Swati Banerjee, Ph.D.

Associate Professor

Cellular and Integrative Physiology

Dr. Swati Banerjee uses the Drosophila model system to investigate the cellular and molecular bases of axonal ensheathment and synaptic development and function. We are currently exploring the following three research themes:

1) Neuron-Glial Interactions and Ensheathment of Axons

Molecular interactions between neurons and glial cells are vital for proper functioning of nervous system across species. Interactions between neurons and glial cells are central in processes such as ensheathment of axons, formation of axo-glial junctions, and maintenance of functional blood-brain and blood-nerve barriers. We use the Drosophila nervous system to investigate the molecular basis of axonal ensheathment. Using genetic, cell biological and biochemical approaches, we have identified several proteins that have fundamental roles in neuron-glial interactions underlying the process of ensheathment of axons both in the PNS and CNS. Our studies in Drosophila are relevant to elucidate the mechanisms regulating vertebrate myelination in health and disease.

2) Trans-Synaptic Adhesion and Signaling in Synaptic Growth and Cytoarchitecture

Our research interest also includes the study of synapse formation and function. Two key synaptic cell adhesion molecules, Neurexin and Neuroligin in Drosophila connect the pre- and postsynaptic terminals of the synapses. In humans, mutations in Neurexin or Neuroligin genes are implicated in Autism Spectrum Disorders and other cognitive disorders. Our recent work indicates that Drosophila Neurexin/Neuroligin 1 regulate components of the BMP signaling pathway. We are interested in deciphering how Neurexin/Neuroligin and related proteins mediate trans-synaptic signaling and shape neural networks to process and refine information.

3) Role of Synaptic and Cytoskeletal Proteins in Aging and Neurodegeneration

Cytoskeletal dysfunction, axonal and synapse loss are among the many hallmarks in neurodegenerative diseases, such as Alzheimer’s disease, Parkinson's disease and amyotrophic lateral sclerosis. In these prolonged diseases, decrease in synapse density and changes in cytoskeletal dynamics are among the important correlates of disease progression. Yet, very little is known about the molecular pathways that maintain axonal, synaptic and cytoskeletal health and their roles in aging and neurodegeneration. We are screening for new synapse maintenance and cytoskeletal genes using the Drosophila as our model system to tackle these important questions.

Related diseases: Multiple Sclerosis, Autism Spectrum Disorders, Parkinson’s and Alzheimer’s disease

Techniques: Genetics, molecular biology, cell biology, biochemistry and electrophysiology

Research & Grants

Neuron-glial interactions, synapse assembly and signaling, cytoskeleton and neurodegeneration

We are currently exploring the following three research themes:

1) Neuron-Glial Interactions and Ensheathment of Axons

2) Trans-Synaptic Adhesion and Signaling in Synaptic Growth and Cytoarchitecture

3) Role of Synaptic and Cytoskeletal Proteins in Aging and Neurodegeneration

Related diseases: Multiple Sclerosis, Autism Spectrum Disorders, Parkinson’s and Alzheimer’s disease

Techniques: Genetics, molecular biology, cell biology, biochemistry and electrophysiology

Research Profile
Publications

Monahan Vargas, E. J., Matamoros, A. J., Qiu, J., Jan, C. H., Wang, Q., Gorczyca, D., Han, T. W., Weissman, J. S., Jan, Y. N., Banerjee, S. and Song, Y. (2020). The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes and Dev. 34: 1-15. doi:10.1101/gad.331330.119.

Shi, Q., Lin, Y. Q., Saliba, A., Xie, J., Neely, G. G. and Banerjee, S. (2019). Tubulin Polymerization Promoting Protein, Ringmaker, and MAP1B Homolog Futsch Coordinate Microtubule Organization and Synaptic Growth. Frontiers in Cell Neurosci. 13:192. doi: 10.3389/fncel.2019.00192.

Banerjee, S. and Riordan, M. (2018). Coordinated Regulation of Axonal Microtubule Organization and Transport by Drosophila Neurexin and BMP Pathway. Scientific Reports, 8(1):17337.

Banerjee, S., Mino, R., Fisher, E. and Bhat, M.A. (2017). A Versatile Genetic Tool to Study Midline Glia Function in the Drosophila CNS. Developmental Biology, 1; 429(1):35-43.

Banerjee, S., Venkatesan, A. and Bhat, M.A. (2017) Neurexin, Neuroligin and Wishful Thinking Coordinate Synaptic Cytoarchitecture and Growth at Neuromuscular Junctions. Mol. Cell. Neurosci.78, 9-24. (Featured on the Cover).

Mino, R.E., Rogers, S.L., Risinger, A.L., Rohena, C., Banerjee, S. and Bhat, M.A. (2016). Drosophila Ringmaker Regulates Microtubule Stabilization and Axonal Extension During Embryonic Development. J. Cell Sci. 129, 3282-3294.

Banerjee, S., Riordan, M. and Bhat, M.A. (2014). Genetic Aspects of Autism Spectrum Disorders: Insights from Animal Models. Frontiers in Cellular Neuroscience 8:58.

Chen, Y.-C., Lin, Y.Q., Banerjee, S., Venken, K., Li, J., Ismat, A., Chen, K., Duraine, L., Bellen, H.J. and Bhat, M.A. (2012). Drosophila Neuroligin 2 is Required Presynaptically and Postsynaptically for proper Synaptic Differentiation and Synaptic Transmission. J. Neurosci. 32: 16018-16030.