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  • Lee Birnbaum
Lee Birnbaum

Contact

210-450-9060

birnbaum@uthscsa.edu

For administrative calls, please contact:

  • Donna Nolan
  • nolandj@uthscsa.edu
  • 210-567-3129

Departments & Divisions

  • Department of Neurology
  • Department of Neurosurgery

Lee Birnbaum

Professor

  • Professional Background

    Education

    • 2007 - MS - Neuro-epidemiology - Columbia University School of Public Health, New York, NY
    • 2001 - MD - Medicine - Ohio State University College of Medicine, Columbus, OH
    • 1997 - BA - Zoology - Miami University, Oxford, OH

    Training

    • 2009 - Endovascular Neurosurgery - Institute for Neurology and Neurosurgery, Roosevelt Hospital, New York, NY
    • 2007 - Stroke and Critical Care - Columbia University Medical Center, New York, NY
    • 2005 - Neurology - University of Louisville, Louisville, KY
    • 2002 - Internal Medicine - Mt. Carmel Health System, Columbus, OH

    Appointments

    • 2021 - Professor/Clinical - University of Texas Health San Antonio, Department of Neurology/Neurosurgery/Radiology, San Antonio, TX
    • 2021 - ACGME Vascular Neurology Program and Director - University of Texas Health San Antonio, Department of Neurology, San Antonio, TX
    • 2021 - Division Chief and Vascular Neurology - University of Texas Health San Antonio, Department of Neurology, San Antonio, TX
  • Research & Grants

    Grants

    RESEARCH GRANTS:

    Federal

     

    Funding Agency: StrokeNet

    Title: Anticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)

    Status: Active

    Period: 11/2019 - 04/2024

    Role: Co-Investigator

    Grant Detail: ASPIRE is a randomized, double-blinded, phase III clinical trial designed to test the efficacy and safety of anticoagulation, compared with aspirin, in patients with a recent ICH and high-risk non-valvular AF (CHA2DS2-VASc score ≥ 2). Seven hundred patients will be enrolled over 3.5 years and followed for study outcomes for a minimum of 12 months and maximum of 36 months. The primary efficacy outcome is any stroke (hemorrhagic or ischemic) or death from any cause. The secondary efficacy outcome is the change in the modified Rankin Scale score. Recruitment will take place at sites coordinated through the NIH/NINDS StrokeNet.

     

     

    Funding Agency: National Institute of Neurological Disorders and Stroke (NINDS)

    Title: AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

    Status: Active

    Period: 01/2018 - Present

    Role: Co-Investigator

    Grant Detail: ARCADIA is a multicenter, biomarker-driven, randomized, double-blind, active-control, phase 3 clinical trial of apixaban versus aspirin in patients who have evidence of atrial cardiopathy and a recent stroke of unknown cause. Eleven hundred subjects will be recruited over 2.5 years at 120 sites in the NINDS StrokeNet consortium. Subjects will be followed for a minimum of 1.5 years and a maximum of 4 years for the primary efficacy outcome of recurrent stroke and the primary safety outcomes of symptomatic intracranial hemorrhage and major hemorrhage other than intracranial hemorrhage.

     

     

    Funding Agency: National Institute of Health

    Title: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)

    Status: Active

    Period: 07/2010 - 07/2017

    Role: Principal Investigator

    Grant Detail: The goal of this study is to identify differences in risk factor distribution, imaging characteristics, and outcomes in a multi-center case control study of intracerebral hemorrhage.

     

    Private

     

     

    Funding Agency: GENENTECH

    Title: A PHASE III, PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF THROMBOLYSIS IN IMAGING-ELIGIBLE, LATE-WINDOW PATIENTS TO ASSESS THE EFFICACY AND SAFETY OF TENECTEPLASE (TIMELESS)

    Status: Active

    Period: 06/2019 - Present

    Role: Co-Principal Investigator

     

    Grant Detail: This study will evaluate the efficacy and safety of tenecteplase compared with placebo in patients with acute ischemic stroke (AIS). All patients will receive standard-of-care therapy according to American Heart Association / American Stroke Association clinical guidelines (2018). To determine eligibility for randomization, all patients will undergo multimodal CT or MRI at baseline. Only patients with a vessel occlusion (ICA or MCA) and penumbral tissue will be randomized.
    The primary analysis is to compare the efficacy of tenecteplase versus placebo in all patients at Day 90.

     

    Funding Agency: ReNeuron Limited

    Title: A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03) in Subjects With Disability Following an Ischemic Stroke

    Status: Active

    Period: 04/2019 - 06/2020

    Role: Co-Investigator

    Grant Detail: This is a randomized, placebo-controlled, multi-center study. Patients with persistent disability 6-12 months following an ischemic stroke will be enrolled following confirmation of eligibility. Patients will be randomized 1:1 to undergo a stereotactic surgery and receive a single administration of CTX0E03 Drug Product by intracerebral implantation or undergo sham surgery only (placebo). Patients will be followed for 12 months after surgery with follow-up assessments occurring at various time points over the 12 months. All eligible patients will be assigned a standardized Physical Therapy (PT) program. Patients will complete their daily PT exercises at home for 12 weeks after their surgery.

     

    Funding Agency: Bayer HealthCare

    Title: NAVIGATE ESUS: Secondary prevention of stroke in patients with Embolic Stroke of Undetermined Source

    Status: Active

    Period: 01/2015 - Present

    Role: Principal Investigator

    Grant Detail: Multicenter, randomized, double-blind, double-dummy, active-comparator, event-driven, superiority phase III study of secondary prevention of stroke and prevention of systemic embolism in patients with a recent Embolic Stroke of Undetermined Source (ESUS), comparing rivaroxaban 15 mg once daily with aspirin 100 mg (NAVIGATE ESUS)

     

    Funding Agency: CEREVAST THERAPEUTICS

    Title: Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke (CLOTBUST-ER)

    Status: Complete

    Period: 05/2014 - 02/2015

    Role: Co-Investigator

    Grant Detail: Phase 3 clinical trial evaluating the use of the company’s proprietary Clotbust ER™ ultrasonic headframe for the treatment of acute ischemic stroke. This worldwide study intends to enroll up to 800 ischemic stroke patients in a randomized, double-blinded clinical trial designed to evaluate the efficacy and safety of the Clotbust ER™ ultrasound device when used in combination with standard intravenous thrombolytic therapy.

     

    Funding Agency: Edwards Lifesciences Corp

    Title: The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII A (PARTNERII A)

    Status: Active

    Period: 09/2012 - 01/2029

    Role: Contributor

    Grant Detail: The safety and effectiveness of the SAPIEN XT transcatheter heart valve with novaflex ASCENDRA/ASCENDRA II Delivery systems in intermediate risk for aortic valve surgery and patients who cannot undergo surgery

     

    Funding Agency: American Nurses‘ Foundation

    Title: Toward a Better Understanding of Readmissions for Elderly Stroke Survivors

    Status: Complete

    Period: 09/2011 - 08/2013

    Role: Co-Investigator

    Grant Detail: The purpose of this mixed-methods study is to identify patient/caregiver and health care system factors that are associated with readmission for older adult stroke survivors in the initial 6 months following a stroke. Through a better appreciation of the factors associated with readmission, including the perspectives of both the stroke survivor and family caregiver and how the current system of care is addressing their needs, we will be positioned to implement and evaluate changes to the system of care to improve outcomes for older adults with stroke and their families.

     

    Funding Agency: Penumbra

    Title: Imaging Guided Patient Selection for Interventional Revascularization Therapy (START)

    Status: Complete

    Period: 07/2010 - 07/2011

    Role: Principal Investigator

     

    Grant Detail: Clinical Outcome in Acute Stroke Treatment after Imaging Guided Patient Selection for Interventional Revascularization Therapy. The objective of this clinical evaluation is to determine the safety and effectiveness of the Penumbra System in a stroke cohort who presents within eight hours from symptom onset and witha know core infarct volume at admission.State

     

    Funding Agency: Lone Star Stroke Research Consortium / Texas Department of State Health Services

    Title: Optimal Delay Time to Initiate Anticoagulation after Ischemic Stroke in Atrial Fibrillation (START): a pragmatic, adaptive randomized clinical trial.

    Status: Active

    Period: 01/2019 - Present

    Role: Co-Investigator

    Grant Detail: Long-term oral anticoagulation is standard for secondary stroke prevention in patients with atrial fibrillation (AFib). However, there is limited data and no consensus on the timing of when to initiate anticoagulation therapy, and concern that starting too soon risks symptomatic hemorrhagic transformation. These data are derived almost exclusively from heparins and Vitamin K antagonists (e.g.,warfarin). Now that NOACs have become the mainstay of stroke prophylaxis in AFib and have more rapid and consistent anticoagulation and fewer strokes (hemorrhagic especially), the question of optimal timing of NOAC initiation is of increasing importance.
    The primary aim is to determine the time-to-treatment interval with the lowest associated risk for adverse events in the context of anticoagulation therapy with NOACs for acute stroke patients with non-valvular AFib. The question will be investigated with a prospective, adaptive, randomized, controlled "dose-exploration" trial with the time to treatment with NOAC therapy treated as the incremental "dose".

     

    Funding Agency: Lone Star Stroke Research Consortium / Texas Department of State Health Services

    Title: Intra-arterial Transfer Time Metric Study (IA-TIMES)

    Status: Complete

    Period: 01/2017 - 06/2019

    Role: Co-Investigator

    Grant Detail: This study will help establish protocols to optimize processes that will accelerate the transfer of these patients in order to receive treatment faster. We, therefore, aim to describe the current landscape of IAT transfer times at Texas CSCs/IAT-capable stroke centers to identify barriers/delays in the transfer process (phase 1). We then seek to develop best practices to optimize the transfer of patients destined for IAT (phase 2)

     

    Funding Agency: Lone Star Stroke Consortium

    Title: Nursing-driven Acute Stroke Care (NAS-Care)

    Status: Complete

    Period: 03/2016 - 01/2018

    Role: Co-Investigator

    Grant Detail: NAS-Care is a quality improvement Lone Star Stroke (LSS) study that aims to determine the effect of nursing-driven stroke protocols in telestroke hospitals. The goal of NAS-Care is to empower emergency department (ED) nurses to be engaged leaders in the stroke code process. Part of this empowerment involves the nursing staff activating stroke codes, performing standing orders, and working in parallel to quickly and efficiently accomplish a common goal – to gather all information needed to make a tP-A decision as quickly as possible.

     

    Funding Agency: Lone Star Stroke Research Consortium / Texas Department of State Health Services

    Title: Efficient Resource Utilization for Patients with Intra-Cerebral Hemorrhage (EnRICH)

    Status: Active

    Period: 01/2016 - Present

    Role: Co-Investigator

    Grant Detail: The EnRICH study is enrolling ICH patients across four large metropolitan areas in Texas. Patients are enrolled from large treatment centers and community hospitals and are followed for long-term outcomes. These data will provide evidence regarding the potential benefit to ICH patients from being managed at a higher level of care (i.e. large stroke treatment centers across the state of Texas). Aspects of ICH care that influence long-term functional and cognitive outcomes are also being studied. In doing so, the study will help guide the development of protocols for optimal management of patients with ICH at hospitals with different levels of care.

     

    Funding Agency: Lone Star Stroke Research Consortium / Texas Department of State Health Services

    Title: Lone Star Stroke TeleStroke Registry (LESTER)

    Status: Active

    Period: 09/2015 - Present

    Role: Co-Investigator

    Grant Detail: LESTER is a telestroke registry that is the first of its kind to seek to understand how stroke care is delivered and how outcomes are achieved with the use of telemedicine in the state. A web-based registry is implemented at sites where a telestroke service is active and primarily involves a stroke coordinator or primary contact who sends a short monthly report on discharge information of admitted stroke patients seen over telemedicine. This will help understand the patterns, mechanisms, and impact of regional stroke care in the context of expanding the telestroke network in the state of Texas.

     

    Funding Agency: School of Nursing - Dean‘s Catalyst Award

    Title: A User-Centered Design Approach to the Development and Feasibility Testing of a Multimodal Mobile Intervention for Stroke Survivors and their Family Caregivers

    Status: Complete

    Period: 06/2013 - 12/2015

    Role: Co-Investigator

    Grant Detail: Purpose/Objectives: The purpose of this pilot study was to develop and test the feasibility of a multimodal mobile intervention for blood pressure control, targeting underserved stroke survivors and their caregivers. Our long-term goal is to improve blood pressure control in persons at risk for recurrent stroke.

  • Service

    Department

    01/2012-Present

    Director, Vascular Neurology Fellowship - Director

    Program Director of Vascular Neurology Fellowship

     

    10/2009-Present

    Director, Stroke Services - Director

    I am the Director of the UHS Stroke Service, a Primary Stroke Center certified by the Joint Commission on the Accreditation of Healthcare Organizations

    Institutional

    01/2018-Present

    Medical Executive Committee - Member at Large

    Member at large

     

    01/2011-Present

    University

    Institutional Review Board - Member

    Active member reviewing research proposals

     

    01/2010-Present

    Reviewer for Clinical and Translational Science Award - Reviewer

    I annually review grant applications for the Clinical and Translational Science Award (CTSA) which was granted to the University of Texas Health Science Center at San Antonio (UTHSCSA) by the NIH.

     

    10/2009-Present

    Department

    Neurology Residency Program Selection Committee - Interviewer

    Assist with interviewing and ranking of applications for the Neurology residency program. Interviews as held weekly over a three-month timeframe.

    Service to the Profession

    07/2012-Present

    Inpatient

    Baptist St. Luke's Hospital - Attending Physician

    Attending physician on the neurology/stroke service one to two weeks per month. Respond to inpatient consults for stroke patients.

     

    01/2010-Present

    Inpatient

    University Hospital Stroke Service - Attending Physician

    Provide 24/7 call coverage of University Health System stroke service one to two weeks per month.

     

    01/2010-Present

    Outpatient

    Stroke Follow-up Clinic - Attending Physician

    Attending physician in Stroke Clinic providing outpatient follow-up and continuity of care for stroke patients recently discharged from University Hospital.

    Community

    06/2012-06/2012

    Sleep and Stroke Risk: Too little sleep could put you at risk for stroke interview by Wendy Rigby.

     

    01/2011-01/2011

    Television Interview with KSAT 12 News-On Pubue Awareness for Novel Stroke Therapies "Curry Spice"

  • Publications

      PUBLICATIONS: ('*' indicates Peer Reviewed)

      Abstract

      1. Aaisha Mozumder MD, Sujani Bandela MD, David Wampler PhD LP, Michele Patterson MSN RN, David Miramontes MD, Emily Kidd MD, Jeanette Tovar BSN RN, Ashley Garza MSN RN, Bonnie Blanchard BSN RN, Adam Blanchette MD, Lee Birnbaum MD MS. Inclusion of Asymmetric Bilateral Weakness Optimizes VAN Pre-hospital LVO Triage 2021 Jun. (Southwest Texas Regional Advisory Council Annual Conference).

       

      2. Paola M Martinez, MD, Lee A Birnbaum, MD, MS, Chen-Pin Wang, PhD, Sudha Seshadri, MD, Helen Hazuda, PhD, Alexa Beiser, PhD. Original and Revised Framingham Stroke Risk Profile Performance in a South Texas Bi-ethnic Cohort 2021 Mar. (International Stroke Conference: Virtual).

       

      3. Arash Shadman MD, Aaisha Mozumder MD, Mateja de Leonni Stanonik MD PhD, Michele Patterson MSN RN, David Wampler PhD LP, Michael Stringfellow EMT-P, Emily Kidd MD, David Miramontes MD, Steven Cope NREMT-P, Cheryl Baker BSN RN, Adam Blanchette MD, Lee Birnbaum MD MS. . Pre-hospital VAN Large Vessel Occlusion Screening Tool Predicts Larger Intracerebral Hemorrhage 2020 Feb. (International Stroke Conference: Los Angeles).

       

      4. Michele Patterson MSN RN APRN-CCNS SCRN, Tracy Moore RHIA, Paula Beth Cline MSN RN MHA, Lee Birnbaum MD MS. Outcomes of the Extended Ischemic Stroke Treatment Window 2020 Feb. (International Stroke Conference: Los Angeles).

       

      5. Birnbaum LA. Similarities and Differences in Intracerebral Hemorrhage Risk Factors by Race/Ethnicity 2019 May. (American Academy of Neurology 71st Annual Meeting).

  • Clinical

    Board Certifications

    • 2009 - Vascular Neurology - American Board of Psychiatry and Neurology
    • 2008 - Neurology - American Board of Psychiatry and Neurology
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