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Mitzi Gonzales, PhD, ABPP-CN
Assistant Professor/Clinical
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases
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Professional Background
Education
- 2015 - PhD - Clinical Psychology - University of Texas at Austin
- 2011 - MA - clinical Psychoogy - University of Texas at Austin
- 2006 - BA - Psychology - Occidental College, Los Angeles, CA
Training
- 2017 - Fellowship - clinical Neuropsychology - VA Northern California
- 2015 - Internship - Clinical Psychology - University of Chicago at Illinois
Highlights
06/2022 Article of the Year. Revisiting apathy in Alzheimer’s disease: From conceptualization to therapeutic approaches). Behavioral Neurology
09/2020 Selected Fellow of the Inaugural Class. Institute on Methods & Protocols for Advancement of Clinical Trials in Alzheimer’s Disease
06/2020 Best Research Abstract. International Society to Advance, Alzheimer’s Research and Treatment
05/2020 Selected Scholar of the Univ of Michigan Pepper Ctr Mock Study Retreat
Appointments
- 10/2022 - Associate Professor with Tenure - UT Health San Antonio, Dept of Radiology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
- 09/2022 - Associate Professor with Tenure - UT Health San Antonio, Dept of Neurology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
- 08/2021-08/2022 - Assistant Professor - UT Health San Antonio, Dept of Neurology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
- 10/2017-06/2021 - Assistant Professor/Clinical - UT Health San Antonio, Dept of Neurology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
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Instruction & Training
- 12/20/2022, Neuropsychological Outcomes Following organ Transplantation, Dell Medical School, UT Austin Neuropsychology Didactics
- 07/20/22, Levy Body Dementia, Dell Medical School, UT Austin Neuropsychology Didactics
- 05/12/21, Parkonson's Dementia & Lewy body Dementia, UTHSCSA School of Medicine Neurology Residency Program
- 03/19/21, Senescene as a Mechanism Underlying Alzheimer's Disease, UTHSCSA School of Medicine, Neurology Grand Rounds
- 01/20/21, Neuropsychological Outcomes Following Organ Transplantation, Dell Medical School, UT Austin Neuropsychology Didactics
- 04/10/2020, Sleep Disturbances - Harbingers and Promoters of Neurodegenerative Disease, UTHSCSA School of Medicine, Neurology Grand Rounds
- 03/13/20, Sleep Disturbances and Dementia, Audie Murphy VA Neuropsychology Grand Rounds
- 05/11/19, Parkinson's Dementia & Lewy body Dementia, UTHSCSA School of Medicine Neurology Resident Program
- 03/15/19, Big Data and Public Health - Issues in Dementia Research, UTHSCSA School of Medicine, Joint MD/MPH Program
- 02/15/19, Professional and Ethical Issues in Clinical Neuropsychology , Audie Murphy VA Neuropsychology Grand Rounds
- 10/22/18, Dementia Updates - American Academy of Neurology and American Psychiatric Association, UTHSCSA School of Medicine, Neurology Grand Rounds
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Research & Grants
Grants
- The RSELVES Study: Remote Sensing of Engagement in Life and Variability in Everyday Support Characterizing Older Mexican (American) Participation in Activity Digitally Reliably and Ecologically with the CART Platform (COMPADRE CART): Implications for Cognition & ADRD Multiethnic Machine Learning Signatures of ADRD
- Epidemiology of Blood Pressure Responses to Perturbations: Correlates & Prognosis for vascular risk, end-organ damage, cognitive aging, and preclinical Alzheimer’s disease
- Identifying ADRD intervention targets by characterizing neurobiological mechanisms of social isolation, loneliness, and social environment using novel imaging, molecular markers, and machine learning
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Service
Department
09/29/2021 UTHSCSA Pepper Center (External Advisory Board Meeting)
05/24/2021 South Texas Alzheimer’s Center (External Advisory Board Meeting)
01/2021 – Present National Alzheimer’s Coordinating (Neuropsychology Lead Center Dementia Consensus Reviews)
06/2020 – Present Neuropsychology Fellowship Progam
05/2020 – Present Biggs Research Assistant Cognitive Assessment Training
10/2019 – Present Neuropsychology Research
Institutional
03/15/2020 UTHSCSA Pepper Center Council (Advisory Board)
06/2020 – Present South Texas Alzheimer’s Center Clinical Core (Co-Leader)
10/2018 – 10/2020 UTHSCSA School of Nursing Caring for the Caregiver Program. (Instructor)Service to the Profession
02/10/2023 Health Education Developments Alzheimer’s And Related Dementias. (Presenter)
10/19/2022 Health Education Preclinical Indicators of Disease (Presenter)
10/03/2022 Health Education Developments in Treatment And Prevention of Alzheimer’s. (Presenter)
09/23/2022 Health Education Dementia and Sleep (Presenter)
03/16/2021 Health Education Participation in Health Science Research (Educator)National
01/2023-Present National Alzheimer’s Coordinating Center Scientific Review Committee
01/2023-Present DISCOVERY Study Cognitive Core Committee
06/2022 Clinical Trials for Alzheimer’s Disease (Abstract Reviewer)
05/2022 American Aging Association (Abstract Reviewer)
01/2021 – Present American Federation for Aging Research National Scientific Advisory Council
06/2018 – Present MarkVCID Clinical Core Committee (Site Leader)
01/2018 – 06/2022 Framingham Heart Study Dementia Dementia Case Consensus Committee (Neuropsychology Lead)Community
10/2018 & 10/2019 South Texas Alzheimer’s Disease Community Conference. (Biggs Representative)
10/2018 & 10/2019 Walk to End Alzheimer’s Disease (Biggs Representative) -
Publications
- Salem, H, Suchting, R, Gonzales, M. M, Seshadri, S, Teixeira, AL. (2023). Apathy as a predictor of conversion from mild cognitive impairment to Alzheimer’s disease: A Texas Alzheimer’s Research and Care Consortium Cohort-based analysis. Journal of Alzheimer’s Disease (online ahead of print).
- Gonzales, M. M, Wiedner, C, Wang, C, Liu, Q, Bis, JC, Li, Z, et al. (2022). A population-based meta-analysis of circulating GFAP for cognition and dementia risk. Annals of Clinical Translational Neurology, 9(10): 1574-1585.
- Gonzales, M. M, Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Kraig, E., & Orr, M. E. (2022). Biological aging processes underlying cognitive decline and neurodegenerative disease. The Journal of Clinical Investigation, 132, e158453.
- Miller, LM, Steele, JS, Wu, CY, Kaye, J, Dodge, HH, Gonzales, M. M, Lyons, KS. (2022). Depressive symptoms in older adult couples: Associations with dyadic physical health, social engagement, and close friends. Frontiers in Psychiatry, 13, 989128.
- Gonzales, M.M, Garbarino, VR, Marques Zilli, E, Petersen, RC, Kirkland, JL, Tchkonia, T, Musi, N, Seshadri, S, Craft, S, Orr, ME. (2022). Senolytic therapy to modulate the progression of Alzheimer’s disease (SToMP-AD): A pilot clinical trial. Journal of Prevention of Alzheimer’s Disease, 9, 22-29.
- Zheng, Y, Habes, M, Gonzales, M.M, Pomponio, R, Nasrallah, I, Khan, S, et al. (2022). Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study. Aging, 14(4), 1691-1712.
- DeVito, LM, Barzilai, N, Cuervo, AM, Niedernhofer, LJ, Milman, S, Levine M, Proislow, D, Ferruci, L, Kuchel, GA, Mannick, J, Justice, J, AL, Gonzales, M.M, Kirkland, JL, Cohen P, Campisi (2022). Extending human healthspan and longevity: a symposium report. Annals of the New York Academy of Sciences, 1507, 70-83.
- Gonzales, M. M., Wang, C. P., Short, M. I., Parent, D. M., Kautz, T., MacCarthy, D et al. (2022). Blood biomarkers for cognitive decline and clinical progression in a Mexican American cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14(1), e12298.
- Quiroz, YT Solis, M, Aranda, MP, Arbaje, AI, Arroyo‐Miranda, M, Cabrera, LY, Carrasquillo, MM, Corrado, MM, Crivell, L, Diminch, ED, Dorsman, KA, Gonzales, MM. et al. (2022). Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium. Alzheimer's & Dementia, 18, 1677-1686.
- Lin, H., Himali, J. J., Satizabal, C. L., Beiser, A. S., Levy, D., Benjamin, E. J., Gonzales, M.M, et al. (2022). Identifying Blood biomarkers for dementia using machine learning methods in the Framingham Heart Study. Cells, 11(9), 1506.
- McGrath, E. R., Beiser, A. S., O’Donnell, A., Yang, Q., Ghosh, S., Gonzales, M.M., et al. (2022). Blood phosphorylated tau 181 as a biomarker for amyloid burden on brain PET in cognitively healthy adults. Journal of Alzheimer's Disease, doi: 10.3233/JAD-215639.
- Salinas, J, Beiser, AS, Samra, JK, O’Donnell, A, DeCarli, CS, Gonzales, M.M, Aparicio, HJ, Seshadri, S (2022). Association of loneliness with 10-year dementia risk and early markers of vulnerability for neurocognitive decline. Neurology, 98, e1337-e1348.
- Baril, AA, Beiser, AS, Sanchez, E, Mysliwiec, V, Redline, S, Gottlieb, DJ, O’Conner, GT, Gonzales, M.M, Jacob, Himali, D, A, Seshadri, S, Himali, JJ, Pase, M (2022). Insomnia symptom severity and cognitive performance: Moderating role of the APOE genotype. Alzheimer’s & Dementia, 18, 408-421.
- González, D.A., Clark, MJ, Gonzales, M. M., Benje, J. (2022). A brief report: An evaluation of item bias on the Functional Activities Questionnaire. Archives of Clinical Neuropsychology (Online ahead of present).
- González, D. A., Resch, Z. J., Gonzales, M. M., Soble, J. R. (2022). A novel method for establishing functional change in older adults with cognitive impairment. Alzheimer’s Disease and Associated Disorders, 36, 238-243.
- Gonzalez, D.A., Gonzales, M.M., Resch, Z.J., Sullivan, A.C., Soble, J.R. (2022). Comprehensive evaluation of the Functional Activities Questionnaire (FAQ) and its reliability and validity. Assessment, 29, 748-763.
- Texeira, AL, Salen, H, Martins, LB, Gonzales, M.M, Seshadri, S, Suchting, R (2022). Factors associated with apathy in Alzheimer’s disease: A cross-sectional analysis of the Texas Alzheimer’s Research and Care Consortium. Journal of Alzheimer’s Disease, 86, 403-411.
- Gonzales, M.M, Krishnamurthy, S, Garbarino, V, Daeihagh, AS, Gilispie, GJ, Deep G, Craft, S, Orr, ME. (2021). A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials. Mechanisms of Ageing and Development, 200, 11589.
- Texeira, AL, Gonzales, M.M, De Souza, LC, Weisenbach, S. (2021). Revisiting apathy in Alzheimer’s disease: From conceptualization to therapeutic approaches. Behavioral Neurology,3, 6319826.
- Gonzales, M.M, Samra, J, O’Donnell, A, Mackin, S.R, Salinas, J, Jacob, M, Satizabal, C.L, Aparicio, H.J, Thibault, E.G, Sanchez, J.S, Finney, R, Rubinstein, Z.B, Mayblyum, D.V, Kiliany, R.J, DeCarli, C.S, Johnson, K.A, Beiser, A.S, Seshadri, S. (2021). Association of midlife depressive symptoms with regional amyloid beta and tau in the Framingham Heart Study. Journal of Alzheimer’s Disease, 82, 249-260.
- Gonzalez, D.A., Resch ZJ, Gonzales, M.M., Soble JR, Fonggang (2021). Cognitive screening with functional assessment improves diagnostic accuracy and attenuates bias. Alzheimer’s & Dementia: Diagnosis, Assessment, & Disease Monitoring, 8, e12250.
- Zill, EM, O’Donnell, A, Salinas, J, Aparicio, HJ, Gonzales, M.M, Jacob, M, Beiser, A, Seshadri, S. (2021). Herpes labialis, Chlamydophila pneumoniae, Helicobacter pylori and cytomegalovirus infections and risk of
dementia: The Framingham Heart Study. Journal of Alzheimer’s Disease, 82, 593-605. - Du, Y, Dennis, B, Liu, J, Meyer, K, Siddiqui, N, Lopez, K, White, C, Myneni, S, Gonzales, M.M, Wang, J. (2021). A conceptual model to improve care for individuals with Alzheimer’s disease and related dementias and their caregivers: Qualitative findings in an online caregiver forum. Journal of Alzheimer’s Disease, 81, 1673-1684.
- Gonzales, M.M, Short, M, Satizabal, C, O'Bryant, S, Tracy, R, Zare, H, Seshadri, S. (2021). Biomarkers for dementia in Hispanic and non-Hispanic white adults. Alzheimer's & Dementia: Translational Research & Clinical Intervention, 7, e12164.
- Gonzales, M.M., Wang, C.P., Quiben, M., MacCarthy, M., Seshadri, S., Jacob, M., & Hazuda, H. (2020). Joint trajectories of cognition and gait speed in Mexican Americans and European American older adults: The San Antonio Longitudinal Study of Aging. International Journal of Geriatric Psychiatry, 35, 897-906.
- Morin, R., Gonzales, M.M., Bickford, D., Insel, P.S., Mackin, R.S. (2019). Impaired financial capacity in late-life depression: Revisiting associations with cognitive functioning. Journal of the International Neuropsychological Society, 25, 1088-1093.
- Gonzales, M.M., Durazo-Arvizu, R.A., Sachdeva, S., Unterman, T.G., O'Brien, M.J., Gallo, L.C., Talavera, G.A., Kaplan, R.C., Cai, J., Schneiderman, N. Giacinto, R.A. & Lamar, M. (2019). Associations of insulin resistance with cognition in individuals without diagnosed diabetes: Results from the Hispanic Community Health Study/Study of Latinos. Diabetes Research and Clinical Practice, 150, 38-47.
- Gonzales, M.M., Insel, P.S., Nelson, C., Tosun, D., Scholl, M., Mattsson, N., Sacuiu, S., Bickford, D., Weiner, M.W., Mackin, R.S., & the Alzheimer’s Disease Neuroimaging Initiative (2018). Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. International Journal of Geriatric Psychiatry, 33, 1305-1311.
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Clinical
Board Certifications
- 2019 - Clinical Neuropsychology American Board of Professional Psychology