Cynthia L Blanco, M.D.
Professor of Pediatrics with Tenure
Greehey Family Foundation Chair in Neonatology Research
Dr. Cynthia Blanco is a Professor of Pediatrics with Tenure. She completed her undergraduate studies and received her MD at the Universidad de Guadalajara in Guadalajara, Jalisco Mexico. She completed her residency in Pediatrics at Texas Tech University and her Post Doctoral degree in Neonatal-Perinatal Medicine at the University of Texas Health Science Center San Antonio with a Masters in Clinical Investigation. She is heavily involved in clinical research and has been well published in peer reviewed journals. Her research interests are in parenteral and enteral nutrition of the critically ill neonate. Her research focus includes enteral nutrition strategies to decrease the incidence of necrotizing enterocolitis with exclusive human nutrition and the biochemical markers involved in pasteurized human milk in relationship with gastrointestinal disease. She has also studied the effects of early and higher intravenous Amino Acid supplementation for ELBW infants and the use of IV Fish oil for parenteral associated disease. Her basic science research relates to glucose metabolism and insulin resistance in prematurity. Due to her passion a Neonatal Nutrition and Bone Institute was established under her leadership at University Hospital. This is one of few centers in the country where full metabolic analyses can be done such as DEXA and body composition analyses by air displacement plethysmography and bone scans with ultrasound. In this Institute, they have implemented the utilization of novel therapies such as Intravenous Fish oil for infants with Parenteral Nutrition Associated Liver disease and short bowel syndrome as a resource to bridge neonates to liver transplant and/or survive them without transplant. Dr. Blanco believes we will continue to improve the health of neonates, children and adults by improving nutrition and metabolism at an early age.
- 2006 - MS - Clinical Investigation - University of Texas Health Science Center San Antonio
- 2005 - Postdoctoral Fellowship - Neonatal-Perinatal Medicine - University of Texas Health Science Center San Antonio
- 2001 - Residency - Pediatrics - Texas Tech University
- 1997 - MD - Medicine - Universidad de Guadalajara
- 1991 - BS - Mathematics - Universidad de Guadalajara
- 1/2019 - Division Chief, Neonatology - University of Texas Health Science Center San Antonio, Pediatrics, San Antonio
- 1/2018 - Greehey Family Foundation Chair in Neonatology Research - University of Texas Health Science Center, Pediatrics, San Antonio
- 9/2016 - Professor of Pediatrics with Tenure - University of Texas Health Science Center, Pediatrics, San Antonio
- 1/2014 - Director, Neonatal Nutrition and Bone Institute - University Health SystemSan Antonio
- 11/2009 - Neonatologist - Community Medicine Associates, Division of Neonatology, San Antonio
Instruction & Training
- 7/2016 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 7/2016 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 1/2015 - Present, Individual Instruction, UTHSCSA
- 11/2014 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 7/2014 - Present, Individual Instruction, UTHSCSA
- 7/2014 - Present, Post-Doctoral Student Supervision, UTHSCSA
- 7/2014 - Present, Individual Instruction, UTHSCSA
- 1/2014 - Present, Individual Instruction, University Health System
- 1/2012 - Present, Individual Instruction, UTHSCSA
- 1/2012 - Present, Individual Instruction, UTHSCSA
- 6/2006 - Present, Neonatal Resuscitation Program, UTHSCSA
- 7/2005 - Present, Journal Club, UTHSCSA
- 7/2005 - Present, Journal Update, UTHSCSA
- 7/2005 - Present, Educational Curriculum, Neonatal Transport Team, University Health System
- 7/2005 - Present, Rotation Student Supervision, UTHSCSA
- 7/2005 - Present, Pediatrics Clerkship, The University of Texas Health Science Center
- 7/2005 - Present, PEDI4023 Neonatal ICU Externship (4th year elective)
Research & Grants
Funding Agency San Antonio Medical Fondation Title San Antonio Medical Foundation Status Active Period 8/2016 - 7/2017 Role Principal Investigator Grant Detail The objective of this study is to determine the effects of maternal obesity and diabetes on infantile body composition, growth and epigenetic changes related to free fatty acid/glucose metabolism and diabetes. Body composition is measured serially utilizing the air displacement plethysmography and dual-enegry X-ray absorptiometry. Cord blood is collected for analyses of promoter methylation status of key genes in the insulin signaling, glucose metabolism and free fatty acid pathways.
Funding Agency Bexar County Hospital District Title University Health System Status Active Period 12/2015 - 12/2017 Role Principal Investigator Grant Detail The primary goal of this project is to investigate the effect of hyperglycemia on pancreatic development and peripheral insulin signaling at critical periods of development in the premature baboon. The central hypothesis is that preterm baboons have decreased pancreatic function and further impairments of insulin signaling in skeletal muscle when compared with preterm baboons not exposed to adverse postnatal environment (hyperglycemia). Pancreatic function is assessed by hyperglycemic clamps and compared to histological endocrine cell development utilizing the CAST system. Insulin signaling molecules and glucose transporters are measured at basal and insulin-stimulated state in skeletal muscle.
Funding Agency Title Clinical Investigator Kickstart Program.Short and long term effects of maternal obesity and diabetes on infantile body composition and epigenetics. Status Active Period 8/2017 - 7/2018 Role Principal Investigator Grant Detail The primary goal of this project is to determine if differentially methylated regions in cord blood of infants of mothers with gestational diabetes and obesity are associated with increased adiposity in offspring. Body composition is measured serially (birth, 3 months and 1 year) by utilizing the air displacement plethysmography and dual-energy x-ray absorptiometry. Methylation status of key genes in the insulin signaling, glucose metabolism, and free fatty acid pathways are measured at 1 year of age. Funding Agency Title Subaward Agreement Utrecht Medisch Centrum (UMC) Status Active Period 6/2014 - 7/2017 Role Co-Investigator Grant Detail Human Mesenchymal Stem Cell Treatment Using the Neonatal Non-human Primate.
The goal of our experiment is to investigate whether human Mesenchymal Stem Cells when given intranasally are capable of migrating to a cerebral lesion in a primate model. The main purpose is to offer additional treatment options to newborns born with a global brain injury.
Blanco CL. Nutrition report card: valuable assessment tool for nutritional management of high risk neonates; 2018 Feb. (Journal of Investigative Medicine).
Blanco CL. Maternal Nutrition, Obesity, and Diabetes: Effects on infant growth and body composition; 2018 Feb. (Journal of Investigative Medicine).
Blanco CL. Maternal vs Donor Human Milk- Does it make a difference?; 2018 Feb. (Journal of Investigative Medicine).
Blanco CL. Maternal Diabetes and Obesity Influences the Fetal Epigonome; 2018 Jan. (EPAS Pediatric Research 2018).
Blanco CL. Insulin resistant preterm baboons have impaired adiponectin secretion due to decreased ppary/insr along with altered adipor1/appl1 signaling at target tissues; 2017 May. (Pediatric Research (EPAS 2017)).
Blanco CL. 6.Regulation of EGF and Prostaglandin Expression During Neonatal Gastrointestinal Injury in a Non-Human Primate Explant Model; 2017 May. (Pediatric Research (EPAS 2017)).
Blanco CL. Higher Percent Body Fat in Infants of Diabetic Mothers vs Healthy Term Infants in a Largely Hispanic Population; 2017 May. (American Diabetes Association).
Blanco CL. Long-Term Neurodevelopmental Outcomes of Extremely Preterm Infants Fed and Exclusive Human Milk-Based Diet versus a Bovine Milk Based Diet; 2017 May. (Pediatric Research (EPAS 2017)).
Blanco CL. Intranasally applied mesenchymal stem cells migrate to injured brain regions of newborn; 2017 May. (Pediatric Research (EPAS 2017)).
Antonishek JD, Shiu V, Blanco CL, and Mittal N. Novel Genetic Mutation of Microvillus Inclusion Disease-Like Phenotype; 2017 Feb. (Journal of Investigative Medicine).
Sorrell MW, Jordan J, Winter L, Dong L, and Blanco CL. Impaired Adiponectin Secretion Along with Adaptations at Target Tissues Contribute to Insulin Resistance of Prematurity; 2017 Feb. (Journal of Investigative Medicine).
Seidner SR, Mobius M, Mustafa SB, McCurnin DC, Blanco CL, Rudiger M, and Thebaud B. Intravenous Administration of Human Umbilical Cord Derived Mesenchymal Stem Cells Decreases Pressor Use and Fluid Requirements in Preterm Baboons of Borderline Viability; 2017 Feb. (Journal of Investigative Medicine).
Escaname EN, Blanco CL. Percent Body Fat Using Air Displacement Plethysmography Correlates with Thigh Skin Fold in Infants of Diabetic Mothers and Healthy Term Infants in a Largely Hispanic Population; 2016 May. (Pediatric Reseach (E-PAS2016)).
Keller L, Blanco CL. Novel Markers of Liver Disease Remain Elevated in Infants With Severe PNALD While on IVFISH Therapy With and Without Soy-Based Intralipid; 2016 May. (Pediatric Research (E-PAS2016)).
Acevedo S, Blanco CL. Modulation of Inflammatory Responses on Term and Preterm Neonatal Gastrointestinal Non-Human Primate Explants; 2016 May. (Pediatric Research (E-PAS 2016)).
Sorrell M, Blanco CL. Decreased Adiponectin Secretion and Altered Signaling at Target Tissues Play a Role in Insulin Resistance of Prematurity; 2016 May. (Pediatric Research (E-PAS2016)).
Palarczyk J, Blanco CL. Glucocorticoids Alter Beta Cell Volume and Early Markers of Baboon Pancreatic Development; 2016 May. (Pediatric Reseach (E-PAS2016)).
Callaway DA, Blanco CL. Hyperglycemia Induces Oxidative Stress and Altered Nephrogenesis in Preterm Baboons; 2016 May. (Pediatric Research (E-PAS2016)).
Penon C, Bedgood M, Robinson A, ElSakka A, Shah S, Blanco CL, and Moreira AM. Lean Body Mass Is a Determinant of Bone Mineral Measurements in United States Asolescents; 2016 Feb. (Journal of Investigative Medicine).
Keller LM, Kerecman J, Goodman Z, Mittal N, and Blanco CL. Novel Markers of Hepatic Injury Correlate with Histological Changes of Neonatal Parenteral Nurtrition Associated Liver Disease; 2016 Feb. (Journal of Investigative Medicine).
Palarczyk JL, Blanco CL, Quinn A, Li J, and Li C. Gluccortoids Alter Beta Cell Volume and Early Markers of Baboon Pancreatic Development; 2016 Feb. (Journal of Investigative Medicine).
McGill-Vargas L, Hanyu L, Anzueto D,Jordan J, Musi N, and Blanco CL. Mechanisms for Abnormal Glucose Homeostasis in Prematurity; 2016 Feb. (Journal of Investigative Medicine).
Sitabkhan A, Moreira AG, Bonagurio K, Lavendar E, Gong A, and Blanco CL. Post Discharge Feeding Regimens Affect Growth Velocity in Very Low Birth Weight Infants; 2016 Feb. (Journal of Investigative Medicine).
Sorrell MW, McGill-Vargas L, Anzueto D, Johnson M,and Blanco CL. The Role of Adiponectin in Glucose Homeostasis in the Premature Baboon Model; 2016 Feb. (Journal of Investigative Medicine).
Callaway D, Blanco CL, Jordan J, Dick E,and McGill-Vargas L. Impact of Hyperglycemia and Prematurity on Nephrogenesis in a Baboon Model; 2016 Feb. (Journal of Investigative Medicine).
Sitabkhan A, Moreira AG, Mittal N, Jacob R, Tragus R, and Blanco CL. Severe Allergic Colitis Can Present With Elemental Formula Feeds in Infants with Severe Intestinal Failure: A Case Series; 2016 Feb. (Journal of Investigative Medicine).
Blanco CL; Hair AB; Hawthorne KM; Moreira AG; Lee ML; Rechtman DJ; Abrams SA. Human Milk Cream Enhances Growth When Utilized as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in VLBW Infants; 2014 Nov. (Pediatric Academic Society; vol. 165, no. 5).
Blanco CL. Favorable Outcomes of Preterm Infants Treated with Fish Oil-Based Intravenous Lipid Emulsion for Parental Nutrition-Associated Liver Disease; 2014 May. (E-PAS2014 (pending Number)).
Blanco CL. Approach to an infant with congenital heart disease. In: In: Toy EC, Toy AL, Eds. Case Files Teaching Case Collection. New YorK: McGraw-Hill Publishers; 2019.
McGill-Vargas L, Gastaldelli A, Liang H, Anzueto Guerra D, Johnson-Pais T, Seidner S, McCurnin D, Muscogiuri G, DeFronzo R, Musi N, Blanco C. Prematurity disrupts glomeruli development, whereas prematurity and hyperglycemia lead to altered nephron maturation and increased oxidative stress in newborn baboons Pediatric Research 2017 Nov;.
Sorrell M, Moreira A, Green K, Jacob R, Tragus R, Keller L, Quinn A, McCurnin D, Gong A, El Sakka A, Mittal N, Blanco C. Favorable Outcomes of Preterm Infants With Parenteral Nutrition?associated Liver Disease Treated With Intravenous Fish Oil?based Lipid Emulsion J Pediatr Gastroenterol Nutr 2017 May;64(5):783-788.
McGill-Vargas L, Gastaldelli A, Liang H, Anzueto Guerra D, Johnson-Pais T, Seidner S, McCurnin D, Muscogiuri G, DeFronzo R, Musi N, Blanco CL. Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons Endocrinology 2017 Jan;158(5):1140-1151.
Hair AB, Bergner EM, Lee ML, Moreira AG, Hawthorne KM, Rechtman DJ, Abrams SA, Blanco CL. Premature Infants 750-1250g Birth Weight Supplemented with a Novel Human Milk Derived Cream are Discharged Sooner Breastfeeding Medicine 2016 Apr;11:133-137.
Raiten D, Steiber A, Carlson S, Griffin I, Anderson D, Hay H, Robin S, Neu J, Georgieff M, Groh-Wargo, Fenton T, and the Pre-B Consultative Working groups (Blanco CL). Working group reports: evaluation of the evidence to support practice guidelines for nutritional care Am J Clin Nutr 2016 Jan;103.
Blanco CL. Transforming Growth Factor- B2 is sequestered in Preterm Human Milk by Chondroitin Sulfate Proteoglycans American journal of Physiology and Gastrointest Liver Physiology 2015 Jun;10.
Blanco CL, Mcgill-Vargas LL, Gastaldelli A, Seidner SR, McCurinin DC, Leland MM, Anzueto DG, Johnson MC, Liang H, DeFronzo RA, Musi N. Peripheral Insulin Resistance and Impaired Insulin Signaling Contribute To Abnormal Glucose Metabolism in Preterm Baboons Endocrinology 2015 Mar;156(3):813-823.
McGil-Vargas LL, Johnson-Pais T, Johnson MC, Blanco CL. Developmental Regulation of Key Gluconeogenic Molecules in Nonhuman Primates Physiology Reports 2014 Dec;2(12).
Hair AB, Blanco CL, Moreira AG, Hawthorne KM, Lee ML, Rechtman DJ, Abrams SA. Randomized Trial of Human Milk Cream as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in Infants 750-1250g Birth Weight J Pediatrics 2014 Nov;165(5):915-920.
Moreira AG, Swischuk L, Malloy M, Mudd D, Blanco C, Geary C. Parathyroid hormone as a marker for metabolic bone disease of prematurity J Perinatol 2014 Oct;34(10):787-791.
Moreira AG, Koele L., Leland M, Seidner SR, Blanco CL. Neonatal Intubation with Direct Laryngoscopy versus Videolaryngoscopy: An Extremely Premature Baboon Model Paediatric Anesthesia 2014 Aug;24(8):840-844.
Kim SE, Lee SY, Blanco CL, Kim JH. Developmental Profiles of the Intrinsic Properties and Synaptic Function of Auditory Neurons in Preterm and Term Baboon Neonates Journal of Neuroscience 2014 Aug;34(34):11399-11404.
Abrams SA, Schanter RJ, Lee ML, Rechtman DJ, H2MF Study Group Blanco, CL. Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products Breastfeed Medicine 2014 Jun;9(6):281-285.
Blanco CL, Moreira AG, McGill-Vargas LL, Anzueto DG, Nathanielsz P, Musi N. Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle J Endocrinol 2014 Apr;221(2):253-260.
Quinn AR, Blanco CL, Perego C, Finzi G, La Rossa S, Capella C, Guardado-Mendoza R, Casiraghi F, Gastaldelli A, Johnson M, Dick EJ, Folli F. The ontogeny of the endocrine pancreas in the fetal/newborn baboon J Endocrinology 2012 Sep;14(3):289-299.
Blanco CL, In: Toy EC, Toy AL, eds. Cyanotic Heart Disease 2018 Jan;. Blanco CL. Transforming growth factor-b2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans Am J Physiol Gastrointest Liver Physiol 2015 Aug;309(3):171-180.
Raiten DJ, Steiber AL, Carlson SE, Griffin I, Anderson D, Hay WW Jr, Robins S, Neu J, Georgieff MK, Groh-Wargo S, Fenton TR Blanco CL Pre-B Consultative Working Groups..
. Pre-B Consultative Working Group Report: Evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the-Pre-B Project American Journal of Clinical Nutrition 2016 Feb;.
- American Board of Pediatrics/Neonatal-Perinatal
- American Board of Pediatrics