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  • Kenneth Yamada
Kenneth Yamada

Contact

kenneth.yamada@nih.gov

Programs

  • Ph.D. in Integrated Biomedical Sciences

Departments & Divisions

  • Department of Cell Systems & Anatomy

Kenneth Yamada, M.D., Ph.D.

NIH Distinguished Investigator Cell Biology Section

National Institutes of Dental and Craniofacial Research

Cell and Developmental Biology Research 

Our research focuses on discovering novel mechanisms and regulators of cell interactions with the extracellular matrix and their roles in craniofacial development and disease. Understanding the underlying mechanisms of these fundamental processes can provide new approaches to tissue regeneration and therapy for diseases such as cancer. Our group explores how coordination between the three-dimensional (3D) extracellular matrix of connective tissue or basement membranes, integrins, signal transduction, and cytoskeleton mediates or regulates 

Associated Diseases: Developmental defects, cancer

Techniques Used: Multiple techniques in cell, molecular, and developmental biology: Advanced fluorescence, brightfield, and 2-photon microscopy, molecular cloning, transfection, RNA interference, viral gene transfer, 1D, 2D and 3D cell culture, organ culture, transgenic mice, knockout mice, protein isolation, gel electrophoresis, western immunoblotting, quantitative PCR

Specific Field of Study: Cell migration, invasion, and organ morphogenesis

  • Publications

      Petrie RJ, Harlin HM, Korsak LI, Yamada KM. Activating the nuclear piston mechanism of 3D migration in tumor cells. J Cell Biol. 2017 Jan 2;216(1):93-100.

      Wang S, Sekiguchi R, Daley WP, Yamada KM. Patterned cell and matrix dynamics in branching morphogenesis. J Cell Biol. 2017 Mar 6;216(3):559-570.

      Artym VV, Swatkoski S, Matsumoto K, Campbell CB, Petrie RJ, Dimitriadis EK, Mueller SC, Bugge TH, Gucek M, Yamada KM. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol. 2015 Feb 2;208(3):331-50.

      Doyle AD, Carvajal N, Jin A, Matsumoto K, Yamada KM. Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. Nat Commun. 2015 Nov 9;6:8720

      Cukierman E, Pankov R, Stevens DR, Yamada KM. Taking cell-matrix adhesions to the third dimension. Science. 2001 Nov 23;294(5547):1708-12.

      Sakai T, Larsen M, Yamada KM. Fibronectin requirement in branching morphogenesis. Nature. 2003 Jun 19;423(6942):876-81.

      Onodera T, Sakai T, Hsu JC, Matsumoto K, Chiorini JA, Yamada KM. Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Science. 2010 Jul 30;329(5991):562-5.

      Endo Y, Ishiwata-Endo H, Yamada KM. Extracellular matrix protein anosmin promotes neural crest formation and regulates FGF, BMP, and WNT activities. Dev Cell 23: 305-316, 2012.

      Kutys ML, Yamada KM. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014 Sep;16(9):909-17.

      Petrie RJ, Koo H, Yamada KM. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science. 2014 Aug 29;345(6200):1062-5.

       

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