Hindu University, India
- 1988 - B.Sc - Botany, Zoology, Chemistry (Honors in Zoology) - Banaras Hindu University, India
Training
- 1999 - Postdoctoral Associate - DNA Repair - Life Sciences Division, Los Alamos National Laboratory
- 1998 - Postdoctoral Associate - Transcription Regulation - Dept. of Biochemistry & Mol. Biology, Pennsylvania State University
- 1996 - Postdoctoral Associate - Transcription Regulation - Dept. of Mol. Biophysics & Biochemistry, Yale University
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Research & Grants
Research in the Burma Laboratory is focused on the responses of mammalian cells to DNA double-strand breaks (DSBs), collectively called the DNA damage response (DDR).
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Publications