Mitzi Gonzales, PhD, ABPP-CN

• Professional Background

  Education

  • 2015 - PhD - Clinical Psychology - University of Texas at Austin
  • 2011 - MA - clinical Psychoogy - University of Texas at Austin
  • 2006 - BA - Psychology - Occidental College, Los Angeles, CA

  Training

  • 2017 - Fellowship - clinical Neuropsychology - VA Northern California
  • 2015 - Internship - Clinical Psychology - University of Chicago at Illinois

  Highlights

  06/2022   Article of the Year.   Revisiting apathy in Alzheimer’s disease: From conceptualization to therapeutic approaches). Behavioral Neurology  
  09/2020   Selected Fellow of the Inaugural Class. Institute on Methods & Protocols for Advancement of Clinical Trials in Alzheimer’s Disease 
  06/2020   Best Research Abstract. International Society to Advance, Alzheimer’s Research and Treatment
  05/2020   Selected Scholar of the Univ of Michigan Pepper Ctr Mock Study Retreat
   

  Appointments

  • 10/2022 - Associate Professor with Tenure - UT Health San Antonio, Dept of Radiology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
  • 09/2022 - Associate Professor with Tenure - UT Health San Antonio, Dept of Neurology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
  • 08/2021-08/2022 - Assistant Professor - UT Health San Antonio, Dept of Neurology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases
  • 10/2017-06/2021 - Assistant Professor/Clinical - UT Health San Antonio, Dept of Neurology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases

• Instruction & Training

  • 12/20/2022, Neuropsychological Outcomes Following organ Transplantation, Dell Medical School, UT Austin Neuropsychology Didactics
  • 07/20/22, Levy Body Dementia, Dell Medical School, UT Austin Neuropsychology Didactics
  • 05/12/21, Parkonson's Dementia & Lewy body Dementia, UTHSCSA School of Medicine Neurology Residency Program
  • 03/19/21, Senescene as a Mechanism Underlying Alzheimer's Disease, UTHSCSA School of Medicine, Neurology Grand Rounds
  • 01/20/21, Neuropsychological Outcomes Following Organ Transplantation, Dell Medical School, UT Austin Neuropsychology Didactics
  • 04/10/2020, Sleep Disturbances - Harbingers and Promoters of Neurodegenerative Disease, UTHSCSA School of Medicine, Neurology Grand Rounds
  • 03/13/20, Sleep Disturbances and Dementia, Audie Murphy VA Neuropsychology Grand Rounds
  • 05/11/19, Parkinson's Dementia & Lewy body Dementia, UTHSCSA School of Medicine Neurology Resident Program
  • 03/15/19, Big Data and Public Health - Issues in Dementia Research, UTHSCSA School of Medicine, Joint MD/MPH Program
  • 02/15/19, Professional and Ethical Issues in Clinical Neuropsychology , Audie Murphy VA Neuropsychology Grand Rounds
  • 10/22/18, Dementia Updates - American Academy of Neurology and American Psychiatric Association, UTHSCSA School of Medicine, Neurology Grand Rounds

• Research & Grants

  Research profile

  Grants

  • The RSELVES Study: Remote Sensing of Engagement in Life and Variability in Everyday Support Characterizing Older Mexican (American) Participation in Activity Digitally Reliably and Ecologically with the CART Platform (COMPADRE CART): Implications for Cognition & ADRD Multiethnic Machine Learning Signatures of ADRD
  • Epidemiology of Blood Pressure Responses to Perturbations: Correlates & Prognosis for vascular risk, end-organ damage, cognitive aging, and preclinical Alzheimer’s disease
  • Identifying ADRD intervention targets by characterizing neurobiological mechanisms of social isolation, loneliness, and social environment using novel imaging, molecular markers, and machine learning

• Service

  Department

  09/29/2021                 UTHSCSA Pepper Center    (External Advisory Board Meeting)
  05/24/2021                 South Texas Alzheimer’s Center    (External Advisory Board Meeting)
  01/2021 – Present      National Alzheimer’s Coordinating    (Neuropsychology Lead Center Dementia Consensus Reviews)
  06/2020 – Present      Neuropsychology Fellowship Progam
  05/2020 – Present      Biggs Research Assistant Cognitive Assessment Training 
  10/2019 – Present      Neuropsychology Research
   

  Institutional

  03/15/2020                  UTHSCSA Pepper Center Council  (Advisory Board)
  06/2020 – Present       South Texas Alzheimer’s Center Clinical Core  (Co-Leader)
  10/2018 –  10/2020     UTHSCSA School of Nursing Caring for the Caregiver Program. (Instructor)               

                                                             

  Service to the Profession

  02/10/2023   Health Education           Developments Alzheimer’s And Related Dementias. (Presenter)
  10/19/2022   Health Education           Preclinical Indicators of Disease  (Presenter)
  10/03/2022   Health Education           Developments in Treatment And Prevention of Alzheimer’s. (Presenter)
  09/23/2022   Health Education           Dementia and Sleep  (Presenter)
  03/16/2021   Health Education           Participation in Health Science Research (Educator)

  National

  01/2023-Present     National Alzheimer’s Coordinating Center Scientific Review Committee 
  01/2023-Present     DISCOVERY Study Cognitive Core Committee 
  06/2022                   Clinical Trials for Alzheimer’s Disease  (Abstract Reviewer)
  05/2022                   American Aging Association  (Abstract Reviewer)
  01/2021 – Present   American Federation for Aging Research National Scientific Advisory Council
  06/2018 – Present   MarkVCID Clinical Core Committee  (Site Leader)
  01/2018 – 06/2022  Framingham Heart Study Dementia Dementia Case Consensus Committee  (Neuropsychology Lead)

   

   

  Community

  10/2018 & 10/2019        South Texas Alzheimer’s Disease Community Conference. (Biggs Representative)
  10/2018 & 10/2019        Walk to End Alzheimer’s Disease  (Biggs Representative) 

              

• Publications

  1. Salem, H, Suchting, R, Gonzales, M. M, Seshadri, S, Teixeira, AL. (2023). Apathy as a predictor of conversion from mild cognitive impairment to Alzheimer’s disease: A Texas Alzheimer’s Research and Care Consortium Cohort-based analysis. Journal of Alzheimer’s Disease (online ahead of print). 
  2. Gonzales, M. M, Wiedner, C, Wang, C, Liu, Q, Bis, JC, Li, Z, et al. (2022). A population-based meta-analysis of circulating GFAP for cognition and dementia risk. Annals of Clinical Translational Neurology, 9(10): 1574-1585.
  3. Gonzales, M. M, Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Kraig, E., & Orr, M. E. (2022). Biological aging processes underlying cognitive decline and neurodegenerative disease. The Journal of Clinical Investigation, 132, e158453.
  4. Miller, LM, Steele, JS, Wu, CY, Kaye, J, Dodge, HH, Gonzales, M. M, Lyons, KS. (2022). Depressive symptoms in older adult couples: Associations with dyadic physical health, social engagement, and close friends. Frontiers in Psychiatry, 13, 989128.
  5. Gonzales, M.M, Garbarino, VR, Marques Zilli, E, Petersen, RC, Kirkland, JL, Tchkonia, T, Musi, N, Seshadri, S, Craft, S, Orr, ME. (2022). Senolytic therapy to modulate the progression of Alzheimer’s disease (SToMP-AD): A pilot clinical trial. Journal of Prevention of Alzheimer’s Disease, 9, 22-29.
  6. Zheng, Y, Habes, M, Gonzales, M.M, Pomponio, R, Nasrallah, I, Khan, S, et al. (2022). Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study. Aging, 14(4), 1691-1712.
  7. DeVito, LM, Barzilai, N, Cuervo, AM, Niedernhofer, LJ, Milman, S, Levine M, Proislow, D, Ferruci, L, Kuchel, GA, Mannick, J, Justice, J, AL, Gonzales, M.M, Kirkland, JL, Cohen P, Campisi (2022). Extending human healthspan and longevity: a symposium report. Annals of the New York Academy of Sciences, 1507, 70-83.
  8. Gonzales, M. M., Wang, C. P., Short, M. I., Parent, D. M., Kautz, T., MacCarthy, D et al. (2022). Blood biomarkers for cognitive decline and clinical progression in a Mexican American cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14(1), e12298.
  9. Quiroz, YT Solis, M, Aranda, MP, Arbaje, AI, Arroyo‐Miranda, M, Cabrera, LY, Carrasquillo, MM, Corrado, MM, Crivell, L, Diminch, ED, Dorsman, KA, Gonzales, MM. et al. (2022). Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium. Alzheimer's & Dementia, 18, 1677-1686.
  10. Lin, H., Himali, J. J., Satizabal, C. L., Beiser, A. S., Levy, D., Benjamin, E. J., Gonzales, M.M, et al. (2022). Identifying Blood biomarkers for dementia using machine learning methods in the Framingham Heart Study. Cells, 11(9), 1506.
  11. McGrath, E. R., Beiser, A. S., O’Donnell, A., Yang, Q., Ghosh, S., Gonzales, M.M., et al. (2022). Blood phosphorylated tau 181 as a biomarker for amyloid burden on brain PET in cognitively healthy adults. Journal of Alzheimer's Disease, doi: 10.3233/JAD-215639. 
  12. Salinas, J, Beiser, AS, Samra, JK, O’Donnell, A, DeCarli, CS, Gonzales, M.M, Aparicio, HJ, Seshadri, S (2022). Association of loneliness with 10-year dementia risk and early markers of vulnerability for neurocognitive decline. Neurology, 98, e1337-e1348.
  13. Baril, AA, Beiser, AS, Sanchez, E, Mysliwiec, V, Redline, S, Gottlieb, DJ, O’Conner, GT, Gonzales, M.M, Jacob, Himali, D, A, Seshadri, S, Himali, JJ, Pase, M (2022). Insomnia symptom severity and cognitive performance: Moderating role of the APOE genotype. Alzheimer’s & Dementia, 18, 408-421.
  14. González, D.A., Clark, MJ, Gonzales, M. M., Benje, J. (2022). A brief report: An evaluation of item bias on the Functional Activities Questionnaire. Archives of Clinical Neuropsychology (Online ahead of present). 
  15. González, D. A., Resch, Z. J., Gonzales, M. M., Soble, J. R. (2022). A novel method for establishing functional change in older adults with cognitive impairment. Alzheimer’s Disease and Associated Disorders, 36, 238-243. 
  16. Gonzalez, D.A., Gonzales, M.M., Resch, Z.J., Sullivan, A.C., Soble, J.R. (2022). Comprehensive evaluation of the Functional Activities Questionnaire (FAQ) and its reliability and validity. Assessment, 29, 748-763. 
  17. Texeira, AL, Salen, H, Martins, LB, Gonzales, M.M, Seshadri, S, Suchting, R (2022). Factors associated with apathy in Alzheimer’s disease: A cross-sectional analysis of the Texas Alzheimer’s Research and Care Consortium. Journal of Alzheimer’s Disease, 86, 403-411.
  18. Gonzales, M.M, Krishnamurthy, S, Garbarino, V, Daeihagh, AS, Gilispie, GJ, Deep G, Craft, S, Orr, ME. (2021). A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials. Mechanisms of Ageing and Development, 200, 11589.
  19. Texeira, AL, Gonzales, M.M, De Souza, LC, Weisenbach, S. (2021). Revisiting apathy in Alzheimer’s disease: From conceptualization to therapeutic approaches. Behavioral Neurology,3, 6319826.
  20. Gonzales, M.M, Samra, J, O’Donnell, A, Mackin, S.R, Salinas, J, Jacob, M, Satizabal, C.L, Aparicio, H.J, Thibault, E.G, Sanchez, J.S,  Finney, R, Rubinstein, Z.B, Mayblyum, D.V, Kiliany, R.J, DeCarli, C.S, Johnson, K.A, Beiser, A.S, Seshadri, S. (2021). Association of midlife depressive symptoms with regional amyloid beta and tau in the Framingham Heart Study. Journal of Alzheimer’s Disease, 82, 249-260.
  21. Gonzalez, D.A., Resch ZJ, Gonzales, M.M., Soble JR, Fonggang (2021). Cognitive screening with functional assessment improves diagnostic accuracy and attenuates bias. Alzheimer’s & Dementia: Diagnosis, Assessment, & Disease Monitoring, 8, e12250.
  22. Zill, EM, O’Donnell, A, Salinas, J, Aparicio, HJ, Gonzales, M.M, Jacob, M, Beiser, A, Seshadri, S. (2021). Herpes labialis, Chlamydophila pneumoniae, Helicobacter pylori and cytomegalovirus infections and risk of
      dementia: The Framingham Heart Study. Journal of Alzheimer’s Disease, 82, 593-605.
  23. Du, Y, Dennis, B, Liu, J, Meyer, K, Siddiqui, N, Lopez, K, White, C, Myneni, S, Gonzales, M.M, Wang, J. (2021). A conceptual model to improve care for individuals with Alzheimer’s disease and related dementias and their caregivers: Qualitative findings in an online caregiver forum. Journal of Alzheimer’s Disease, 81, 1673-1684.
  24. Gonzales, M.M, Short, M, Satizabal, C, O'Bryant, S, Tracy, R, Zare, H, Seshadri, S. (2021). Biomarkers for dementia in Hispanic and non-Hispanic white adults. Alzheimer's & Dementia: Translational Research & Clinical Intervention, 7, e12164.
  25. Gonzales, M.M., Wang, C.P., Quiben, M., MacCarthy, M., Seshadri, S., Jacob, M., & Hazuda, H. (2020). Joint trajectories of cognition and gait speed in Mexican Americans and European American older adults: The San Antonio Longitudinal Study of Aging.  International Journal of Geriatric Psychiatry, 35, 897-906.
  26. Morin, R., Gonzales, M.M., Bickford, D., Insel, P.S., Mackin, R.S. (2019). Impaired financial capacity in late-life depression: Revisiting associations with cognitive functioning. Journal of the International Neuropsychological Society, 25, 1088-1093. 
  27. Gonzales, M.M., Durazo-Arvizu, R.A., Sachdeva, S., Unterman, T.G., O'Brien, M.J., Gallo, L.C., Talavera, G.A., Kaplan, R.C., Cai, J., Schneiderman, N. Giacinto, R.A. & Lamar, M. (2019). Associations of insulin resistance with cognition in individuals without diagnosed diabetes: Results from the Hispanic Community Health Study/Study of Latinos. Diabetes Research and Clinical Practice, 150, 38-47.
  28. Gonzales, M.M., Insel, P.S., Nelson, C., Tosun, D., Scholl, M., Mattsson, N., Sacuiu, S., Bickford, D., Weiner, M.W., Mackin, R.S., & the Alzheimer’s Disease Neuroimaging Initiative (2018). Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. International Journal of Geriatric Psychiatry, 33, 1305-1311. 

• Clinical

  Provider profile

  Board Certifications

  • 2019 - Clinical Neuropsychology American Board of Professional Psychology